Mutagenetix > Incidental Mutation

Incidental Mutation 'R0582:Taar3'

56473

Institutional Source

Beutler Lab

Gene Symbol

Taar3

Ensembl Gene

ENSMUSG00000069708

Gene Name

trace amine-associated receptor 3

Synonyms

MMRRC Submission

038772-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.145) question?

Stock #

R0582 (G1)

Quality Score

173

Status

Validated

Chromosome

Chromosomal Location

23825456-23826487 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23825715 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 87 (Y87C)

Ref Sequence

ENSEMBL: ENSMUSP00000036817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045152]

AlphaFold

Q5QD16

Predicted Effect

probably damaging
Transcript: ENSMUST00000045152
AA Change: Y87C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000036817
Gene: ENSMUSG00000069708
AA Change: Y87C

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	42	320	1.8e-13	PFAM
Pfam:7tm_1	48	309	1.4e-53	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.4%
20x: 94.6%

Validation Efficiency

100% (45/45)

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	A	T	12: 118,904,147 (GRCm39)	M186K	probably benign	Het
Afm	T	C	5: 90,672,639 (GRCm39)		probably benign	Het
Arfgef3	G	A	10: 18,487,038 (GRCm39)	A1332V	probably damaging	Het
Atp11a	T	C	8: 12,881,214 (GRCm39)	S451P	probably benign	Het
Birc6	T	A	17: 74,950,332 (GRCm39)	V3189E	probably damaging	Het
Ccdc150	C	T	1: 54,368,670 (GRCm39)	A626V	probably benign	Het
Ccdc50	G	A	16: 27,263,409 (GRCm39)		probably benign	Het
Cntln	T	C	4: 84,802,978 (GRCm39)	S93P	probably damaging	Het
Ctnna2	C	A	6: 77,735,400 (GRCm39)	V106L	probably benign	Het
Ctnnal1	G	C	4: 56,813,228 (GRCm39)	Q668E	probably damaging	Het
Cyp1a2	G	A	9: 57,587,529 (GRCm39)		probably benign	Het
Dnah8	A	G	17: 30,937,935 (GRCm39)	D1604G	probably benign	Het
Dscaml1	A	T	9: 45,579,562 (GRCm39)	I370F	possibly damaging	Het
Duxf4	A	T	10: 58,071,508 (GRCm39)	S235R	probably benign	Het
Ears2	T	C	7: 121,654,881 (GRCm39)	E129G	probably benign	Het
Igsf10	T	C	3: 59,227,188 (GRCm39)	I2162V	probably benign	Het
Ints9	C	T	14: 65,217,598 (GRCm39)	P42S	probably damaging	Het
Ipp	T	C	4: 116,372,664 (GRCm39)	L231S	probably damaging	Het
Lyn	T	A	4: 3,743,296 (GRCm39)	L72Q	probably damaging	Het
Nfe2l2	T	A	2: 75,507,112 (GRCm39)	E329D	probably damaging	Het
Or2h2c	G	C	17: 37,422,347 (GRCm39)	L176V	probably benign	Het
Or52a24	G	A	7: 103,381,880 (GRCm39)	C249Y	possibly damaging	Het
Pdyn	A	C	2: 129,531,658 (GRCm39)	L44R	probably damaging	Het
Pkd1l1	A	G	11: 8,881,699 (GRCm39)		probably benign	Het
Prpf40a	A	T	2: 53,035,704 (GRCm39)	F695L	probably damaging	Het
Rnf217	A	G	10: 31,484,763 (GRCm39)	Y140H	possibly damaging	Het
Sema6c	C	T	3: 95,076,508 (GRCm39)	R265C	probably damaging	Het
Slc7a8	C	A	14: 54,995,901 (GRCm39)	C167F	probably damaging	Het
Snap47	A	T	11: 59,319,259 (GRCm39)	L293*	probably null	Het
Snx3	A	T	10: 42,409,276 (GRCm39)		probably benign	Het
Sycp2l	T	A	13: 41,291,431 (GRCm39)		probably benign	Het
Tm4sf4	T	C	3: 57,341,278 (GRCm39)		probably benign	Het
Tssc4	T	C	7: 142,624,246 (GRCm39)	S185P	probably damaging	Het
Ttc28	G	T	5: 111,331,162 (GRCm39)	A430S	probably damaging	Het
Ulbp3	G	A	10: 3,075,082 (GRCm39)		noncoding transcript	Het
Vmn2r27	T	C	6: 124,201,249 (GRCm39)	D236G	probably benign	Het
Vps54	G	T	11: 21,250,137 (GRCm39)	D508Y	probably damaging	Het
Wdr53	G	A	16: 32,070,726 (GRCm39)	V24M	probably damaging	Het
Xirp2	T	G	2: 67,339,210 (GRCm39)	L484V	probably benign	Het
Zfyve26	T	C	12: 79,292,996 (GRCm39)	D2051G	probably damaging	Het

Other mutations in Taar3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01019:Taar3	APN	10	23,826,330 (GRCm39)	missense	probably damaging	1.00
IGL01777:Taar3	APN	10	23,825,903 (GRCm39)	missense	probably benign	0.39
IGL01940:Taar3	APN	10	23,825,855 (GRCm39)	missense	probably damaging	1.00
IGL02120:Taar3	APN	10	23,826,065 (GRCm39)	missense	probably benign	0.33
PIT4445001:Taar3	UTSW	10	23,825,586 (GRCm39)	missense	possibly damaging	0.85
R1925:Taar3	UTSW	10	23,826,483 (GRCm39)	missense	probably benign	0.22
R2261:Taar3	UTSW	10	23,826,053 (GRCm39)	missense	probably benign	0.00
R4088:Taar3	UTSW	10	23,825,757 (GRCm39)	missense	possibly damaging	0.46
R4504:Taar3	UTSW	10	23,825,471 (GRCm39)	missense	possibly damaging	0.84
R4505:Taar3	UTSW	10	23,825,471 (GRCm39)	missense	possibly damaging	0.84
R4507:Taar3	UTSW	10	23,825,471 (GRCm39)	missense	possibly damaging	0.84
R4925:Taar3	UTSW	10	23,826,441 (GRCm39)	missense	probably damaging	0.99
R6221:Taar3	UTSW	10	23,825,970 (GRCm39)	missense	possibly damaging	0.92
R6451:Taar3	UTSW	10	23,825,705 (GRCm39)	missense	possibly damaging	0.96
R7290:Taar3	UTSW	10	23,826,298 (GRCm39)	nonsense	probably null
R7414:Taar3	UTSW	10	23,825,715 (GRCm39)	missense	probably damaging	1.00
R8432:Taar3	UTSW	10	23,826,053 (GRCm39)	missense	probably benign	0.11
X0057:Taar3	UTSW	10	23,825,544 (GRCm39)	missense	probably benign	0.13

Predicted Primers

PCR Primer
(F):5'- TTCCGTGTCCGCATGATAATGTACC -3'
(R):5'- TCTGCATACCAGAAACATTGGCCTC -3'

Sequencing Primer
(F):5'- ACCTGTTTATGACTGGAGCC -3'
(R):5'- CAGCAGTCTCTTGATCATGGATAC -3'

Posted On

2013-07-11