Incidental Mutation 'R7267:Ctnnd2'
ID 565025
Institutional Source Beutler Lab
Gene Symbol Ctnnd2
Ensembl Gene ENSMUSG00000022240
Gene Name catenin delta 2
Synonyms Nprap, Catnd2, neurojugin, catenin (cadherin associated protein), delta 2
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7267 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 30172739-31029487 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 30683501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 501 (Q501K)
Ref Sequence ENSEMBL: ENSMUSP00000080427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081728] [ENSMUST00000226119]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000081728
AA Change: Q501K

PolyPhen 2 Score 0.130 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000080427
Gene: ENSMUSG00000022240
AA Change: Q501K

DomainStartEndE-ValueType
coiled coil region 50 84 N/A INTRINSIC
low complexity region 87 97 N/A INTRINSIC
low complexity region 148 159 N/A INTRINSIC
low complexity region 216 230 N/A INTRINSIC
low complexity region 238 257 N/A INTRINSIC
ARM 577 617 1.85e-8 SMART
ARM 621 662 1.15e-9 SMART
ARM 663 720 1.51e1 SMART
ARM 722 769 2.74e1 SMART
ARM 830 871 4.88e0 SMART
ARM 902 942 2.76e-7 SMART
low complexity region 964 973 N/A INTRINSIC
ARM 995 1039 5.64e-4 SMART
low complexity region 1086 1099 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000226119
AA Change: Q501K

PolyPhen 2 Score 0.206 (Sensitivity: 0.92; Specificity: 0.88)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a reporter allele exhibit abnormal conditioning, spatial learning and coordination behaviors and abnormal long term potentiation. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Targeted(1)

Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A G 12: 118,916,205 (GRCm39) I37T probably damaging Het
Ackr2 A G 9: 121,737,874 (GRCm39) Y83C probably damaging Het
Adam19 C T 11: 46,012,403 (GRCm39) Q300* probably null Het
Anxa7 C T 14: 20,519,474 (GRCm39) A115T probably benign Het
Aoc1l3 AGGCCCAGCCTGATCCTAAATTTCCTATCCCCATCAGCAAAGGTGGCCCTCAAGTGGCCCAGCC AGGCCCAGCC 6: 48,964,952 (GRCm39) probably benign Het
Atad2b A T 12: 5,077,105 (GRCm39) R1109* probably null Het
Batf2 A G 19: 6,221,396 (GRCm39) T69A probably benign Het
Best1 A G 19: 9,964,177 (GRCm39) C428R probably benign Het
Birc6 A G 17: 74,892,980 (GRCm39) T973A probably benign Het
Bmp2k C T 5: 97,216,293 (GRCm39) T597I unknown Het
Bmpr1a G A 14: 34,165,836 (GRCm39) P57L possibly damaging Het
Camk2d A T 3: 126,591,379 (GRCm39) H283L possibly damaging Het
Cd86 CA CAA 16: 36,426,917 (GRCm39) probably null Het
Ces1b C A 8: 93,806,132 (GRCm39) K36N possibly damaging Het
Ces2a T A 8: 105,465,672 (GRCm39) M308K probably benign Het
Cyb561d1 T C 3: 108,106,629 (GRCm39) T197A probably benign Het
Dedd2 C A 7: 24,918,391 (GRCm39) A55S probably damaging Het
Dnah2 C T 11: 69,391,643 (GRCm39) R684Q probably damaging Het
Elovl3 A G 19: 46,122,979 (GRCm39) Y185C probably damaging Het
Fgf3 C T 7: 144,392,569 (GRCm39) A42V probably damaging Het
Gabra5 A G 7: 57,140,529 (GRCm39) L56P probably damaging Het
Gm19410 T G 8: 36,281,997 (GRCm39) V1860G possibly damaging Het
Gm21663 G T 5: 26,143,751 (GRCm39) N190K probably damaging Het
Grm3 T A 5: 9,639,581 (GRCm39) I155L probably benign Het
Hadha A G 5: 30,327,755 (GRCm39) I495T probably damaging Het
Herc4 C T 10: 63,109,365 (GRCm39) A200V possibly damaging Het
Itga3 C A 11: 94,967,188 (GRCm39) probably benign Het
Krt6a C T 15: 101,602,289 (GRCm39) S132N probably benign Het
Lpar1 T C 4: 58,486,857 (GRCm39) N138S possibly damaging Het
Lrrc42 T A 4: 107,096,983 (GRCm39) T247S probably damaging Het
Man2b1 T A 8: 85,813,804 (GRCm39) V256E probably damaging Het
Map3k4 G T 17: 12,490,536 (GRCm39) Y298* probably null Het
Mars1 A G 10: 127,144,455 (GRCm39) V195A probably benign Het
Mdm4 A T 1: 132,922,311 (GRCm39) V278E probably benign Het
Mdp1 A G 14: 55,897,544 (GRCm39) V37A probably damaging Het
Med13 A G 11: 86,199,652 (GRCm39) I685T probably benign Het
Mobp A G 9: 119,996,914 (GRCm39) N15S probably damaging Het
Nbn T A 4: 15,979,320 (GRCm39) M435K probably benign Het
Nfs1 A G 2: 155,965,703 (GRCm39) V126A probably benign Het
Npepl1 T A 2: 173,963,909 (GRCm39) V480E probably damaging Het
Nr2e3 G A 9: 59,855,972 (GRCm39) S155F possibly damaging Het
Oplah T C 15: 76,189,209 (GRCm39) D278G probably benign Het
Or4c124 A T 2: 89,156,157 (GRCm39) Y122* probably null Het
Or51q1c A G 7: 103,653,046 (GRCm39) H188R probably benign Het
Pard3 T C 8: 128,098,056 (GRCm39) Y366H probably damaging Het
Pcdhb11 A G 18: 37,555,006 (GRCm39) N112S possibly damaging Het
Pde11a A G 2: 76,168,189 (GRCm39) S255P probably damaging Het
Piezo1 T C 8: 123,224,268 (GRCm39) H745R Het
Pkn2 A T 3: 142,517,776 (GRCm39) S441T possibly damaging Het
Pld1 A C 3: 28,130,550 (GRCm39) H450P probably damaging Het
Plekhs1 T A 19: 56,459,209 (GRCm39) H22Q probably damaging Het
Prss44 A C 9: 110,645,611 (GRCm39) Y285S probably damaging Het
Qpctl T C 7: 18,878,852 (GRCm39) E249G probably benign Het
Rcsd1 A T 1: 165,491,185 (GRCm39) S50T probably damaging Het
Runx2 G A 17: 45,125,079 (GRCm39) P80L probably damaging Het
Scube1 T A 15: 83,505,266 (GRCm39) N496Y probably damaging Het
Skic3 A G 13: 76,328,196 (GRCm39) M1415V probably benign Het
Slc16a8 AGGCC A 15: 79,136,125 (GRCm39) probably null Het
Slc38a4 T A 15: 96,903,781 (GRCm39) T407S probably benign Het
Slc51a T G 16: 32,298,590 (GRCm39) I56L probably benign Het
Slc6a18 T G 13: 73,819,755 (GRCm39) I272L probably damaging Het
Sorl1 A G 9: 42,035,375 (GRCm39) L12P possibly damaging Het
Sycp2l A T 13: 41,300,070 (GRCm39) D428V possibly damaging Het
Syne1 C T 10: 5,178,218 (GRCm39) R4752Q probably damaging Het
Tbc1d9 C A 8: 83,997,957 (GRCm39) H1171Q probably damaging Het
Thsd1 G A 8: 22,733,597 (GRCm39) V215I probably benign Het
Tmem143 T A 7: 45,557,598 (GRCm39) M208K probably benign Het
Tmem63b C T 17: 45,977,048 (GRCm39) V440I probably benign Het
Tnik A T 3: 28,700,776 (GRCm39) S918C probably damaging Het
Ttn A G 2: 76,733,751 (GRCm39) I4508T unknown Het
Vav2 A G 2: 27,173,334 (GRCm39) F497L probably damaging Het
Zc3h14 G A 12: 98,751,988 (GRCm39) R730Q probably damaging Het
Zfp560 G A 9: 20,259,384 (GRCm39) H493Y probably damaging Het
Other mutations in Ctnnd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00597:Ctnnd2 APN 15 30,647,287 (GRCm39) missense possibly damaging 0.73
IGL01612:Ctnnd2 APN 15 31,005,164 (GRCm39) missense probably damaging 1.00
IGL01923:Ctnnd2 APN 15 30,480,974 (GRCm39) missense probably damaging 0.99
IGL02183:Ctnnd2 APN 15 31,020,886 (GRCm39) missense probably damaging 1.00
IGL02186:Ctnnd2 APN 15 30,480,939 (GRCm39) missense probably damaging 0.99
IGL02226:Ctnnd2 APN 15 30,847,482 (GRCm39) missense probably benign 0.01
IGL02307:Ctnnd2 APN 15 30,647,357 (GRCm39) missense possibly damaging 0.86
IGL02407:Ctnnd2 APN 15 30,966,914 (GRCm39) missense probably damaging 1.00
IGL02474:Ctnnd2 APN 15 30,669,708 (GRCm39) missense possibly damaging 0.71
IGL02718:Ctnnd2 APN 15 31,027,762 (GRCm39) missense probably damaging 1.00
IGL03249:Ctnnd2 APN 15 30,683,382 (GRCm39) missense probably benign 0.45
IGL03328:Ctnnd2 APN 15 30,921,993 (GRCm39) splice site probably benign
carpe UTSW 15 30,905,966 (GRCm39) missense probably damaging 1.00
diem UTSW 15 30,683,493 (GRCm39) missense possibly damaging 0.85
P0016:Ctnnd2 UTSW 15 30,967,084 (GRCm39) missense probably benign 0.00
R0130:Ctnnd2 UTSW 15 30,922,059 (GRCm39) missense probably damaging 1.00
R0408:Ctnnd2 UTSW 15 30,634,823 (GRCm39) missense probably damaging 1.00
R0611:Ctnnd2 UTSW 15 31,009,230 (GRCm39) missense possibly damaging 0.75
R0894:Ctnnd2 UTSW 15 30,332,301 (GRCm39) splice site probably benign
R1112:Ctnnd2 UTSW 15 30,922,026 (GRCm39) missense probably damaging 1.00
R1459:Ctnnd2 UTSW 15 30,847,445 (GRCm39) missense probably damaging 1.00
R1529:Ctnnd2 UTSW 15 30,887,267 (GRCm39) missense possibly damaging 0.91
R1532:Ctnnd2 UTSW 15 30,922,014 (GRCm39) missense probably damaging 1.00
R1701:Ctnnd2 UTSW 15 30,922,127 (GRCm39) missense probably damaging 1.00
R1807:Ctnnd2 UTSW 15 30,620,017 (GRCm39) missense probably damaging 1.00
R1881:Ctnnd2 UTSW 15 31,005,227 (GRCm39) splice site probably benign
R1960:Ctnnd2 UTSW 15 30,647,257 (GRCm39) missense probably damaging 0.96
R2121:Ctnnd2 UTSW 15 30,669,660 (GRCm39) missense probably damaging 1.00
R3839:Ctnnd2 UTSW 15 31,009,174 (GRCm39) splice site probably null
R3967:Ctnnd2 UTSW 15 30,647,075 (GRCm39) missense possibly damaging 0.81
R3980:Ctnnd2 UTSW 15 30,669,589 (GRCm39) missense probably benign 0.14
R4207:Ctnnd2 UTSW 15 30,972,973 (GRCm39) missense probably damaging 0.99
R4279:Ctnnd2 UTSW 15 30,905,966 (GRCm39) missense probably damaging 1.00
R4498:Ctnnd2 UTSW 15 30,620,020 (GRCm39) missense probably damaging 1.00
R4622:Ctnnd2 UTSW 15 31,009,259 (GRCm39) missense probably benign 0.00
R4622:Ctnnd2 UTSW 15 30,887,315 (GRCm39) missense probably benign 0.17
R4860:Ctnnd2 UTSW 15 30,881,313 (GRCm39) missense probably damaging 1.00
R4860:Ctnnd2 UTSW 15 30,881,313 (GRCm39) missense probably damaging 1.00
R4979:Ctnnd2 UTSW 15 31,009,221 (GRCm39) missense probably damaging 1.00
R5086:Ctnnd2 UTSW 15 30,683,493 (GRCm39) missense possibly damaging 0.85
R5330:Ctnnd2 UTSW 15 30,332,261 (GRCm39) missense probably damaging 1.00
R5459:Ctnnd2 UTSW 15 30,887,334 (GRCm39) missense probably damaging 1.00
R5595:Ctnnd2 UTSW 15 30,669,689 (GRCm39) missense probably benign 0.07
R5809:Ctnnd2 UTSW 15 30,847,523 (GRCm39) missense probably damaging 1.00
R5987:Ctnnd2 UTSW 15 30,683,387 (GRCm39) missense probably benign
R6245:Ctnnd2 UTSW 15 30,905,894 (GRCm39) missense probably damaging 1.00
R6379:Ctnnd2 UTSW 15 30,634,844 (GRCm39) missense probably damaging 1.00
R6737:Ctnnd2 UTSW 15 30,966,980 (GRCm39) nonsense probably null
R6979:Ctnnd2 UTSW 15 30,619,376 (GRCm39) missense probably damaging 0.99
R7133:Ctnnd2 UTSW 15 30,480,995 (GRCm39) missense possibly damaging 0.47
R7179:Ctnnd2 UTSW 15 30,683,510 (GRCm39) missense possibly damaging 0.95
R7275:Ctnnd2 UTSW 15 30,905,855 (GRCm39) missense possibly damaging 0.94
R7386:Ctnnd2 UTSW 15 30,966,914 (GRCm39) missense probably damaging 1.00
R7649:Ctnnd2 UTSW 15 31,027,630 (GRCm39) missense probably benign 0.11
R7814:Ctnnd2 UTSW 15 31,020,874 (GRCm39) missense probably benign 0.00
R7849:Ctnnd2 UTSW 15 31,027,733 (GRCm39) missense probably damaging 1.00
R7857:Ctnnd2 UTSW 15 30,620,076 (GRCm39) missense probably benign 0.01
R8057:Ctnnd2 UTSW 15 30,847,497 (GRCm39) missense possibly damaging 0.89
R8236:Ctnnd2 UTSW 15 30,647,164 (GRCm39) missense probably benign
R8260:Ctnnd2 UTSW 15 30,634,879 (GRCm39) missense possibly damaging 0.84
R8411:Ctnnd2 UTSW 15 30,647,179 (GRCm39) missense probably benign 0.33
R8802:Ctnnd2 UTSW 15 30,967,022 (GRCm39) missense probably damaging 1.00
R8891:Ctnnd2 UTSW 15 30,620,076 (GRCm39) missense probably benign 0.01
R8907:Ctnnd2 UTSW 15 30,905,873 (GRCm39) missense probably damaging 1.00
R8989:Ctnnd2 UTSW 15 30,669,660 (GRCm39) missense probably damaging 1.00
R9017:Ctnnd2 UTSW 15 30,881,316 (GRCm39) missense probably damaging 0.96
R9035:Ctnnd2 UTSW 15 30,332,162 (GRCm39) missense possibly damaging 0.77
R9061:Ctnnd2 UTSW 15 30,806,884 (GRCm39) missense probably damaging 1.00
R9303:Ctnnd2 UTSW 15 30,967,037 (GRCm39) missense probably damaging 0.99
R9475:Ctnnd2 UTSW 15 30,881,276 (GRCm39) missense probably damaging 1.00
Z1088:Ctnnd2 UTSW 15 30,966,959 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- GTTTCTGTGAGCAGGTCCTC -3'
(R):5'- AAGCAGGCAGTAACAGCTC -3'

Sequencing Primer
(F):5'- CAGGTCCTCAATTTTTTACTTTG -3'
(R):5'- GGCAGTAACAGCTCACAGC -3'
Posted On 2019-06-26