Incidental Mutation 'R7271:Fndc11'
ID565278
Institutional Source Beutler Lab
Gene Symbol Fndc11
Ensembl Gene ENSMUSG00000047841
Gene Namefibronectin type III domain containing 11
Synonyms1700026M20Rik, BC051628
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.112) question?
Stock #R7271 (G1)
Quality Score225.009
Status Validated
Chromosome2
Chromosomal Location181220013-181222854 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 181222100 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 233 (V233I)
Ref Sequence ENSEMBL: ENSMUSP00000056320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050026] [ENSMUST00000108835]
Predicted Effect possibly damaging
Transcript: ENSMUST00000050026
AA Change: V233I

PolyPhen 2 Score 0.532 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000056320
Gene: ENSMUSG00000047841
AA Change: V233I

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
low complexity region 125 137 N/A INTRINSIC
low complexity region 140 154 N/A INTRINSIC
SCOP:d1fna__ 224 309 2e-8 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000108835
AA Change: V233I

PolyPhen 2 Score 0.532 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000104463
Gene: ENSMUSG00000047841
AA Change: V233I

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
low complexity region 125 137 N/A INTRINSIC
low complexity region 140 154 N/A INTRINSIC
SCOP:d1fna__ 224 309 2e-8 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430105I19Rik T A 2: 118,760,683 probably null Het
Afg1l C T 10: 42,415,548 probably null Het
Ahnak2 A T 12: 112,780,802 V70E Het
Alpk3 A G 7: 81,078,454 E444G possibly damaging Het
Amer2 T A 14: 60,379,674 D439E possibly damaging Het
Ano6 A G 15: 95,913,900 Y222C probably damaging Het
Atp4a A C 7: 30,722,519 K827Q probably benign Het
Atp9a G A 2: 168,734,127 Het
Casp7 T A 19: 56,436,361 C171S probably damaging Het
Ccng2 C G 5: 93,273,343 S237R probably benign Het
Cdkl1 A G 12: 69,748,811 L315S probably benign Het
Crybg1 G T 10: 43,997,623 S1163* probably null Het
Csmd1 A T 8: 17,027,279 W121R probably damaging Het
Cyyr1 A T 16: 85,465,605 M88K possibly damaging Het
Dlc1 T C 8: 36,582,800 Q587R probably damaging Het
Dock2 T C 11: 34,273,750 E1128G possibly damaging Het
Dynap T A 18: 70,241,249 T69S possibly damaging Het
Esr1 T C 10: 4,783,874 C225R probably damaging Het
Fbxo31 C T 8: 121,578,764 probably benign Het
Fto T C 8: 91,485,190 F381S probably damaging Het
Gm10471 G A 5: 26,087,995 T67I probably benign Het
Gtf2ird1 A G 5: 134,404,904 L223P probably benign Het
Ifi214 A T 1: 173,529,476 H20Q probably damaging Het
Impa2 T A 18: 67,306,736 I101N probably damaging Het
Kidins220 A T 12: 25,011,571 T854S probably benign Het
Lamb1 T A 12: 31,287,424 C385S probably damaging Het
Lrrc8c A G 5: 105,607,987 S543G probably benign Het
Maats1 A G 16: 38,328,346 I240T probably damaging Het
Manba A T 3: 135,542,376 Y342F probably damaging Het
Map3k1 T C 13: 111,756,697 D758G probably benign Het
Mtor G T 4: 148,546,485 A2300S possibly damaging Het
Musk T A 4: 58,373,409 M793K probably damaging Het
Nup133 A C 8: 123,922,414 I563S probably benign Het
Olfr1117-ps1 T A 2: 87,284,381 N30K probably benign Het
Olfr1283 A G 2: 111,369,348 T239A probably damaging Het
Olfr479 G A 7: 108,055,216 R78Q probably damaging Het
Olfr935 A T 9: 38,994,657 Y259* probably null Het
Pcdh12 C A 18: 38,283,047 V342F probably damaging Het
Pcdhb4 T A 18: 37,308,169 H177Q possibly damaging Het
Pcnx2 G A 8: 125,886,951 A587V probably benign Het
Phkb C T 8: 86,043,789 P896S probably damaging Het
Prss36 A G 7: 127,944,705 S165P probably benign Het
Prss43 A G 9: 110,828,603 D190G probably damaging Het
Psmd14 T C 2: 61,761,012 V53A probably damaging Het
Sel1l3 T G 5: 53,116,362 H1054P probably damaging Het
Selenoh T C 2: 84,670,287 R70G probably damaging Het
Serpinb9d A G 13: 33,194,634 Q21R probably benign Het
Slc29a1 T C 17: 45,588,362 E262G probably benign Het
Slc7a14 A G 3: 31,224,235 L407P probably damaging Het
Smyd4 T C 11: 75,390,499 V266A possibly damaging Het
Spata31d1a T A 13: 59,702,099 R738S probably benign Het
Srcin1 C T 11: 97,551,889 G38S probably damaging Het
Stab2 A T 10: 87,003,108 probably null Het
Syde2 A G 3: 146,020,276 N1308D possibly damaging Het
Trip11 A T 12: 101,884,352 M1151K probably damaging Het
Ttll4 A T 1: 74,688,661 I861F possibly damaging Het
Zfp319 G A 8: 95,331,843 probably benign Het
Zfp518b T C 5: 38,674,564 N33D probably benign Het
Zfp874a T A 13: 67,443,296 I90F probably benign Het
Zmiz2 G T 11: 6,399,593 V412L probably damaging Het
Other mutations in Fndc11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02006:Fndc11 APN 2 181222091 missense probably damaging 0.96
IGL02123:Fndc11 APN 2 181221650 missense probably benign 0.00
R1639:Fndc11 UTSW 2 181221581 missense possibly damaging 0.92
R1946:Fndc11 UTSW 2 181221834 missense probably benign 0.00
R2146:Fndc11 UTSW 2 181222125 missense probably damaging 1.00
R2235:Fndc11 UTSW 2 181222274 missense possibly damaging 0.90
R5254:Fndc11 UTSW 2 181222163 missense possibly damaging 0.77
R6044:Fndc11 UTSW 2 181221666 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTTGTGGAACAGCAGTTGG -3'
(R):5'- AGACCAGGGTGTAGCTTTCTG -3'

Sequencing Primer
(F):5'- GCAGACCTATCAGTTGTCATGGAC -3'
(R):5'- CTGCCCTCTTGATAGTGAACTTGTAG -3'
Posted On2019-06-26