Incidental Mutation 'R7283:Vmn2r26'
| ID |
565793 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r26
|
| Ensembl Gene |
ENSMUSG00000096630 |
| Gene Name |
vomeronasal 2, receptor 26 |
| Synonyms |
V2r1b |
| MMRRC Submission |
045361-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R7283 (G1)
|
| Quality Score |
167.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
124024758-124062035 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 124025955 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 108
(L108P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032238
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032238]
|
| AlphaFold |
Q6TAC4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032238
AA Change: L108P
PolyPhen 2
Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: L108P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
471 |
1.5e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
4.6e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
1.5e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.5%
|
| Validation Efficiency |
100% (72/72) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833439L19Rik |
A |
G |
13: 54,552,691 (GRCm38) |
V278A |
probably benign |
Het |
| Abcc3 |
C |
T |
11: 94,357,047 (GRCm38) |
A1207T |
probably benign |
Het |
| Abce1 |
C |
A |
8: 79,685,256 (GRCm38) |
G592* |
probably null |
Het |
| Acad10 |
A |
C |
5: 121,649,475 (GRCm38) |
V137G |
possibly damaging |
Het |
| Adcy3 |
A |
G |
12: 4,203,563 (GRCm38) |
I672V |
not run |
Het |
| Adgrb1 |
A |
T |
15: 74,580,663 (GRCm38) |
Q1166L |
possibly damaging |
Het |
| Ankrd44 |
A |
T |
1: 54,729,796 (GRCm38) |
N465K |
probably damaging |
Het |
| Avpr1b |
A |
G |
1: 131,609,731 (GRCm38) |
T418A |
probably benign |
Het |
| Azin1 |
G |
A |
15: 38,501,408 (GRCm38) |
T33I |
probably damaging |
Het |
| Bicra |
T |
C |
7: 15,972,500 (GRCm38) |
T1339A |
probably damaging |
Het |
| Bltp2 |
A |
G |
11: 78,274,828 (GRCm38) |
Q1346R |
probably damaging |
Het |
| Cacna1s |
A |
G |
1: 136,073,708 (GRCm38) |
Y299C |
probably damaging |
Het |
| Clip1 |
A |
C |
5: 123,613,794 (GRCm38) |
C641W |
|
Het |
| Clip3 |
T |
C |
7: 30,305,812 (GRCm38) |
S524P |
probably damaging |
Het |
| Cnpy4 |
A |
T |
5: 138,192,882 (GRCm38) |
H240L |
probably benign |
Het |
| Cyp2b19 |
T |
C |
7: 26,766,914 (GRCm38) |
Y381H |
probably damaging |
Het |
| Cyp3a13 |
T |
A |
5: 137,905,556 (GRCm38) |
N280I |
probably benign |
Het |
| Diaph3 |
A |
G |
14: 86,866,584 (GRCm38) |
F788S |
probably damaging |
Het |
| Drc7 |
A |
G |
8: 95,071,579 (GRCm38) |
N484S |
probably damaging |
Het |
| Erap1 |
G |
A |
13: 74,673,784 (GRCm38) |
|
probably null |
Het |
| Fat4 |
A |
T |
3: 38,889,693 (GRCm38) |
I912F |
probably damaging |
Het |
| Hsd3b3 |
T |
A |
3: 98,742,357 (GRCm38) |
K217* |
probably null |
Het |
| Igkv12-89 |
A |
G |
6: 68,835,077 (GRCm38) |
V36A |
probably damaging |
Het |
| Invs |
T |
A |
4: 48,392,526 (GRCm38) |
|
probably null |
Het |
| Ipo8 |
T |
A |
6: 148,824,481 (GRCm38) |
Y30F |
possibly damaging |
Het |
| Kctd14 |
T |
C |
7: 97,451,486 (GRCm38) |
M1T |
probably null |
Het |
| Klrb1c |
A |
T |
6: 128,784,257 (GRCm38) |
C136S |
probably benign |
Het |
| Morn2 |
A |
G |
17: 80,297,259 (GRCm38) |
E48G |
probably damaging |
Het |
| Myh1 |
A |
T |
11: 67,201,844 (GRCm38) |
|
probably null |
Het |
| Nbeal1 |
G |
C |
1: 60,237,151 (GRCm38) |
V684L |
probably benign |
Het |
| Nfxl1 |
A |
G |
5: 72,529,050 (GRCm38) |
S603P |
probably benign |
Het |
| Nlrc3 |
G |
A |
16: 3,947,877 (GRCm38) |
A351V |
probably benign |
Het |
| Nlrp4f |
G |
A |
13: 65,195,538 (GRCm38) |
R76* |
probably null |
Het |
| Or1e1f |
T |
C |
11: 73,964,808 (GRCm38) |
S67P |
probably damaging |
Het |
| Or52n1 |
G |
T |
7: 104,733,593 (GRCm38) |
T257K |
probably damaging |
Het |
| Or5h22 |
A |
T |
16: 59,074,192 (GRCm38) |
M296K |
probably benign |
Het |
| Or7e176 |
A |
C |
9: 20,260,259 (GRCm38) |
I140L |
probably damaging |
Het |
| Or8k41 |
A |
T |
2: 86,483,139 (GRCm38) |
I201N |
probably damaging |
Het |
| Papolg |
A |
G |
11: 23,867,394 (GRCm38) |
V601A |
not run |
Het |
| Pde4dip |
T |
C |
3: 97,758,882 (GRCm38) |
T349A |
probably benign |
Het |
| Pdlim5 |
T |
C |
3: 142,311,980 (GRCm38) |
|
probably null |
Het |
| Pkhd1l1 |
A |
G |
15: 44,503,280 (GRCm38) |
N718S |
probably benign |
Het |
| Plcxd3 |
A |
G |
15: 4,516,919 (GRCm38) |
H135R |
probably damaging |
Het |
| Plxna2 |
A |
T |
1: 194,644,883 (GRCm38) |
Y375F |
probably damaging |
Het |
| Prkca |
C |
T |
11: 108,340,645 (GRCm38) |
|
probably null |
Het |
| Prkdc |
A |
G |
16: 15,717,764 (GRCm38) |
S1663G |
probably benign |
Het |
| Ptbp3 |
T |
C |
4: 59,514,384 (GRCm38) |
T80A |
probably benign |
Het |
| Ptpn4 |
C |
T |
1: 119,682,531 (GRCm38) |
V696I |
possibly damaging |
Het |
| Pygl |
A |
T |
12: 70,216,568 (GRCm38) |
W175R |
possibly damaging |
Het |
| Rftn1 |
A |
G |
17: 50,047,441 (GRCm38) |
Y298H |
probably damaging |
Het |
| Rit2 |
A |
G |
18: 31,316,839 (GRCm38) |
|
probably null |
Het |
| Runx1t1 |
G |
A |
4: 13,846,935 (GRCm38) |
G240R |
probably damaging |
Het |
| Scn10a |
A |
G |
9: 119,664,779 (GRCm38) |
|
probably null |
Het |
| Serpina16 |
A |
C |
12: 103,672,432 (GRCm38) |
|
probably null |
Het |
| Slc17a3 |
A |
T |
13: 23,855,848 (GRCm38) |
M290L |
|
Het |
| Slc6a4 |
A |
T |
11: 77,010,696 (GRCm38) |
M86L |
probably benign |
Het |
| Spag7 |
A |
T |
11: 70,665,313 (GRCm38) |
V46E |
probably benign |
Het |
| Spata31h1 |
G |
A |
10: 82,291,297 (GRCm38) |
R1960W |
possibly damaging |
Het |
| Sptlc1 |
T |
C |
13: 53,344,878 (GRCm38) |
I271V |
probably benign |
Het |
| Stk17b |
A |
C |
1: 53,757,515 (GRCm38) |
H364Q |
probably benign |
Het |
| Strc |
T |
C |
2: 121,379,452 (GRCm38) |
H130R |
probably damaging |
Het |
| Stxbp1 |
T |
A |
2: 32,815,014 (GRCm38) |
D148V |
probably damaging |
Het |
| Tirap |
G |
A |
9: 35,188,929 (GRCm38) |
P153L |
probably damaging |
Het |
| Tmco3 |
G |
A |
8: 13,319,605 (GRCm38) |
|
probably null |
Het |
| Tmem51 |
T |
A |
4: 142,031,783 (GRCm38) |
D218V |
probably damaging |
Het |
| Trim40 |
A |
T |
17: 36,882,662 (GRCm38) |
D218E |
probably benign |
Het |
| Ttc21b |
T |
C |
2: 66,208,718 (GRCm38) |
D934G |
probably damaging |
Het |
| Washc2 |
C |
A |
6: 116,227,418 (GRCm38) |
P429Q |
probably damaging |
Het |
| Wipi1 |
A |
G |
11: 109,611,311 (GRCm38) |
M1T |
probably null |
Het |
| Zfp438 |
A |
G |
18: 5,214,712 (GRCm38) |
V82A |
probably damaging |
Het |
| Zfp853 |
G |
C |
5: 143,287,738 (GRCm38) |
A724G |
unknown |
Het |
|
| Other mutations in Vmn2r26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01070:Vmn2r26
|
APN |
6 |
124,061,607 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01370:Vmn2r26
|
APN |
6 |
124,061,756 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01603:Vmn2r26
|
APN |
6 |
124,053,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01651:Vmn2r26
|
APN |
6 |
124,050,673 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02282:Vmn2r26
|
APN |
6 |
124,061,625 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02425:Vmn2r26
|
APN |
6 |
124,061,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02551:Vmn2r26
|
APN |
6 |
124,026,141 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL02690:Vmn2r26
|
APN |
6 |
124,026,132 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL03002:Vmn2r26
|
APN |
6 |
124,039,795 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL03270:Vmn2r26
|
APN |
6 |
124,050,819 (GRCm38) |
missense |
probably benign |
0.16 |
|
R0032:Vmn2r26
|
UTSW |
6 |
124,039,899 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R0052:Vmn2r26
|
UTSW |
6 |
124,062,033 (GRCm38) |
makesense |
probably null |
|
|
R0083:Vmn2r26
|
UTSW |
6 |
124,053,981 (GRCm38) |
splice site |
probably null |
|
|
R0682:Vmn2r26
|
UTSW |
6 |
124,061,170 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1061:Vmn2r26
|
UTSW |
6 |
124,061,644 (GRCm38) |
missense |
probably benign |
0.12 |
|
R1077:Vmn2r26
|
UTSW |
6 |
124,053,913 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1263:Vmn2r26
|
UTSW |
6 |
124,050,708 (GRCm38) |
missense |
probably benign |
|
|
R1579:Vmn2r26
|
UTSW |
6 |
124,039,747 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1741:Vmn2r26
|
UTSW |
6 |
124,061,472 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r26
|
UTSW |
6 |
124,061,410 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R1838:Vmn2r26
|
UTSW |
6 |
124,024,771 (GRCm38) |
missense |
probably benign |
