Incidental Mutation 'R7289:Cdc42bpa'
| ID |
566203 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cdc42bpa
|
| Ensembl Gene |
ENSMUSG00000026490 |
| Gene Name |
CDC42 binding protein kinase alpha |
| Synonyms |
DMPK-like, A930014J19Rik |
| MMRRC Submission |
045396-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.834)
|
| Stock # |
R7289 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
179788037-179993168 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 179889362 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 203
(K203*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106746
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076687]
[ENSMUST00000097450]
[ENSMUST00000097453]
[ENSMUST00000111117]
[ENSMUST00000134959]
[ENSMUST00000212756]
|
| AlphaFold |
Q3UU96 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000076687
AA Change: K203*
|
| SMART Domains |
Protein: ENSMUSP00000075980
Gene: ENSMUSG00000026490
AA Change: K203*
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
588 |
N/A |
INTRINSIC |
|
coiled coil region
|
632 |
735 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
800 |
860 |
2.7e-29 |
PFAM |
|
C1
|
919 |
968 |
4.09e-7 |
SMART |
|
PH
|
989 |
1109 |
6.02e-8 |
SMART |
|
CNH
|
1134 |
1411 |
3.37e-17 |
SMART |
|
low complexity region
|
1456 |
1468 |
N/A |
INTRINSIC |
|
PBD
|
1477 |
1512 |
2.05e-10 |
SMART |
|
low complexity region
|
1531 |
1546 |
N/A |
INTRINSIC |
|
low complexity region
|
1567 |
1580 |
N/A |
INTRINSIC |
|
low complexity region
|
1606 |
1620 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000097450
AA Change: K203*
|
| SMART Domains |
Protein: ENSMUSP00000095059
Gene: ENSMUSG00000026490
AA Change: K203*
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.2e-29 |
PFAM |
|
C1
|
1000 |
1049 |
4.09e-7 |
SMART |
|
PH
|
1070 |
1190 |
6.02e-8 |
SMART |
|
CNH
|
1215 |
1492 |
3.37e-17 |
SMART |
|
low complexity region
|
1537 |
1549 |
N/A |
INTRINSIC |
|
PBD
|
1558 |
1593 |
2.05e-10 |
SMART |
|
low complexity region
|
1612 |
1627 |
N/A |
INTRINSIC |
|
low complexity region
|
1648 |
1661 |
N/A |
INTRINSIC |
|
low complexity region
|
1687 |
1701 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000097453
AA Change: K203*
|
| SMART Domains |
Protein: ENSMUSP00000095062
Gene: ENSMUSG00000026490
AA Change: K203*
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.5e-29 |
PFAM |
|
C1
|
972 |
1021 |
4.09e-7 |
SMART |
|
PH
|
1042 |
1162 |
6.02e-8 |
SMART |
|
CNH
|
1187 |
1464 |
3.37e-17 |
SMART |
|
low complexity region
|
1509 |
1521 |
N/A |
INTRINSIC |
|
PBD
|
1530 |
1565 |
2.05e-10 |
SMART |
|
low complexity region
|
1584 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1620 |
1633 |
N/A |
INTRINSIC |
|
low complexity region
|
1659 |
1673 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000111117
AA Change: K203*
|
| SMART Domains |
Protein: ENSMUSP00000106746
Gene: ENSMUSG00000026490
AA Change: K203*
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
low complexity region
|
484 |
499 |
N/A |
INTRINSIC |
|
Pfam:KELK
|
529 |
608 |
1.1e-32 |
PFAM |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.6e-29 |
PFAM |
|
C1
|
1013 |
1062 |
4.09e-7 |
SMART |
|
PH
|
1083 |
1203 |
6.02e-8 |
SMART |
|
CNH
|
1228 |
1505 |
3.37e-17 |
SMART |
|
low complexity region
|
1550 |
1562 |
N/A |
INTRINSIC |
|
PBD
|
1571 |
1606 |
2.05e-10 |
SMART |
|
low complexity region
|
1625 |
1640 |
N/A |
INTRINSIC |
|
low complexity region
|
1661 |
1674 |
N/A |
INTRINSIC |
|
low complexity region
|
1700 |
1714 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134959
|
| SMART Domains |
Protein: ENSMUSP00000142018
Gene: ENSMUSG00000026490
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4AW2|A
|
2 |
90 |
1e-58 |
PDB |
|
SCOP:d1koba_
|
50 |
90 |
7e-5 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000212756
AA Change: K203*
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aars2 |
G |
A |
17: 45,818,550 (GRCm39) |
D112N |
probably damaging |
Het |
| Abca7 |
T |
A |
10: 79,845,778 (GRCm39) |
I1580K |
probably damaging |
Het |
| Aebp1 |
A |
G |
11: 5,815,059 (GRCm39) |
D234G |
probably damaging |
Het |
| Agap1 |
T |
A |
1: 89,383,153 (GRCm39) |
M1K |
probably null |
Het |
| Agrn |
A |
T |
4: 156,263,389 (GRCm39) |
L345H |
probably damaging |
Het |
| Amfr |
A |
G |
8: 94,725,754 (GRCm39) |
M209T |
possibly damaging |
Het |
| Angel2 |
G |
A |
1: 190,673,371 (GRCm39) |
R338H |
possibly damaging |
Het |
| Ankrd27 |
C |
T |
7: 35,330,674 (GRCm39) |
A866V |
probably damaging |
Het |
| Apc |
G |
A |
18: 34,448,324 (GRCm39) |
R1740Q |
probably damaging |
Het |
| Arhgap32 |
A |
T |
9: 32,168,233 (GRCm39) |
S739C |
possibly damaging |
Het |
| Arhgap32 |
G |
C |
9: 32,168,234 (GRCm39) |
S739T |
probably benign |
Het |
| Arhgef2 |
C |
T |
3: 88,543,192 (GRCm39) |
S418L |
probably benign |
Het |
| Arhgef25 |
T |
C |
10: 127,019,641 (GRCm39) |
T472A |
possibly damaging |
Het |
| Atrnl1 |
C |
T |
19: 57,638,846 (GRCm39) |
S328F |
probably benign |
Het |
| Bahcc1 |
C |
T |
11: 120,171,000 (GRCm39) |
A1514V |
probably benign |
Het |
| Calcoco2 |
C |
T |
11: 95,990,823 (GRCm39) |
E305K |
unknown |
Het |
| Ccn1 |
C |
T |
3: 145,354,428 (GRCm39) |
W161* |
probably null |
Het |
| Cmc1 |
A |
T |
9: 117,904,250 (GRCm39) |
I47N |
possibly damaging |
Het |
| Cntln |
A |
G |
4: 84,964,540 (GRCm39) |
E656G |
possibly damaging |
Het |
| Dcun1d3 |
T |
C |
7: 119,458,864 (GRCm39) |
K57R |
possibly damaging |
Het |
| Ddx23 |
T |
C |
15: 98,546,492 (GRCm39) |
E559G |
probably damaging |
Het |
| Dennd6a |
G |
A |
14: 26,333,193 (GRCm39) |
R367Q |
probably damaging |
Het |
| Desi2 |
A |
T |
1: 178,083,702 (GRCm39) |
|
probably benign |
Het |
| Dido1 |
T |
C |
2: 180,301,424 (GRCm39) |
D2160G |
unknown |
Het |
| Efcab3 |
T |
C |
11: 104,929,184 (GRCm39) |
M4838T |
probably benign |
Het |
| Epb41 |
A |
G |
4: 131,718,520 (GRCm39) |
|
probably null |
Het |
| Esrrb |
T |
A |
12: 86,517,331 (GRCm39) |
|
probably null |
Het |
| Fabp1 |
C |
A |
6: 71,180,111 (GRCm39) |
T94N |
probably benign |
Het |
| Fam120a |
A |
T |
13: 49,045,482 (GRCm39) |
C785S |
probably damaging |
Het |
| Fam243 |
T |
C |
16: 92,117,710 (GRCm39) |
I193V |
probably damaging |
Het |
| Foxc1 |
A |
G |
13: 31,991,243 (GRCm39) |
Y18C |
probably damaging |
Het |
| Fshr |
T |
C |
17: 89,293,272 (GRCm39) |
T469A |
probably benign |
Het |
| Gm14399 |
T |
A |
2: 174,972,204 (GRCm39) |
H517L |
unknown |
Het |
| Gm39115 |
G |
T |
7: 141,689,297 (GRCm39) |
Q159K |
unknown |
Het |
| Gm7347 |
T |
A |
5: 26,262,306 (GRCm39) |
I72F |
possibly damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,559,466 (GRCm39) |
V2395A |
possibly damaging |
Het |
| Ighv5-17 |
T |
G |
12: 113,822,858 (GRCm39) |
T88P |
probably damaging |
Het |
| Insm2 |
T |
A |
12: 55,647,329 (GRCm39) |
Y358N |
probably damaging |
Het |
| Kazn |
A |
T |
4: 141,844,486 (GRCm39) |
L409Q |
|
Het |
| Kcnj5 |
A |
C |
9: 32,234,045 (GRCm39) |
L90R |
probably damaging |
Het |
| Kcnv2 |
A |
T |
19: 27,311,084 (GRCm39) |
T484S |
probably damaging |
Het |
| Kdm3b |
T |
C |
18: 34,927,557 (GRCm39) |
Y140H |
probably benign |
Het |
| Kifbp |
A |
C |
10: 62,401,895 (GRCm39) |
C261W |
probably damaging |
Het |
| Krt25 |
C |
T |
11: 99,212,098 (GRCm39) |
A180T |
probably benign |
Het |
| Mmp1a |
A |
G |
9: 7,467,294 (GRCm39) |
E290G |
probably damaging |
Het |
| Muc21 |
G |
A |
17: 35,929,761 (GRCm39) |
A1475V |
unknown |
Het |
| Nr3c1 |
T |
C |
18: 39,547,654 (GRCm39) |
T755A |
probably benign |
Het |
| Nr3c1 |
A |
T |
18: 39,555,786 (GRCm39) |
I517N |
probably benign |
Het |
| Nxpe2 |
A |
G |
9: 48,234,339 (GRCm39) |
|
probably null |
Het |
| Oaz1 |
C |
A |
10: 80,662,673 (GRCm39) |
T27K |
possibly damaging |
Het |
| Or4p7 |
A |
T |
2: 88,222,050 (GRCm39) |
H153L |
probably damaging |
Het |
| Or51f5 |
T |
C |
7: 102,424,634 (GRCm39) |
I301T |
probably damaging |
Het |
| Or5t5 |
G |
T |
2: 86,617,034 (GRCm39) |
C320F |
probably benign |
Het |
| Or6z3 |
T |
A |
7: 6,463,777 (GRCm39) |
W90R |
probably benign |
Het |
| Or8k21 |
A |
G |
2: 86,145,369 (GRCm39) |
M87T |
probably benign |
Het |
| Or8s5 |
A |
G |
15: 98,237,943 (GRCm39) |
V309A |
probably damaging |
Het |
| Pafah2 |
A |
T |
4: 134,147,308 (GRCm39) |
K319M |
probably damaging |
Het |
| Pask |
A |
T |
1: 93,259,309 (GRCm39) |
V236E |
probably damaging |
Het |
| Pcdh1 |
T |
C |
18: 38,322,966 (GRCm39) |
T956A |
probably damaging |
Het |
| Pcdhb18 |
C |
A |
18: 37,623,700 (GRCm39) |
N343K |
probably damaging |
Het |
| Pcsk2 |
A |
T |
2: 143,532,343 (GRCm39) |
I164F |
probably damaging |
Het |
| Phf1 |
T |
C |
17: 27,154,289 (GRCm39) |
Y169H |
probably damaging |
Het |
| Pkdrej |
T |
A |
15: 85,705,301 (GRCm39) |
I212F |
probably benign |
Het |
| Pnkp |
T |
A |
7: 44,508,114 (GRCm39) |
W146R |
probably damaging |
Het |
| Prkcb |
A |
T |
7: 122,143,910 (GRCm39) |
I325F |
probably benign |
Het |
| Ptpn21 |
C |
T |
12: 98,670,450 (GRCm39) |
D239N |
probably benign |
Het |
| Ptprb |
A |
G |
10: 116,164,070 (GRCm39) |
T626A |
probably damaging |
Het |
| Pttg1 |
T |
C |
11: 43,311,916 (GRCm39) |
N180D |
probably benign |
Het |
| Raly |
G |
A |
2: 154,703,774 (GRCm39) |
R115Q |
probably damaging |
Het |
| Rims2 |
A |
T |
15: 39,301,114 (GRCm39) |
M474L |
probably benign |
Het |
| Sash1 |
A |
T |
10: 8,605,960 (GRCm39) |
I810N |
probably damaging |
Het |
| Scnn1g |
T |
A |
7: 121,337,304 (GRCm39) |
L55* |
probably null |
Het |
| Sema6b |
A |
T |
17: 56,432,573 (GRCm39) |
D543E |
possibly damaging |
Het |
| Serpina11 |
C |
T |
12: 103,952,761 (GRCm39) |
G5E |
unknown |
Het |
| Sesn3 |
A |
T |
9: 14,187,848 (GRCm39) |
M1L |
probably benign |
Het |
| Sez6 |
T |
A |
11: 77,865,149 (GRCm39) |
I632N |
possibly damaging |
Het |
| Sgo2b |
A |
T |
8: 64,394,192 (GRCm39) |
I49N |
probably damaging |
Het |
| Slc30a2 |
A |
T |
4: 134,071,524 (GRCm39) |
I86F |
possibly damaging |
Het |
| Slc38a6 |
T |
A |
12: 73,333,786 (GRCm39) |
W30R |
probably benign |
Het |
| Spata31g1 |
A |
T |
4: 42,972,379 (GRCm39) |
T571S |
probably benign |
Het |
| Spata31g1 |
A |
T |
4: 42,973,252 (GRCm39) |
I862F |
possibly damaging |
Het |
| Stk31 |
T |
G |
6: 49,415,393 (GRCm39) |
V576G |
probably benign |
Het |
| Szt2 |
G |
A |
4: 118,233,075 (GRCm39) |
T2297I |
unknown |
Het |
| Tmem208 |
T |
C |
8: 106,061,418 (GRCm39) |
F148S |
possibly damaging |
Het |
| Tprg1l |
A |
G |
4: 154,245,031 (GRCm39) |
L19P |
possibly damaging |
Het |
| Tubg2 |
C |
A |
11: 101,050,897 (GRCm39) |
N207K |
probably damaging |
Het |
| Ube2n |
G |
T |
10: 95,377,612 (GRCm39) |
K130N |
probably benign |
Het |
| Usp36 |
T |
C |
11: 118,164,355 (GRCm39) |
Y384C |
probably damaging |
Het |
| Vcan |
A |
T |
13: 89,840,852 (GRCm39) |
L1564* |
probably null |
Het |
| Xkr6 |
A |
T |
14: 64,035,748 (GRCm39) |
D283V |
unknown |
Het |
| Zfp654 |
T |
C |
16: 64,605,523 (GRCm39) |
H352R |
probably benign |
Het |
| Zfp819 |
T |
A |
7: 43,266,506 (GRCm39) |
C330S |
probably damaging |
Het |
| Zfp970 |
G |
T |
2: 177,167,086 (GRCm39) |
C220F |
probably damaging |
Het |
|
| Other mutations in Cdc42bpa |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00498:Cdc42bpa
|
APN |
1 |
179,933,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00807:Cdc42bpa
|
APN |
1 |
179,969,018 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL00972:Cdc42bpa
|
APN |
1 |
179,902,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01084:Cdc42bpa
|
APN |
1 |
179,969,839 (GRCm39) |
splice site |
probably benign |
|
|
IGL01149:Cdc42bpa
|
APN |
1 |
179,902,137 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01377:Cdc42bpa
|
APN |
1 |
179,892,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01541:Cdc42bpa
|
APN |
1 |
179,978,723 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL01657:Cdc42bpa
|
APN |
1 |
179,939,431 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01720:Cdc42bpa
|
APN |
1 |
179,938,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02227:Cdc42bpa
|
APN |
1 |
179,921,989 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02234:Cdc42bpa
|
APN |
1 |
179,978,756 (GRCm39) |
nonsense |
probably null |
|
|
IGL02253:Cdc42bpa
|
APN |
1 |
179,859,161 (GRCm39) |
splice site |
probably benign |
|
|
IGL02587:Cdc42bpa
|
APN |
1 |
179,921,510 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02671:Cdc42bpa
|
APN |
1 |
179,889,387 (GRCm39) |
missense |
probably benign |
|
|
IGL02746:Cdc42bpa
|
APN |
1 |
179,939,312 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02756:Cdc42bpa
|
APN |
1 |
179,936,824 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02994:Cdc42bpa
|
APN |
1 |
179,827,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03073:Cdc42bpa
|
APN |
1 |
179,921,941 (GRCm39) |
splice site |
probably benign |
|
|
IGL03295:Cdc42bpa
|
APN |
1 |
179,977,769 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0022:Cdc42bpa
|
UTSW |
1 |
179,788,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Cdc42bpa
|
UTSW |
1 |
179,859,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0125:Cdc42bpa
|
UTSW |
1 |
179,788,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0268:Cdc42bpa
|
UTSW |
1 |
179,983,347 (GRCm39) |
intron |
probably benign |
|
|
R0472:Cdc42bpa
|
UTSW |
1 |
179,867,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0492:Cdc42bpa
|
UTSW |
1 |
179,928,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0609:Cdc42bpa
|
UTSW |
1 |
179,867,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Cdc42bpa
|
UTSW |
1 |
179,972,400 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0738:Cdc42bpa
|
UTSW |
1 |
179,827,027 (GRCm39) |
splice site |
probably benign |
|
|
R1547:Cdc42bpa
|
UTSW |
1 |
179,902,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1553:Cdc42bpa
|
UTSW |
1 |
179,921,540 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1601:Cdc42bpa
|
UTSW |
1 |
179,892,566 (GRCm39) |
nonsense |
probably null |
|
|
R1709:Cdc42bpa
|
UTSW |
1 |
179,894,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2101:Cdc42bpa
|
UTSW |
1 |
179,974,533 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2279:Cdc42bpa
|
UTSW |
1 |
179,864,484 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2357:Cdc42bpa
|
UTSW |
1 |
179,894,792 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2373:Cdc42bpa
|
UTSW |
1 |
179,939,349 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2570:Cdc42bpa
|
UTSW |
1 |
179,977,742 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3709:Cdc42bpa
|
UTSW |
1 |
179,892,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Cdc42bpa
|
UTSW |
1 |
179,892,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3816:Cdc42bpa
|
UTSW |
1 |
179,972,451 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3854:Cdc42bpa
|
UTSW |
1 |
179,983,543 (GRCm39) |
intron |
probably benign |
|
|
R3855:Cdc42bpa
|
UTSW |
1 |
179,983,543 (GRCm39) |
intron |
probably benign |
|
|
R3917:Cdc42bpa
|
UTSW |
1 |
179,933,719 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4604:Cdc42bpa
|
UTSW |
1 |
179,936,759 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4622:Cdc42bpa
|
UTSW |
1 |
179,902,223 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4664:Cdc42bpa
|
UTSW |
1 |
179,972,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4665:Cdc42bpa
|
UTSW |
1 |
179,972,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4887:Cdc42bpa
|
UTSW |
1 |
179,972,200 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4989:Cdc42bpa
|
UTSW |
1 |
179,965,366 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5033:Cdc42bpa
|
UTSW |
1 |
179,892,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5050:Cdc42bpa
|
UTSW |
1 |
179,900,018 (GRCm39) |
nonsense |
probably null |
|
|
R5077:Cdc42bpa
|
UTSW |
1 |
179,922,098 (GRCm39) |
intron |
probably benign |
|
|
R5196:Cdc42bpa
|
UTSW |
1 |
179,899,978 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5276:Cdc42bpa
|
UTSW |
1 |
179,965,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5313:Cdc42bpa
|
UTSW |
1 |
179,911,998 (GRCm39) |
missense |
probably benign |
|
|
R5364:Cdc42bpa
|
UTSW |
1 |
179,894,747 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5372:Cdc42bpa
|
UTSW |
1 |
179,892,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5405:Cdc42bpa
|
UTSW |
1 |
179,966,085 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5405:Cdc42bpa
|
UTSW |
1 |
179,894,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5646:Cdc42bpa
|
UTSW |
1 |
179,933,659 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5713:Cdc42bpa
|
UTSW |
1 |
179,911,975 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6012:Cdc42bpa
|
UTSW |
1 |
179,892,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6029:Cdc42bpa
|
UTSW |
1 |
179,939,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Cdc42bpa
|
UTSW |
1 |
179,921,561 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6609:Cdc42bpa
|
UTSW |
1 |
179,928,839 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7122:Cdc42bpa
|
UTSW |
1 |
179,892,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7670:Cdc42bpa
|
UTSW |
1 |
179,892,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7912:Cdc42bpa
|
UTSW |
1 |
179,921,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8139:Cdc42bpa
|
UTSW |
1 |
179,896,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8362:Cdc42bpa
|
UTSW |
1 |
179,989,690 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8378:Cdc42bpa
|
UTSW |
1 |
179,989,709 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8794:Cdc42bpa
|
UTSW |
1 |
179,894,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8835:Cdc42bpa
|
UTSW |
1 |
179,896,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cdc42bpa
|
UTSW |
1 |
179,958,373 (GRCm39) |
intron |
probably benign |
|
|
R9012:Cdc42bpa
|
UTSW |
1 |
179,859,077 (GRCm39) |
missense |
|
|
|
R9110:Cdc42bpa
|
UTSW |
1 |
179,945,258 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9178:Cdc42bpa
|
UTSW |
1 |
179,958,401 (GRCm39) |
missense |
|
|
|
R9184:Cdc42bpa
|
UTSW |
1 |
179,972,301 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9204:Cdc42bpa
|
UTSW |
1 |
179,939,460 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9227:Cdc42bpa
|
UTSW |
1 |
179,933,638 (GRCm39) |
missense |
probably benign |
|
|
R9230:Cdc42bpa
|
UTSW |
1 |
179,933,638 (GRCm39) |
missense |
probably benign |
|
|
R9299:Cdc42bpa
|
UTSW |
1 |
179,972,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9366:Cdc42bpa
|
UTSW |
1 |
179,921,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9381:Cdc42bpa
|
UTSW |
1 |
179,969,048 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9461:Cdc42bpa
|
UTSW |
1 |
179,969,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9559:Cdc42bpa
|
UTSW |
1 |
179,939,459 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0026:Cdc42bpa
|
UTSW |
1 |
179,788,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Cdc42bpa
|
UTSW |
1 |
179,892,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCACACCAATGATTGTATTAGTCT -3'
(R):5'- GTGCAAGCAGGGCTCTCTAG -3'
Sequencing Primer
(F):5'- TCTGATCCATAGAACTCTGGAAGGTG -3'
(R):5'- GCAGGGCTCTCTAGAACATAG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation