Incidental Mutation 'R7254:Tada1'
ID 564118
Institutional Source Beutler Lab
Gene Symbol Tada1
Ensembl Gene ENSMUSG00000026563
Gene Name transcriptional adaptor 1
Synonyms Tada1l, 2900026B15Rik
MMRRC Submission 045315-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7254 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 166206736-166221190 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 166216217 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 139 (C139*)
Ref Sequence ENSEMBL: ENSMUSP00000027846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027846] [ENSMUST00000131487] [ENSMUST00000135673] [ENSMUST00000169324]
AlphaFold Q99LM9
Predicted Effect probably null
Transcript: ENSMUST00000027846
AA Change: C139*
SMART Domains Protein: ENSMUSP00000027846
Gene: ENSMUSG00000026563
AA Change: C139*

DomainStartEndE-ValueType
Pfam:SAGA-Tad1 6 131 3.2e-18 PFAM
Pfam:SAGA-Tad1 116 194 4.8e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131487
SMART Domains Protein: ENSMUSP00000116477
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
KRAB 47 107 1.53e-19 SMART
Pfam:BrkDBD 195 247 2.1e-29 PFAM
CENPB 256 323 3.93e-21 SMART
Pfam:DDE_1 355 567 1.4e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135673
SMART Domains Protein: ENSMUSP00000120352
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
KRAB 47 107 1.53e-19 SMART
Pfam:BrkDBD 195 247 2.1e-29 PFAM
CENPB 256 323 3.93e-21 SMART
Pfam:DDE_1 355 567 1.4e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169324
SMART Domains Protein: ENSMUSP00000127395
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 6 18 N/A INTRINSIC
low complexity region 31 46 N/A INTRINSIC
KRAB 66 126 1.53e-19 SMART
Pfam:BrkDBD 214 266 8.7e-29 PFAM
CENPB 275 342 3.93e-21 SMART
Pfam:DDE_1 414 586 1.5e-48 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406B18Rik A T 7: 43,147,623 (GRCm39) D249E probably damaging Het
Acacb A C 5: 114,347,812 (GRCm39) probably null Het
Adnp A G 2: 168,025,918 (GRCm39) V459A probably damaging Het
Arid3b T C 9: 57,704,037 (GRCm39) K304E probably damaging Het
Ash1l G T 3: 88,977,816 (GRCm39) R2713L probably damaging Het
Bmpr1a A C 14: 34,136,720 (GRCm39) D490E probably benign Het
Cacna1g A T 11: 94,323,393 (GRCm39) C1270* probably null Het
Cep295nl G T 11: 118,223,866 (GRCm39) P326Q probably damaging Het
Cfap100 T C 6: 90,383,043 (GRCm39) I377V unknown Het
Creb1 C T 1: 64,615,436 (GRCm39) Q223* probably null Het
Ctsc G A 7: 87,958,767 (GRCm39) G349D probably damaging Het
Ddx41 G A 13: 55,681,769 (GRCm39) R311* probably null Het
Dpcd A G 19: 45,565,473 (GRCm39) Q149R probably benign Het
Dse T A 10: 34,060,144 (GRCm39) probably benign Het
Dync2i1 A G 12: 116,226,205 (GRCm39) probably benign Het
Eef2k C T 7: 120,488,488 (GRCm39) H458Y probably benign Het
Gipr A T 7: 18,897,538 (GRCm39) V90E probably damaging Het
Gm14412 A T 2: 177,009,189 (GRCm39) D22E probably damaging Het
Gm21886 A T 18: 80,132,950 (GRCm39) C69* probably null Het
Gm5114 G A 7: 39,058,390 (GRCm39) L410F probably benign Het
Gmip T A 8: 70,269,118 (GRCm39) probably null Het
Gtf2f1 T C 17: 57,314,101 (GRCm39) T128A possibly damaging Het
Hnrnpr A G 4: 136,059,886 (GRCm39) E330G possibly damaging Het
Hoxd9 T A 2: 74,528,718 (GRCm39) W107R probably damaging Het
Iars1 T C 13: 49,876,554 (GRCm39) probably null Het
Idh2 TCCCAGGGCC TCC 7: 79,748,079 (GRCm39) probably null Het
Ifi213 G T 1: 173,421,529 (GRCm39) P120Q probably damaging Het
Il6 A T 5: 30,219,906 (GRCm39) Q94L probably benign Het
Kcnab1 A G 3: 65,226,908 (GRCm39) S196G probably benign Het
Kcnv1 C T 15: 44,976,604 (GRCm39) V228I probably benign Het
Lars2 A G 9: 123,284,028 (GRCm39) T739A possibly damaging Het
Med13 T C 11: 86,210,661 (GRCm39) S494G probably benign Het
Mtrf1 GCCTTC GC 14: 79,660,931 (GRCm39) probably null Het
Myh9 T G 15: 77,650,024 (GRCm39) Q1646P probably damaging Het
Nif3l1 T A 1: 58,489,625 (GRCm39) S171R probably benign Het
Or13n4 A G 7: 106,422,777 (GRCm39) *319Q probably null Het
Or1e1c A G 11: 73,266,201 (GRCm39) I212V probably benign Het
Or1r1 A G 11: 73,874,603 (GRCm39) V277A probably benign Het
Or51f23 A G 7: 102,452,765 (GRCm39) T27A probably benign Het
Or5b113 A T 19: 13,342,475 (GRCm39) D161V probably benign Het
Or6c5b T C 10: 129,245,649 (GRCm39) V138A probably benign Het
Or8c8 T C 9: 38,164,719 (GRCm39) M2T probably benign Het
Pak5 A T 2: 135,958,684 (GRCm39) S135T possibly damaging Het
Prr29 A T 11: 106,265,684 (GRCm39) M1L probably damaging Het
Ptpn13 T A 5: 103,742,502 (GRCm39) V2407E probably damaging Het
Ralgapa1 T A 12: 55,741,978 (GRCm39) H1310L probably damaging Het
Raph1 T C 1: 60,538,767 (GRCm39) S393G unknown Het
Rgl2 T C 17: 34,153,964 (GRCm39) F457L possibly damaging Het
Ror2 A G 13: 53,272,756 (GRCm39) I303T possibly damaging Het
Runx2 G A 17: 45,125,079 (GRCm39) P80L probably damaging Het
Scn10a C T 9: 119,447,921 (GRCm39) D1378N probably damaging Het
Serpinc1 T A 1: 160,821,188 (GRCm39) C91S probably benign Het
Sorbs1 G C 19: 40,365,244 (GRCm39) R180G probably benign Het
Spata31d1e T C 13: 59,889,790 (GRCm39) I677V probably benign Het
Tbr1 T A 2: 61,636,386 (GRCm39) V254E probably damaging Het
Timd4 A T 11: 46,734,016 (GRCm39) I340F probably benign Het
Tubb2a T C 13: 34,258,515 (GRCm39) Y425C probably damaging Het
Zfp292 A T 4: 34,819,476 (GRCm39) M287K probably damaging Het
Other mutations in Tada1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01462:Tada1 APN 1 166,216,294 (GRCm39) missense probably damaging 1.00
IGL02458:Tada1 APN 1 166,220,203 (GRCm39) missense probably damaging 0.99
R0959:Tada1 UTSW 1 166,216,198 (GRCm39) missense probably benign 0.13
R1442:Tada1 UTSW 1 166,214,319 (GRCm39) missense possibly damaging 0.90
R1586:Tada1 UTSW 1 166,214,319 (GRCm39) missense possibly damaging 0.90
R4790:Tada1 UTSW 1 166,219,523 (GRCm39) missense possibly damaging 0.87
R5344:Tada1 UTSW 1 166,207,081 (GRCm39) intron probably benign
R6782:Tada1 UTSW 1 166,217,541 (GRCm39) missense probably benign 0.25
R7679:Tada1 UTSW 1 166,219,540 (GRCm39) missense probably benign
R7733:Tada1 UTSW 1 166,217,511 (GRCm39) missense probably damaging 0.99
R7831:Tada1 UTSW 1 166,217,442 (GRCm39) missense probably damaging 1.00
R9140:Tada1 UTSW 1 166,216,177 (GRCm39) missense probably benign 0.38
R9175:Tada1 UTSW 1 166,210,005 (GRCm39) missense probably damaging 0.98
R9657:Tada1 UTSW 1 166,214,312 (GRCm39) missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- ATTCCCAGGTATGGCAGATG -3'
(R):5'- ACAGTGTGAAGTGTCTCTCCTTC -3'

Sequencing Primer
(F):5'- ATAGGTTCCAGCCTCAGA -3'
(R):5'- CTCCTTCAATGATGACAGAGAGTGC -3'
Posted On 2019-06-26