Incidental Mutation 'R7269:Vmn2r2'
ID 565126
Institutional Source Beutler Lab
Gene Symbol Vmn2r2
Ensembl Gene ENSMUSG00000043897
Gene Name vomeronasal 2, receptor 2
Synonyms
MMRRC Submission 045320-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R7269 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 64022699-64049349 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 64033998 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 508 (T508I)
Ref Sequence ENSEMBL: ENSMUSP00000135110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077958] [ENSMUST00000177151]
AlphaFold L7N2E9
Predicted Effect probably benign
Transcript: ENSMUST00000077958
AA Change: T424I

PolyPhen 2 Score 0.093 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000077109
Gene: ENSMUSG00000043897
AA Change: T424I

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 4.5e-80 PFAM
Pfam:NCD3G 458 511 8.3e-18 PFAM
Pfam:7tm_3 542 779 1.3e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177151
AA Change: T508I

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000135110
Gene: ENSMUSG00000043897
AA Change: T508I

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 83 500 1.6e-84 PFAM
Pfam:NCD3G 542 595 2.6e-17 PFAM
Pfam:7tm_3 628 862 1.9e-47 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 98% (85/87)
Allele List at MGI
Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A T 18: 24,606,013 (GRCm39) N36I probably damaging Het
A430033K04Rik T A 5: 138,645,014 (GRCm39) Y300N possibly damaging Het
Adipor2 T C 6: 119,347,205 (GRCm39) Q26R probably benign Het
Ahnak T A 19: 8,983,981 (GRCm39) M1755K probably damaging Het
Ahnak2 A T 12: 112,780,802 (GRCm38) V70E Het
AI837181 C A 19: 5,476,462 (GRCm39) S208R probably damaging Het
Arhgap35 T G 7: 16,295,652 (GRCm39) M1138L probably benign Het
Card14 T G 11: 119,228,573 (GRCm39) L633R probably damaging Het
Carmil3 A G 14: 55,731,352 (GRCm39) T144A probably benign Het
Cbfa2t2 T A 2: 154,357,895 (GRCm39) N223K probably benign Het
Ccdc39 T C 3: 33,884,254 (GRCm39) I363V probably benign Het
Ccng2 C G 5: 93,421,202 (GRCm39) S237R probably benign Het
Ccpg1 G T 9: 72,920,609 (GRCm39) R741S probably benign Het
Cenpc1 A G 5: 86,161,366 (GRCm39) F855L probably damaging Het
Cenpc1 A T 5: 86,180,277 (GRCm39) M665K probably benign Het
Cp A G 3: 20,037,641 (GRCm39) H832R probably damaging Het
Defa24 A G 8: 22,224,565 (GRCm39) I5V probably benign Het
Dlc1 A C 8: 37,046,407 (GRCm39) L730R probably damaging Het
Dmbt1 A T 7: 130,668,351 (GRCm39) I536F unknown Het
Dscam G A 16: 96,479,601 (GRCm39) T1182I probably benign Het
Eea1 A T 10: 95,854,000 (GRCm39) I553F probably damaging Het
Far1 T C 7: 113,160,654 (GRCm39) V400A probably benign Het
Fbrsl1 A T 5: 110,580,880 (GRCm39) S126T probably benign Het
Frmpd2 A T 14: 33,244,838 (GRCm39) E552V possibly damaging Het
Gm5431 T A 11: 48,779,237 (GRCm39) T562S probably benign Het
