Mutagenetix > Incidental Mutation

Incidental Mutation 'R0635:Zfp808'

56628

Institutional Source

Beutler Lab

Gene Symbol

Zfp808

Ensembl Gene

ENSMUSG00000074867

Gene Name

zinc finger protein 808

Synonyms

Gm7036

MMRRC Submission

038824-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R0635 (G1)

Quality Score

128

Status

Validated

Chromosome

Chromosomal Location

62129886-62236144 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 62172419 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 487 (H487Q)

Ref Sequence

ENSEMBL: ENSMUSP00000097048 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099449] [ENSMUST00000221772]

AlphaFold

B8JJZ4

Predicted Effect

probably damaging
Transcript: ENSMUST00000099449
AA Change: H487Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000097048
Gene: ENSMUSG00000074867
AA Change: H487Q

Domain	Start	End	E-Value	Type
KRAB	4	66	2.1e-17	SMART
ZnF_C2H2	133	155	2.4e-3	SMART
ZnF_C2H2	161	183	8.34e-3	SMART
ZnF_C2H2	189	211	2.75e-3	SMART
ZnF_C2H2	217	239	1.98e-4	SMART
ZnF_C2H2	245	267	3.21e-4	SMART
ZnF_C2H2	273	295	2.43e-4	SMART
ZnF_C2H2	301	323	8.6e-5	SMART
ZnF_C2H2	329	351	4.54e-4	SMART
ZnF_C2H2	357	379	9.22e-5	SMART
ZnF_C2H2	385	407	8.22e-2	SMART
ZnF_C2H2	413	435	1.56e-2	SMART
ZnF_C2H2	441	463	5.99e-4	SMART
ZnF_C2H2	469	491	2.79e-4	SMART
ZnF_C2H2	497	519	4.54e-4	SMART
ZnF_C2H2	525	547	1.95e-3	SMART
ZnF_C2H2	553	575	4.24e-4	SMART
ZnF_C2H2	581	603	2.27e-4	SMART
ZnF_C2H2	609	631	2.27e-4	SMART
ZnF_C2H2	637	659	9.08e-4	SMART
ZnF_C2H2	665	687	1.4e-4	SMART
ZnF_C2H2	693	715	4.24e-4	SMART
ZnF_C2H2	721	743	1.26e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221542

Predicted Effect

probably benign
Transcript: ENSMUST00000221772

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222809

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222947

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223094

Meta Mutation Damage Score

0.5223

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.4%
20x: 94.9%

Validation Efficiency

99% (68/69)

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3632451O06Rik	A	G	14: 49,773,143	L369S	probably benign	Het
4932429P05Rik	T	C	X: 89,752,522		probably benign	Het
5730455P16Rik	A	T	11: 80,374,065		probably benign	Het
Adamts15	A	G	9: 30,904,770	L631P	probably damaging	Het
Adamts17	T	C	7: 66,908,605	F266L	probably damaging	Het
Adgrb1	C	A	15: 74,540,892	Q488K	possibly damaging	Het
Cep290	A	G	10: 100,492,676	D109G	probably damaging	Het
Chil5	A	T	3: 106,017,203	Y229N	possibly damaging	Het
Cntnap1	A	G	11: 101,183,459	T742A	probably benign	Het
Col6a3	A	T	1: 90,808,086		probably null	Het
Col6a5	G	A	9: 105,928,606	P1034S	unknown	Het
Daxx	T	A	17: 33,912,644	D442E	probably benign	Het
Dmxl1	T	C	18: 49,851,423		probably benign	Het
Dnah11	A	G	12: 118,007,996	F2942S	probably damaging	Het
Fam71a	T	C	1: 191,163,727	T240A	probably benign	Het
Glg1	A	G	8: 111,163,764		probably benign	Het
Gm10272	G	A	10: 77,706,701		probably benign	Het
Gm17333	AAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAA	AAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAA	16: 77,852,878		noncoding transcript	Het
Haao	A	G	17: 83,838,574	F83S	probably damaging	Het
Hdgfl2	T	A	17: 56,096,057	L177Q	probably damaging	Het
Hrh1	T	C	6: 114,480,145	V129A	probably damaging	Het
Ift43	T	A	12: 86,085,081		probably benign	Het
Il21r	T	C	7: 125,632,506	Y369H	probably damaging	Het
Il2ra	C	T	2: 11,680,366	T171M	probably benign	Het
Lao1	C	T	4: 118,968,296	R438C	probably benign	Het
Lrrcc1	G	A	3: 14,559,228	S350N	probably benign	Het
Mageb5	T	A	X: 91,779,993	Y260F	probably benign	Het
March5	A	T	19: 37,220,408	I159F	possibly damaging	Het
Mgat4a	G	A	1: 37,452,294	A282V	probably benign	Het
Mipep	G	A	14: 60,829,390	V420I	probably damaging	Het
Morc2b	A	T	17: 33,137,687	F370L	possibly damaging	Het
Mt1	A	T	8: 94,179,821		probably null	Het
Ncapd2	A	G	6: 125,173,036	V943A	probably benign	Het
Nkd2	T	C	13: 73,826,894	D58G	probably benign	Het
Nol8	C	G	13: 49,676,758	S1106C	probably benign	Het
Nrm	C	A	17: 35,864,264	Y61*	probably null	Het
Nusap1	A	G	2: 119,627,667	T95A	probably damaging	Het
Ocln	T	A	13: 100,506,236	Q197L	probably damaging	Het
Olfr495	T	A	7: 108,395,764	F215I	probably benign	Het
Oxtr	A	G	6: 112,489,200	Y200H	probably damaging	Het
Paip2b	T	C	6: 83,809,909	E115G	possibly damaging	Het
Pcm1	T	A	8: 41,267,179		probably benign	Het
Pcnt	T	C	10: 76,404,585	D1205G	probably damaging	Het
Phka1	G	A	X: 102,621,400	R186C	probably damaging	Het
Pik3cb	A	G	9: 99,064,218		probably benign	Het
Pik3r1	C	T	13: 101,757,418	R81K	probably benign	Het
Ppa1	A	G	10: 61,665,440	D162G	probably benign	Het
Ppa1	A	G	10: 61,666,970	R191G	probably damaging	Het
Prss22	T	A	17: 23,996,688	T87S	probably benign	Het
Rgr	T	A	14: 37,038,947	R218*	probably null	Het
Rreb1	A	T	13: 37,941,564	Q1282L	possibly damaging	Het
Scel	T	A	14: 103,583,139		probably null	Het
Sema6b	A	G	17: 56,129,971		probably null	Het
Slc4a1	T	C	11: 102,352,672	E711G	possibly damaging	Het
Snx19	C	A	9: 30,428,810	L415M	probably damaging	Het
Snx19	T	G	9: 30,428,811	L415R	probably damaging	Het
Specc1	G	A	11: 62,118,903	R495Q	probably damaging	Het
Tead1	T	C	7: 112,891,706		probably benign	Het
Timm10b	A	C	7: 105,640,688		probably benign	Het
Ubxn7	T	A	16: 32,367,417		probably benign	Het
Vmn2r116	T	A	17: 23,386,887	Y258N	possibly damaging	Het
Vmn2r77	T	A	7: 86,811,175	F570I	probably benign	Het
Vmn2r98	T	C	17: 19,080,497	V587A	probably benign	Het
Zfp398	T	C	6: 47,863,140	I101T	probably damaging	Het

Other mutations in Zfp808

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01609:Zfp808	APN	13	62173209	missense	probably damaging	0.96
IGL02517:Zfp808	APN	13	62173218	makesense	probably null
IGL02809:Zfp808	APN	13	62173180	missense	probably benign	0.00
IGL02882:Zfp808	APN	13	62173180	missense	probably benign	0.00
IGL02941:Zfp808	APN	13	62173130	missense	possibly damaging	0.82
IGL03184:Zfp808	APN	13	62169567	missense	possibly damaging	0.90
LCD18:Zfp808	UTSW	13	62166651	intron	probably benign
R0387:Zfp808	UTSW	13	62169478	missense	probably damaging	1.00
R0472:Zfp808	UTSW	13	62172306	missense	probably damaging	1.00
R0544:Zfp808	UTSW	13	62169434	splice site	probably benign
R0981:Zfp808	UTSW	13	62171673	missense	possibly damaging	0.47
R1446:Zfp808	UTSW	13	62173007	missense	probably damaging	1.00
R1569:Zfp808	UTSW	13	62172900	nonsense	probably null
R1573:Zfp808	UTSW	13	62171497	missense	possibly damaging	0.52
R1761:Zfp808	UTSW	13	62171646	missense	possibly damaging	0.71
R1796:Zfp808	UTSW	13	62171856	missense	probably damaging	1.00
R1993:Zfp808	UTSW	13	62172907	missense	probably benign	0.10
R2656:Zfp808	UTSW	13	62172852	missense	possibly damaging	0.63
R2938:Zfp808	UTSW	13	62171218	missense	probably benign
R3027:Zfp808	UTSW	13	62171590	missense	probably benign	0.33
R3777:Zfp808	UTSW	13	62171903	missense	probably damaging	0.97
R3779:Zfp808	UTSW	13	62171903	missense	probably damaging	0.97
R3801:Zfp808	UTSW	13	62172083	missense	probably damaging	1.00
R3802:Zfp808	UTSW	13	62172083	missense	probably damaging	1.00
R3804:Zfp808	UTSW	13	62172083	missense	probably damaging	1.00
R4024:Zfp808	UTSW	13	62171730	missense	possibly damaging	0.71
R4741:Zfp808	UTSW	13	62171949	missense	probably damaging	1.00
R4791:Zfp808	UTSW	13	62171231	missense	probably damaging	0.97
R4809:Zfp808	UTSW	13	62171292	nonsense	probably null
R4907:Zfp808	UTSW	13	62171473	missense	possibly damaging	0.71
R5056:Zfp808	UTSW	13	62172630	missense	probably damaging	1.00
R5760:Zfp808	UTSW	13	62171926	missense	probably damaging	1.00
R5869:Zfp808	UTSW	13	62171255	missense	probably damaging	1.00
R6230:Zfp808	UTSW	13	62172322	missense	probably benign	0.19
R6372:Zfp808	UTSW	13	62172477	missense	probably damaging	1.00
R6545:Zfp808	UTSW	13	62171895	missense	probably benign	0.02
R6620:Zfp808	UTSW	13	62172824	missense	probably benign	0.08
R6622:Zfp808	UTSW	13	62171832	missense	possibly damaging	0.90
R6813:Zfp808	UTSW	13	62173035	missense	probably damaging	0.99
R6920:Zfp808	UTSW	13	62173168	missense	probably benign	0.05
R7511:Zfp808	UTSW	13	62172823	missense	probably benign
R7666:Zfp808	UTSW	13	62171411	missense	probably benign
R7747:Zfp808	UTSW	13	62171505	missense	probably benign	0.39
R7763:Zfp808	UTSW	13	62172664	missense	probably benign	0.28
R7779:Zfp808	UTSW	13	62172757	missense	possibly damaging	0.68
R8147:Zfp808	UTSW	13	62173120	missense	probably damaging	1.00
R8182:Zfp808	UTSW	13	62171707	missense	probably damaging	0.96
R8260:Zfp808	UTSW	13	62172738	missense	probably benign	0.01
R8434:Zfp808	UTSW	13	62172112	missense	probably damaging	1.00
R8822:Zfp808	UTSW	13	62173055	missense	probably damaging	1.00
R9330:Zfp808	UTSW	13	62172160	missense	probably benign	0.00
R9564:Zfp808	UTSW	13	62172847	missense	possibly damaging	0.49
RF005:Zfp808	UTSW	13	62171299	missense	probably benign	0.14
RF024:Zfp808	UTSW	13	62171299	missense	probably benign	0.14

Predicted Primers

Posted On

2013-07-11