Mutagenetix > Incidental Mutation

Incidental Mutation 'R7252:Vmn2r23'

563993

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R7252 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 123741581 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 631 (V631D)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

probably damaging
Transcript: ENSMUST00000172391
AA Change: V631D

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: V631D

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

99% (81/82)

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930480E11Rik	G	T	X: 78,370,705	M345I	probably benign	Het
A730017C20Rik	A	G	18: 59,066,908		probably null	Het
Abcc2	T	A	19: 43,827,949	I1226N	probably damaging	Het
Adarb2	A	G	13: 8,570,180	E234G	probably benign	Het
Ankrd52	T	C	10: 128,381,996	S282P	probably damaging	Het
Arhgef12	A	T	9: 43,015,909	S306R	probably benign	Het
Baiap2	G	T	11: 120,003,039	A514S	probably benign	Het
BC030500	T	A	8: 58,911,804		probably null	Het
C1qtnf12	T	A	4: 155,962,615	W13R	unknown	Het
C87977	T	C	4: 144,212,940	D9G	possibly damaging	Het
Ccdc158	A	G	5: 92,650,788	V351A	probably benign	Het
Cct8	T	C	16: 87,484,919	E485G	probably benign	Het
Cep85	T	C	4: 134,148,031	D542G	probably benign	Het
Clhc1	T	A	11: 29,563,937	S340R	probably benign	Het
Cnot4	A	T	6: 35,069,427	D168E	probably damaging	Het
Cntn5	G	A	9: 9,831,635	T375I	probably benign	Het
Ctc1	T	A	11: 69,026,174	I298N	probably damaging	Het
Dchs2	T	A	3: 83,325,303	N2198K	probably benign	Het
Ddx6	G	A	9: 44,623,753		probably null	Het
Defb11	A	G	8: 21,905,457	I68T	probably benign	Het
Dip2a	C	T	10: 76,273,202	V1212I	not run	Het
Dopey1	T	A	9: 86,500,821	I269N	probably damaging	Het
Efna3	C	T	3: 89,316,664	G73S	possibly damaging	Het
Fam98b	C	G	2: 117,263,892	R228G	probably damaging	Het
Fancd2	A	T	6: 113,556,285	N521I	probably damaging	Het
Farsa	A	G	8: 84,861,328	D134G	probably damaging	Het
Fat2	A	T	11: 55,311,262	F329I	probably damaging	Het
Gm14399	A	T	2: 175,133,198	I43K	probably damaging	Het
Gpr15	A	G	16: 58,718,397	S110P	probably damaging	Het
Gpr157	T	C	4: 150,098,874	V167A	probably benign	Het
Hacd4	A	G	4: 88,426,763	I134T	possibly damaging	Het
Hpgd	T	A	8: 56,298,426	N96K	probably damaging	Het
Insm2	A	T	12: 55,600,520	T350S	probably benign	Het
Iqch	C	T	9: 63,512,236		probably null	Het
Kmt2d	A	G	15: 98,844,266	S4338P	unknown	Het
Krtap9-3	A	G	11: 99,597,970	S29P	probably benign	Het
Kyat3	T	A	3: 142,720,458	S87T	probably benign	Het
Mrpl46	T	C	7: 78,780,588	T145A	probably benign	Het
Neb	A	G	2: 52,324,961		probably null	Het
Olfr1232	T	A	2: 89,326,285		probably benign	Het
Olfr170	A	T	16: 19,606,499	H55Q	probably damaging	Het
Olfr461	A	G	6: 40,544,769	I70T	probably benign	Het
Olfr829	A	G	9: 18,857,252	Y200C	probably damaging	Het
Olfr986	C	T	9: 40,187,361	T82I	probably benign	Het
Otogl	T	C	10: 107,821,943	D1042G	probably benign	Het
Paxip1	C	T	5: 27,760,086	V659I	probably damaging	Het
Pfkl	A	G	10: 77,993,429	W382R	probably damaging	Het
Pfn1	A	G	11: 70,654,471	W4R	probably damaging	Het
Pik3c2b	G	A	1: 133,094,734	R1138H	probably benign	Het
Pkd1l3	A	G	8: 109,660,698	D1758G	probably benign	Het
Pmpca	G	C	2: 26,395,034	E424Q	possibly damaging	Het
Prdm12	A	G	2: 31,642,374	N132S	possibly damaging	Het
Prokr2	T	A	2: 132,381,440	M61L	probably benign	Het
Ralgapa2	T	C	2: 146,342,751		probably null	Het
Ralgps1	A	T	2: 33,168,188	D301E	probably benign	Het
Rcbtb2	T	C	14: 73,166,780	Y231H	probably damaging	Het
Rcc2	G	A	4: 140,702,275	C40Y	probably benign	Het
Relb	C	A	7: 19,612,613	E345*	probably null	Het
Rhbdl3	A	C	11: 80,337,585	M294L	possibly damaging	Het
Rpl24	G	A	16: 55,970,116	A112T	possibly damaging	Het
Rsbn1l	C	T	5: 20,908,198	R442Q	probably damaging	Het
Rxfp3	A	T	15: 11,035,939	I449N	probably benign	Het
Sema4c	A	C	1: 36,550,015	C677G	probably damaging	Het
Sf3b3	A	C	8: 110,839,930	I256S	probably damaging	Het
Shank1	C	T	7: 44,327,161	A561V	unknown	Het
Slc39a6	G	T	18: 24,601,385	N82K	possibly damaging	Het
Slc3a2	T	C	19: 8,723,157		probably benign	Het
Stard13	T	C	5: 151,063,169	Q292R	probably benign	Het
Tgm6	A	G	2: 130,144,964	R451G	probably damaging	Het
Tspo	G	T	15: 83,572,265	G83V	probably damaging	Het
Ubxn10	T	C	4: 138,720,876	Q163R	probably benign	Het
Ushbp1	A	G	8: 71,394,602	S129P	probably benign	Het
Vmn2r24	T	C	6: 123,787,232	I356T	possibly damaging	Het
Vmn2r84	C	T	10: 130,386,410	C647Y	probably damaging	Het
Vps13a	T	C	19: 16,661,064	E2356G	probably benign	Het
