Incidental Mutation 'R7282:Cntn4'
| ID |
565725 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cntn4
|
| Ensembl Gene |
ENSMUSG00000064293 |
| Gene Name |
contactin 4 |
| Synonyms |
BIG-2A, Axcam |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.318)
|
| Stock # |
R7282 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
105654621-106676271 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 106502421 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 393
(I393F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108886
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079416]
[ENSMUST00000089208]
[ENSMUST00000113258]
[ENSMUST00000113260]
[ENSMUST00000113261]
[ENSMUST00000113264]
|
| AlphaFold |
Q69Z26 |
| PDB Structure |
Immunoglobulin domains 1-4 of mouse CNTN4 [X-RAY DIFFRACTION]
PTPRG CNTN4 complex [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000079416
AA Change: I393F
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000078385
Gene: ENSMUSG00000064293
AA Change: I393F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000089208
AA Change: I393F
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000086616
Gene: ENSMUSG00000064293
AA Change: I393F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
FN3
|
700 |
786 |
8.39e0 |
SMART |
|
FN3
|
801 |
886 |
1.33e-6 |
SMART |
|
FN3
|
901 |
981 |
9.85e-1 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113258
AA Change: I393F
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000108883
Gene: ENSMUSG00000064293
AA Change: I393F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113260
AA Change: I393F
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000108885
Gene: ENSMUSG00000064293
AA Change: I393F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113261
AA Change: I393F
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000108886
Gene: ENSMUSG00000064293
AA Change: I393F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113264
AA Change: I393F
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000108889
Gene: ENSMUSG00000064293
AA Change: I393F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
FN3
|
700 |
786 |
8.39e0 |
SMART |
|
FN3
|
801 |
886 |
1.33e-6 |
SMART |
|
FN3
|
901 |
981 |
9.85e-1 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit aberrant projection of olfactory axons to multiple glomeruli in the olfactory bulb. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810065E05Rik |
C |
A |
11: 58,316,582 (GRCm39) |
D187E |
probably damaging |
Het |
| Abl2 |
T |
C |
1: 156,457,630 (GRCm39) |
Y299H |
probably damaging |
Het |
| Acsl3 |
T |
A |
1: 78,659,709 (GRCm39) |
N120K |
probably damaging |
Het |
| Aldh1a1 |
A |
G |
19: 20,606,434 (GRCm39) |
K255R |
possibly damaging |
Het |
| Baz2b |
C |
T |
2: 59,750,781 (GRCm39) |
R1205H |
probably benign |
Het |
| Btbd8 |
G |
T |
5: 107,655,062 (GRCm39) |
V954L |
probably benign |
Het |
| Btbd8 |
A |
G |
5: 107,658,371 (GRCm39) |
D1647G |
probably damaging |
Het |
| Carmil1 |
A |
G |
13: 24,197,387 (GRCm39) |
S1350P |
probably benign |
Het |
| Cecr2 |
A |
T |
6: 120,738,582 (GRCm39) |
N325I |
|
Het |
| Cep120 |
C |
T |
18: 53,873,161 (GRCm39) |
A57T |
probably damaging |
Het |
| Chst8 |
T |
C |
7: 34,447,628 (GRCm39) |
|
probably null |
Het |
| Crocc |
T |
C |
4: 140,749,652 (GRCm39) |
D1494G |
probably damaging |
Het |
| Cwc25 |
T |
C |
11: 97,638,832 (GRCm39) |
E364G |
possibly damaging |
Het |
| Dnah7a |
C |
A |
1: 53,724,059 (GRCm39) |
|
probably null |
Het |
| Drg2 |
A |
G |
11: 60,345,519 (GRCm39) |
E5G |
probably benign |
Het |
| Ehd4 |
T |
C |
2: 119,921,729 (GRCm39) |
H509R |
probably damaging |
Het |
| Enam |
A |
T |
5: 88,650,186 (GRCm39) |
N565I |
probably damaging |
Het |
| Evi2a |
G |
T |
11: 79,418,249 (GRCm39) |
N120K |
probably benign |
Het |
| Faim |
A |
G |
9: 98,874,179 (GRCm39) |
T2A |
probably benign |
Het |
| Fcgbpl1 |
A |
G |
7: 27,843,833 (GRCm39) |
N907S |
probably benign |
Het |
| Fmnl1 |
T |
C |
11: 103,087,091 (GRCm39) |
V836A |
unknown |
Het |
| Fosb |
T |
C |
7: 19,039,113 (GRCm39) |
I224V |
possibly damaging |
Het |
| Frem3 |
A |
T |
8: 81,338,660 (GRCm39) |
T318S |
probably damaging |
Het |
| Gm9972 |
G |
A |
11: 42,927,631 (GRCm39) |
G93R |
unknown |
Het |
| Gtf2a1 |
A |
T |
12: 91,534,609 (GRCm39) |
I215N |
possibly damaging |
Het |
| Hs3st3b1 |
A |
G |
11: 63,812,397 (GRCm39) |
V106A |
probably benign |
Het |
| Igkv19-93 |
T |
C |
6: 68,713,485 (GRCm39) |
D48G |
probably benign |
Het |
| Itgb8 |
A |
T |
12: 119,201,443 (GRCm39) |
W31R |
probably benign |
Het |
| Kmt2d |
A |
T |
15: 98,751,985 (GRCm39) |
W1995R |
unknown |
Het |
| Lama3 |
G |
T |
18: 12,572,449 (GRCm39) |
Q551H |
probably damaging |
Het |
| Lama5 |
T |
C |
2: 179,843,588 (GRCm39) |
Y453C |
probably damaging |
Het |
| Lbhd2 |
G |
A |
12: 111,376,724 (GRCm39) |
R57H |
probably damaging |
Het |
| Lcmt2 |
A |
G |
2: 120,969,271 (GRCm39) |
V384A |
probably damaging |
Het |
| Lgsn |
T |
G |
1: 31,242,452 (GRCm39) |
L178R |
probably damaging |
Het |
| Lhcgr |
C |
T |
17: 89,065,811 (GRCm39) |
V193I |
probably benign |
Het |
| Lta4h |
T |
C |
10: 93,289,373 (GRCm39) |
M1T |
probably null |
Het |
| Ly6l |
T |
C |
15: 75,321,345 (GRCm39) |
S14P |
probably damaging |
Het |
| Met |
C |
A |
6: 17,547,011 (GRCm39) |
C881* |
probably null |
Het |
| Mettl21e |
A |
T |
1: 44,249,399 (GRCm39) |
Y86N |
probably damaging |
Het |
| Mgam |
A |
G |
6: 40,740,045 (GRCm39) |
T1673A |
probably benign |
Het |
| Mgam |
A |
T |
6: 40,633,446 (GRCm39) |
N251Y |
possibly damaging |
Het |
| Mmp27 |
T |
A |
9: 7,578,231 (GRCm39) |
V357D |
probably damaging |
Het |
| Muc2 |
A |
G |
7: 141,306,481 (GRCm39) |
E740G |
|
Het |
| Myoc |
C |
A |
1: 162,476,413 (GRCm39) |
S372R |
probably benign |
Het |
| Ncor2 |
A |
T |
5: 125,097,104 (GRCm39) |
M1358K |
|
Het |
| Nol6 |
A |
G |
4: 41,119,468 (GRCm39) |
S613P |
probably benign |
Het |
| Nuggc |
T |
A |
14: 65,855,072 (GRCm39) |
I334N |
probably damaging |
Het |
| Nxnl2 |
C |
T |
13: 51,325,542 (GRCm39) |
P62S |
probably damaging |
Het |
| Ogfod1 |
C |
T |
8: 94,764,067 (GRCm39) |
H51Y |
possibly damaging |
Het |
| Olfml1 |
T |
A |
7: 107,189,530 (GRCm39) |
D198E |
possibly damaging |
Het |
| Or2t26 |
A |
C |
11: 49,039,945 (GRCm39) |
N287T |
probably damaging |
Het |
| Ovch2 |
C |
T |
7: 107,393,577 (GRCm39) |
R183H |
possibly damaging |
Het |
| Plxnd1 |
A |
T |
6: 115,937,798 (GRCm39) |
L1516Q |
probably damaging |
Het |
| Pramel27 |
A |
G |
4: 143,578,451 (GRCm39) |
N237S |
possibly damaging |
Het |
| Prrc2c |
A |
G |
1: 162,507,543 (GRCm39) |
V2448A |
possibly damaging |
Het |
| Rexo5 |
C |
T |
7: 119,417,636 (GRCm39) |
T212I |
probably damaging |
Het |
| Rgl2 |
C |
T |
17: 34,152,403 (GRCm39) |
R367W |
probably damaging |
Het |
| Rnf213 |
T |
G |
11: 119,328,818 (GRCm39) |
I2030S |
|
Het |
| Rtf1 |
C |
T |
2: 119,505,580 (GRCm39) |
A11V |
unknown |
Het |
| Setdb1 |
T |
G |
3: 95,245,985 (GRCm39) |
T647P |
probably damaging |
Het |
| Shisa6 |
G |
C |
11: 66,393,480 (GRCm39) |
P272R |
possibly damaging |
Het |
| Slc25a54 |
G |
T |
3: 109,023,817 (GRCm39) |
G471* |
probably null |
Het |
| Slc30a1 |
A |
G |
1: 191,641,544 (GRCm39) |
T397A |
probably benign |
Het |
| Slc7a14 |
A |
G |
3: 31,281,302 (GRCm39) |
F336S |
possibly damaging |
Het |
| Slitrk3 |
C |
T |
3: 72,957,798 (GRCm39) |
V325I |
possibly damaging |
Het |
| Sptan1 |
A |
G |
2: 29,876,941 (GRCm39) |
Y361C |
probably damaging |
Het |
| Stard9 |
A |
G |
2: 120,528,984 (GRCm39) |
D1747G |
probably benign |
Het |
| Taf3 |
T |
C |
2: 9,956,253 (GRCm39) |
E638G |
probably damaging |
Het |
| Tbc1d8 |
T |
C |
1: 39,411,614 (GRCm39) |
D1074G |
probably benign |
Het |
| Tecrl |
G |
A |
5: 83,502,754 (GRCm39) |
H32Y |
probably benign |
Het |
| Tgm3 |
T |
A |
2: 129,866,481 (GRCm39) |
M133K |
probably benign |
Het |
| Tmem131 |
A |
G |
1: 36,880,685 (GRCm39) |
F195S |
probably damaging |
Het |
| Tmem82 |
T |
C |
4: 141,342,261 (GRCm39) |
I314V |
possibly damaging |
Het |
| Trappc10 |
T |
C |
10: 78,043,327 (GRCm39) |
E555G |
probably damaging |
Het |
| Ubn2 |
A |
T |
6: 38,429,811 (GRCm39) |
K176* |
probably null |
Het |
| Ucp1 |
G |
A |
8: 84,020,531 (GRCm39) |
G114R |
probably benign |
Het |
| Unc5c |
A |
G |
3: 141,383,751 (GRCm39) |
D43G |
probably damaging |
Het |
| Vmn2r3 |
C |
T |
3: 64,168,825 (GRCm39) |
V571M |
possibly damaging |
Het |
| Vwa3a |
A |
T |
7: 120,385,688 (GRCm39) |
I677L |
probably benign |
Het |
| Wdr48 |
T |
C |
9: 119,740,147 (GRCm39) |
S319P |
probably damaging |
Het |
|
| Other mutations in Cntn4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Cntn4
|
APN |
6 |
106,483,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00725:Cntn4
|
APN |
6 |
106,639,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Cntn4
|
APN |
6 |
106,595,239 (GRCm39) |
splice site |
probably benign |
|
|
IGL01432:Cntn4
|
APN |
6 |
106,655,295 (GRCm39) |
splice site |
probably benign |
|
|
IGL01585:Cntn4
|
APN |
6 |
106,595,289 (GRCm39) |
nonsense |
probably null |
|
|
IGL01710:Cntn4
|
APN |
6 |
106,527,392 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01870:Cntn4
|
APN |
6 |
106,466,676 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01933:Cntn4
|
APN |
6 |
106,671,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01937:Cntn4
|
APN |
6 |
106,414,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01945:Cntn4
|
APN |
6 |
106,414,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02007:Cntn4
|
APN |
6 |
106,632,490 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02506:Cntn4
|
APN |
6 |
106,595,349 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02561:Cntn4
|
APN |
6 |
106,500,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03080:Cntn4
|
APN |
6 |
106,632,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03338:Cntn4
|
APN |
6 |
106,632,550 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03097:Cntn4
|
UTSW |
6 |
106,330,673 (GRCm39) |
missense |
probably benign |
0.10 |
|
LCD18:Cntn4
|
UTSW |
6 |
106,530,901 (GRCm39) |
intron |
probably benign |
|
|
R0083:Cntn4
|
UTSW |
6 |
106,502,330 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0098:Cntn4
|
UTSW |
6 |
106,595,385 (GRCm39) |
splice site |
probably benign |
|
|
R0501:Cntn4
|
UTSW |
6 |
106,595,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Cntn4
|
UTSW |
6 |
106,639,539 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0633:Cntn4
|
UTSW |
6 |
106,656,209 (GRCm39) |
splice site |
probably null |
|
|
R0730:Cntn4
|
UTSW |
6 |
106,527,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0849:Cntn4
|
UTSW |
6 |
106,644,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0883:Cntn4
|
UTSW |
6 |
106,644,501 (GRCm39) |
splice site |
probably benign |
|
|
R0926:Cntn4
|
UTSW |
6 |
106,632,542 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1199:Cntn4
|
UTSW |
6 |
106,330,558 (GRCm39) |
splice site |
probably benign |
|
|
R1293:Cntn4
|
UTSW |
6 |
106,330,685 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1296:Cntn4
|
UTSW |
6 |
106,486,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1344:Cntn4
|
UTSW |
6 |
106,321,831 (GRCm39) |
splice site |
probably null |
|
|
R1418:Cntn4
|
UTSW |
6 |
106,321,831 (GRCm39) |
splice site |
probably null |
|
|
R1660:Cntn4
|
UTSW |
6 |
106,656,258 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1751:Cntn4
|
UTSW |
6 |
106,595,371 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1883:Cntn4
|
UTSW |
6 |
106,656,353 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1884:Cntn4
|
UTSW |
6 |
106,656,353 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1899:Cntn4
|
UTSW |
6 |
106,652,774 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1906:Cntn4
|
UTSW |
6 |
106,330,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2048:Cntn4
|
UTSW |
6 |
106,414,825 (GRCm39) |
splice site |
probably benign |
|
|
R2113:Cntn4
|
UTSW |
6 |
106,466,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3177:Cntn4
|
UTSW |
6 |
106,414,925 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3277:Cntn4
|
UTSW |
6 |
106,414,925 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3944:Cntn4
|
UTSW |
6 |
106,595,375 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4401:Cntn4
|
UTSW |
6 |
106,466,625 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4540:Cntn4
|
UTSW |
6 |
106,652,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Cntn4
|
UTSW |
6 |
106,414,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4697:Cntn4
|
UTSW |
6 |
106,502,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4810:Cntn4
|
UTSW |
6 |
106,632,572 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4816:Cntn4
|
UTSW |
6 |
106,527,458 (GRCm39) |
missense |
probably benign |
|
|
R4873:Cntn4
|
UTSW |
6 |
106,414,874 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4875:Cntn4
|
UTSW |
6 |
106,414,874 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4953:Cntn4
|
UTSW |
6 |
106,502,379 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5288:Cntn4
|
UTSW |
6 |
106,158,765 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R5336:Cntn4
|
UTSW |
6 |
106,639,595 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5386:Cntn4
|
UTSW |
6 |
106,158,765 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R5477:Cntn4
|
UTSW |
6 |
106,650,911 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5514:Cntn4
|
UTSW |
6 |
106,649,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Cntn4
|
UTSW |
6 |
106,656,397 (GRCm39) |
splice site |
silent |
|
|
R6334:Cntn4
|
UTSW |
6 |
106,321,747 (GRCm39) |
missense |
probably benign |
|
|
R6334:Cntn4
|
UTSW |
6 |
106,483,153 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6904:Cntn4
|
UTSW |
6 |
106,674,544 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6985:Cntn4
|
UTSW |
6 |
106,656,378 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7246:Cntn4
|
UTSW |
6 |
106,483,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7585:Cntn4
|
UTSW |
6 |
106,466,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7667:Cntn4
|
UTSW |
6 |
106,656,856 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7781:Cntn4
|
UTSW |
6 |
106,500,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7882:Cntn4
|
UTSW |
6 |
106,330,684 (GRCm39) |
missense |
probably benign |
|
|
R8081:Cntn4
|
UTSW |
6 |
106,651,568 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8105:Cntn4
|
UTSW |
6 |
106,330,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8221:Cntn4
|
UTSW |
6 |
106,486,471 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8910:Cntn4
|
UTSW |
6 |
106,632,497 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8911:Cntn4
|
UTSW |
6 |
106,330,743 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8916:Cntn4
|
UTSW |
6 |
106,652,915 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9249:Cntn4
|
UTSW |
6 |
106,466,722 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9376:Cntn4
|
UTSW |
6 |
106,639,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9616:Cntn4
|
UTSW |
6 |
106,674,525 (GRCm39) |
nonsense |
probably null |
|
|
R9767:Cntn4
|
UTSW |
6 |
106,655,395 (GRCm39) |
missense |
probably benign |
0.40 |
|
Z1176:Cntn4
|
UTSW |
6 |
106,500,524 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Cntn4
|
UTSW |
6 |
106,486,425 (GRCm39) |
missense |
probably benign |
0.28 |
|
Z1177:Cntn4
|
UTSW |
6 |
106,639,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cntn4
|
UTSW |
6 |
106,527,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATTAAGCCCTCTTGACAGAAC -3'
(R):5'- AAAGTGGCCTCTTCCCATTGC -3'
Sequencing Primer
(F):5'- GCCCTCTTGACAGAACATGTAG -3'
(R):5'- CATTGCTTGCAGGCTATATGAC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation