Incidental Mutation 'R7283:Olfr872'
ID 565803
Institutional Source Beutler Lab
Gene Symbol Olfr872
Ensembl Gene ENSMUSG00000066897
Gene Name olfactory receptor 872
Synonyms GA_x6K02T2PVTD-13999915-14000844, MOR145-3
MMRRC Submission 045361-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R7283 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 20237119-20261643 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to C at 20260259 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 140 (I140L)
Ref Sequence ENSEMBL: ENSMUSP00000083665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086474]
AlphaFold E9PVW2
Predicted Effect probably damaging
Transcript: ENSMUST00000086474
AA Change: I140L

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000083665
Gene: ENSMUSG00000066897
AA Change: I140L

DomainStartEndE-ValueType
Pfam:7tm_4 45 321 3.8e-45 PFAM
Pfam:7TM_GPCR_Srsx 49 310 1.4e-9 PFAM
Pfam:7tm_1 55 304 4.2e-21 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 100% (72/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610507B11Rik A G 11: 78,274,828 Q1346R probably damaging Het
4833439L19Rik A G 13: 54,552,691 V278A probably benign Het
4932415D10Rik G A 10: 82,291,297 R1960W possibly damaging Het
Abcc3 C T 11: 94,357,047 A1207T probably benign Het
Abce1 C A 8: 79,685,256 G592* probably null Het
Acad10 A C 5: 121,649,475 V137G possibly damaging Het
Adcy3 A G 12: 4,203,563 I672V not run Het
Adgrb1 A T 15: 74,580,663 Q1166L possibly damaging Het
Ankrd44 A T 1: 54,729,796 N465K probably damaging Het
Avpr1b A G 1: 131,609,731 T418A probably benign Het
Azin1 G A 15: 38,501,408 T33I probably damaging Het
Bicra T C 7: 15,972,500 T1339A probably damaging Het
Cacna1s A G 1: 136,073,708 Y299C probably damaging Het
Clip1 A C 5: 123,613,794 C641W Het
Clip3 T C 7: 30,305,812 S524P probably damaging Het
Cnpy4 A T 5: 138,192,882 H240L probably benign Het
Cyp2b19 T C 7: 26,766,914 Y381H probably damaging Het
Cyp3a13 T A 5: 137,905,556 N280I probably benign Het
Diaph3 A G 14: 86,866,584 F788S probably damaging Het
Drc7 A G 8: 95,071,579 N484S probably damaging Het
Erap1 G A 13: 74,673,784 probably null Het
Fat4 A T 3: 38,889,693 I912F probably damaging Het
Hsd3b3 T A 3: 98,742,357 K217* probably null Het
Igkv12-89 A G 6: 68,835,077 V36A probably damaging Het
Invs T A 4: 48,392,526 probably null Het
Ipo8 T A 6: 148,824,481 Y30F possibly damaging Het
Kctd14 T C 7: 97,451,486 M1T probably null Het
Klrb1c A T 6: 128,784,257 C136S probably benign Het
Morn2 A G 17: 80,297,259 E48G probably damaging Het
Myh1 A T 11: 67,201,844 probably null Het
Nbeal1 G C 1: 60,237,151 V684L probably benign Het
Nfxl1 A G 5: 72,529,050 S603P probably benign Het
Nlrc3 G A 16: 3,947,877 A351V probably benign Het
Nlrp4f G A 13: 65,195,538 R76* probably null Het
Olfr190 A T 16: 59,074,192 M296K probably benign Het
Olfr228 A T 2: 86,483,139 I201N probably damaging Het
Olfr397 T C 11: 73,964,808 S67P probably damaging Het
Olfr664 G T 7: 104,733,593 T257K probably damaging Het
Papolg A G 11: 23,867,394 V601A not run Het
Pde4dip T C 3: 97,758,882 T349A probably benign Het
Pdlim5 T C 3: 142,311,980 probably null Het
Pkhd1l1 A G 15: 44,503,280 N718S probably benign Het
Plcxd3 A G 15: 4,516,919 H135R probably damaging Het
Plxna2 A T 1: 194,644,883 Y375F probably damaging Het
Prkca C T 11: 108,340,645 probably null Het
Prkdc A G 16: 15,717,764 S1663G probably benign Het
Ptbp3 T C 4: 59,514,384 T80A probably benign Het
Ptpn4 C T 1: 119,682,531 V696I possibly damaging Het
Pygl A T 12: 70,216,568 W175R possibly damaging Het
Rftn1 A G 17: 50,047,441 Y298H probably damaging Het
Rit2 A G 18: 31,316,839 probably null Het
Runx1t1 G A 4: 13,846,935 G240R probably damaging Het
Scn10a A G 9: 119,664,779 probably null Het
Serpina16 A C 12: 103,672,432 probably null Het
Slc17a3 A T 13: 23,855,848 M290L Het
Slc6a4 A T 11: 77,010,696 M86L probably benign Het
Spag7 A T 11: 70,665,313 V46E probably benign Het
Sptlc1 T C 13: 53,344,878 I271V probably benign Het
Stk17b A C 1: 53,757,515 H364Q probably benign Het
Strc T C 2: 121,379,452 H130R probably damaging Het
Stxbp1 T A 2: 32,815,014 D148V probably damaging Het
Tirap G A 9: 35,188,929 P153L probably damaging Het
Tmco3 G A 8: 13,319,605 probably null Het
Tmem51 T A 4: 142,031,783 D218V probably damaging Het
Trim40 A T 17: 36,882,662 D218E probably benign Het
Ttc21b T C 2: 66,208,718 D934G probably damaging Het
Vmn2r26 T C 6: 124,025,955 L108P probably damaging Het
Washc2 C A 6: 116,227,418 P429Q probably damaging Het
Wipi1 A G 11: 109,611,311 M1T probably null Het
Zfp438 A G 18: 5,214,712 V82A probably damaging Het
Zfp853 G C 5: 143,287,738 A724G unknown Het
Other mutations in Olfr872
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01904:Olfr872 APN 9 20260290 missense probably damaging 0.99
IGL02048:Olfr872 APN 9 20260488 missense possibly damaging 0.79
IGL02232:Olfr872 APN 9 20260215 missense probably damaging 1.00
IGL02314:Olfr872 APN 9 20260478 missense probably benign 0.03
IGL03290:Olfr872 APN 9 20260260 missense probably damaging 1.00
R0410:Olfr872 UTSW 9 20260501 missense probably benign 0.03
R1482:Olfr872 UTSW 9 20260724 missense possibly damaging 0.89
R1521:Olfr872 UTSW 9 20260432 missense possibly damaging 0.91
R4930:Olfr872 UTSW 9 20260017 missense probably damaging 1.00
R5457:Olfr872 UTSW 9 20260278 missense probably damaging 1.00
R5870:Olfr872 UTSW 9 20260578 missense probably benign
R6141:Olfr872 UTSW 9 20260458 missense probably benign 0.00
R8691:Olfr872 UTSW 9 20260451 missense probably benign 0.36
R8882:Olfr872 UTSW 9 20259960 missense probably benign 0.06
R9556:Olfr872 UTSW 9 20260355 missense probably benign 0.00
R9618:Olfr872 UTSW 9 20260343 missense possibly damaging 0.80
R9752:Olfr872 UTSW 9 20259908 missense probably benign 0.10
X0025:Olfr872 UTSW 9 20260486 missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGTCTGACATTTGTTTGATCTCCAC -3'
(R):5'- ACAACTGACAGGTGAGACCC -3'

Sequencing Primer
(F):5'- CCACTATAGTCCCAAGGATGATTTGG -3'
(R):5'- CAGGTGGAAAAGGCTTTATACTTTCC -3'
Posted On 2019-06-26