|Institutional Source||Beutler Lab|
|Gene Name||interleukin 21|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7259 (G1)|
|Chromosomal Location||37222759-37232636 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (1 bp from exon)|
|DNA Base Change (assembly)||C to A at 37227654 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000124668 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000029273] [ENSMUST00000161015]|
|Coding Region Coverage||
|Validation Efficiency||100% (64/64)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
PHENOTYPE: Mice homozygous for disruptions in this gene develop normally and have a normal life span. One allele exhibits enhanced IgE isotype switch and IgE production after antigen immunization. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il21||
(F):5'- AGTTCTAGTAGGGTTTCTAGACAGAC -3'
(R):5'- AATTGTCTCTCCTTTCAGGGGC -3'
(F):5'- TGGAGGTGACACCACTTTTCAAAG -3'
(R):5'- GCACTGTGAGCATGCAGC -3'