Incidental Mutation 'R7258:Or8k37'
ID 564398
Institutional Source Beutler Lab
Gene Symbol Or8k37
Ensembl Gene ENSMUSG00000110804
Gene Name olfactory receptor family 8 subfamily K member 37
Synonyms MOR192-3, MOR192-2, GA_x6K02T2Q125-48121788-48120847, Olfr1084
MMRRC Submission 045386-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.221) question?
Stock # R7258 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 86469109-86470062 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 86469345 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 236 (K236*)
Ref Sequence ENSEMBL: ENSMUSP00000150546 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000216851]
AlphaFold A0A1L1STZ9
Predicted Effect probably null
Transcript: ENSMUST00000216851
AA Change: K236*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik A C 8: 88,312,805 (GRCm39) S197R probably damaging Het
Abcc12 T C 8: 87,287,486 (GRCm39) R120G possibly damaging Het
Abhd14b A G 9: 106,327,418 (GRCm39) I67V probably benign Het
Alpk1 A T 3: 127,518,115 (GRCm39) V62E probably damaging Het
Ankar A G 1: 72,690,886 (GRCm39) V1196A probably benign Het
Ccr5 A T 9: 123,925,311 (GRCm39) K305* probably null Het
Cdc42bpb T C 12: 111,292,518 (GRCm39) H339R probably damaging Het
Cdhr18 A T 14: 13,899,648 (GRCm38) F91L Het
Cep290 T G 10: 100,334,970 (GRCm39) M330R probably benign Het
Cyfip2 T C 11: 46,115,004 (GRCm39) Y901C probably benign Het
Ddx54 T G 5: 120,758,812 (GRCm39) Y352D probably damaging Het
Defa35 A T 8: 21,555,245 (GRCm39) H55L possibly damaging Het
Dnmt3b T A 2: 153,525,519 (GRCm39) probably null Het
Enpep A C 3: 129,125,724 (GRCm39) L136R probably benign Het
Epb41l2 G A 10: 25,360,185 (GRCm39) A516T probably damaging Het
Frmd4a A T 2: 4,305,764 (GRCm39) Q13L probably benign Het
Frmpd1 C A 4: 45,269,974 (GRCm39) D271E possibly damaging Het
Gbp5 T A 3: 142,212,542 (GRCm39) L410H probably damaging Het
Gipc2 T C 3: 151,871,352 (GRCm39) E58G probably damaging Het
Gm6309 A T 5: 146,105,106 (GRCm39) V269E probably benign Het
Grm5 A T 7: 87,723,914 (GRCm39) T735S probably damaging Het
H6pd T C 4: 150,080,819 (GRCm39) M9V probably benign Het
Hmcn1 A G 1: 150,591,574 (GRCm39) I1875T probably benign Het
Hrc T A 7: 44,985,720 (GRCm39) D290E possibly damaging Het
Iftap T C 2: 101,440,937 (GRCm39) D22G probably null Het
Ippk C A 13: 49,587,338 (GRCm39) Q136K probably benign Het
Kcnv1 T C 15: 44,972,711 (GRCm39) T391A probably damaging Het
Kdm5b A C 1: 134,548,759 (GRCm39) E1088A probably damaging Het
L1td1 C T 4: 98,625,101 (GRCm39) A432V probably benign Het
Ly86 A G 13: 37,529,473 (GRCm39) D20G probably benign Het
Myo1g A G 11: 6,459,416 (GRCm39) I818T possibly damaging Het
Nms A G 1: 38,986,051 (GRCm39) T121A probably benign Het
Or1e31 T G 11: 73,690,206 (GRCm39) I126L probably damaging Het
Or1j4 T A 2: 36,740,352 (GRCm39) I98K probably damaging Het
Or51af1 G C 7: 103,141,796 (GRCm39) C96W probably damaging Het
Or6b3 A T 1: 92,438,898 (GRCm39) I284N possibly damaging Het
Or6c69 T A 10: 129,748,156 (GRCm39) probably benign Het
Pcdhb9 T C 18: 37,535,167 (GRCm39) L387P probably damaging Het
Pcsk1 G A 13: 75,241,305 (GRCm39) R95H probably damaging Het
Pde11a T C 2: 75,970,250 (GRCm39) D502G possibly damaging Het
Plekhg2 T C 7: 28,064,203 (GRCm39) D446G probably benign Het
Ptch1 T C 13: 63,721,108 (GRCm39) K54E not run Het
Rasal2 A T 1: 156,985,270 (GRCm39) L826M probably damaging Het
Rnf213 A G 11: 119,343,401 (GRCm39) I3589V Het
Sin3b T C 8: 73,476,836 (GRCm39) C757R probably benign Het
Slc41a1 T A 1: 131,769,780 (GRCm39) V300D probably benign Het
Snorc A C 1: 87,402,789 (GRCm39) I40L probably benign Het
Snrpa1 T C 7: 65,719,891 (GRCm39) F162L probably damaging Het
Sox30 C A 11: 45,871,379 (GRCm39) A78E unknown Het
Ssc4d G T 5: 135,991,941 (GRCm39) A401E probably damaging Het
Steap3 A G 1: 120,171,716 (GRCm39) F130L possibly damaging Het
Stx5a A G 19: 8,732,271 (GRCm39) probably null Het
Tgfbr2 A T 9: 115,958,898 (GRCm39) I172N probably damaging Het
Tgm4 A G 9: 122,891,556 (GRCm39) D557G probably benign Het
Tmprss11c A G 5: 86,419,272 (GRCm39) S96P probably damaging Het
Trpa1 T G 1: 14,973,473 (GRCm39) T282P probably damaging Het
Uba5 A T 9: 103,940,132 (GRCm39) V5E unknown Het
Ugt2b36 A T 5: 87,228,762 (GRCm39) L427H probably damaging Het
Utp14b T A 1: 78,642,691 (GRCm39) H196Q probably benign Het
Vmn2r44 T A 7: 8,380,848 (GRCm39) L348F probably damaging Het
Vmn2r93 T G 17: 18,525,403 (GRCm39) L354V probably benign Het
Wwc2 T A 8: 48,296,034 (GRCm39) N1079Y unknown Het
Zfp653 T C 9: 21,977,116 (GRCm39) D145G probably benign Het
Zfp777 T C 6: 48,002,731 (GRCm39) E453G probably damaging Het
Zfp936 T A 7: 42,839,803 (GRCm39) H423Q probably damaging Het
Zfyve9 A T 4: 108,514,151 (GRCm39) Y496N possibly damaging Het
Other mutations in Or8k37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01132:Or8k37 APN 2 86,469,510 (GRCm39) missense probably benign 0.01
IGL01376:Or8k37 APN 2 86,469,953 (GRCm39) missense probably benign 0.00
IGL01387:Or8k37 APN 2 86,469,594 (GRCm39) missense probably benign 0.03
IGL01549:Or8k37 APN 2 86,469,876 (GRCm39) missense possibly damaging 0.95
IGL01549:Or8k37 APN 2 86,469,705 (GRCm39) missense probably benign 0.29
IGL01572:Or8k37 APN 2 86,469,283 (GRCm39) missense possibly damaging 0.92
IGL02084:Or8k37 APN 2 86,469,980 (GRCm39) missense possibly damaging 0.89
IGL02289:Or8k37 APN 2 86,469,863 (GRCm39) missense probably damaging 1.00
IGL02422:Or8k37 APN 2 86,469,560 (GRCm39) missense probably damaging 0.99
IGL02691:Or8k37 APN 2 86,469,182 (GRCm39) missense probably damaging 1.00
IGL02829:Or8k37 APN 2 86,469,599 (GRCm39) missense possibly damaging 0.60
IGL02859:Or8k37 APN 2 86,469,992 (GRCm39) missense probably benign 0.01
R0441:Or8k37 UTSW 2 86,469,674 (GRCm39) missense probably damaging 1.00
R0546:Or8k37 UTSW 2 86,469,573 (GRCm39) missense possibly damaging 0.86
R1186:Or8k37 UTSW 2 86,469,807 (GRCm39) missense probably damaging 1.00
R4465:Or8k37 UTSW 2 86,469,478 (GRCm39) missense probably benign 0.28
R4554:Or8k37 UTSW 2 86,469,123 (GRCm39) missense possibly damaging 0.74
R4670:Or8k37 UTSW 2 86,469,512 (GRCm39) missense possibly damaging 0.95
R4945:Or8k37 UTSW 2 86,469,833 (GRCm39) missense probably damaging 0.99
R5348:Or8k37 UTSW 2 86,469,150 (GRCm39) missense probably benign 0.39
R5888:Or8k37 UTSW 2 86,469,488 (GRCm39) missense probably damaging 0.98
R7001:Or8k37 UTSW 2 86,469,495 (GRCm39) missense probably benign 0.20
R7526:Or8k37 UTSW 2 86,470,013 (GRCm39) missense possibly damaging 0.93
R7646:Or8k37 UTSW 2 86,469,513 (GRCm39) missense probably damaging 1.00
R7915:Or8k37 UTSW 2 86,469,110 (GRCm39) makesense probably null
Predicted Primers PCR Primer
(F):5'- CACATCTTTGTTCCTCAGACTGTAG -3'
(R):5'- TGCTCTACACTGTCATCGTG -3'

Sequencing Primer
(F):5'- CTGTAGATCAGGGGATTCAATAAAG -3'
(R):5'- CTGTGGCTACAATGTCATCAATC -3'
Posted On 2019-06-26