Incidental Mutation 'R7267:Grm3'
ID 564984
Institutional Source Beutler Lab
Gene Symbol Grm3
Ensembl Gene ENSMUSG00000003974
Gene Name glutamate receptor, metabotropic 3
Synonyms mGluR3, mGlu3, 0710001G23Rik, Gprc1c
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7267 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 9535541-9775170 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 9639581 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 155 (I155L)
Ref Sequence ENSEMBL: ENSMUSP00000004076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004076]
AlphaFold Q9QYS2
Predicted Effect probably benign
Transcript: ENSMUST00000004076
AA Change: I155L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000004076
Gene: ENSMUSG00000003974
AA Change: I155L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 67 473 4.8e-102 PFAM
Pfam:NCD3G 505 555 2.4e-14 PFAM
Pfam:7tm_3 588 825 4.7e-62 PFAM
low complexity region 849 861 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A G 12: 118,916,205 (GRCm39) I37T probably damaging Het
Ackr2 A G 9: 121,737,874 (GRCm39) Y83C probably damaging Het
Adam19 C T 11: 46,012,403 (GRCm39) Q300* probably null Het
Anxa7 C T 14: 20,519,474 (GRCm39) A115T probably benign Het
Aoc1l3 AGGCCCAGCCTGATCCTAAATTTCCTATCCCCATCAGCAAAGGTGGCCCTCAAGTGGCCCAGCC AGGCCCAGCC 6: 48,964,952 (GRCm39) probably benign Het
Atad2b A T 12: 5,077,105 (GRCm39) R1109* probably null Het
Batf2 A G 19: 6,221,396 (GRCm39) T69A probably benign Het
Best1 A G 19: 9,964,177 (GRCm39) C428R probably benign Het
Birc6 A G 17: 74,892,980 (GRCm39) T973A probably benign Het
Bmp2k C T 5: 97,216,293 (GRCm39) T597I unknown Het
Bmpr1a G A 14: 34,165,836 (GRCm39) P57L possibly damaging Het
Camk2d A T 3: 126,591,379 (GRCm39) H283L possibly damaging Het
Cd86 CA CAA 16: 36,426,917 (GRCm39) probably null Het
Ces1b C A 8: 93,806,132 (GRCm39) K36N possibly damaging Het
Ces2a T A 8: 105,465,672 (GRCm39) M308K probably benign Het
Ctnnd2 C A 15: 30,683,501 (GRCm39) Q501K probably benign Het
Cyb561d1 T C 3: 108,106,629 (GRCm39) T197A probably benign Het
Dedd2 C A 7: 24,918,391 (GRCm39) A55S probably damaging Het
Dnah2 C T 11: 69,391,643 (GRCm39) R684Q probably damaging Het
Elovl3 A G 19: 46,122,979 (GRCm39) Y185C probably damaging Het
Fgf3 C T 7: 144,392,569 (GRCm39) A42V probably damaging Het
Gabra5 A G 7: 57,140,529 (GRCm39) L56P probably damaging Het
Gm19410 T G 8: 36,281,997 (GRCm39) V1860G possibly damaging Het
Gm21663 G T 5: 26,143,751 (GRCm39) N190K probably damaging Het
Hadha A G 5: 30,327,755 (GRCm39) I495T probably damaging Het
Herc4 C T 10: 63,109,365 (GRCm39) A200V possibly damaging Het
Itga3 C A 11: 94,967,188 (GRCm39) probably benign Het
Krt6a C T 15: 101,602,289 (GRCm39) S132N probably benign Het
Lpar1 T C 4: 58,486,857 (GRCm39) N138S possibly damaging Het
Lrrc42 T A 4: 107,096,983 (GRCm39) T247S probably damaging Het
Man2b1 T A 8: 85,813,804 (GRCm39) V256E probably damaging Het
Map3k4 G T 17: 12,490,536 (GRCm39) Y298* probably null Het
Mars1 A G 10: 127,144,455 (GRCm39) V195A probably benign Het
Mdm4 A T 1: 132,922,311 (GRCm39) V278E probably benign Het
Mdp1 A G 14: 55,897,544 (GRCm39) V37A probably damaging Het
Med13 A G 11: 86,199,652 (GRCm39) I685T probably benign Het
Mobp A G 9: 119,996,914 (GRCm39) N15S probably damaging Het
Nbn T A 4: 15,979,320 (GRCm39) M435K probably benign Het
Nfs1 A G 2: 155,965,703 (GRCm39) V126A probably benign Het
Npepl1 T A 2: 173,963,909 (GRCm39) V480E probably damaging Het
Nr2e3 G A 9: 59,855,972 (GRCm39) S155F possibly damaging Het
Oplah T C 15: 76,189,209 (GRCm39) D278G probably benign Het
Or4c124 A T 2: 89,156,157 (GRCm39) Y122* probably null Het
Or51q1c A G 7: 103,653,046 (GRCm39) H188R probably benign Het
Pard3 T C 8: 128,098,056 (GRCm39) Y366H probably damaging Het
Pcdhb11 A G 18: 37,555,006 (GRCm39) N112S possibly damaging Het
Pde11a A G 2: 76,168,189 (GRCm39) S255P probably damaging Het
Piezo1 T C 8: 123,224,268 (GRCm39) H745R Het
Pkn2 A T 3: 142,517,776 (GRCm39) S441T possibly damaging Het
Pld1 A C 3: 28,130,550 (GRCm39) H450P probably damaging Het
Plekhs1 T A 19: 56,459,209 (GRCm39) H22Q probably damaging Het
Prss44 A C 9: 110,645,611 (GRCm39) Y285S probably damaging Het
Qpctl T C 7: 18,878,852 (GRCm39) E249G probably benign Het
Rcsd1 A T 1: 165,491,185 (GRCm39) S50T probably damaging Het
Runx2 G A 17: 45,125,079 (GRCm39) P80L probably damaging Het
Scube1 T A 15: 83,505,266 (GRCm39) N496Y probably damaging Het
Skic3 A G 13: 76,328,196 (GRCm39) M1415V probably benign Het
Slc16a8 AGGCC A 15: 79,136,125 (GRCm39) probably null Het
Slc38a4 T A 15: 96,903,781 (GRCm39) T407S probably benign Het
Slc51a T G 16: 32,298,590 (GRCm39) I56L probably benign Het
Slc6a18 T G 13: 73,819,755 (GRCm39) I272L probably damaging Het
Sorl1 A G 9: 42,035,375 (GRCm39) L12P possibly damaging Het
Sycp2l A T 13: 41,300,070 (GRCm39) D428V possibly damaging Het
Syne1 C T 10: 5,178,218 (GRCm39) R4752Q probably damaging Het
Tbc1d9 C A 8: 83,997,957 (GRCm39) H1171Q probably damaging Het
Thsd1 G A 8: 22,733,597 (GRCm39) V215I probably benign Het
Tmem143 T A 7: 45,557,598 (GRCm39) M208K probably benign Het
Tmem63b C T 17: 45,977,048 (GRCm39) V440I probably benign Het
Tnik A T 3: 28,700,776 (GRCm39) S918C probably damaging Het
Ttn A G 2: 76,733,751 (GRCm39) I4508T unknown Het
Vav2 A G 2: 27,173,334 (GRCm39) F497L probably damaging Het
Zc3h14 G A 12: 98,751,988 (GRCm39) R730Q probably damaging Het
Zfp560 G A 9: 20,259,384 (GRCm39) H493Y probably damaging Het
Other mutations in Grm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00495:Grm3 APN 5 9,562,290 (GRCm39) missense probably benign
IGL01393:Grm3 APN 5 9,639,856 (GRCm39) missense probably benign 0.00
IGL01398:Grm3 APN 5 9,535,762 (GRCm39) unclassified probably benign
IGL01825:Grm3 APN 5 9,561,600 (GRCm39) missense probably damaging 1.00
IGL01966:Grm3 APN 5 9,561,486 (GRCm39) missense probably damaging 0.98
IGL02367:Grm3 APN 5 9,561,660 (GRCm39) missense probably damaging 1.00
IGL02526:Grm3 APN 5 9,639,847 (GRCm39) missense probably damaging 1.00
IGL02972:Grm3 APN 5 9,562,410 (GRCm39) missense probably damaging 1.00
IGL03356:Grm3 APN 5 9,562,206 (GRCm39) missense possibly damaging 0.89
BB002:Grm3 UTSW 5 9,639,880 (GRCm39) missense probably benign 0.09
BB012:Grm3 UTSW 5 9,639,880 (GRCm39) missense probably benign 0.09
R0032:Grm3 UTSW 5 9,561,452 (GRCm39) splice site probably null
R0032:Grm3 UTSW 5 9,561,452 (GRCm39) splice site probably null
R0389:Grm3 UTSW 5 9,554,794 (GRCm39) missense probably damaging 1.00
R0455:Grm3 UTSW 5 9,562,477 (GRCm39) missense probably benign
R0538:Grm3 UTSW 5 9,562,446 (GRCm39) missense possibly damaging 0.95
R0553:Grm3 UTSW 5 9,620,048 (GRCm39) missense probably benign 0.16
R1124:Grm3 UTSW 5 9,620,297 (GRCm39) missense probably benign
R1163:Grm3 UTSW 5 9,620,738 (GRCm39) missense probably benign 0.34
R1440:Grm3 UTSW 5 9,639,958 (GRCm39) missense probably benign
R1635:Grm3 UTSW 5 9,561,520 (GRCm39) missense probably damaging 1.00
R1734:Grm3 UTSW 5 9,639,742 (GRCm39) missense probably benign 0.00
R1895:Grm3 UTSW 5 9,562,123 (GRCm39) missense probably damaging 1.00
R1926:Grm3 UTSW 5 9,554,881 (GRCm39) missense probably damaging 0.98
R1940:Grm3 UTSW 5 9,561,682 (GRCm39) missense probably damaging 1.00
R1946:Grm3 UTSW 5 9,562,123 (GRCm39) missense probably damaging 1.00
R2004:Grm3 UTSW 5 9,639,793 (GRCm39) missense possibly damaging 0.57
R2005:Grm3 UTSW 5 9,639,793 (GRCm39) missense possibly damaging 0.57
R2006:Grm3 UTSW 5 9,639,793 (GRCm39) missense possibly damaging 0.57
R3116:Grm3 UTSW 5 9,620,752 (GRCm39) missense probably damaging 1.00
R4083:Grm3 UTSW 5 9,562,054 (GRCm39) missense probably benign
R4537:Grm3 UTSW 5 9,562,083 (GRCm39) missense probably benign 0.02
R4855:Grm3 UTSW 5 9,620,047 (GRCm39) missense probably damaging 0.98
R5060:Grm3 UTSW 5 9,620,167 (GRCm39) missense probably damaging 0.99
R5093:Grm3 UTSW 5 9,639,766 (GRCm39) missense probably benign 0.01
R5419:Grm3 UTSW 5 9,620,233 (GRCm39) missense probably damaging 1.00
R5525:Grm3 UTSW 5 9,554,872 (GRCm39) missense probably damaging 1.00
R5642:Grm3 UTSW 5 9,620,536 (GRCm39) missense probably benign 0.21
R5804:Grm3 UTSW 5 9,620,155 (GRCm39) missense probably benign 0.33
R5915:Grm3 UTSW 5 9,561,927 (GRCm39) missense probably damaging 1.00
R5966:Grm3 UTSW 5 9,561,930 (GRCm39) missense probably damaging 0.98
R6151:Grm3 UTSW 5 9,561,556 (GRCm39) missense probably damaging 1.00
R6419:Grm3 UTSW 5 9,620,201 (GRCm39) missense probably damaging 1.00
R7555:Grm3 UTSW 5 9,620,000 (GRCm39) missense probably benign 0.00
R7657:Grm3 UTSW 5 9,561,452 (GRCm39) splice site probably null
R7925:Grm3 UTSW 5 9,639,880 (GRCm39) missense probably benign 0.09
R8032:Grm3 UTSW 5 9,562,272 (GRCm39) missense probably benign 0.11
R8227:Grm3 UTSW 5 9,620,242 (GRCm39) missense possibly damaging 0.65
R8462:Grm3 UTSW 5 9,562,365 (GRCm39) missense probably benign
R8500:Grm3 UTSW 5 9,561,726 (GRCm39) missense probably benign 0.21
R8696:Grm3 UTSW 5 9,562,311 (GRCm39) missense probably damaging 1.00
R8807:Grm3 UTSW 5 9,561,499 (GRCm39) missense probably damaging 1.00
R8828:Grm3 UTSW 5 9,554,725 (GRCm39) missense probably benign 0.00
R8876:Grm3 UTSW 5 9,561,580 (GRCm39) missense probably damaging 1.00
R8896:Grm3 UTSW 5 9,562,483 (GRCm39) missense possibly damaging 0.91
R9035:Grm3 UTSW 5 9,620,464 (GRCm39) missense probably damaging 0.99
R9779:Grm3 UTSW 5 9,561,656 (GRCm39) missense possibly damaging 0.74
X0020:Grm3 UTSW 5 9,562,195 (GRCm39) missense probably damaging 1.00
X0025:Grm3 UTSW 5 9,535,790 (GRCm39) missense probably damaging 1.00
X0026:Grm3 UTSW 5 9,562,238 (GRCm39) nonsense probably null
Z1088:Grm3 UTSW 5 9,620,183 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CTGGGAAGTACCACTCACAG -3'
(R):5'- TGCTTCCAGGAGTGAAGCTG -3'

Sequencing Primer
(F):5'- TGGGAAGTACCACTCACAGTTTAC -3'
(R):5'- CTGGGGGTTCACATTTTGGATAC -3'
Posted On 2019-06-26