Incidental Mutation 'R7266:Grm2'
ID 564941
Institutional Source Beutler Lab
Gene Symbol Grm2
Ensembl Gene ENSMUSG00000023192
Gene Name glutamate receptor, metabotropic 2
Synonyms mGluR2, Gprc1b, 4930441L02Rik
MMRRC Submission 045389-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.466) question?
Stock # R7266 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 106521733-106533308 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 106524370 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 311 (V311I)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023959] [ENSMUST00000201681]
AlphaFold Q14BI2
Predicted Effect probably damaging
Transcript: ENSMUST00000023959
AA Change: V782I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000023959
Gene: ENSMUSG00000023192
AA Change: V782I

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 60 460 1.3e-96 PFAM
Pfam:NCD3G 496 546 3.7e-13 PFAM
Pfam:7tm_3 579 816 4.3e-63 PFAM
Predicted Effect
Predicted Effect possibly damaging
Transcript: ENSMUST00000201681
AA Change: V504I

PolyPhen 2 Score 0.669 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000144631
Gene: ENSMUSG00000023192
AA Change: V504I

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 60 460 4.1e-95 PFAM
Pfam:7tm_3 458 538 4.6e-18 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
PHENOTYPE: Mice homozygous for disruptions in this gene display subtile behavioral modifications and moderate abnormalities in long term depression and EPSP in the hippocampus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T A 8: 25,157,639 (GRCm39) I104F probably benign Het
Adgrg7 C T 16: 56,590,674 (GRCm39) V166I probably benign Het
Agfg1 G T 1: 82,859,966 (GRCm39) V278L probably benign Het
Alpk3 A G 7: 80,742,328 (GRCm39) E715G possibly damaging Het
Ap2m1 A G 16: 20,362,095 (GRCm39) Y401C probably damaging Het
Arhgef28 C T 13: 98,101,960 (GRCm39) S838N probably benign Het
Ash2l A T 8: 26,317,233 (GRCm39) Y373* probably null Het
Best2 C T 8: 85,734,393 (GRCm39) V442I probably benign Het
Col4a2 T C 8: 11,475,542 (GRCm39) probably null Het
Fat2 T A 11: 55,175,856 (GRCm39) D1619V probably damaging Het
Fer1l6 A T 15: 58,499,446 (GRCm39) N1272I probably benign Het
Gcc1 T A 6: 28,417,995 (GRCm39) *779C probably null Het
Gm12216 G A 11: 53,750,077 (GRCm39) probably benign Het
Immt T A 6: 71,851,689 (GRCm39) D683E probably benign Het
Itga8 T G 2: 12,237,712 (GRCm39) D336A probably damaging Het
Jhy T C 9: 40,872,453 (GRCm39) T19A probably benign Het
Kcnq2 T C 2: 180,776,885 (GRCm39) M1V probably null Het
Kctd17 A T 15: 78,317,214 (GRCm39) I117F probably damaging Het
Lrp6 T C 6: 134,484,364 (GRCm39) T420A probably damaging Het
Manba T C 3: 135,223,673 (GRCm39) S187P probably damaging Het
Mef2b A T 8: 70,616,938 (GRCm39) D13V probably damaging Het
Mical2 T C 7: 111,902,963 (GRCm39) F145L probably damaging Het
Mphosph8 T A 14: 56,922,497 (GRCm39) D551E possibly damaging Het
Mplkipl1 A G 19: 61,163,973 (GRCm39) V154A possibly damaging Het
Myo10 C G 15: 25,783,067 (GRCm39) R1170G probably damaging Het
Myo16 A C 8: 10,322,687 (GRCm39) Q39P unknown Het
Myo1f A G 17: 33,820,668 (GRCm39) E837G probably benign Het
Nell2 T A 15: 95,333,274 (GRCm39) I128F possibly damaging Het
Or1i2 A G 10: 78,448,448 (GRCm39) V9A probably benign Het
Pcdh15 A T 10: 74,215,222 (GRCm39) R659* probably null Het
Pcdhga1 A G 18: 37,973,028 (GRCm39) Q881R possibly damaging Het
Plekhm2 T G 4: 141,369,770 (GRCm39) E75A possibly damaging Het
Prc1 A G 7: 79,957,405 (GRCm39) K357E possibly damaging Het
Pxk T A 14: 8,146,220 (GRCm38) C377S probably benign Het
Ralgapa2 T C 2: 146,176,488 (GRCm39) E1696G probably damaging Het
Rbbp6 T A 7: 122,600,590 (GRCm39) S1532R unknown Het
Scn5a G T 9: 119,391,626 (GRCm39) A22E probably benign Het
Sctr G A 1: 119,949,955 (GRCm39) R48Q probably benign Het
Siae T C 9: 37,534,309 (GRCm39) V115A probably damaging Het
Slc16a6 A G 11: 109,344,107 (GRCm39) C563R probably benign Het
Sntg1 A C 1: 8,752,243 (GRCm39) V58G possibly damaging Het
Snx11 C T 11: 96,663,985 (GRCm39) V36M probably damaging Het
Stk3 C A 15: 34,959,182 (GRCm39) S330I probably benign Het
Synpo A G 18: 60,762,631 (GRCm39) F92S probably benign Het
Tle1 A G 4: 72,057,924 (GRCm39) probably null Het
Tmem117 A G 15: 94,829,684 (GRCm39) D173G possibly damaging Het
Tmem217b C A 17: 29,738,347 (GRCm39) V140L probably benign Het
Tmprss5 T C 9: 49,025,841 (GRCm39) W338R probably benign Het
Tnfrsf19 T C 14: 61,212,147 (GRCm39) T168A possibly damaging Het
Trhde C T 10: 114,636,776 (GRCm39) G144S possibly damaging Het
Trim56 G T 5: 137,143,097 (GRCm39) Q140K probably damaging Het
Ttn C T 2: 76,562,918 (GRCm39) V28679M probably damaging Het
Ubxn8 G A 8: 34,113,231 (GRCm39) R208C probably damaging Het
Vmn2r72 G T 7: 85,387,482 (GRCm39) S694* probably null Het
Wdr38 T A 2: 38,890,276 (GRCm39) W137R probably damaging Het
Zdhhc6 G T 19: 55,292,932 (GRCm39) N271K probably damaging Het
Zfyve9 A G 4: 108,575,744 (GRCm39) S446P possibly damaging Het
Zmynd8 T C 2: 165,649,492 (GRCm39) Q867R possibly damaging Het
Zswim3 T C 2: 164,662,402 (GRCm39) I294T probably benign Het
Other mutations in Grm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1053:Grm2 UTSW 9 106,525,356 (GRCm39) missense probably damaging 0.98
R1116:Grm2 UTSW 9 106,525,126 (GRCm39) missense probably damaging 0.97
R1593:Grm2 UTSW 9 106,528,113 (GRCm39) missense probably damaging 1.00
R1619:Grm2 UTSW 9 106,524,670 (GRCm39) missense probably damaging 1.00
R2174:Grm2 UTSW 9 106,524,994 (GRCm39) missense probably benign 0.05
R2357:Grm2 UTSW 9 106,524,780 (GRCm39) missense probably damaging 0.99
R3115:Grm2 UTSW 9 106,524,822 (GRCm39) missense probably damaging 0.97
R4453:Grm2 UTSW 9 106,531,078 (GRCm39) missense probably damaging 0.97
R4700:Grm2 UTSW 9 106,531,130 (GRCm39) missense probably benign 0.18
R4854:Grm2 UTSW 9 106,531,331 (GRCm39) missense possibly damaging 0.80
R4871:Grm2 UTSW 9 106,524,844 (GRCm39) missense probably benign 0.00
R4888:Grm2 UTSW 9 106,527,865 (GRCm39) missense probably damaging 0.98
R4999:Grm2 UTSW 9 106,531,189 (GRCm39) missense probably damaging 1.00
R5617:Grm2 UTSW 9 106,528,275 (GRCm39) splice site probably null
R5620:Grm2 UTSW 9 106,527,645 (GRCm39) missense probably damaging 0.96
R6021:Grm2 UTSW 9 106,527,999 (GRCm39) missense probably damaging 1.00
R6089:Grm2 UTSW 9 106,531,090 (GRCm39) missense probably damaging 1.00
R6662:Grm2 UTSW 9 106,525,252 (GRCm39) missense probably benign 0.01
R7061:Grm2 UTSW 9 106,528,424 (GRCm39) missense probably damaging 0.98
R7270:Grm2 UTSW 9 106,528,257 (GRCm39) missense probably damaging 0.98
R7479:Grm2 UTSW 9 106,531,050 (GRCm39) missense possibly damaging 0.84
R7542:Grm2 UTSW 9 106,528,368 (GRCm39) missense probably damaging 0.98
R8960:Grm2 UTSW 9 106,531,345 (GRCm39) missense probably benign 0.06
R9028:Grm2 UTSW 9 106,528,384 (GRCm39) missense possibly damaging 0.86
R9150:Grm2 UTSW 9 106,524,657 (GRCm39) missense
R9333:Grm2 UTSW 9 106,525,416 (GRCm39) missense possibly damaging 0.71
R9345:Grm2 UTSW 9 106,528,287 (GRCm39) missense probably damaging 0.98
R9520:Grm2 UTSW 9 106,525,230 (GRCm39) missense
R9594:Grm2 UTSW 9 106,524,408 (GRCm39) missense probably damaging 1.00
Z1177:Grm2 UTSW 9 106,522,264 (GRCm39) missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- CATGATGGACACTTGGCACC -3'
(R):5'- TGGTGACCTTGCGCTGTAAC -3'

Sequencing Primer
(F):5'- ACCTCCCTGGACATTTCTCCAAG -3'
(R):5'- TTGCGCTGTAACCACCGTG -3'
Posted On 2019-06-26