Incidental Mutation 'R7261:Arhgap21'
| ID |
564597 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgap21
|
| Ensembl Gene |
ENSMUSG00000036591 |
| Gene Name |
Rho GTPase activating protein 21 |
| Synonyms |
ARHGAP10, 5530401C11Rik |
| MMRRC Submission |
045387-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.570)
|
| Stock # |
R7261 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
20852730-20973692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20885177 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 677
(F677L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122497
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114594]
[ENSMUST00000141298]
[ENSMUST00000154230]
[ENSMUST00000173194]
[ENSMUST00000174584]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114594
AA Change: F671L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000110241
Gene: ENSMUSG00000036591
AA Change: F671L
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
58 |
159 |
1.03e-16 |
SMART |
|
low complexity region
|
351 |
362 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
625 |
635 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
925 |
N/A |
INTRINSIC |
|
PH
|
930 |
1040 |
2.09e-16 |
SMART |
|
RhoGAP
|
1157 |
1334 |
3.26e-62 |
SMART |
|
low complexity region
|
1381 |
1399 |
N/A |
INTRINSIC |
|
low complexity region
|
1448 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1533 |
1565 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1593 |
N/A |
INTRINSIC |
|
low complexity region
|
1891 |
1900 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141298
AA Change: F677L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000120357
Gene: ENSMUSG00000036591
AA Change: F677L
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154230
AA Change: F677L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000122497
Gene: ENSMUSG00000036591
AA Change: F677L
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173194
AA Change: F667L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000133851
Gene: ENSMUSG00000036591
AA Change: F667L
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
347 |
358 |
N/A |
INTRINSIC |
|
low complexity region
|
441 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
907 |
921 |
N/A |
INTRINSIC |
|
PH
|
926 |
1036 |
2.09e-16 |
SMART |
|
RhoGAP
|
1153 |
1330 |
3.26e-62 |
SMART |
|
low complexity region
|
1377 |
1395 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1561 |
N/A |
INTRINSIC |
|
low complexity region
|
1569 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
1887 |
1896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174584
AA Change: F506L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000133347
Gene: ENSMUSG00000036591
AA Change: F506L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
186 |
197 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
294 |
N/A |
INTRINSIC |
|
low complexity region
|
460 |
470 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
760 |
N/A |
INTRINSIC |
|
PH
|
765 |
875 |
2.09e-16 |
SMART |
|
RhoGAP
|
992 |
1169 |
3.26e-62 |
SMART |
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.5%
|
| Validation Efficiency |
99% (84/85) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaca |
T |
C |
11: 84,259,526 (GRCm39) |
F1954L |
probably damaging |
Het |
| Acmsd |
T |
G |
1: 127,687,561 (GRCm39) |
I281R |
probably damaging |
Het |
| Adamts2 |
A |
T |
11: 50,677,424 (GRCm39) |
M742L |
possibly damaging |
Het |
| Adgrf4 |
G |
A |
17: 42,978,326 (GRCm39) |
T339I |
probably benign |
Het |
| Aff1 |
T |
C |
5: 103,976,245 (GRCm39) |
S448P |
probably damaging |
Het |
| Agbl2 |
A |
T |
2: 90,619,288 (GRCm39) |
S38C |
possibly damaging |
Het |
| Akap7 |
C |
T |
10: 25,147,416 (GRCm39) |
D105N |
possibly damaging |
Het |
| Atf6b |
G |
T |
17: 34,869,792 (GRCm39) |
V271F |
probably damaging |
Het |
| B3gnt5 |
A |
G |
16: 19,588,123 (GRCm39) |
Y114C |
probably damaging |
Het |
| Casp7 |
T |
A |
19: 56,424,765 (GRCm39) |
D161E |
probably benign |
Het |
| Catsper4 |
TTCTC |
TTC |
4: 133,954,423 (GRCm39) |
|
probably null |
Het |
| Ccdc162 |
T |
C |
10: 41,437,136 (GRCm39) |
T1758A |
probably benign |
Het |
| Cfap74 |
C |
A |
4: 155,549,831 (GRCm39) |
P155T |
unknown |
Het |
| Champ1 |
A |
G |
8: 13,928,517 (GRCm39) |
D225G |
possibly damaging |
Het |
| Chrng |
A |
T |
1: 87,134,962 (GRCm39) |
|
probably null |
Het |
| Cnksr1 |
T |
C |
4: 133,963,084 (GRCm39) |
|
probably null |
Het |
| Col15a1 |
G |
A |
4: 47,269,088 (GRCm39) |
G582D |
probably benign |
Het |
| Cwc25 |
A |
G |
11: 97,648,585 (GRCm39) |
V81A |
possibly damaging |
Het |
| Ddhd1 |
A |
G |
14: 45,894,688 (GRCm39) |
Y261H |
probably damaging |
Het |
| Defa29 |
A |
G |
8: 21,816,818 (GRCm39) |
|
probably null |
Het |
| Diaph3 |
A |
C |
14: 87,202,893 (GRCm39) |
C666G |
probably benign |
Het |
| Dlx2 |
A |
G |
2: 71,375,019 (GRCm39) |
Y282H |
probably damaging |
Het |
| Dsc3 |
A |
T |
18: 20,113,814 (GRCm39) |
Y369* |
probably null |
Het |
| Dtwd1 |
A |
G |
2: 126,000,424 (GRCm39) |
N120S |
probably benign |
Het |
| Dysf |
G |
A |
6: 84,169,992 (GRCm39) |
S1761N |
probably damaging |
Het |
| Enthd1 |
A |
T |
15: 80,444,416 (GRCm39) |
N46K |
probably damaging |
Het |
| Epha7 |
T |
A |
4: 28,813,418 (GRCm39) |
I12N |
probably benign |
Het |
| Fam171a2 |
T |
A |
11: 102,328,900 (GRCm39) |
N620Y |
probably damaging |
Het |
| Garin4 |
T |
C |
1: 190,896,308 (GRCm39) |
S112G |
unknown |
Het |
| Gfpt2 |
A |
T |
11: 49,714,078 (GRCm39) |
E278D |
possibly damaging |
Het |
| Gm3285 |
A |
G |
10: 77,698,244 (GRCm39) |
Q131R |
unknown |
Het |
| Gpcpd1 |
A |
C |
2: 132,410,619 (GRCm39) |
C23G |
probably damaging |
Het |
| Gtpbp4 |
A |
T |
13: 9,037,954 (GRCm39) |
H228Q |
probably benign |
Het |
| Hdac7 |
A |
G |
15: 97,704,415 (GRCm39) |
V500A |
probably benign |
Het |
| Hykk |
T |
G |
9: 54,828,010 (GRCm39) |
M83R |
possibly damaging |
Het |
| Idi1 |
A |
G |
13: 8,936,931 (GRCm39) |
I101V |
probably benign |
Het |
| Irs2 |
A |
T |
8: 11,057,018 (GRCm39) |
H471Q |
possibly damaging |
Het |
| Itsn1 |
T |
C |
16: 91,702,194 (GRCm39) |
V12A |
probably benign |
Het |
| Jak2 |
A |
G |
19: 29,288,385 (GRCm39) |
I1079V |
possibly damaging |
Het |
| Kcnt2 |
G |
A |
1: 140,282,255 (GRCm39) |
R80H |
possibly damaging |
Het |
| Lamb2 |
T |
C |
9: 108,358,496 (GRCm39) |
Y178H |
probably damaging |
Het |
| Lgr5 |
A |
T |
10: 115,423,370 (GRCm39) |
L10Q |
possibly damaging |
Het |
| Lnx1 |
G |
T |
5: 74,838,175 (GRCm39) |
S29* |
probably null |
Het |
| Lpcat3 |
T |
A |
6: 124,675,050 (GRCm39) |
F57I |
probably benign |
Het |
| Manf |
T |
C |
9: 106,769,088 (GRCm39) |
T4A |
probably benign |
Het |
| Map2k3 |
G |
A |
11: 60,836,393 (GRCm39) |
|
probably null |
Het |
| Myh14 |
G |
A |
7: 44,273,761 (GRCm39) |
Q1329* |
probably null |
Het |
| Myocd |
T |
C |
11: 65,078,422 (GRCm39) |
S458G |
probably damaging |
Het |
| Ncor2 |
T |
C |
5: 125,187,143 (GRCm39) |
|
probably null |
Het |
| Ndufs8 |
A |
T |
19: 3,961,606 (GRCm39) |
N23K |
probably benign |
Het |
| Nkx6-1 |
T |
C |
5: 101,812,006 (GRCm39) |
K32R |
unknown |
Het |
| Nlrp3 |
T |
G |
11: 59,439,272 (GRCm39) |
V283G |
possibly damaging |
Het |
| Nme3 |
A |
G |
17: 25,116,037 (GRCm39) |
|
probably null |
Het |
| Or1o3 |
A |
G |
17: 37,574,076 (GRCm39) |
F160L |
probably benign |
Het |
| Or8g23 |
C |
T |
9: 38,971,504 (GRCm39) |
V153M |
possibly damaging |
Het |
| Parvg |
T |
C |
15: 84,215,297 (GRCm39) |
|
probably null |
Het |
| Peg10 |
T |
A |
6: 4,756,591 (GRCm39) |
M389K |
unknown |
Het |
| Phf23 |
G |
T |
11: 69,890,091 (GRCm39) |
C340F |
possibly damaging |
Het |
| Piwil2 |
A |
G |
14: 70,611,860 (GRCm39) |
Y929H |
probably damaging |
Het |
| Prss39 |
A |
G |
1: 34,539,369 (GRCm39) |
D203G |
probably damaging |
Het |
| Prss54 |
G |
T |
8: 96,286,367 (GRCm39) |
D235E |
probably benign |
Het |
| Prtg |
T |
A |
9: 72,815,117 (GRCm39) |
M1015K |
possibly damaging |
Het |
| Rbbp8 |
T |
C |
18: 11,838,799 (GRCm39) |
I160T |
probably damaging |
Het |
| Rxylt1 |
A |
T |
10: 121,924,822 (GRCm39) |
D293E |
probably benign |
Het |
| Scn10a |
C |
A |
9: 119,438,790 (GRCm39) |
C1692F |
probably damaging |
Het |
| Scn11a |
C |
T |
9: 119,648,899 (GRCm39) |
D55N |
probably damaging |
Het |
| Secisbp2 |
G |
T |
13: 51,836,498 (GRCm39) |
V768F |
probably damaging |
Het |
| Skic3 |
A |
G |
13: 76,261,698 (GRCm39) |
T138A |
probably benign |
Het |
| Spag16 |
T |
C |
1: 70,338,780 (GRCm39) |
I426T |
possibly damaging |
Het |
| Sspo |
G |
A |
6: 48,427,011 (GRCm39) |
V250M |
possibly damaging |
Het |
| Strbp |
A |
T |
2: 37,531,149 (GRCm39) |
|
probably null |
Het |
| Sv2c |
C |
T |
13: 96,224,809 (GRCm39) |
V167M |
probably damaging |
Het |
| Tdpoz1 |
G |
A |
3: 93,577,794 (GRCm39) |
S330L |
not run |
Het |
| Tigd2 |
T |
A |
6: 59,188,052 (GRCm39) |
D306E |
probably benign |
Het |
| Trrap |
C |
T |
5: 144,782,287 (GRCm39) |
P3278S |
possibly damaging |
Het |
| Vdac1 |
A |
T |
11: 52,265,761 (GRCm39) |
K28N |
probably damaging |
Het |
| Vmn1r84 |
A |
T |
7: 12,096,069 (GRCm39) |
M208K |
probably damaging |
Het |
| Vmn2r77 |
A |
T |
7: 86,460,518 (GRCm39) |
K615* |
probably null |
Het |
| Vps11 |
A |
G |
9: 44,265,800 (GRCm39) |
L493P |
probably damaging |
Het |
| Zbtb21 |
T |
C |
16: 97,754,179 (GRCm39) |
I35V |
possibly damaging |
Het |
| Zbtb26 |
A |
T |
2: 37,326,667 (GRCm39) |
M123K |
possibly damaging |
Het |
| Zfp236 |
A |
T |
18: 82,627,470 (GRCm39) |
D1576E |
possibly damaging |
Het |
|
| Other mutations in Arhgap21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Arhgap21
|
APN |
2 |
20,860,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01472:Arhgap21
|
APN |
2 |
20,854,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01634:Arhgap21
|
APN |
2 |
20,919,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01766:Arhgap21
|
APN |
2 |
20,854,448 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02097:Arhgap21
|
APN |
2 |
20,884,813 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02197:Arhgap21
|
APN |
2 |
20,885,117 (GRCm39) |
missense |
probably benign |
|
|
IGL02264:Arhgap21
|
APN |
2 |
20,864,850 (GRCm39) |
splice site |
probably null |
|
|
IGL02346:Arhgap21
|
APN |
2 |
20,884,762 (GRCm39) |
splice site |
probably benign |
|
|
IGL02418:Arhgap21
|
APN |
2 |
20,885,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02605:Arhgap21
|
APN |
2 |
20,860,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02701:Arhgap21
|
APN |
2 |
20,896,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03019:Arhgap21
|
APN |
2 |
20,865,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Arhgap21
|
APN |
2 |
20,919,532 (GRCm39) |
missense |
probably benign |
|
|
IGL03265:Arhgap21
|
APN |
2 |
20,854,439 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03379:Arhgap21
|
APN |
2 |
20,885,500 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0304:Arhgap21
|
UTSW |
2 |
20,864,612 (GRCm39) |
splice site |
probably benign |
|
|
R0363:Arhgap21
|
UTSW |
2 |
20,885,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0498:Arhgap21
|
UTSW |
2 |
20,867,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Arhgap21
|
UTSW |
2 |
20,919,610 (GRCm39) |
nonsense |
probably null |
|
|
R0633:Arhgap21
|
UTSW |
2 |
20,860,198 (GRCm39) |
nonsense |
probably null |
|
|
R0905:Arhgap21
|
UTSW |
2 |
20,854,745 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1550:Arhgap21
|
UTSW |
2 |
20,886,576 (GRCm39) |
nonsense |
probably null |
|
|
R1570:Arhgap21
|
UTSW |
2 |
20,885,651 (GRCm39) |
missense |
probably benign |
|
|
R1686:Arhgap21
|
UTSW |
2 |
20,886,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1746:Arhgap21
|
UTSW |
2 |
20,865,910 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1864:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2209:Arhgap21
|
UTSW |
2 |
20,854,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2211:Arhgap21
|
UTSW |
2 |
20,886,451 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2276:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2279:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2336:Arhgap21
|
UTSW |
2 |
20,884,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2516:Arhgap21
|
UTSW |
2 |
20,859,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Arhgap21
|
UTSW |
2 |
20,855,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3877:Arhgap21
|
UTSW |
2 |
20,864,717 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4017:Arhgap21
|
UTSW |
2 |
20,896,915 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4232:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4233:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4234:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4236:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4434:Arhgap21
|
UTSW |
2 |
20,972,146 (GRCm39) |
missense |
probably benign |
|
|
R4686:Arhgap21
|
UTSW |
2 |
20,868,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4817:Arhgap21
|
UTSW |
2 |
20,854,967 (GRCm39) |
missense |
probably benign |
|
|
R4834:Arhgap21
|
UTSW |
2 |
20,870,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4845:Arhgap21
|
UTSW |
2 |
20,885,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4889:Arhgap21
|
UTSW |
2 |
20,885,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4904:Arhgap21
|
UTSW |
2 |
20,854,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4911:Arhgap21
|
UTSW |
2 |
20,863,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4994:Arhgap21
|
UTSW |
2 |
20,854,701 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5067:Arhgap21
|
UTSW |
2 |
20,884,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5086:Arhgap21
|
UTSW |
2 |
20,853,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5281:Arhgap21
|
UTSW |
2 |
20,854,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5364:Arhgap21
|
UTSW |
2 |
20,854,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5420:Arhgap21
|
UTSW |
2 |
20,885,897 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5476:Arhgap21
|
UTSW |
2 |
20,885,497 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5831:Arhgap21
|
UTSW |
2 |
20,868,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5949:Arhgap21
|
UTSW |
2 |
20,853,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5994:Arhgap21
|
UTSW |
2 |
20,886,187 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6014:Arhgap21
|
UTSW |
2 |
20,886,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Arhgap21
|
UTSW |
2 |
20,885,543 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6817:Arhgap21
|
UTSW |
2 |
20,885,107 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6821:Arhgap21
|
UTSW |
2 |
20,853,659 (GRCm39) |
missense |
probably benign |
|
|
R6844:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6870:Arhgap21
|
UTSW |
2 |
20,885,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Arhgap21
|
UTSW |
2 |
20,855,142 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7011:Arhgap21
|
UTSW |
2 |
20,853,689 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7144:Arhgap21
|
UTSW |
2 |
20,870,198 (GRCm39) |
missense |
probably benign |
|
|
R7237:Arhgap21
|
UTSW |
2 |
20,854,783 (GRCm39) |
nonsense |
probably null |
|
|
R7558:Arhgap21
|
UTSW |
2 |
20,860,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7566:Arhgap21
|
UTSW |
2 |
20,917,102 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,855,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,854,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Arhgap21
|
UTSW |
2 |
20,867,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7822:Arhgap21
|
UTSW |
2 |
20,885,524 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7965:Arhgap21
|
UTSW |
2 |
20,854,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7986:Arhgap21
|
UTSW |
2 |
20,867,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8028:Arhgap21
|
UTSW |
2 |
20,885,216 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8209:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Arhgap21
|
UTSW |
2 |
20,854,221 (GRCm39) |
missense |
probably benign |
|
|
R8486:Arhgap21
|
UTSW |
2 |
20,865,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8508:Arhgap21
|
UTSW |
2 |
20,858,991 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8835:Arhgap21
|
UTSW |
2 |
20,972,144 (GRCm39) |
nonsense |
probably null |
|
|
R9140:Arhgap21
|
UTSW |
2 |
20,886,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Arhgap21
|
UTSW |
2 |
20,858,983 (GRCm39) |
missense |
probably null |
0.04 |
|
R9204:Arhgap21
|
UTSW |
2 |
20,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9227:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9230:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9308:Arhgap21
|
UTSW |
2 |
20,854,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9374:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9449:Arhgap21
|
UTSW |
2 |
20,885,464 (GRCm39) |
missense |
probably benign |
|
|
R9454:Arhgap21
|
UTSW |
2 |
20,870,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9499:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9544:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9552:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Arhgap21
|
UTSW |
2 |
20,896,953 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9588:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9749:Arhgap21
|
UTSW |
2 |
20,854,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1191:Arhgap21
|
UTSW |
2 |
20,886,283 (GRCm39) |
missense |
probably benign |
0.30 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTATCTAGCACATCTGGCTGCTG -3'
(R):5'- ATTTTCCAACCACGACTGGGG -3'
Sequencing Primer
(F):5'- AGCACATCTGGCTGCTGAATTTC -3'
(R):5'- ACTTCAACGGGGTATTGCAC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation