Incidental Mutation 'R7258:Kdm5b'
| ID |
564392 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kdm5b
|
| Ensembl Gene |
ENSMUSG00000042207 |
| Gene Name |
lysine (K)-specific demethylase 5B |
| Synonyms |
Jarid1b, Plu1, Rb-Bp2, 2210016I17Rik, 2010009J12Rik, PLU-1, D1Ertd202e |
| MMRRC Submission |
045386-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.268)
|
| Stock # |
R7258 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
134560171-134635285 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 134621021 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Alanine
at position 1088
(E1088A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000038138
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047714]
[ENSMUST00000112198]
|
| AlphaFold |
Q80Y84 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047714
AA Change: E1088A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000038138
Gene: ENSMUSG00000042207
AA Change: E1088A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
744 |
2.2e-17 |
PFAM |
|
Pfam:PLU-1
|
757 |
1088 |
5.6e-92 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
PHD
|
1486 |
1536 |
1.18e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112198
AA Change: E1088A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000107817
Gene: ENSMUSG00000042207
AA Change: E1088A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
745 |
6.7e-21 |
PFAM |
|
Pfam:PLU-1
|
756 |
1088 |
6e-94 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
98% (63/64) |
| MGI Phenotype |
FUNCTION: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body weight, background-sensitive premature mortality, decreased female fertility, delayed mammary gland development, decreased serum estradiol levels, and reduced mammary epithelial cell proliferation in early puberty. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3110079O15Rik |
A |
C |
1: 87,475,067 (GRCm38) |
I40L |
probably benign |
Het |
| 4933402J07Rik |
A |
C |
8: 87,586,177 (GRCm38) |
S197R |
probably damaging |
Het |
| Abcc12 |
T |
C |
8: 86,560,857 (GRCm38) |
R120G |
possibly damaging |
Het |
| Abhd14b |
A |
G |
9: 106,450,219 (GRCm38) |
I67V |
probably benign |
Het |
| Alpk1 |
A |
T |
3: 127,724,466 (GRCm38) |
V62E |
probably damaging |
Het |
| Ankar |
A |
G |
1: 72,651,727 (GRCm38) |
V1196A |
probably benign |
Het |
| B230118H07Rik |
T |
C |
2: 101,610,592 (GRCm38) |
D22G |
probably null |
Het |
| Ccr5 |
A |
T |
9: 124,125,274 (GRCm38) |
K305* |
probably null |
Het |
| Cdc42bpb |
T |
C |
12: 111,326,084 (GRCm38) |
H339R |
probably damaging |
Het |
| Cep290 |
T |
G |
10: 100,499,108 (GRCm38) |
M330R |
probably benign |
Het |
| Cyfip2 |
T |
C |
11: 46,224,177 (GRCm38) |
Y901C |
probably benign |
Het |
| Ddx54 |
T |
G |
5: 120,620,747 (GRCm38) |
Y352D |
probably damaging |
Het |
| Defa35 |
A |
T |
8: 21,065,229 (GRCm38) |
H55L |
possibly damaging |
Het |
| Dnmt3b |
T |
A |
2: 153,683,599 (GRCm38) |
|
probably null |
Het |
| Enpep |
A |
C |
3: 129,332,075 (GRCm38) |
L136R |
probably benign |
Het |
| Epb41l2 |
G |
A |
10: 25,484,287 (GRCm38) |
A516T |
probably damaging |
Het |
| Frmd4a |
A |
T |
2: 4,300,953 (GRCm38) |
Q13L |
probably benign |
Het |
| Frmpd1 |
C |
A |
4: 45,269,974 (GRCm38) |
D271E |
possibly damaging |
Het |
| Gbp5 |
T |
A |
3: 142,506,781 (GRCm38) |
L410H |
probably damaging |
Het |
| Gipc2 |
T |
C |
3: 152,165,715 (GRCm38) |
E58G |
probably damaging |
Het |
| Gm281 |
A |
T |
14: 13,899,648 (GRCm38) |
F91L |
|
Het |
| Gm6309 |
A |
T |
5: 146,168,296 (GRCm38) |
V269E |
probably benign |
Het |
| Grm5 |
A |
T |
7: 88,074,706 (GRCm38) |
T735S |
probably damaging |
Het |
| H6pd |
T |
C |
4: 149,996,362 (GRCm38) |
M9V |
probably benign |
Het |
| Hmcn1 |
A |
G |
1: 150,715,823 (GRCm38) |
I1875T |
probably benign |
Het |
| Hrc |
T |
A |
7: 45,336,296 (GRCm38) |
D290E |
possibly damaging |
Het |
| Ippk |
C |
A |
13: 49,433,862 (GRCm38) |
Q136K |
probably benign |
Het |
| Kcnv1 |
T |
C |
15: 45,109,315 (GRCm38) |
T391A |
probably damaging |
Het |
| L1td1 |
C |
T |
4: 98,736,864 (GRCm38) |
A432V |
probably benign |
Het |
| Ly86 |
A |
G |
13: 37,345,497 (GRCm38) |
D20G |
probably benign |
Het |
| Myo1g |
A |
G |
11: 6,509,416 (GRCm38) |
I818T |
possibly damaging |
Het |
| Nms |
A |
G |
1: 38,946,970 (GRCm38) |
T121A |
probably benign |
Het |
| Olfr1084 |
T |
A |
2: 86,639,001 (GRCm38) |
K236* |
probably null |
Het |
| Olfr1414 |
A |
T |
1: 92,511,176 (GRCm38) |
I284N |
possibly damaging |
Het |
| Olfr350 |
T |
A |
2: 36,850,340 (GRCm38) |
I98K |
probably damaging |
Het |
| Olfr391-ps |
T |
G |
11: 73,799,380 (GRCm38) |
I126L |
probably damaging |
Het |
| Olfr609 |
G |
C |
7: 103,492,589 (GRCm38) |
C96W |
probably damaging |
Het |
| Olfr816 |
T |
A |
10: 129,912,287 (GRCm38) |
|
probably benign |
Het |
| Pcdhb9 |
T |
C |
18: 37,402,114 (GRCm38) |
L387P |
probably damaging |
Het |
| Pcsk1 |
G |
A |
13: 75,093,186 (GRCm38) |
R95H |
probably damaging |
Het |
| Pde11a |
T |
C |
2: 76,139,906 (GRCm38) |
D502G |
possibly damaging |
Het |
| Plekhg2 |
T |
C |
7: 28,364,778 (GRCm38) |
D446G |
probably benign |
Het |
| Ptch1 |
T |
C |
13: 63,573,294 (GRCm38) |
K54E |
not run |
Het |
| Rasal2 |
A |
T |
1: 157,157,700 (GRCm38) |
L826M |
probably damaging |
Het |
| Rnf213 |
A |
G |
11: 119,452,575 (GRCm38) |
I3589V |
|
Het |
| Sin3b |
T |
C |
8: 72,750,208 (GRCm38) |
C757R |
probably benign |
Het |
| Slc41a1 |
T |
A |
1: 131,842,042 (GRCm38) |
V300D |
probably benign |
Het |
| Snrpa1 |
T |
C |
7: 66,070,143 (GRCm38) |
F162L |
probably damaging |
Het |
| Sox30 |
C |
A |
11: 45,980,552 (GRCm38) |
A78E |
unknown |
Het |
| Ssc4d |
G |
T |
5: 135,963,087 (GRCm38) |
A401E |
probably damaging |
Het |
| Steap3 |
A |
G |
1: 120,243,986 (GRCm38) |
F130L |
possibly damaging |
Het |
| Stx5a |
A |
G |
19: 8,754,907 (GRCm38) |
|
probably null |
Het |
| Tgfbr2 |
A |
T |
9: 116,129,830 (GRCm38) |
I172N |
probably damaging |
Het |
| Tgm4 |
A |
G |
9: 123,062,491 (GRCm38) |
D557G |
probably benign |
Het |
| Tmprss11c |
A |
G |
5: 86,271,413 (GRCm38) |
S96P |
probably damaging |
Het |
| Trpa1 |
T |
G |
1: 14,903,249 (GRCm38) |
T282P |
probably damaging |
Het |
| Uba5 |
A |
T |
9: 104,062,933 (GRCm38) |
V5E |
unknown |
Het |
| Ugt2b36 |
A |
T |
5: 87,080,903 (GRCm38) |
L427H |
probably damaging |
Het |
| Utp14b |
T |
A |
1: 78,664,974 (GRCm38) |
H196Q |
probably benign |
Het |
| Vmn2r44 |
T |
A |
7: 8,377,849 (GRCm38) |
L348F |
probably damaging |
Het |
| Vmn2r93 |
T |
G |
17: 18,305,141 (GRCm38) |
L354V |
probably benign |
Het |
| Wwc2 |
T |
A |
8: 47,842,999 (GRCm38) |
N1079Y |
unknown |
Het |
| Zfp653 |
T |
C |
9: 22,065,820 (GRCm38) |
D145G |
probably benign |
Het |
| Zfp777 |
T |
C |
6: 48,025,797 (GRCm38) |
E453G |
probably damaging |
Het |
| Zfp936 |
T |
A |
7: 43,190,379 (GRCm38) |
H423Q |
probably damaging |
Het |
| Zfyve9 |
A |
T |
4: 108,656,954 (GRCm38) |
Y496N |
possibly damaging |
Het |
|
| Other mutations in Kdm5b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00230:Kdm5b
|
APN |
1 |
134,620,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01458:Kdm5b
|
APN |
1 |
134,621,986 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL01567:Kdm5b
|
APN |
1 |
134,602,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01625:Kdm5b
|
APN |
1 |
134,617,968 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL01970:Kdm5b
|
APN |
1 |
134,600,727 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02183:Kdm5b
|
APN |
1 |
134,624,931 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02592:Kdm5b
|
APN |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02695:Kdm5b