|
|
R1956:Vmn2r26
|
UTSW |
6 |
124,053,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r26
|
UTSW |
6 |
124,061,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Vmn2r26
|
UTSW |
6 |
124,061,237 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2327:Vmn2r26
|
UTSW |
6 |
124,039,749 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2417:Vmn2r26
|
UTSW |
6 |
124,061,350 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3930:Vmn2r26
|
UTSW |
6 |
124,025,979 (GRCm38) |
missense |
probably benign |
|
|
R4490:Vmn2r26
|
UTSW |
6 |
124,050,738 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4629:Vmn2r26
|
UTSW |
6 |
124,061,191 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R4655:Vmn2r26
|
UTSW |
6 |
124,061,416 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4709:Vmn2r26
|
UTSW |
6 |
124,053,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r26
|
UTSW |
6 |
124,026,111 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r26
|
UTSW |
6 |
124,061,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5482:Vmn2r26
|
UTSW |
6 |
124,061,326 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R5517:Vmn2r26
|
UTSW |
6 |
124,050,717 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5737:Vmn2r26
|
UTSW |
6 |
124,039,449 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r26
|
UTSW |
6 |
124,025,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5873:Vmn2r26
|
UTSW |
6 |
124,061,674 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5907:Vmn2r26
|
UTSW |
6 |
124,039,871 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6086:Vmn2r26
|
UTSW |
6 |
124,039,560 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R6134:Vmn2r26
|
UTSW |
6 |
124,061,485 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6391:Vmn2r26
|
UTSW |
6 |
124,061,389 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r26
|
UTSW |
6 |
124,026,080 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6637:Vmn2r26
|
UTSW |
6 |
124,061,691 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6927:Vmn2r26
|
UTSW |
6 |
124,039,098 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R6953:Vmn2r26
|
UTSW |
6 |
124,039,782 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7173:Vmn2r26
|
UTSW |
6 |
124,061,296 (GRCm38) |
missense |
probably benign |
0.16 |
|
R7206:Vmn2r26
|
UTSW |
6 |
124,039,768 (GRCm38) |
missense |
probably benign |
0.17 |
|
R7208:Vmn2r26
|
UTSW |
6 |
124,061,989 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7506:Vmn2r26
|
UTSW |
6 |
124,039,741 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7672:Vmn2r26
|
UTSW |
6 |
124,039,647 (GRCm38) |
missense |
probably benign |
0.25 |
|
R7674:Vmn2r26
|
UTSW |
6 |
124,039,362 (GRCm38) |
missense |
probably benign |
|
|
R7696:Vmn2r26
|
UTSW |
6 |
124,061,535 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7716:Vmn2r26
|
UTSW |
6 |
124,061,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7831:Vmn2r26
|
UTSW |
6 |
124,039,799 (GRCm38) |
nonsense |
probably null |
|
|
R8063:Vmn2r26
|
UTSW |
6 |
124,024,955 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8331:Vmn2r26
|
UTSW |
6 |
124,061,928 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8352:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8445:Vmn2r26
|
UTSW |
6 |
124,026,036 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8452:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8681:Vmn2r26
|
UTSW |
6 |
124,024,918 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8914:Vmn2r26
|
UTSW |
6 |
124,062,024 (GRCm38) |
missense |
probably benign |
|
|
R9333:Vmn2r26
|
UTSW |
6 |
124,026,050 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9351:Vmn2r26
|
UTSW |
6 |
124,039,374 (GRCm38) |
missense |
probably benign |
|
|
R9436:Vmn2r26
|
UTSW |
6 |
124,025,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9515:Vmn2r26
|
UTSW |
6 |
124,061,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF010:Vmn2r26
|
UTSW |
6 |
124,039,489 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCTTTATATGCCTTAGATTGCTG -3'
(R):5'- CTTAGAACTCGGGAGATCTGAATG -3'
Sequencing Primer
(F):5'- TCCAAAATTTGAGAGGGAGCACTG -3'
(R):5'- GGATATTGATGTTGAAATGCCTCC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation