Incidental Mutation 'R7266:Fer1l6'
ID 564956
Institutional Source Beutler Lab
Gene Symbol Fer1l6
Ensembl Gene ENSMUSG00000037106
Gene Name fer-1 like family member 6
Synonyms EG631797
MMRRC Submission 045389-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R7266 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 58381897-58536936 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58499446 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 1272 (N1272I)
Ref Sequence ENSEMBL: ENSMUSP00000125718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161028]
AlphaFold E0CZ42
Predicted Effect probably benign
Transcript: ENSMUST00000161028
AA Change: N1272I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000125718
Gene: ENSMUSG00000037106
AA Change: N1272I

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
C2 83 179 4.09e-12 SMART
FerI 165 235 2.06e-36 SMART
C2 243 354 5.19e-14 SMART
low complexity region 412 449 N/A INTRINSIC
FerB 714 787 2.53e-45 SMART
C2 829 936 8.84e-8 SMART
C2 1000 1099 3.05e0 SMART
low complexity region 1189 1203 N/A INTRINSIC
low complexity region 1256 1270 N/A INTRINSIC
C2 1361 1460 5.78e-12 SMART
low complexity region 1518 1529 N/A INTRINSIC
C2 1601 1731 1.01e-2 SMART
Pfam:Ferlin_C 1765 1857 2.3e-40 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T A 8: 25,157,639 (GRCm39) I104F probably benign Het
Adgrg7 C T 16: 56,590,674 (GRCm39) V166I probably benign Het
Agfg1 G T 1: 82,859,966 (GRCm39) V278L probably benign Het
Alpk3 A G 7: 80,742,328 (GRCm39) E715G possibly damaging Het
Ap2m1 A G 16: 20,362,095 (GRCm39) Y401C probably damaging Het
Arhgef28 C T 13: 98,101,960 (GRCm39) S838N probably benign Het
Ash2l A T 8: 26,317,233 (GRCm39) Y373* probably null Het
Best2 C T 8: 85,734,393 (GRCm39) V442I probably benign Het
Col4a2 T C 8: 11,475,542 (GRCm39) probably null Het
Fat2 T A 11: 55,175,856 (GRCm39) D1619V probably damaging Het
Gcc1 T A 6: 28,417,995 (GRCm39) *779C probably null Het
Gm12216 G A 11: 53,750,077 (GRCm39) probably benign Het
Grm2 C T 9: 106,524,370 (GRCm39) V311I Het
Immt T A 6: 71,851,689 (GRCm39) D683E probably benign Het
Itga8 T G 2: 12,237,712 (GRCm39) D336A probably damaging Het
Jhy T C 9: 40,872,453 (GRCm39) T19A probably benign Het
Kcnq2 T C 2: 180,776,885 (GRCm39) M1V probably null Het
Kctd17 A T 15: 78,317,214 (GRCm39) I117F probably damaging Het
Lrp6 T C 6: 134,484,364 (GRCm39) T420A probably damaging Het
Manba T C 3: 135,223,673 (GRCm39) S187P probably damaging Het
Mef2b A T 8: 70,616,938 (GRCm39) D13V probably damaging Het
Mical2 T C 7: 111,902,963 (GRCm39) F145L probably damaging Het
Mphosph8 T A 14: 56,922,497 (GRCm39) D551E possibly damaging Het
Mplkipl1 A G 19: 61,163,973 (GRCm39) V154A possibly damaging Het
Myo10 C G 15: 25,783,067 (GRCm39) R1170G probably damaging Het
Myo16 A C 8: 10,322,687 (GRCm39) Q39P unknown Het
Myo1f A G 17: 33,820,668 (GRCm39) E837G probably benign Het
Nell2 T A 15: 95,333,274 (GRCm39) I128F possibly damaging Het
Or1i2 A G 10: 78,448,448 (GRCm39) V9A probably benign Het
Pcdh15 A T 10: 74,215,222 (GRCm39) R659* probably null Het
Pcdhga1 A G 18: 37,973,028 (GRCm39) Q881R possibly damaging Het
Plekhm2 T G 4: 141,369,770 (GRCm39) E75A possibly damaging Het
Prc1 A G 7: 79,957,405 (GRCm39) K357E possibly damaging Het
Pxk T A 14: 8,146,220 (GRCm38) C377S probably benign Het
Ralgapa2 T C 2: 146,176,488 (GRCm39) E1696G probably damaging Het
Rbbp6 T A 7: 122,600,590 (GRCm39) S1532R unknown Het
Scn5a G T 9: 119,391,626 (GRCm39) A22E probably benign Het
Sctr G A 1: 119,949,955 (GRCm39) R48Q probably benign Het
Siae T C 9: 37,534,309 (GRCm39) V115A probably damaging Het
Slc16a6 A G 11: 109,344,107 (GRCm39) C563R probably benign Het
Sntg1 A C 1: 8,752,243 (GRCm39) V58G possibly damaging Het
Snx11 C T 11: 96,663,985 (GRCm39) V36M probably damaging Het
Stk3 C A 15: 34,959,182 (GRCm39) S330I probably benign Het
Synpo A G 18: 60,762,631 (GRCm39) F92S probably benign Het
Tle1 A G 4: 72,057,924 (GRCm39) probably null Het
Tmem117 A G 15: 94,829,684 (GRCm39) D173G possibly damaging Het
Tmem217b C A 17: 29,738,347 (GRCm39) V140L probably benign Het
Tmprss5 T C 9: 49,025,841 (GRCm39) W338R probably benign Het
Tnfrsf19 T C 14: 61,212,147 (GRCm39) T168A possibly damaging Het
Trhde C T 10: 114,636,776 (GRCm39) G144S possibly damaging Het
Trim56 G T 5: 137,143,097 (GRCm39) Q140K probably damaging Het
Ttn C T 2: 76,562,918 (GRCm39) V28679M probably damaging Het
Ubxn8 G A 8: 34,113,231 (GRCm39) R208C probably damaging Het
Vmn2r72 G T 7: 85,387,482 (GRCm39) S694* probably null Het
Wdr38 T A 2: 38,890,276 (GRCm39) W137R probably damaging Het
Zdhhc6 G T 19: 55,292,932 (GRCm39) N271K probably damaging Het
Zfyve9 A G 4: 108,575,744 (GRCm39) S446P possibly damaging Het
Zmynd8 T C 2: 165,649,492 (GRCm39) Q867R possibly damaging Het
Zswim3 T C 2: 164,662,402 (GRCm39) I294T probably benign Het
Other mutations in Fer1l6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0009:Fer1l6 UTSW 15 58,534,636 (GRCm39) missense probably damaging 1.00
R0141:Fer1l6 UTSW 15 58,430,251 (GRCm39) missense probably damaging 1.00
R0178:Fer1l6 UTSW 15 58,509,763 (GRCm39) splice site probably null
R0304:Fer1l6 UTSW 15 58,462,411 (GRCm39) missense probably benign 0.08
R0379:Fer1l6 UTSW 15 58,420,187 (GRCm39) missense probably benign 0.05
R0457:Fer1l6 UTSW 15 58,509,943 (GRCm39) critical splice donor site probably null
R0546:Fer1l6 UTSW 15 58,430,257 (GRCm39) splice site probably null
R0602:Fer1l6 UTSW 15 58,449,794 (GRCm39) missense probably damaging 0.98
R0619:Fer1l6 UTSW 15 58,534,784 (GRCm39) splice site probably null
R0669:Fer1l6 UTSW 15 58,425,573 (GRCm39) splice site probably null
R0854:Fer1l6 UTSW 15 58,431,037 (GRCm39) missense probably benign 0.00
R0948:Fer1l6 UTSW 15 58,435,924 (GRCm39) missense probably benign 0.00
R1180:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R1483:Fer1l6 UTSW 15 58,509,819 (GRCm39) missense possibly damaging 0.84
R1627:Fer1l6 UTSW 15 58,513,728 (GRCm39) missense probably benign 0.41
R1635:Fer1l6 UTSW 15 58,518,930 (GRCm39) missense probably damaging 1.00
R1834:Fer1l6 UTSW 15 58,429,718 (GRCm39) missense possibly damaging 0.58
R1921:Fer1l6 UTSW 15 58,497,080 (GRCm39) missense probably damaging 1.00
R2000:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R2041:Fer1l6 UTSW 15 58,430,155 (GRCm39) missense probably damaging 1.00
R2144:Fer1l6 UTSW 15 58,499,383 (GRCm39) missense probably benign
R2145:Fer1l6 UTSW 15 58,499,383 (GRCm39) missense probably benign
R2981:Fer1l6 UTSW 15 58,435,926 (GRCm39) missense probably damaging 0.99
R4164:Fer1l6 UTSW 15 58,431,087 (GRCm39) missense possibly damaging 0.83
R4192:Fer1l6 UTSW 15 58,518,998 (GRCm39) missense probably damaging 1.00
R4273:Fer1l6 UTSW 15 58,499,371 (GRCm39) missense probably benign 0.41
R4573:Fer1l6 UTSW 15 58,498,129 (GRCm39) critical splice donor site probably null
R4581:Fer1l6 UTSW 15 58,512,075 (GRCm39) missense probably damaging 1.00
R4624:Fer1l6 UTSW 15 58,425,554 (GRCm39) missense probably damaging 1.00
R4755:Fer1l6 UTSW 15 58,512,060 (GRCm39) missense probably benign 0.09
R4774:Fer1l6 UTSW 15 58,449,798 (GRCm39) missense probably damaging 0.99
R4894:Fer1l6 UTSW 15 58,490,751 (GRCm39) missense probably damaging 1.00
R4896:Fer1l6 UTSW 15 58,509,869 (GRCm39) missense probably damaging 1.00
R4921:Fer1l6 UTSW 15 58,472,160 (GRCm39) critical splice acceptor site probably null
R4962:Fer1l6 UTSW 15 58,443,250 (GRCm39) missense probably benign 0.03
R5029:Fer1l6 UTSW 15 58,515,769 (GRCm39) missense probably benign 0.00
R5134:Fer1l6 UTSW 15 58,512,003 (GRCm39) missense probably damaging 1.00
R5175:Fer1l6 UTSW 15 58,422,126 (GRCm39) missense probably damaging 1.00
R5227:Fer1l6 UTSW 15 58,453,752 (GRCm39) nonsense probably null
R5561:Fer1l6 UTSW 15 58,532,674 (GRCm39) missense probably damaging 0.97
R5621:Fer1l6 UTSW 15 58,430,175 (GRCm39) missense probably damaging 1.00
R5670:Fer1l6 UTSW 15 58,494,331 (GRCm39) missense probably benign 0.00
R5745:Fer1l6 UTSW 15 58,443,238 (GRCm39) missense probably benign 0.01
R5807:Fer1l6 UTSW 15 58,462,399 (GRCm39) nonsense probably null
R5823:Fer1l6 UTSW 15 58,462,352 (GRCm39) nonsense probably null
R5892:Fer1l6 UTSW 15 58,435,917 (GRCm39) missense probably benign
R6006:Fer1l6 UTSW 15 58,518,893 (GRCm39) missense probably damaging 1.00
R6137:Fer1l6 UTSW 15 58,431,055 (GRCm39) missense probably damaging 0.97
R6195:Fer1l6 UTSW 15 58,509,806 (GRCm39) missense probably damaging 1.00
R6234:Fer1l6 UTSW 15 58,432,488 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,509,855 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,497,026 (GRCm39) nonsense probably null
R6271:Fer1l6 UTSW 15 58,513,767 (GRCm39) missense probably benign 0.01
R6336:Fer1l6 UTSW 15 58,431,081 (GRCm39) nonsense probably null
R6784:Fer1l6 UTSW 15 58,443,275 (GRCm39) missense possibly damaging 0.63
R6852:Fer1l6 UTSW 15 58,466,727 (GRCm39) missense probably damaging 1.00
R7030:Fer1l6 UTSW 15 58,501,227 (GRCm39) missense probably damaging 1.00
R7088:Fer1l6 UTSW 15 58,435,899 (GRCm39) missense possibly damaging 0.69
R7181:Fer1l6 UTSW 15 58,447,146 (GRCm39) missense probably benign 0.00
R7226:Fer1l6 UTSW 15 58,462,384 (GRCm39) missense probably benign 0.00
R7463:Fer1l6 UTSW 15 58,445,450 (GRCm39) nonsense probably null
R7464:Fer1l6 UTSW 15 58,445,096 (GRCm39) splice site probably null
R7469:Fer1l6 UTSW 15 58,462,419 (GRCm39) splice site probably null
R7483:Fer1l6 UTSW 15 58,513,794 (GRCm39) missense possibly damaging 0.83
R7491:Fer1l6 UTSW 15 58,472,281 (GRCm39) missense probably damaging 1.00
R7534:Fer1l6 UTSW 15 58,509,875 (GRCm39) missense probably damaging 1.00
R7562:Fer1l6 UTSW 15 58,432,331 (GRCm39) missense probably benign 0.00
R7580:Fer1l6 UTSW 15 58,430,245 (GRCm39) missense probably benign 0.41
R7599:Fer1l6 UTSW 15 58,499,438 (GRCm39) missense probably benign
R7607:Fer1l6 UTSW 15 58,534,581 (GRCm39) nonsense probably null
R7677:Fer1l6 UTSW 15 58,474,139 (GRCm39) missense probably benign 0.00
R8202:Fer1l6 UTSW 15 58,502,486 (GRCm39) missense probably damaging 1.00
R8261:Fer1l6 UTSW 15 58,432,345 (GRCm39) missense possibly damaging 0.84
R8847:Fer1l6 UTSW 15 58,414,012 (GRCm39) missense possibly damaging 0.72
R9022:Fer1l6 UTSW 15 58,455,329 (GRCm39) missense probably damaging 0.99
R9030:Fer1l6 UTSW 15 58,502,594 (GRCm39) missense probably damaging 1.00
R9160:Fer1l6 UTSW 15 58,515,715 (GRCm39) missense possibly damaging 0.94
R9180:Fer1l6 UTSW 15 58,494,230 (GRCm39) missense probably benign 0.19
R9289:Fer1l6 UTSW 15 58,490,766 (GRCm39) missense probably damaging 1.00
R9559:Fer1l6 UTSW 15 58,429,759 (GRCm39) missense possibly damaging 0.88
R9562:Fer1l6 UTSW 15 58,490,370 (GRCm39) missense possibly damaging 0.70
R9682:Fer1l6 UTSW 15 58,422,113 (GRCm39) missense probably benign 0.03
R9775:Fer1l6 UTSW 15 58,497,098 (GRCm39) missense probably benign
X0021:Fer1l6 UTSW 15 58,441,051 (GRCm39) nonsense probably null
X0027:Fer1l6 UTSW 15 58,501,189 (GRCm39) missense probably damaging 1.00
X0063:Fer1l6 UTSW 15 58,490,423 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGGGCAGCCACAGACATTG -3'
(R):5'- CAGGCTTCATTGTCTTGACTTG -3'

Sequencing Primer
(F):5'- GCCACAGACATTGCACTTACATATG -3'
(R):5'- AGGCTTCATTGTCTTGACTTGTTTAC -3'
Posted On 2019-06-26