|Institutional Source||Beutler Lab|
|Gene Name||mitogen-activated protein kinase 11|
|Synonyms||P38b, p38beta, Prkm11, Sapk2|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7290 (G1)|
|Chromosomal Location||89142486-89149628 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 89144308 bp|
|Amino Acid Change||Aspartic acid to Glycine at position 283 (D283G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000086204 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000088823] [ENSMUST00000088827]|
|Predicted Effect||probably damaging
AA Change: D283G
PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
AA Change: D283G
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a normal phenotype. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mapk11||
(F):5'- GCTCTGAGAAAAGGCAACCC -3'
(R):5'- GTTAGTTAGCCCTCCAAGCTC -3'
(F):5'- AGGTTCACGGACACTGCTCTC -3'
(R):5'- AAGCTCTTCTTATGTGTCTCCAGG -3'