Incidental Mutation 'R0583:Or8k38'
| ID |
56493 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or8k38
|
| Ensembl Gene |
ENSMUSG00000075176 |
| Gene Name |
olfactory receptor family 8 subfamily K member 38 |
| Synonyms |
Olfr1085, MOR191-1, GA_x6K02T2Q125-48147264-48146323 |
| MMRRC Submission |
038773-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0583 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
86487859-86488800 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 86488704 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 33
(I33F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150955
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099879]
[ENSMUST00000213279]
[ENSMUST00000214566]
|
| AlphaFold |
Q7TR64 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099879
AA Change: I33F
PolyPhen 2
Score 0.199 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000097464
Gene: ENSMUSG00000075176
AA Change: I33F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
307 |
4.6e-49 |
PFAM |
|
Pfam:7tm_1
|
41 |
290 |
1.1e-18 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213279
AA Change: I33F
PolyPhen 2
Score 0.199 (Sensitivity: 0.92; Specificity: 0.88)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000214566
AA Change: I33F
PolyPhen 2
Score 0.199 (Sensitivity: 0.92; Specificity: 0.88)
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.1%
- 20x: 93.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 52 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
A |
G |
9: 57,164,926 (GRCm39) |
S483P |
probably benign |
Het |
| 5730480H06Rik |
A |
G |
5: 48,537,470 (GRCm39) |
H169R |
probably damaging |
Het |
| Actn1 |
T |
A |
12: 80,245,803 (GRCm39) |
I127F |
probably damaging |
Het |
| Cadm3 |
T |
G |
1: 173,168,738 (GRCm39) |
T277P |
probably benign |
Het |
| Cast |
T |
C |
13: 74,861,797 (GRCm39) |
T629A |
probably damaging |
Het |
| Cblc |
C |
A |
7: 19,526,486 (GRCm39) |
C201F |
probably benign |
Het |
| Ccdc154 |
T |
A |
17: 25,387,398 (GRCm39) |
D375E |
possibly damaging |
Het |
| Cdk6 |
A |
G |
5: 3,523,183 (GRCm39) |
D201G |
probably damaging |
Het |
| Cep95 |
T |
C |
11: 106,705,449 (GRCm39) |
V478A |
probably benign |
Het |
| Ciita |
T |
C |
16: 10,341,668 (GRCm39) |
|
probably null |
Het |
| Clec4e |
A |
G |
6: 123,260,653 (GRCm39) |
F135S |
probably damaging |
Het |
| Cntn6 |
A |
G |
6: 104,753,275 (GRCm39) |
D337G |
possibly damaging |
Het |
| Crlf3 |
A |
T |
11: 79,950,107 (GRCm39) |
H174Q |
probably damaging |
Het |
| Cyb5r1 |
T |
A |
1: 134,335,339 (GRCm39) |
F93I |
probably damaging |
Het |
| Dop1b |
T |
C |
16: 93,552,374 (GRCm39) |
I271T |
probably benign |
Het |
| Duxf1 |
G |
A |
10: 58,059,210 (GRCm39) |
L515F |
probably damaging |
Het |
| Fcho1 |
T |
C |
8: 72,168,369 (GRCm39) |
Y218C |
probably damaging |
Het |
| Fhad1 |
C |
T |
4: 141,631,301 (GRCm39) |
M1297I |
probably benign |
Het |
| Igdcc4 |
T |
C |
9: 65,029,095 (GRCm39) |
V244A |
possibly damaging |
Het |
| Ikzf5 |
A |
G |
7: 130,993,514 (GRCm39) |
|
probably null |
Het |
| Ilvbl |
T |
A |
10: 78,419,101 (GRCm39) |
V450E |
probably damaging |
Het |
| Kcns3 |
T |
G |
12: 11,141,479 (GRCm39) |
N407H |
probably damaging |
Het |
| Klhl11 |
T |
C |
11: 100,355,150 (GRCm39) |
K224E |
possibly damaging |
Het |
| Klra17 |
T |
A |
6: 129,845,656 (GRCm39) |
D186V |
probably damaging |
Het |
| Lrrc37a |
T |
C |
11: 103,389,263 (GRCm39) |
D2054G |
probably benign |
Het |
| Mef2a |
G |
T |
7: 66,884,896 (GRCm39) |
S406* |
probably null |
Het |
| Mrgbp |
A |
G |
2: 180,226,239 (GRCm39) |
N104S |
probably benign |
Het |
| Mroh2a |
GT |
GTT |
1: 88,183,888 (GRCm39) |
|
probably null |
Het |
| Muc5ac |
C |
A |
7: 141,361,345 (GRCm39) |
T1552N |
probably damaging |
Het |
| Muc5b |
T |
A |
7: 141,410,435 (GRCm39) |
Y1269* |
probably null |
Het |
| Myef2 |
T |
C |
2: 124,939,901 (GRCm39) |
|
probably null |
Het |
| Myg1 |
C |
T |
15: 102,246,225 (GRCm39) |
Q367* |
probably null |
Het |
| Nalcn |
T |
C |
14: 123,531,755 (GRCm39) |
N1365S |
possibly damaging |
Het |
| Nfu1 |
T |
C |
6: 86,986,934 (GRCm39) |
C18R |
probably benign |
Het |
| Nkx2-6 |
A |
T |
14: 69,412,228 (GRCm39) |
Q132L |
probably damaging |
Het |
| Or10a3b |
C |
T |
7: 108,444,621 (GRCm39) |
A199T |
possibly damaging |
Het |
| Pak3 |
TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
X: 142,526,889 (GRCm39) |
|
probably benign |
Het |
| Prh1 |
A |
T |
6: 132,548,796 (GRCm39) |
Q101L |
unknown |
Het |
| Ribc2 |
A |
T |
15: 85,017,115 (GRCm39) |
|
probably null |
Het |
| Rnf19a |
C |
A |
15: 36,253,151 (GRCm39) |
R396L |
probably damaging |
Het |
| Sdad1 |
A |
G |
5: 92,452,923 (GRCm39) |
I105T |
probably damaging |
Het |
| Sec24b |
G |
T |
3: 129,834,960 (GRCm39) |
Y79* |
probably null |
Het |
| Tatdn2 |
A |
G |
6: 113,679,486 (GRCm39) |
E277G |
possibly damaging |
Het |
| Tex10 |
A |
C |
4: 48,451,952 (GRCm39) |
F725V |
probably damaging |
Het |
| Themis3 |
T |
C |
17: 66,866,748 (GRCm39) |
D164G |
probably benign |
Het |
| Ubxn7 |
T |
C |
16: 32,194,732 (GRCm39) |
W220R |
probably damaging |
Het |
| Usp33 |
C |
A |
3: 152,073,891 (GRCm39) |
R246S |
probably damaging |
Het |
| Vmn2r102 |
T |
A |
17: 19,897,043 (GRCm39) |
V130E |
probably benign |
Het |
| Vmn2r112 |
C |
T |
17: 22,837,930 (GRCm39) |
P797L |
probably damaging |
Het |
| Vmn2r114 |
ATTT |
ATT |
17: 23,509,906 (GRCm39) |
|
probably null |
Het |
| Yme1l1 |
T |
C |
2: 23,076,262 (GRCm39) |
V340A |
probably damaging |
Het |
| Zfta |
A |
G |
19: 7,397,639 (GRCm39) |
D62G |
probably damaging |
Het |
|
| Other mutations in Or8k38 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00940:Or8k38
|
APN |
2 |
86,488,070 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01137:Or8k38
|
APN |
2 |
86,488,055 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL01329:Or8k38
|
APN |
2 |
86,488,551 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL01398:Or8k38
|
APN |
2 |
86,488,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02248:Or8k38
|
APN |
2 |
86,488,061 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02699:Or8k38
|
APN |
2 |
86,488,691 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL02818:Or8k38
|
APN |
2 |
86,488,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03095:Or8k38
|
APN |
2 |
86,488,775 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03218:Or8k38
|
APN |
2 |
86,488,703 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0121:Or8k38
|
UTSW |
2 |
86,488,163 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0546:Or8k38
|
UTSW |
2 |
86,488,235 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0980:Or8k38
|
UTSW |
2 |
86,488,209 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2067:Or8k38
|
UTSW |
2 |
86,488,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Or8k38
|
UTSW |
2 |
86,488,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3760:Or8k38
|
UTSW |
2 |
86,488,232 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4530:Or8k38
|
UTSW |
2 |
86,487,905 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4809:Or8k38
|
UTSW |
2 |
86,488,029 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5940:Or8k38
|
UTSW |
2 |
86,488,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6027:Or8k38
|
UTSW |
2 |
86,488,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6417:Or8k38
|
UTSW |
2 |
86,488,510 (GRCm39) |
nonsense |
probably null |
|
|
R6420:Or8k38
|
UTSW |
2 |
86,488,510 (GRCm39) |
nonsense |
probably null |
|
|
R6619:Or8k38
|
UTSW |
2 |
86,488,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6762:Or8k38
|
UTSW |
2 |
86,488,188 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6946:Or8k38
|
UTSW |
2 |
86,487,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7673:Or8k38
|
UTSW |
2 |
86,488,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7718:Or8k38
|
UTSW |
2 |
86,488,373 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8461:Or8k38
|
UTSW |
2 |
86,487,890 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8506:Or8k38
|
UTSW |
2 |
86,488,745 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8977:Or8k38
|
UTSW |
2 |
86,488,472 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9172:Or8k38
|
UTSW |
2 |
86,487,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9211:Or8k38
|
UTSW |
2 |
86,488,024 (GRCm39) |
nonsense |
probably null |
|
|
R9337:Or8k38
|
UTSW |
2 |
86,488,476 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9713:Or8k38
|
UTSW |
2 |
86,488,041 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGATATATGGGACCGCCACAAGTACC -3'
(R):5'- AGAAACAAATCCCTGTTACTGCCTCTG -3'
Sequencing Primer
(F):5'- GGAGACTGAATTATGCTCTGCAAC -3'
(R):5'- GACAATGTCTCAAgtttttgtttttg -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation