Incidental Mutation 'R0584:Grp'
ID 56588
Institutional Source Beutler Lab
Gene Symbol Grp
Ensembl Gene ENSMUSG00000024517
Gene Name gastrin releasing peptide
Synonyms BLP
MMRRC Submission 038774-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0584 (G1)
Quality Score 125
Status Validated
Chromosome 18
Chromosomal Location 66005891-66019667 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 66006766 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 30 (A30E)
Ref Sequence ENSEMBL: ENSMUSP00000133437 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025395] [ENSMUST00000173530] [ENSMUST00000173985]
AlphaFold Q8R1I2
Predicted Effect possibly damaging
Transcript: ENSMUST00000025395
AA Change: A30E

PolyPhen 2 Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000025395
Gene: ENSMUSG00000024517
AA Change: A30E

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Bombesin 43 56 9.1e-10 PFAM
low complexity region 82 95 N/A INTRINSIC
low complexity region 98 112 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000173530
AA Change: A30E

PolyPhen 2 Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000139014
Gene: ENSMUSG00000024517
AA Change: A30E

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Bombesin 43 56 1.2e-11 PFAM
low complexity region 82 95 N/A INTRINSIC
low complexity region 98 112 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000173985
AA Change: A30E

PolyPhen 2 Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000133437
Gene: ENSMUSG00000024517
AA Change: A30E

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Bombesin 43 56 3.5e-11 PFAM
low complexity region 82 95 N/A INTRINSIC
low complexity region 98 112 N/A INTRINSIC
Meta Mutation Damage Score 0.2191 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.2%
  • 20x: 93.7%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: This gene encodes a neuropeptide hormone that affects various biological processes such as neuroendocrine regulation, gastrointestinal secretion, nociception, cell proliferation and inflammation. The encoded protein undergoes proteolytic processing to generate multiple mature peptides with biological activity. [provided by RefSeq, Aug 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit attenuated scratching response to chloroquine, SLIGRL and BAM8-22. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T C 10: 79,847,564 (GRCm39) S1745P probably damaging Het
Agfg2 G A 5: 137,665,992 (GRCm39) T89I probably damaging Het
Agtr1a A G 13: 30,565,017 (GRCm39) I27M probably damaging Het
Armh1 A T 4: 117,087,047 (GRCm39) L206Q probably damaging Het
Asxl2 A T 12: 3,546,632 (GRCm39) E472V probably damaging Het
Atp2c2 T A 8: 120,465,157 (GRCm39) V313E probably benign Het
Casp12 A G 9: 5,352,268 (GRCm39) I87V probably null Het
Ccl25 C T 8: 4,404,085 (GRCm39) probably benign Het
Col9a1 T C 1: 24,263,571 (GRCm39) probably benign Het
Cyth4 A G 15: 78,494,078 (GRCm39) probably null Het
Dnah9 A G 11: 65,881,315 (GRCm39) Y2587H probably damaging Het
Dppa3 T C 6: 122,606,951 (GRCm39) I147T probably benign Het
Fam120b T C 17: 15,622,384 (GRCm39) S121P probably damaging Het
Fam209 C T 2: 172,316,081 (GRCm39) T152M probably benign Het
Fam98a A G 17: 75,851,772 (GRCm39) L103P probably damaging Het
Fcho1 T C 8: 72,168,369 (GRCm39) Y218C probably damaging Het
Fitm1 T C 14: 55,814,113 (GRCm39) V203A probably benign Het
Gcn1 G A 5: 115,733,074 (GRCm39) R1037Q probably damaging Het
Gm11563 A G 11: 99,549,451 (GRCm39) I101T unknown Het
Gpd1l A G 9: 114,743,412 (GRCm39) F163L probably damaging Het
H1f7 C A 15: 98,154,958 (GRCm39) E64* probably null Het
Icosl T C 10: 77,907,709 (GRCm39) Y90H possibly damaging Het
Itsn2 A G 12: 4,747,180 (GRCm39) T1194A probably benign Het
Lrp6 A G 6: 134,433,039 (GRCm39) S1431P probably damaging Het
Ltbp1 T C 17: 75,670,467 (GRCm39) S1503P probably damaging Het
Mef2a G T 7: 66,884,896 (GRCm39) S406* probably null Het
Myh13 G T 11: 67,251,200 (GRCm39) E1360* probably null Het
Nop58 A G 1: 59,745,919 (GRCm39) D400G probably benign Het
Or5p79 T C 7: 108,221,622 (GRCm39) L201P probably benign Het
Or6c205 T C 10: 129,086,817 (GRCm39) V138A probably benign Het
Oscp1 A G 4: 125,977,387 (GRCm39) probably null Het
Pde9a A T 17: 31,678,951 (GRCm39) Y264F probably damaging Het
Pkhd1 T A 1: 20,309,660 (GRCm39) K2763* probably null Het
Prkci T A 3: 31,079,289 (GRCm39) C42* probably null Het
Ptprr T C 10: 116,087,063 (GRCm39) V270A probably damaging Het
Rsf1 T A 7: 97,311,335 (GRCm39) N688K possibly damaging Het
S1pr3 A T 13: 51,573,697 (GRCm39) M293L probably benign Het
Scn10a A C 9: 119,499,597 (GRCm39) L232R probably damaging Het
Sirt5 T A 13: 43,548,204 (GRCm39) probably null Het
Sp6 C T 11: 96,913,091 (GRCm39) T268M probably damaging Het
Spag5 A G 11: 78,194,921 (GRCm39) N76S possibly damaging Het
Tecta T C 9: 42,259,204 (GRCm39) N1560D possibly damaging Het
Togaram1 T C 12: 65,014,279 (GRCm39) L510P probably damaging Het
Umps A G 16: 33,779,494 (GRCm39) I401T probably damaging Het
Vars2 A G 17: 35,977,578 (GRCm39) V118A possibly damaging Het
Other mutations in Grp
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4362001:Grp UTSW 18 66,019,297 (GRCm39) missense probably benign 0.18
R1144:Grp UTSW 18 66,013,041 (GRCm39) missense probably damaging 0.99
R4865:Grp UTSW 18 66,013,041 (GRCm39) missense probably damaging 1.00
R5085:Grp UTSW 18 66,013,230 (GRCm39) missense probably benign
R6084:Grp UTSW 18 66,013,008 (GRCm39) missense probably damaging 0.99
R6198:Grp UTSW 18 66,013,057 (GRCm39) missense possibly damaging 0.96
R6325:Grp UTSW 18 66,006,824 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TAGATGGATGGTTTCCCAGCCAGG -3'
(R):5'- TGCTCACAGGTGCTAAGCGGAAAG -3'

Sequencing Primer
(F):5'- TATATAAAGTCCAGGGCCGC -3'
(R):5'- AAGGGATCAGTGTGCCACC -3'
Posted On 2013-07-11