Incidental Mutation 'R7288:Wdr90'
ID 566194
Institutional Source Beutler Lab
Gene Symbol Wdr90
Ensembl Gene ENSMUSG00000073434
Gene Name WD repeat domain 90
Synonyms 3230401M21Rik
MMRRC Submission 045395-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R7288 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 26063745-26080475 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 26065286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 1657 (S1657P)
Ref Sequence ENSEMBL: ENSMUSP00000078426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043897] [ENSMUST00000079461] [ENSMUST00000176709] [ENSMUST00000176923]
AlphaFold Q6ZPG2
Predicted Effect probably benign
Transcript: ENSMUST00000043897
SMART Domains Protein: ENSMUSP00000044639
Gene: ENSMUSG00000025733

DomainStartEndE-ValueType
Pfam:Roc 6 122 4.1e-11 PFAM
Pfam:Ras 6 168 2.3e-18 PFAM
EFh 188 216 1.27e1 SMART
Pfam:EF_assoc_2 219 305 2.2e-35 PFAM
EFh 308 336 1.23e-1 SMART
Pfam:EF_assoc_1 341 412 1.8e-25 PFAM
Blast:AAA 416 547 7e-18 BLAST
SCOP:d1mh1__ 422 532 4e-8 SMART
transmembrane domain 595 617 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000079461
AA Change: S1657P

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000078426
Gene: ENSMUSG00000073434
AA Change: S1657P

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 183 5e-26 PFAM
Pfam:DUF667 210 271 3.7e-9 PFAM
low complexity region 381 396 N/A INTRINSIC
WD40 478 519 5.94e0 SMART
WD40 522 565 3.2e0 SMART
WD40 572 612 3.3e1 SMART
WD40 687 725 1.15e1 SMART
WD40 728 766 5.75e-1 SMART
WD40 768 808 9.24e-4 SMART
WD40 811 850 4.13e0 SMART
WD40 853 892 4.62e-1 SMART
WD40 950 993 1.07e1 SMART
WD40 996 1035 5.75e-1 SMART
WD40 1040 1077 1.58e-2 SMART
WD40 1290 1334 5.23e-3 SMART
WD40 1337 1378 1.27e-1 SMART
WD40 1384 1419 1.83e2 SMART
WD40 1422 1469 3.08e0 SMART
WD40 1472 1509 9.9e0 SMART
WD40 1568 1607 9.02e-7 SMART
WD40 1610 1655 5.75e-1 SMART
WD40 1659 1697 2.98e-1 SMART
WD40 1700 1749 6.14e1 SMART
WD40 1850 1888 1.92e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176591
Predicted Effect probably benign
Transcript: ENSMUST00000176709
SMART Domains Protein: ENSMUSP00000135436
Gene: ENSMUSG00000025733

DomainStartEndE-ValueType
Pfam:Arf 1 121 1.6e-6 PFAM
Pfam:MMR_HSR1 6 118 1.4e-6 PFAM
Pfam:Miro 6 120 7.8e-20 PFAM
Pfam:Ras 6 121 7.2e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176751
Predicted Effect probably benign
Transcript: ENSMUST00000176923
AA Change: S1639P

PolyPhen 2 Score 0.399 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000135420
Gene: ENSMUSG00000073434
AA Change: S1639P

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 252 5.1e-14 PFAM
low complexity region 363 378 N/A INTRINSIC
WD40 460 501 5.94e0 SMART
WD40 504 547 3.2e0 SMART
WD40 554 594 3.3e1 SMART
WD40 669 707 1.15e1 SMART
WD40 710 748 5.75e-1 SMART
WD40 750 790 9.24e-4 SMART
WD40 793 832 4.13e0 SMART
WD40 835 874 4.62e-1 SMART
WD40 932 975 1.07e1 SMART
WD40 978 1017 5.75e-1 SMART
WD40 1022 1059 1.58e-2 SMART
WD40 1272 1316 5.23e-3 SMART
WD40 1319 1360 1.27e-1 SMART
WD40 1366 1401 1.83e2 SMART
WD40 1404 1451 3.08e0 SMART
WD40 1454 1491 9.9e0 SMART
WD40 1550 1589 9.02e-7 SMART
WD40 1592 1637 5.75e-1 SMART
WD40 1641 1679 2.98e-1 SMART
WD40 1682 1731 6.14e1 SMART
WD40 1832 1870 1.92e-1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik T A 11: 58,771,131 (GRCm39) D204E probably benign Het
Adh1 T G 3: 137,988,493 (GRCm39) D155E probably benign Het
Akt1s1 T C 7: 44,498,571 (GRCm39) L2P unknown Het
Ash1l T A 3: 88,873,199 (GRCm39) probably benign Het
Bend7 C T 2: 4,757,641 (GRCm39) P228S probably damaging Het
Bpifc T C 10: 85,824,585 (GRCm39) E218G possibly damaging Het
Cdk6 T A 5: 3,479,001 (GRCm39) F127Y probably benign Het
Cgnl1 A T 9: 71,632,846 (GRCm39) H168Q possibly damaging Het
Chd7 C T 4: 8,847,093 (GRCm39) T1612I possibly damaging Het
Col4a4 A T 1: 82,470,184 (GRCm39) C782S unknown Het
Copg2 T A 6: 30,801,341 (GRCm39) I364L probably damaging Het
Crygb A G 1: 65,121,084 (GRCm39) L81P probably benign Het
Cyp4f18 A T 8: 72,747,017 (GRCm39) M326K probably damaging Het
Dhx34 A G 7: 15,949,361 (GRCm39) S356P probably benign Het
Dmbt1 C T 7: 130,685,519 (GRCm39) Q855* probably null Het
Dnai3 T C 3: 145,787,007 (GRCm39) T343A probably damaging Het
Dnph1 A G 17: 46,809,938 (GRCm39) N160S probably benign Het
Esrra A T 19: 6,890,139 (GRCm39) C228* probably null Het
Evpl T C 11: 116,114,775 (GRCm39) N972D probably benign Het
Fat3 T C 9: 15,909,888 (GRCm39) D2038G probably damaging Het
Fhit T A 14: 9,763,784 (GRCm38) R102W probably damaging Het
Gal3st1 A T 11: 3,948,609 (GRCm39) D272V probably damaging Het
Gal3st1 T A 11: 3,948,651 (GRCm39) V286D probably damaging Het
Gemin4 A T 11: 76,104,206 (GRCm39) M185K possibly damaging Het
Hecw1 T C 13: 14,490,821 (GRCm39) I311V probably benign Het
Ift172 T C 5: 31,442,630 (GRCm39) Y179C probably damaging Het
Ighv7-3 C T 12: 114,116,963 (GRCm39) W66* probably null Het
Iqgap3 T A 3: 88,016,142 (GRCm39) I975N probably damaging Het
Khdrbs3 A G 15: 68,921,262 (GRCm39) E281G possibly damaging Het
Lamb2 A T 9: 108,365,523 (GRCm39) T1369S probably benign Het
Mettl8 A T 2: 70,812,382 (GRCm39) D84E probably benign Het
Mrgprb3 C A 7: 48,293,059 (GRCm39) C164F probably damaging Het
Mtg2 A G 2: 179,725,180 (GRCm39) Y131C probably damaging Het
Nacc1 C T 8: 85,403,174 (GRCm39) A234T probably benign Het
Nsmaf C T 4: 6,416,641 (GRCm39) V551I probably benign Het
Or13a26 T A 7: 140,284,942 (GRCm39) C259* probably null Het
Or7e175 T A 9: 20,048,737 (GRCm39) Y108* probably null Het
Oxr1 C T 15: 41,677,004 (GRCm39) P187L not run Het
Pcdhb12 T A 18: 37,569,068 (GRCm39) D71E probably benign Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,341,589 (GRCm39) probably null Het
Pkm A G 9: 59,576,196 (GRCm39) S127G probably benign Het
Plxna2 T A 1: 194,479,227 (GRCm39) L1296H probably damaging Het
Ppil6 C G 10: 41,374,524 (GRCm39) T135R probably benign Het
Ppp2r3d T C 9: 101,004,203 (GRCm39) Y378C probably damaging Het
Rabep2 C T 7: 126,043,377 (GRCm39) R426C probably damaging Het
Rad21 A T 15: 51,845,976 (GRCm39) H31Q possibly damaging Het
Rad50 G T 11: 53,545,776 (GRCm39) Y1182* probably null Het
Serpinb9c C T 13: 33,335,883 (GRCm39) A218T possibly damaging Het
Slc34a1 C A 13: 24,003,095 (GRCm39) H248Q probably benign Het
Slc45a4 C A 15: 73,458,785 (GRCm39) E255* probably null Het
Slc8a3 T A 12: 81,263,598 (GRCm39) K596N possibly damaging Het
Tbc1d32 A C 10: 55,927,483 (GRCm39) probably null Het
Tbl2 T A 5: 135,183,253 (GRCm39) I112N possibly damaging Het
Tchp A C 5: 114,853,630 (GRCm39) K238T probably damaging Het
Tfap2d G A 1: 19,189,207 (GRCm39) G251D probably damaging Het
Thrb T A 14: 18,030,186 (GRCm38) M324K probably damaging Het
Tmem259 A T 10: 79,814,300 (GRCm39) L328Q probably damaging Het
Tmtc2 T C 10: 105,249,469 (GRCm39) H88R probably damaging Het
Tnfrsf21 A G 17: 43,348,709 (GRCm39) H107R possibly damaging Het
Trib1 T C 15: 59,526,471 (GRCm39) V347A probably benign Het
Ung T A 5: 114,269,315 (GRCm39) L9* probably null Het
Vmn1r195 G T 13: 22,463,174 (GRCm39) V215F probably damaging Het
Wdsub1 A T 2: 59,708,487 (GRCm39) Y129N possibly damaging Het
Zfp369 T G 13: 65,432,832 (GRCm39) probably null Het
Zfp770 G T 2: 114,026,142 (GRCm39) C642* probably null Het
Zfp981 C T 4: 146,622,100 (GRCm39) R342C probably benign Het
Zhx3 A C 2: 160,623,042 (GRCm39) V375G probably damaging Het
Other mutations in Wdr90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Wdr90 APN 17 26,068,338 (GRCm39) missense probably damaging 1.00
IGL01118:Wdr90 APN 17 26,073,661 (GRCm39) missense probably damaging 1.00
IGL01964:Wdr90 APN 17 26,067,383 (GRCm39) missense probably benign
IGL02116:Wdr90 APN 17 26,078,466 (GRCm39) missense probably benign 0.12
IGL02172:Wdr90 APN 17 26,069,408 (GRCm39) missense probably benign 0.22
IGL02716:Wdr90 APN 17 26,076,194 (GRCm39) missense probably damaging 0.96
IGL02961:Wdr90 APN 17 26,067,649 (GRCm39) nonsense probably null
IGL03229:Wdr90 APN 17 26,064,437 (GRCm39) splice site probably benign
IGL03367:Wdr90 APN 17 26,066,765 (GRCm39) splice site probably benign
IGL03098:Wdr90 UTSW 17 26,078,961 (GRCm39) intron probably benign
R0111:Wdr90 UTSW 17 26,067,418 (GRCm39) splice site probably benign
R0454:Wdr90 UTSW 17 26,079,023 (GRCm39) missense probably damaging 0.96
R0457:Wdr90 UTSW 17 26,079,459 (GRCm39) missense probably benign 0.00
R0488:Wdr90 UTSW 17 26,067,591 (GRCm39) missense probably damaging 1.00
R0622:Wdr90 UTSW 17 26,074,632 (GRCm39) missense probably damaging 1.00
R0671:Wdr90 UTSW 17 26,065,367 (GRCm39) missense probably benign 0.04
R0799:Wdr90 UTSW 17 26,079,104 (GRCm39) missense probably benign 0.38
R1177:Wdr90 UTSW 17 26,065,028 (GRCm39) missense possibly damaging 0.85
R1460:Wdr90 UTSW 17 26,079,422 (GRCm39) missense possibly damaging 0.82
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1544:Wdr90 UTSW 17 26,068,284 (GRCm39) missense possibly damaging 0.69
R2057:Wdr90 UTSW 17 26,074,173 (GRCm39) missense probably benign 0.05
R2087:Wdr90 UTSW 17 26,065,577 (GRCm39) missense probably damaging 1.00
R2159:Wdr90 UTSW 17 26,070,715 (GRCm39) missense probably benign
R2208:Wdr90 UTSW 17 26,079,362 (GRCm39) missense probably damaging 1.00
R2345:Wdr90 UTSW 17 26,078,136 (GRCm39) missense probably benign 0.05
R2391:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2394:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2520:Wdr90 UTSW 17 26,074,326 (GRCm39) missense probably damaging 1.00
R3798:Wdr90 UTSW 17 26,069,472 (GRCm39) missense probably benign 0.01
R3979:Wdr90 UTSW 17 26,078,252 (GRCm39) missense probably benign 0.00
R4111:Wdr90 UTSW 17 26,068,342 (GRCm39) missense possibly damaging 0.94
R4326:Wdr90 UTSW 17 26,072,705 (GRCm39) missense probably benign 0.25
R4459:Wdr90 UTSW 17 26,079,976 (GRCm39) missense possibly damaging 0.95
R4697:Wdr90 UTSW 17 26,074,337 (GRCm39) missense probably benign 0.03
R4735:Wdr90 UTSW 17 26,078,424 (GRCm39) missense probably benign
R4907:Wdr90 UTSW 17 26,079,624 (GRCm39) intron probably benign
R5070:Wdr90 UTSW 17 26,065,307 (GRCm39) missense probably damaging 1.00
R5230:Wdr90 UTSW 17 26,074,277 (GRCm39) missense probably benign 0.01
R5268:Wdr90 UTSW 17 26,069,819 (GRCm39) missense probably damaging 1.00
R5287:Wdr90 UTSW 17 26,080,441 (GRCm39) utr 5 prime probably benign
R5382:Wdr90 UTSW 17 26,064,572 (GRCm39) missense probably damaging 1.00
R5511:Wdr90 UTSW 17 26,063,995 (GRCm39) unclassified probably benign
R5545:Wdr90 UTSW 17 26,064,830 (GRCm39) missense probably damaging 1.00
R5707:Wdr90 UTSW 17 26,076,166 (GRCm39) missense probably benign 0.00
R5973:Wdr90 UTSW 17 26,065,381 (GRCm39) missense probably damaging 1.00
R5973:Wdr90 UTSW 17 26,064,107 (GRCm39) missense probably damaging 0.99
R6385:Wdr90 UTSW 17 26,067,504 (GRCm39) missense probably damaging 1.00
R6481:Wdr90 UTSW 17 26,064,885 (GRCm39) missense probably damaging 0.99
R7078:Wdr90 UTSW 17 26,068,623 (GRCm39) missense probably damaging 1.00
R7214:Wdr90 UTSW 17 26,064,367 (GRCm39) missense probably benign 0.00
R7304:Wdr90 UTSW 17 26,070,480 (GRCm39) missense probably benign 0.10
R7309:Wdr90 UTSW 17 26,079,676 (GRCm39) missense probably benign 0.02
R7391:Wdr90 UTSW 17 26,065,502 (GRCm39) missense probably benign 0.08
R7622:Wdr90 UTSW 17 26,073,083 (GRCm39) missense probably benign 0.00
R7646:Wdr90 UTSW 17 26,079,104 (GRCm39) missense probably benign 0.38
R7772:Wdr90 UTSW 17 26,080,465 (GRCm39) start gained probably benign
R7779:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7780:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7781:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7782:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7812:Wdr90 UTSW 17 26,071,532 (GRCm39) missense probably damaging 1.00
R7870:Wdr90 UTSW 17 26,079,513 (GRCm39) missense probably damaging 0.96
R7911:Wdr90 UTSW 17 26,069,723 (GRCm39) missense probably benign 0.00
R8126:Wdr90 UTSW 17 26,067,951 (GRCm39) missense possibly damaging 0.48
R8260:Wdr90 UTSW 17 26,064,141 (GRCm39) missense probably damaging 1.00
R8315:Wdr90 UTSW 17 26,064,399 (GRCm39) missense probably benign 0.21
R8919:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8938:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8940:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R9038:Wdr90 UTSW 17 26,076,200 (GRCm39) missense
R9079:Wdr90 UTSW 17 26,076,403 (GRCm39) missense
R9401:Wdr90 UTSW 17 26,064,750 (GRCm39) small insertion probably benign
R9471:Wdr90 UTSW 17 26,080,015 (GRCm39) missense possibly damaging 0.72
R9642:Wdr90 UTSW 17 26,072,694 (GRCm39) critical splice donor site probably null
X0064:Wdr90 UTSW 17 26,067,537 (GRCm39) missense probably damaging 1.00
Z1176:Wdr90 UTSW 17 26,079,470 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGAGACTATGATGCCATTATGTGAG -3'
(R):5'- TGATCCAGTTTCAGGTGCTG -3'

Sequencing Primer
(F):5'- TGATGCCATTATGTGAGCCCAAC -3'
(R):5'- ACACTAGAGCTGTCTCTG -3'
Posted On 2019-06-26