|Institutional Source||Beutler Lab|
|Gene Name||transmembrane 4 superfamily member 4|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0582 (G1)|
|Chromosomal Location||57425314-57441677 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 57433857 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000029377 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000029377]|
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||100% (45/45)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tm4sf4||
(F):5'- AGGCCATCATGTTCAGCGTCAG -3'
(R):5'- TTTGGATGGGACAGGTGACACAAC -3'
(F):5'- TATACTGAATGGCGTAACTGGAC -3'
(R):5'- TTTCTCCAGATAACTGAGGCATC -3'