|
APN |
1 |
134,604,485 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02697:Kdm5b
|
APN |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
IGL03036:Kdm5b
|
APN |
1 |
134,608,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03056:Kdm5b
|
APN |
1 |
134,587,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03206:Kdm5b
|
APN |
1 |
134,627,317 (GRCm38) |
missense |
probably benign |
|
|
IGL03342:Kdm5b
|
APN |
1 |
134,602,576 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03388:Kdm5b
|
APN |
1 |
134,627,322 (GRCm38) |
missense |
probably benign |
|
|
amaryllis
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
PIT4486001:Kdm5b
|
UTSW |
1 |
134,628,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0233:Kdm5b
|
UTSW |
1 |
134,604,634 (GRCm38) |
splice site |
probably benign |
|
|
R0334:Kdm5b
|
UTSW |
1 |
134,604,522 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0504:Kdm5b
|
UTSW |
1 |
134,621,023 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0505:Kdm5b
|
UTSW |
1 |
134,602,571 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0521:Kdm5b
|
UTSW |
1 |
134,618,033 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R1004:Kdm5b
|
UTSW |
1 |
134,588,904 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1087:Kdm5b
|
UTSW |
1 |
134,600,637 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1126:Kdm5b
|
UTSW |
1 |
134,613,991 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1221:Kdm5b
|
UTSW |
1 |
134,599,091 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1230:Kdm5b
|
UTSW |
1 |
134,613,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1345:Kdm5b
|
UTSW |
1 |
134,630,550 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1482:Kdm5b
|
UTSW |
1 |
134,624,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Kdm5b
|
UTSW |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1653:Kdm5b
|
UTSW |
1 |
134,602,481 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1693:Kdm5b
|
UTSW |
1 |
134,597,576 (GRCm38) |
splice site |
probably benign |
|
|
R1721:Kdm5b
|
UTSW |
1 |
134,613,181 (GRCm38) |
splice site |
probably benign |
|
|
R1741:Kdm5b
|
UTSW |
1 |
134,618,017 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1762:Kdm5b
|
UTSW |
1 |
134,604,467 (GRCm38) |
nonsense |
probably null |
|
|
R1820:Kdm5b
|
UTSW |
1 |
134,597,670 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1872:Kdm5b
|
UTSW |
1 |
134,624,994 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1966:Kdm5b
|
UTSW |
1 |
134,613,873 (GRCm38) |
splice site |
probably null |
|
|
R2056:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2059:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2405:Kdm5b
|
UTSW |
1 |
134,609,016 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3417:Kdm5b
|
UTSW |
1 |
134,587,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3771:Kdm5b
|
UTSW |
1 |
134,613,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3783:Kdm5b
|
UTSW |
1 |
134,630,542 (GRCm38) |
missense |
probably benign |
|
|
R3803:Kdm5b
|
UTSW |
1 |
134,615,941 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3980:Kdm5b
|
UTSW |
1 |
134,619,670 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3983:Kdm5b
|
UTSW |
1 |
134,631,304 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4013:Kdm5b
|
UTSW |
1 |
134,627,329 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4162:Kdm5b
|
UTSW |
1 |
134,625,161 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4701:Kdm5b
|
UTSW |
1 |
134,606,012 (GRCm38) |
intron |
probably benign |
|
|
R4791:Kdm5b
|
UTSW |
1 |
134,630,800 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4836:Kdm5b
|
UTSW |
1 |
134,593,315 (GRCm38) |
splice site |
probably null |
|
|
R4924:Kdm5b
|
UTSW |
1 |
134,631,351 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5135:Kdm5b
|
UTSW |
1 |
134,588,746 (GRCm38) |
intron |
probably benign |
|
|
R5248:Kdm5b
|
UTSW |
1 |
134,620,997 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5290:Kdm5b
|
UTSW |
1 |
134,622,099 (GRCm38) |
splice site |
probably null |
|
|
R5358:Kdm5b
|
UTSW |
1 |
134,607,694 (GRCm38) |
nonsense |
probably null |
|
|
R5388:Kdm5b
|
UTSW |
1 |
134,608,897 (GRCm38) |
nonsense |
probably null |
|
|
R5396:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5397:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5398:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5399:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5529:Kdm5b
|
UTSW |
1 |
134,588,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5540:Kdm5b
|
UTSW |
1 |
134,631,241 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5661:Kdm5b
|
UTSW |
1 |
134,599,073 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5663:Kdm5b
|
UTSW |
1 |
134,630,635 (GRCm38) |
missense |
probably benign |
|
|
R5822:Kdm5b
|
UTSW |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
R6226:Kdm5b
|
UTSW |
1 |
134,608,878 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6368:Kdm5b
|
UTSW |
1 |
134,599,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6681:Kdm5b
|
UTSW |
1 |
134,613,269 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6715:Kdm5b
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7132:Kdm5b
|
UTSW |
1 |
134,599,106 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7202:Kdm5b
|
UTSW |
1 |
134,624,759 (GRCm38) |
missense |
probably benign |
|
|
R7335:Kdm5b
|
UTSW |
1 |
134,560,439 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7420:Kdm5b
|
UTSW |
1 |
134,604,497 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7426:Kdm5b
|
UTSW |
1 |
134,595,833 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7452:Kdm5b
|
UTSW |
1 |
134,624,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7595:Kdm5b
|
UTSW |
1 |
134,608,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7612:Kdm5b
|
UTSW |
1 |
134,624,918 (GRCm38) |
nonsense |
probably null |
|
|
R7704:Kdm5b
|
UTSW |
1 |
134,587,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7846:Kdm5b
|
UTSW |
1 |
134,617,840 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8115:Kdm5b
|
UTSW |
1 |
134,619,673 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8146:Kdm5b
|
UTSW |
1 |
134,625,126 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8160:Kdm5b
|
UTSW |
1 |
134,613,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8527:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8542:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8930:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8950:Kdm5b
|
UTSW |
1 |
134,613,926 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R9089:Kdm5b
|
UTSW |
1 |
134,607,768 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9109:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9133:Kdm5b
|
UTSW |
1 |
134,602,585 (GRCm38) |
missense |
probably benign |
|
|
R9298:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9423:Kdm5b
|
UTSW |
1 |
134,587,967 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9630:Kdm5b
|
UTSW |
1 |
134,585,233 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9670:Kdm5b
|
UTSW |
1 |
134,630,502 (GRCm38) |
nonsense |
probably null |
|
|
X0063:Kdm5b
|
UTSW |
1 |
134,588,876 (GRCm38) |
missense |
probably benign |
0.07 |
|
Z1176:Kdm5b
|
UTSW |
1 |
134,625,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Kdm5b
|
UTSW |
1 |
134,595,798 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACGTGTGCCAGTGTTAGAG -3'
(R):5'- AAGCCCTGAACTGAAGAGGC -3'
Sequencing Primer
(F):5'- GAGACACTCATTGAACTTGTTGC -3'
(R):5'- CCTGAGAACAGAGAGACTTATCTTAC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation