Incidental Mutation 'R7290:Or8g22'
ID 566325
Institutional Source Beutler Lab
Gene Symbol Or8g22
Ensembl Gene ENSMUSG00000095194
Gene Name olfactory receptor family 8 subfamily G member 22, pseudogene 1
Synonyms Olfr936, MOR171-37, EG628171, GA_x6K02T2PVTD-32743332-32742397
MMRRC Submission 045362-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R7290 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 38957910-38958845 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38958694 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 7 (L7P)
Ref Sequence ENSEMBL: ENSMUSP00000137209 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178303] [ENSMUST00000216912]
AlphaFold J3KMV2
Predicted Effect unknown
Transcript: ENSMUST00000178303
AA Change: L7P
SMART Domains Protein: ENSMUSP00000137209
Gene: ENSMUSG00000095194
AA Change: L7P

DomainStartEndE-ValueType
Pfam:7tm_1 1 246 6e-21 PFAM
Pfam:7tm_4 1 264 6.9e-49 PFAM
Predicted Effect silent
Transcript: ENSMUST00000216912
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Feb 2010]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a T A 11: 109,921,714 (GRCm39) M1447L probably benign Het
Adam30 G A 3: 98,070,257 (GRCm39) V697I probably benign Het
Adamts12 A G 15: 11,277,452 (GRCm39) N689D probably benign Het
Adamts15 T C 9: 30,813,906 (GRCm39) K753R probably benign Het
Adra2a T C 19: 54,034,835 (GRCm39) F64L probably damaging Het
Ankub1 A G 3: 57,580,345 (GRCm39) L104P probably damaging Het
Arel1 A G 12: 84,988,719 (GRCm39) V10A probably benign Het
Atad2 A T 15: 57,962,047 (GRCm39) N1165K probably benign Het
Atp6v0d2 T A 4: 19,880,060 (GRCm39) D279V probably benign Het
Cadps A T 14: 12,616,099 (GRCm38) D310E probably damaging Het
Caskin2 T C 11: 115,695,615 (GRCm39) I249V possibly damaging Het
Cdh23 T C 10: 60,212,620 (GRCm39) N1598S probably benign Het
Cep250 A T 2: 155,834,682 (GRCm39) Q2202H probably benign Het
Ces5a T A 8: 94,261,311 (GRCm39) T35S probably damaging Het
Cnot11 G A 1: 39,579,020 (GRCm39) W295* probably null Het
Cntnap5a G T 1: 116,149,619 (GRCm39) W565L probably damaging Het
Dgka T C 10: 128,569,468 (GRCm39) E148G probably damaging Het
Dnah14 G A 1: 181,455,739 (GRCm39) D955N probably benign Het
Erbin G A 13: 103,998,834 (GRCm39) T184I probably damaging Het
Fam20c G T 5: 138,793,309 (GRCm39) G477W probably damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fgfr4 T C 13: 55,309,262 (GRCm39) V433A probably benign Het
Gal3st1 A T 11: 3,948,093 (GRCm39) Q100L possibly damaging Het
Gfra2 T C 14: 71,163,380 (GRCm39) F221S probably damaging Het
Gm19965 G A 1: 116,748,921 (GRCm39) V201M Het
Gnb1l A T 16: 18,382,806 (GRCm39) T282S probably benign Het
Gpr171 A T 3: 59,005,147 (GRCm39) N209K probably benign Het
Greb1 G A 12: 16,761,739 (GRCm39) T547I probably damaging Het
Ifi214 A T 1: 173,357,097 (GRCm39) V2E probably benign Het
Ighv1-71 T C 12: 115,706,267 (GRCm39) M1V probably null Het
Itm2b C T 14: 73,605,785 (GRCm39) G67D probably damaging Het
Kif21a A T 15: 90,851,432 (GRCm39) C995* probably null Het
Kifc2 A T 15: 76,544,904 (GRCm39) Y13F probably damaging Het
Lamb1 T A 12: 31,315,595 (GRCm39) V59D probably benign Het
Lhx1 A T 11: 84,412,703 (GRCm39) D163E probably damaging Het
Lrrc1 A T 9: 77,365,121 (GRCm39) Y187N probably benign Het
Map3k1 C A 13: 111,904,645 (GRCm39) V380F probably damaging Het
Mapk11 T C 15: 89,028,511 (GRCm39) D283G probably damaging Het
Mccc2 G T 13: 100,091,207 (GRCm39) A430D probably damaging Het
Mest A G 6: 30,747,158 (GRCm39) N340S unknown Het
Mms22l T C 4: 24,517,139 (GRCm39) L340P probably benign Het
Mrnip A G 11: 50,087,808 (GRCm39) Y110C possibly damaging Het
Mtmr4 A G 11: 87,502,063 (GRCm39) T706A probably benign Het
Muc21 G A 17: 35,929,761 (GRCm39) A1475V unknown Het
Ncstn A G 1: 171,900,373 (GRCm39) F234S probably benign Het
Nrp1 T C 8: 129,202,777 (GRCm39) probably null Het
Nup37 T G 10: 88,010,356 (GRCm39) C217G probably damaging Het
Pdzrn3 T C 6: 101,128,206 (GRCm39) N820S probably benign Het
Pgap1 A T 1: 54,587,225 (GRCm39) F117Y possibly damaging Het
Phip A T 9: 82,753,346 (GRCm39) F1799L possibly damaging Het
Ppm1f T A 16: 16,728,819 (GRCm39) F74I probably benign Het
Prpf8 C A 11: 75,384,783 (GRCm39) N775K possibly damaging Het
Ptdss2 T C 7: 140,731,693 (GRCm39) I167T possibly damaging Het
Ptpn18 G A 1: 34,501,892 (GRCm39) probably null Het
Rbl2 C A 8: 91,841,669 (GRCm39) A955D probably benign Het
Rgl1 A G 1: 152,420,146 (GRCm39) S366P possibly damaging Het
Rit2 A T 18: 31,376,221 (GRCm39) M38K possibly damaging Het
Robo1 A G 16: 72,801,408 (GRCm39) M1011V probably benign Het
Senp6 A T 9: 80,043,797 (GRCm39) E809D probably benign Het
Stard3 G A 11: 98,269,045 (GRCm39) probably null Het
Taar3 T G 10: 23,826,298 (GRCm39) Y281* probably null Het
Tacc2 G T 7: 130,331,103 (GRCm39) K352N probably benign Het
Tamalin G A 15: 101,129,419 (GRCm39) S234N probably damaging Het
Tasor T A 14: 27,160,610 (GRCm39) I124N probably damaging Het
Tdpoz4 G A 3: 93,704,155 (GRCm39) V151I not run Het
Tenm2 A G 11: 35,914,298 (GRCm39) L2413P probably damaging Het
Tgm6 T C 2: 129,983,110 (GRCm39) V233A probably damaging Het
Tlx3 G A 11: 33,153,514 (GRCm39) probably benign Het
Tmem94 G T 11: 115,677,082 (GRCm39) R118L possibly damaging Het
Trim23 C A 13: 104,323,941 (GRCm39) H133Q probably damaging Het
Unc80 A T 1: 66,640,356 (GRCm39) D1421V probably damaging Het
Vmn1r172 A G 7: 23,360,048 (GRCm39) N311S unknown Het
Vps25 T A 11: 101,149,775 (GRCm39) L153Q probably damaging Het
Wbp1l G T 19: 46,611,876 (GRCm39) probably benign Het
Ythdc2 A G 18: 44,970,558 (GRCm39) I291V possibly damaging Het
Zfp2 A G 11: 50,791,570 (GRCm39) C158R probably damaging Het
Zfp786 G A 6: 47,796,929 (GRCm39) P670S probably damaging Het
Zfp827 G A 8: 79,916,442 (GRCm39) R339H possibly damaging Het
Zmym6 C T 4: 127,017,294 (GRCm39) A1025V possibly damaging Het
Other mutations in Or8g22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01928:Or8g22 APN 9 38,958,709 (GRCm39) missense unknown
R0086:Or8g22 UTSW 9 38,958,191 (GRCm39) missense probably benign 0.00
R0561:Or8g22 UTSW 9 38,958,669 (GRCm39) missense probably damaging 0.99
R0650:Or8g22 UTSW 9 38,957,996 (GRCm39) missense probably benign 0.01
R1221:Or8g22 UTSW 9 38,958,483 (GRCm39) missense probably damaging 1.00
R1384:Or8g22 UTSW 9 38,958,200 (GRCm39) missense possibly damaging 0.70
R1680:Or8g22 UTSW 9 38,958,296 (GRCm39) missense probably benign 0.43
R1733:Or8g22 UTSW 9 38,958,678 (GRCm39) missense unknown
R3767:Or8g22 UTSW 9 38,958,707 (GRCm39) missense unknown
R4786:Or8g22 UTSW 9 38,958,783 (GRCm39) nonsense probably null
R4944:Or8g22 UTSW 9 38,958,158 (GRCm39) missense probably damaging 1.00
R5186:Or8g22 UTSW 9 38,958,265 (GRCm39) nonsense probably null
R5403:Or8g22 UTSW 9 38,957,999 (GRCm39) missense probably damaging 1.00
R6037:Or8g22 UTSW 9 38,958,403 (GRCm39) missense probably damaging 1.00
R6037:Or8g22 UTSW 9 38,958,403 (GRCm39) missense probably damaging 1.00
R6156:Or8g22 UTSW 9 38,958,671 (GRCm39) missense possibly damaging 0.90
R6217:Or8g22 UTSW 9 38,958,039 (GRCm39) makesense probably null
R6711:Or8g22 UTSW 9 38,958,162 (GRCm39) makesense probably null
R6919:Or8g22 UTSW 9 38,958,827 (GRCm39) utr 5 prime probably benign
R7022:Or8g22 UTSW 9 38,958,379 (GRCm39) nonsense probably null
R7275:Or8g22 UTSW 9 38,958,815 (GRCm39) utr 5 prime probably benign
R7644:Or8g22 UTSW 9 38,958,638 (GRCm39) missense probably damaging 1.00
R8906:Or8g22 UTSW 9 38,958,077 (GRCm39) missense possibly damaging 0.87
R9099:Or8g22 UTSW 9 38,958,026 (GRCm39) missense probably benign 0.00
Z1176:Or8g22 UTSW 9 38,958,215 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CAGCCAGCATGAAACATTCTG -3'
(R):5'- GCAACTGTGTCCCTCTAAATCC -3'

Sequencing Primer
(F):5'- GCCAGCATGAAACATTCTGAAACAAC -3'
(R):5'- TATTTTCCTTTCAGAATCTGACTGAG -3'
Posted On 2019-06-26