Mutagenetix > Incidental Mutation

Incidental Mutation 'R7272:Or1e31'

565360

Institutional Source

Beutler Lab

Gene Symbol

Or1e31

Ensembl Gene

ENSMUSG00000070382

Gene Name

olfactory receptor family 1 subfamily E member 31

Synonyms

MOR135-24, Olfr391, Olfr391-ps1, Olfr391-ps, GA_x6K02T2P1NL-3951666-3950698, MOR135-30_i

MMRRC Submission

045391-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R7272 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

73689579-73693810 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 73689695 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 296 (D296V)

Ref Sequence

ENSEMBL: ENSMUSP00000151029 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000214485]

AlphaFold

A0A0U1RNJ4

Predicted Effect

probably damaging
Transcript: ENSMUST00000214485
AA Change: D296V

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

100% (55/55)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	T	C	13: 77,471,655 (GRCm39)	I1020T	probably benign	Het
2310057N15Rik	A	T	16: 88,570,523 (GRCm39)	Y172*	probably null	Het
4930558K02Rik	T	A	1: 161,770,092 (GRCm39)	Y139F	possibly damaging	Het
A830018L16Rik	T	G	1: 11,658,695 (GRCm39)	M202R	probably damaging	Het
Abca12	T	C	1: 71,287,591 (GRCm39)	E2450G	probably damaging	Het
Ank2	C	T	3: 126,736,782 (GRCm39)	R3034H	unknown	Het
Anxa9	A	G	3: 95,213,184 (GRCm39)	I54T	probably damaging	Het
Ash1l	A	G	3: 88,961,941 (GRCm39)		probably null	Het
Aspm	T	C	1: 139,386,066 (GRCm39)	I570T	probably benign	Het
Bcar3	A	T	3: 122,302,045 (GRCm39)	I247F	possibly damaging	Het
Cep350	A	G	1: 155,829,334 (GRCm39)	V130A	probably damaging	Het
Cep89	A	T	7: 35,137,888 (GRCm39)	R757S	probably benign	Het
Cryga	A	T	1: 65,142,381 (GRCm39)	I4N	probably damaging	Het
Cyp2d26	T	A	15: 82,676,764 (GRCm39)	Y194F	probably benign	Het
Edn2	G	A	4: 120,019,143 (GRCm39)	R44H	probably damaging	Het
Ep400	G	A	5: 110,903,511 (GRCm39)	Q363*	probably null	Het
Gpr33	T	C	12: 52,070,848 (GRCm39)	T64A	probably damaging	Het
Ice2	T	A	9: 69,324,365 (GRCm39)	S763T	possibly damaging	Het
Itgad	C	A	7: 127,804,245 (GRCm39)	F1169L	probably damaging	Het
Kcnv1	A	G	15: 44,976,576 (GRCm39)	L237P	probably benign	Het
Kctd18	T	C	1: 57,995,710 (GRCm39)	E356G	probably damaging	Het
Krt33a	C	T	11: 99,902,837 (GRCm39)	R329Q	probably damaging	Het
Lama2	C	A	10: 27,000,552 (GRCm39)	G1657C	probably damaging	Het
Marchf3	T	G	18: 56,895,593 (GRCm39)	R217S	probably benign	Het
Mmel1	A	T	4: 154,978,547 (GRCm39)	T660S	probably damaging	Het
Ms4a7	T	A	19: 11,310,642 (GRCm39)	K59*	probably null	Het
Mss51	G	A	14: 20,534,981 (GRCm39)	T263I	probably damaging	Het
Ncaph2	A	G	15: 89,248,385 (GRCm39)	M199V	probably benign	Het
Ndufa4	G	A	6: 11,905,209 (GRCm39)	Q62*	probably null	Het
Nectin4	A	G	1: 171,214,212 (GRCm39)	T456A	probably damaging	Het
Nek1	T	C	8: 61,578,120 (GRCm39)	M1214T	probably benign	Het
Nsf	T	A	11: 103,718,064 (GRCm39)	L710F	probably damaging	Het
Nynrin	G	T	14: 56,107,872 (GRCm39)	G993V	probably damaging	Het
Pbk	T	A	14: 66,052,621 (GRCm39)	Y155N	probably damaging	Het
Plec	T	C	15: 76,059,153 (GRCm39)	I3595V	possibly damaging	Het
Pom121	G	A	5: 135,409,941 (GRCm39)	T1072I	unknown	Het
Sdc1	T	A	12: 8,840,554 (GRCm39)	H106Q	probably benign	Het
Slc44a3	T	C	3: 121,254,764 (GRCm39)	D618G	probably damaging	Het
Slc9c1	A	G	16: 45,401,878 (GRCm39)	D755G	possibly damaging	Het
Slfn9	T	C	11: 82,872,387 (GRCm39)	Y783C	probably benign	Het
Sorl1	C	T	9: 41,975,006 (GRCm39)		probably null	Het
Spindoc	C	T	19: 7,360,085 (GRCm39)	E28K	possibly damaging	Het
Sptbn1	T	C	11: 30,064,859 (GRCm39)	D1880G	possibly damaging	Het
Sspn	T	A	6: 145,907,200 (GRCm39)	D210E	probably benign	Het
Stx12	A	T	4: 132,584,687 (GRCm39)	I219K	possibly damaging	Het
Syne2	T	C	12: 76,095,417 (GRCm39)	V508A	probably benign	Het
Tkt	G	T	14: 30,287,564 (GRCm39)	R186L	probably damaging	Het
Trmt10a	T	A	3: 137,860,527 (GRCm39)	M241K	probably damaging	Het
Vgll2	C	A	10: 51,903,758 (GRCm39)	A207E	possibly damaging	Het
Vmn1r114	A	G	7: 20,545,543 (GRCm39)	F190S	probably damaging	Het
Xpot	C	T	10: 121,453,094 (GRCm39)		probably null	Het
Yrdc	G	A	4: 124,744,820 (GRCm39)	A85T	probably benign	Het
Zfp385c	C	T	11: 100,520,865 (GRCm39)	R265K	possibly damaging	Het
Zgrf1	A	T	3: 127,392,409 (GRCm39)	I1310F	probably damaging	Het

Other mutations in Or1e31

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R2967:Or1e31	UTSW	11	73,689,933 (GRCm39)	missense	possibly damaging	0.95
R4782:Or1e31	UTSW	11	73,689,665 (GRCm39)	missense	probably benign	0.00
R5011:Or1e31	UTSW	11	73,690,473 (GRCm39)	missense	possibly damaging	0.56
R5984:Or1e31	UTSW	11	73,690,407 (GRCm39)	missense	possibly damaging	0.95
R6276:Or1e31	UTSW	11	73,690,229 (GRCm39)	missense	probably damaging	1.00
R6338:Or1e31	UTSW	11	73,690,145 (GRCm39)	missense	possibly damaging	0.93
R6835:Or1e31	UTSW	11	73,690,061 (GRCm39)	missense	possibly damaging	0.95
R6968:Or1e31	UTSW	11	73,690,205 (GRCm39)	missense	possibly damaging	0.86
R7125:Or1e31	UTSW	11	73,689,990 (GRCm39)	missense	probably benign	0.00
R7258:Or1e31	UTSW	11	73,690,206 (GRCm39)	missense	probably damaging	0.98
R7665:Or1e31	UTSW	11	73,689,787 (GRCm39)	missense	probably benign	0.03
R8053:Or1e31	UTSW	11	73,689,822 (GRCm39)	missense	probably benign	0.22
R8314:Or1e31	UTSW	11	73,690,568 (GRCm39)	missense	noncoding transcript
R9089:Or1e31	UTSW	11	73,690,052 (GRCm39)	missense	probably damaging	1.00
R9328:Or1e31	UTSW	11	73,690,478 (GRCm39)	missense	probably damaging	1.00
R9788:Or1e31	UTSW	11	73,689,768 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- CAAAGACCACCTTTCTTACTTTGAC -3'
(R):5'- GGATCTACAAGGTCTTCTCCACC -3'

Sequencing Primer
(F):5'- TTTGACTACTCCACAAAAACTCTTC -3'
(R):5'- CTGTGGTTCCCATCTGTCTGTG -3'

Posted On

2019-06-26