Incidental Mutation 'R7274:Zp2'
ID 565452
Institutional Source Beutler Lab
Gene Symbol Zp2
Ensembl Gene ENSMUSG00000030911
Gene Name zona pellucida glycoprotein 2
Synonyms Zp-2
MMRRC Submission 067851-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R7274 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 119725995-119744514 bp(-) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) A to G at 119731614 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Arginine at position 714 (*714R)
Ref Sequence ENSEMBL: ENSMUSP00000033207 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033207] [ENSMUST00000207726] [ENSMUST00000208874]
AlphaFold P20239
Predicted Effect probably null
Transcript: ENSMUST00000033207
AA Change: *714R
SMART Domains Protein: ENSMUSP00000033207
Gene: ENSMUSG00000030911
AA Change: *714R

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
ZP 364 630 1.06e-86 SMART
low complexity region 655 668 N/A INTRINSIC
transmembrane domain 684 703 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000207726
Predicted Effect probably benign
Transcript: ENSMUST00000208874
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]
PHENOTYPE: Female homozygous mutants exhibit a thin zona pellucida matrix in early ovarian follicles that becomes disassociated in pre-ovulatory follicles. Few oocytes are produced, and any that are fertilized fail to survive to the two-cell stage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1190005I06Rik T C 8: 121,338,005 (GRCm39) S69G possibly damaging Het
Alg12 G A 15: 88,690,910 (GRCm39) S337F probably damaging Het
Bcl11a T C 11: 24,113,985 (GRCm39) S443P probably damaging Het
C1qtnf4 T C 2: 90,719,885 (GRCm39) Y53H probably damaging Het
Cacna1d T A 14: 29,864,600 (GRCm39) E454V probably damaging Het
Cacna1h A G 17: 25,597,811 (GRCm39) F1761S probably damaging Het
Cacna1i A T 15: 80,261,023 (GRCm39) I1344F possibly damaging Het
Cat T C 2: 103,307,235 (GRCm39) N33D probably benign Het
Cdh17 C T 4: 11,783,174 (GRCm39) Q172* probably null Het
Chrna2 A G 14: 66,386,675 (GRCm39) I274V probably benign Het
Cog2 T G 8: 125,262,258 (GRCm39) S299A possibly damaging Het
Cpa6 C A 1: 10,479,524 (GRCm39) M236I probably damaging Het
Crym T A 7: 119,789,742 (GRCm39) Q242L probably benign Het
Ddx60 T C 8: 62,393,142 (GRCm39) probably null Het
Eif4a3l1 A G 6: 136,306,396 (GRCm39) T286A possibly damaging Het
Epdr1 A T 13: 19,777,458 (GRCm39) I180N possibly damaging Het
Fancd2os G A 6: 113,574,851 (GRCm39) L52F probably benign Het
Fbxo16 C A 14: 65,558,716 (GRCm39) R292S probably benign Het
Fn1 T C 1: 71,667,272 (GRCm39) Q820R probably benign Het
Gm4131 T A 14: 62,704,301 (GRCm39) Y140F possibly damaging Het
Grin2a T C 16: 9,396,986 (GRCm39) R1034G possibly damaging Het
Hypk A G 2: 121,284,805 (GRCm39) probably benign Het
Ighmbp2 A G 19: 3,314,951 (GRCm39) V823A probably benign Het
Irf5 A G 6: 29,534,039 (GRCm39) N95S probably damaging Het
Kdr A T 5: 76,125,360 (GRCm39) M379K probably benign Het
Kif19a G T 11: 114,656,281 (GRCm39) probably benign Het
Klhdc4 T C 8: 122,526,397 (GRCm39) probably null Het
Lama2 A T 10: 26,995,976 (GRCm39) I1717N probably damaging Het
Lama4 A T 10: 38,968,295 (GRCm39) Q1479L probably benign Het
Lgr5 T A 10: 115,288,410 (GRCm39) T745S probably damaging Het
Lifr T A 15: 7,196,540 (GRCm39) probably null Het
Llgl1 C T 11: 60,596,812 (GRCm39) R138C possibly damaging Het
Mccc1 A T 3: 36,044,005 (GRCm39) V246E probably damaging Het
Mdn1 T A 4: 32,725,944 (GRCm39) L2621H probably benign Het
Mecr C A 4: 131,581,089 (GRCm39) A80D probably damaging Het
Mia2 A G 12: 59,154,905 (GRCm39) E206G probably damaging Het
Nubpl A G 12: 52,179,203 (GRCm39) probably benign Het
Obscn C T 11: 59,024,053 (GRCm39) R539H probably damaging Het
Or4n4b T A 14: 50,535,879 (GRCm39) T296S probably benign Het
Or8h10 A G 2: 86,808,867 (GRCm39) V91A probably benign Het
Pde5a A T 3: 122,648,895 (GRCm39) K838* probably null Het
Pgm3 A G 9: 86,444,650 (GRCm39) L295P probably damaging Het
Pkp2 T C 16: 16,064,793 (GRCm39) L439P possibly damaging Het
Polr1a T A 6: 71,897,500 (GRCm39) C205* probably null Het
Rab3gap1 T A 1: 127,855,249 (GRCm39) I429K probably benign Het
Rassf8 T C 6: 145,761,295 (GRCm39) V207A probably benign Het
Sacs T A 14: 61,451,530 (GRCm39) D4525E possibly damaging Het
Sec24a A T 11: 51,598,082 (GRCm39) L864Q probably damaging Het
Spats2l C A 1: 57,918,672 (GRCm39) Y35* probably null Het
Sptlc2 A T 12: 87,388,380 (GRCm39) D367E probably benign Het
Ssc4d T C 5: 135,996,810 (GRCm39) D97G possibly damaging Het
Tjp1 A G 7: 65,177,400 (GRCm39) Y3H possibly damaging Het
Tkt T A 14: 30,291,102 (GRCm39) probably null Het
Trim60 T A 8: 65,453,133 (GRCm39) N372I possibly damaging Het
Trpm2 T C 10: 77,759,389 (GRCm39) N1132D probably benign Het
Tsc22d1 T C 14: 76,654,154 (GRCm39) I211T probably damaging Het
Ttc39b T C 4: 83,180,088 (GRCm39) K132E possibly damaging Het
Ttn C T 2: 76,553,932 (GRCm39) V30924I probably damaging Het
Tubgcp6 G A 15: 88,987,173 (GRCm39) Q1267* probably null Het
Zfp30 C A 7: 29,492,043 (GRCm39) T180N probably benign Het
Other mutations in Zp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Zp2 APN 7 119,732,623 (GRCm39) missense probably benign 0.00
IGL00707:Zp2 APN 7 119,732,636 (GRCm39) missense probably benign 0.03
IGL00916:Zp2 APN 7 119,737,397 (GRCm39) missense probably damaging 1.00
IGL01554:Zp2 APN 7 119,737,548 (GRCm39) missense possibly damaging 0.78
IGL01845:Zp2 APN 7 119,737,414 (GRCm39) missense probably damaging 1.00
IGL02111:Zp2 APN 7 119,731,641 (GRCm39) missense possibly damaging 0.75
IGL02145:Zp2 APN 7 119,739,074 (GRCm39) critical splice acceptor site probably null
IGL02155:Zp2 APN 7 119,743,340 (GRCm39) missense probably benign 0.00
IGL02178:Zp2 APN 7 119,732,973 (GRCm39) missense possibly damaging 0.85
IGL02646:Zp2 APN 7 119,734,564 (GRCm39) missense possibly damaging 0.92
IGL03220:Zp2 APN 7 119,736,450 (GRCm39) missense possibly damaging 0.90
PIT4687001:Zp2 UTSW 7 119,741,102 (GRCm39) missense probably benign 0.00
R0138:Zp2 UTSW 7 119,736,423 (GRCm39) missense probably damaging 0.96
R0197:Zp2 UTSW 7 119,742,799 (GRCm39) splice site probably benign
R0519:Zp2 UTSW 7 119,737,372 (GRCm39) missense probably damaging 1.00
R0573:Zp2 UTSW 7 119,734,693 (GRCm39) splice site probably benign
R0879:Zp2 UTSW 7 119,734,757 (GRCm39) missense probably damaging 1.00
R0883:Zp2 UTSW 7 119,742,799 (GRCm39) splice site probably benign
R1160:Zp2 UTSW 7 119,735,268 (GRCm39) missense probably damaging 1.00
R1235:Zp2 UTSW 7 119,737,566 (GRCm39) missense possibly damaging 0.57
R1753:Zp2 UTSW 7 119,737,328 (GRCm39) missense probably benign
R1883:Zp2 UTSW 7 119,732,624 (GRCm39) missense probably benign 0.02
R1995:Zp2 UTSW 7 119,734,388 (GRCm39) missense probably damaging 0.97
R2196:Zp2 UTSW 7 119,737,529 (GRCm39) missense probably benign
R2850:Zp2 UTSW 7 119,737,529 (GRCm39) missense probably benign
R3715:Zp2 UTSW 7 119,741,057 (GRCm39) missense possibly damaging 0.95
R3931:Zp2 UTSW 7 119,731,580 (GRCm39) intron probably benign
R4082:Zp2 UTSW 7 119,734,475 (GRCm39) missense probably benign 0.01
R4731:Zp2 UTSW 7 119,737,343 (GRCm39) missense probably damaging 0.96
R4732:Zp2 UTSW 7 119,737,343 (GRCm39) missense probably damaging 0.96
R4733:Zp2 UTSW 7 119,737,343 (GRCm39) missense probably damaging 0.96
R4754:Zp2 UTSW 7 119,737,541 (GRCm39) missense probably benign 0.01
R4863:Zp2 UTSW 7 119,734,995 (GRCm39) missense probably damaging 1.00
R5274:Zp2 UTSW 7 119,737,315 (GRCm39) missense possibly damaging 0.92
R5392:Zp2 UTSW 7 119,734,987 (GRCm39) nonsense probably null
R5877:Zp2 UTSW 7 119,732,562 (GRCm39) missense probably null 0.94
R6390:Zp2 UTSW 7 119,740,453 (GRCm39) missense probably benign 0.23
R6404:Zp2 UTSW 7 119,734,765 (GRCm39) missense possibly damaging 0.73
R6546:Zp2 UTSW 7 119,731,748 (GRCm39) missense probably benign 0.00
R6622:Zp2 UTSW 7 119,741,136 (GRCm39) missense probably benign
R6622:Zp2 UTSW 7 119,731,748 (GRCm39) missense probably benign 0.00
R6707:Zp2 UTSW 7 119,733,145 (GRCm39) missense possibly damaging 0.85
R7275:Zp2 UTSW 7 119,734,576 (GRCm39) splice site probably null
R7541:Zp2 UTSW 7 119,735,279 (GRCm39) missense probably damaging 1.00
R7585:Zp2 UTSW 7 119,733,167 (GRCm39) missense probably damaging 1.00
R7709:Zp2 UTSW 7 119,734,998 (GRCm39) missense probably damaging 1.00
R7742:Zp2 UTSW 7 119,731,731 (GRCm39) missense unknown
R7767:Zp2 UTSW 7 119,736,392 (GRCm39) missense probably benign 0.01
R7771:Zp2 UTSW 7 119,742,865 (GRCm39) missense probably damaging 0.96
R8391:Zp2 UTSW 7 119,726,179 (GRCm39) missense probably benign 0.00
R8872:Zp2 UTSW 7 119,733,025 (GRCm39) missense probably benign 0.14
R8880:Zp2 UTSW 7 119,742,835 (GRCm39) missense possibly damaging 0.80
R9673:Zp2 UTSW 7 119,733,238 (GRCm39) missense probably damaging 1.00
X0017:Zp2 UTSW 7 119,732,608 (GRCm39) missense probably damaging 1.00
X0023:Zp2 UTSW 7 119,732,590 (GRCm39) missense probably damaging 1.00
Z1176:Zp2 UTSW 7 119,734,402 (GRCm39) missense not run
Z1177:Zp2 UTSW 7 119,734,432 (GRCm39) missense probably damaging 1.00
Z1177:Zp2 UTSW 7 119,734,402 (GRCm39) missense not run
Predicted Primers PCR Primer
(F):5'- TCTTAAAACAGAAGGCAACAGACTG -3'
(R):5'- GCTCAGCCTGACCTTATGAC -3'

Sequencing Primer
(F):5'- TCAGCCAGAAAGTGCTTGTC -3'
(R):5'- AGCCTGACCTTATGACTTGAATACC -3'
Posted On 2019-06-26