Wdr64	A	G	1: 175,775,674	T614A	probably benign	Het
Zdhhc16	G	T	19: 41,941,551	W271L	probably damaging	Het
Zer1	A	C	2: 30,101,892	S652A	probably damaging	Het
Zfp287	A	G	11: 62,724,829	V224A	probably damaging	Het
Zfp438	A	T	18: 5,214,874	L28*	probably null	Het
Zfp830	G	A	11: 82,764,708	A113T	probably benign	Het
Zfp865	G	T	7: 5,034,417		probably benign	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123729725	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123729596	missense	probably benign
IGL01073:Vmn2r23	APN	6	123712800	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123704424	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123704407	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123741886	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123741860	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123741744	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123741836	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123704478	missense	probably benign
IGL02831:Vmn2r23	APN	6	123704385	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123704396	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123741619	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123741782	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123704374	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123729626	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123729721	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123742135	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123742004	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123713270	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123713427	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123729690	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123702915	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123713010	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123741499	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123704425	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123742188	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123713170	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123741389	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123729738	missense	probably benign
R4506:Vmn2r23	UTSW	6	123702925	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123741730	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123741826	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123733349	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123713002	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123733273	missense	probably benign
R5761:Vmn2r23	UTSW	6	123712759	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123712942	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123741895	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123704400	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123712902	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123713425	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123733273	missense	probably benign
R6925:Vmn2r23	UTSW	6	123704553	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123713022	missense	probably benign
R7215:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R7403:Vmn2r23	UTSW	6	123704579	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123704541	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123741353	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123704640	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123741656	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123713472	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123703032	missense
R8966:Vmn2r23	UTSW	6	123742120	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123742079	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123741823	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123712713	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123712713	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123713116	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123713161	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123742108	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123729725	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- TGCATCAAGTGTCCTGAAGATC -3'
(R):5'- CCACATTTGTAAGGTGCTTCG -3'

Sequencing Primer
(F):5'- CAAGTGTCCTGAAGATCAGTATCC -3'
(R):5'- CGTGGTTTGATGGACTTGAAGGC -3'

Posted On

2019-06-26