|Institutional Source||Beutler Lab|
|Gene Name||lemur tyrosine kinase 2|
|Synonyms||AATYK2, A330101P12Rik, KPI2, cprk, KPI-2, 2900041G10Rik, BREK|
|Is this an essential gene?||Possibly essential (E-score: 0.560)|
|Stock #||R7286 (G1)|
|Chromosomal Location||144100436-144188204 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||C to T at 144174360 bp (GRCm38)|
|Amino Acid Change||Glutamine to Stop codon at position 633 (Q633*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000048238 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041804]|
AA Change: Q633*
AA Change: Q633*
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a null mutation in this gene display partial prenatal lethality, male infertility, and azoospermia. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Lmtk2||
(F):5'- AAGCAGCAGCAATCTGGGAC -3'
(R):5'- ATCTTGGTGCAAAAGGCTTTC -3'
(F):5'- TGCACTGCTCACAACTGAAGTAG -3'
(R):5'- CTTTCTGATAAGCACAGAGGGCC -3'