Gm5475 T C 15: 100,324,890 (GRCm39) F106S unknown Het
Gpr12 T C 5: 146,520,188 (GRCm39) T245A probably damaging Het
Gsta2 A G 9: 78,239,419 (GRCm39) Y166H probably benign Het
H6pd A G 4: 150,067,369 (GRCm39) V347A probably benign Het
Ifih1 T C 2: 62,475,977 (GRCm39) T100A probably benign Het
Ift70b A G 2: 75,767,838 (GRCm39) F305S probably damaging Het
Itga2 C T 13: 115,023,225 (GRCm39) W59* probably null Het
Knstrn T A 2: 118,661,869 (GRCm39) probably null Het
Kprp A G 3: 92,731,178 (GRCm39) V624A probably damaging Het
Lmbrd2 A G 15: 9,194,771 (GRCm39) Y591C probably damaging Het
Map7d1 A G 4: 126,126,666 (GRCm39) V842A unknown Het
Mboat2 A T 12: 24,881,708 (GRCm39) T4S probably benign Het
Mcph1 T A 8: 18,657,288 (GRCm39) probably null Het
Mrtfb A T 16: 13,218,898 (GRCm39) M515L possibly damaging Het
Muc5b A G 7: 141,411,272 (GRCm39) D1406G unknown Het
Mylk G A 16: 34,605,381 (GRCm39) G3D probably damaging Het
Ndst4 A G 3: 125,232,007 (GRCm39) D192G probably damaging Het
Nemp1 G T 10: 127,531,345 (GRCm39) R361L probably damaging Het
Nol4 A C 18: 23,172,846 (GRCm39) V85G probably benign Het
Nrbf2 G A 10: 67,103,605 (GRCm39) T166M probably damaging Het
Obscn T C 11: 58,933,838 (GRCm39) E5342G probably damaging Het
Or10al7 C A 17: 38,366,442 (GRCm39) C5F probably damaging Het
Or4f47 T A 2: 111,972,905 (GRCm39) F205Y probably damaging Het
Or4p19 C T 2: 88,242,839 (GRCm39) M54I possibly damaging Het
Or51d1 T G 7: 102,348,252 (GRCm39) L269R probably damaging Het
Or7d10 A G 9: 19,831,631 (GRCm39) N42S possibly damaging Het
Pakap G T 4: 57,855,217 (GRCm39) R182L probably damaging Het
Pde4dip A G 3: 97,674,275 (GRCm39) S214P probably damaging Het
Per3 A T 4: 151,116,393 (GRCm39) C278* probably null Het
Pi4k2a T C 19: 42,079,125 (GRCm39) L62P probably damaging Het
Plekha7 C A 7: 115,780,447 (GRCm39) G126W probably damaging Het
Ppp1r13b T C 12: 111,801,353 (GRCm39) K567E probably damaging Het
Pradc1 T A 6: 85,424,548 (GRCm39) Q134L probably benign Het
Pwp2 A G 10: 78,012,170 (GRCm39) F628L probably benign Het
Rab5c C T 11: 100,606,928 (GRCm39) G217D probably benign Het
Rad51ap2 G T 12: 11,506,807 (GRCm39) S243I possibly damaging Het
Rasgrp4 C A 7: 28,847,855 (GRCm39) R432S probably damaging Het
Rhot2 C T 17: 26,061,402 (GRCm39) probably null Het
Scn2a T A 2: 65,594,113 (GRCm39) L1654Q probably damaging Het
Skint6 A T 4: 112,711,686 (GRCm39) probably null Het
Slc22a28 T A 19: 8,094,491 (GRCm39) T177S probably benign Het
Slc25a24 G T 3: 109,065,960 (GRCm39) Q272H probably null Het
Slc3a1 A T 17: 85,339,873 (GRCm39) I144F probably damaging Het
Smg9 C T 7: 24,105,495 (GRCm39) R176C possibly damaging Het
Sorl1 A T 9: 41,948,499 (GRCm39) L762Q probably damaging Het
Srebf2 C A 15: 82,088,270 (GRCm39) P1079T probably benign Het
Sub1 A T 15: 11,993,937 (GRCm39) S4T probably benign Het
Tacr1 A T 6: 82,469,692 (GRCm39) Y192F probably benign Het
Tm4sf19 A T 16: 32,224,814 (GRCm39) H54L probably damaging Het
Tnxb T C 17: 34,914,428 (GRCm39) L1838P probably damaging Het
Trmt1l T C 1: 151,333,539 (GRCm39) S681P possibly damaging Het
Ttn A G 2: 76,738,176 (GRCm39) V4167A unknown Het
Unc13d T A 11: 115,959,056 (GRCm39) M702L probably benign Het
Vgll3 A G 16: 65,636,404 (GRCm39) H240R probably benign Het
Vmn1r189 C G 13: 22,286,737 (GRCm39) W33C probably benign Het
Vmn2r17 G A 5: 109,576,337 (GRCm39) A403T possibly damaging Het
Vps54 T A 11: 21,227,670 (GRCm39) probably null Het
Wfs1 G A 5: 37,125,134 (GRCm39) Q586* probably null Het
Zbp1 A T 2: 173,055,665 (GRCm39) H166Q unknown Het
Zcchc3 G A 2: 152,256,294 (GRCm39) A135V probably benign Het
Zfp51 T C 17: 21,683,960 (GRCm39) Y192H probably benign Het
Zkscan2 T C 7: 123,088,994 (GRCm39) T426A probably benign Het
Other mutations in Vmn2r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00326:Vmn2r2 APN 3 64,041,319 (GRCm39) splice site probably benign
IGL00980:Vmn2r2 APN 3 64,024,601 (GRCm39) missense probably benign 0.11
IGL01389:Vmn2r2 APN 3 64,024,430 (GRCm39) missense probably damaging 0.97
IGL01804:Vmn2r2 APN 3 64,041,677 (GRCm39) missense possibly damaging 0.91
IGL02750:Vmn2r2 APN 3 64,024,823 (GRCm39) missense probably damaging 1.00
IGL02829:Vmn2r2 APN 3 64,026,172 (GRCm39) splice site probably benign
IGL03036:Vmn2r2 APN 3 64,024,321 (GRCm39) missense probably benign 0.01
IGL03174:Vmn2r2 APN 3 64,024,544 (GRCm39) nonsense probably null
PIT4151001:Vmn2r2 UTSW 3 64,024,334 (GRCm39) missense possibly damaging 0.67
R0029:Vmn2r2 UTSW 3 64,024,365 (GRCm39) missense probably benign 0.00
R0310:Vmn2r2 UTSW 3 64,042,039 (GRCm39) missense probably damaging 1.00
R0357:Vmn2r2 UTSW 3 64,041,320 (GRCm39) splice site probably null
R0637:Vmn2r2 UTSW 3 64,033,999 (GRCm39) missense probably benign 0.00
R1626:Vmn2r2 UTSW 3 64,041,921 (GRCm39) missense possibly damaging 0.61
R1662:Vmn2r2 UTSW 3 64,024,551 (GRCm39) missense probably benign 0.00
R1710:Vmn2r2 UTSW 3 64,024,820 (GRCm39) missense probably benign 0.19
R1797:Vmn2r2 UTSW 3 64,042,128 (GRCm39) missense probably benign 0.00
R1862:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
R1971:Vmn2r2 UTSW 3 64,034,121 (GRCm39) missense probably damaging 1.00
R2051:Vmn2r2 UTSW 3 64,024,766 (GRCm39) missense possibly damaging 0.77
R2099:Vmn2r2 UTSW 3 64,024,474 (GRCm39) missense probably damaging 1.00
R2275:Vmn2r2 UTSW 3 64,023,930 (GRCm39) missense probably benign 0.00
R3078:Vmn2r2 UTSW 3 64,042,053 (GRCm39) missense probably benign 0.22
R3418:Vmn2r2 UTSW 3 64,024,320 (GRCm39) missense probably benign 0.00
R3419:Vmn2r2 UTSW 3 64,024,320 (GRCm39) missense probably benign 0.00
R3959:Vmn2r2 UTSW 3 64,047,947 (GRCm39) missense probably benign
R4230:Vmn2r2 UTSW 3 64,041,912 (GRCm39) missense probably benign 0.00
R4258:Vmn2r2 UTSW 3 64,042,118 (GRCm39) missense probably damaging 1.00
R4810:Vmn2r2 UTSW 3 64,044,883 (GRCm39) missense probably damaging 1.00
R4822:Vmn2r2 UTSW 3 64,041,960 (GRCm39) missense probably damaging 0.99
R4919:Vmn2r2 UTSW 3 64,024,578 (GRCm39) missense possibly damaging 0.56
R4925:Vmn2r2 UTSW 3 64,044,892 (GRCm39) start codon destroyed probably null 0.03
R4954:Vmn2r2 UTSW 3 64,047,905 (GRCm39) missense probably benign 0.00
R5071:Vmn2r2 UTSW 3 64,024,321 (GRCm39) missense probably benign 0.01
R5315:Vmn2r2 UTSW 3 64,024,377 (GRCm39) missense probably benign 0.37
R5450:Vmn2r2 UTSW 3 64,034,011 (GRCm39) missense probably benign
R5577:Vmn2r2 UTSW 3 64,024,416 (GRCm39) missense probably benign 0.00
R5595:Vmn2r2 UTSW 3 64,034,036 (GRCm39) missense possibly damaging 0.74
R5727:Vmn2r2 UTSW 3 64,024,608 (GRCm39) missense probably benign 0.41
R5810:Vmn2r2 UTSW 3 64,024,815 (GRCm39) missense probably damaging 1.00
R5919:Vmn2r2 UTSW 3 64,044,723 (GRCm39) missense probably benign 0.39
R6052:Vmn2r2 UTSW 3 64,024,782 (GRCm39) missense possibly damaging 0.56
R6084:Vmn2r2 UTSW 3 64,024,467 (GRCm39) missense probably benign 0.01
R6299:Vmn2r2 UTSW 3 64,024,074 (GRCm39) nonsense probably null
R6762:Vmn2r2 UTSW 3 64,041,870 (GRCm39) missense probably damaging 1.00
R6858:Vmn2r2 UTSW 3 64,044,915 (GRCm39) missense probably damaging 1.00
R6889:Vmn2r2 UTSW 3 64,024,688 (GRCm39) missense probably damaging 0.99
R6990:Vmn2r2 UTSW 3 64,024,608 (GRCm39) missense probably benign 0.02
R7195:Vmn2r2 UTSW 3 64,023,900 (GRCm39) missense probably benign 0.01
R7699:Vmn2r2 UTSW 3 64,024,536 (GRCm39) missense possibly damaging 0.69
R7717:Vmn2r2 UTSW 3 64,042,019 (GRCm39) missense possibly damaging 0.95
R7798:Vmn2r2 UTSW 3 64,041,518 (GRCm39) missense possibly damaging 0.60
R7914:Vmn2r2 UTSW 3 64,041,526 (GRCm39) missense probably benign 0.20
R7974:Vmn2r2 UTSW 3 64,024,808 (GRCm39) missense probably damaging 0.99
R8394:Vmn2r2 UTSW 3 64,044,858 (GRCm39) missense probably damaging 1.00
R8478:Vmn2r2 UTSW 3 64,024,257 (GRCm39) missense possibly damaging 0.87
R8731:Vmn2r2 UTSW 3 64,024,404 (GRCm39) missense probably benign 0.16
R9035:Vmn2r2 UTSW 3 64,024,172 (GRCm39) missense probably damaging 1.00
R9182:Vmn2r2 UTSW 3 64,044,802 (GRCm39) missense probably damaging 1.00
R9225:Vmn2r2 UTSW 3 64,034,021 (GRCm39) missense probably benign 0.00
R9266:Vmn2r2 UTSW 3 64,024,057 (GRCm39) missense probably damaging 0.98
R9427:Vmn2r2 UTSW 3 64,041,945 (GRCm39) missense probably damaging 1.00
R9659:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
R9666:Vmn2r2 UTSW 3 64,023,870 (GRCm39) missense probably benign 0.08
R9771:Vmn2r2 UTSW 3 64,042,079 (GRCm39) missense possibly damaging 0.88
R9788:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
X0024:Vmn2r2 UTSW 3 64,044,707 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGCTACACTAAGGAAATTCATTTGG -3'
(R):5'- ACTCAGCATGCCTATAATACTATTCAC -3'

Sequencing Primer
(F):5'- ATGGCAAAAATGTTAGGTGTTTTGC -3'
(R):5'- TGCCTATAATACTATTCACTGCATTG -3'
Posted On 2019-06-26