Mutagenetix > Incidental Mutation

Incidental Mutation 'R7293:Dync2h1'

566561

Institutional Source

Beutler Lab

Gene Symbol

Dync2h1

Ensembl Gene

ENSMUSG00000047193

Gene Name

dynein cytoplasmic 2 heavy chain 1

Synonyms

4432416O06Rik, DHC2, D030010H02Rik, D330044F14Rik, Dnchc2, DHC1b, b2b414Clo

MMRRC Submission

045398-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7293 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

6928503-7184446 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 7001454 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 3845 (S3845P)

Ref Sequence

ENSEMBL: ENSMUSP00000046733 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048417] [ENSMUST00000140466] [ENSMUST00000147193]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000048417
AA Change: S3845P

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000046733
Gene: ENSMUSG00000047193
AA Change: S3845P

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	187	676	1.6e-43	PFAM
Pfam:DHC_N2	1117	1523	4.1e-120	PFAM
AAA	1684	1830	3.72e-2	SMART
AAA	1971	2127	2.18e0	SMART
AAA	2283	2431	1.66e0	SMART
low complexity region	2588	2602	N/A	INTRINSIC
Pfam:AAA_8	2618	2881	6.8e-27	PFAM
Pfam:MT	2894	3230	5.4e-28	PFAM
Pfam:AAA_9	3242	3471	1.1e-50	PFAM
Pfam:Dynein_heavy	3605	4304	2.3e-136	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000140466
AA Change: S3845P

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000120007
Gene: ENSMUSG00000047193
AA Change: S3845P

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	187	676	1.6e-43	PFAM
Pfam:DHC_N2	1117	1523	4.1e-120	PFAM
AAA	1684	1830	3.72e-2	SMART
AAA	1971	2127	2.18e0	SMART
AAA	2283	2431	1.66e0	SMART
low complexity region	2588	2602	N/A	INTRINSIC
Pfam:AAA_8	2618	2881	6.8e-27	PFAM
Pfam:MT	2894	3230	5.4e-28	PFAM
Pfam:AAA_9	3242	3471	1.1e-50	PFAM
Pfam:Dynein_heavy	3605	4304	2.3e-136	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000147193
AA Change: S3852P

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000116679
Gene: ENSMUSG00000047193
AA Change: S3852P

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	188	674	4e-45	PFAM
Pfam:DHC_N2	1118	1521	5.5e-111	PFAM
AAA	1684	1830	3.72e-2	SMART
AAA	1971	2127	2.18e0	SMART
AAA	2283	2431	1.66e0	SMART
low complexity region	2588	2602	N/A	INTRINSIC
Pfam:AAA_8	2618	2880	4.4e-27	PFAM
Pfam:MT	2894	3230	1.3e-27	PFAM
Pfam:AAA_9	3246	3477	1e-79	PFAM
Pfam:Dynein_heavy	3618	4310	8.5e-158	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

97% (74/76)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
PHENOTYPE: Homozygotes for a gene trap allele show complete embryonic lethality with altered heart looping and brain morphology. Chemically induced mutants show randomized heart looping and polydactyly. Holoprosencephaly or exencephaly, micrognathia, and cardiac, renal, airway and eye defects may be observed. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310050C09Rik	A	T	3: 92,868,819 (GRCm38)	C186S	probably benign	Het
Abcc2	G	A	19: 43,807,053 (GRCm38)	G416E	probably damaging	Het
Acsl5	G	T	19: 55,291,210 (GRCm38)	W460L	probably damaging	Het
Adam2	A	G	14: 66,035,185 (GRCm38)	F614S	probably benign	Het
Adamts5	G	A	16: 85,899,945 (GRCm38)	T108I	probably benign	Het
Agmat	C	T	4: 141,755,935 (GRCm38)	Q227*	probably null	Het
Alg11	A	G	8: 22,065,379 (GRCm38)	N219D	probably damaging	Het
Amhr2	A	G	15: 102,447,393 (GRCm38)	T258A	probably benign	Het
Ankrd53	A	G	6: 83,763,196 (GRCm38)	E82G	probably null	Het
Blzf1	T	A	1: 164,295,883 (GRCm38)	T292S	possibly damaging	Het
Capza1	T	C	3: 104,840,835 (GRCm38)	D71G	probably benign	Het
Cc2d1b	T	C	4: 108,631,676 (GRCm38)	F770L	probably benign	Het
Cckbr	A	T	7: 105,434,645 (GRCm38)	Q260L	probably benign	Het
Cep162	T	C	9: 87,203,783 (GRCm38)	T1163A	probably benign	Het
Chd9	T	C	8: 91,034,079 (GRCm38)	S2151P	unknown	Het
Clk1	T	A	1: 58,414,613 (GRCm38)	T301S	probably benign	Het
Cmya5	T	A	13: 93,092,797 (GRCm38)	S1928C	possibly damaging	Het
Col24a1	C	T	3: 145,486,304 (GRCm38)	Q1273*	probably null	Het
Col4a4	T	C	1: 82,523,943 (GRCm38)	D363G	unknown	Het
Copb1	A	T	7: 114,219,602 (GRCm38)	M827K	probably damaging	Het
Crocc	C	T	4: 141,043,556 (GRCm38)	A351T	probably benign	Het
Crybg1	T	C	10: 44,003,432 (GRCm38)	T587A	probably damaging	Het
Csrnp3	A	G	2: 65,949,000 (GRCm38)	R19G	probably damaging	Het
Cyb5rl	T	C	4: 107,080,946 (GRCm38)	I165T	probably damaging	Het
Dnah1	A	T	14: 31,287,863 (GRCm38)	I1916N	probably damaging	Het
Dvl1	T	C	4: 155,856,168 (GRCm38)	M415T	possibly damaging	Het
Eif3b	A	G	5: 140,419,428 (GRCm38)	Q23R	probably benign	Het
Esam	G	T	9: 37,537,724 (GRCm38)	R376L	probably damaging	Het
Fat3	A	C	9: 15,915,296 (GRCm38)	S305R		Het
Fat3	G	C	9: 15,915,040 (GRCm38)	H391D		Het
Fgd3	T	C	13: 49,264,658 (GRCm38)	D644G	probably benign	Het
Fgf7	T	C	2: 126,035,752 (GRCm38)	L13P	probably damaging	Het
Gas2l1	A	G	11: 5,064,338 (GRCm38)	Y41H	probably damaging	Het
Glg1	A	T	8: 111,168,743 (GRCm38)	I812N	probably damaging	Het
Glp1r	C	T	17: 30,924,625 (GRCm38)	H212Y	probably benign	Het
Gm5622	G	T	14: 51,655,882 (GRCm38)	E89*	probably null	Het
Gpr158	G	A	2: 21,576,939 (GRCm38)	V410I	possibly damaging	Het
Ighv1-53	A	T	12: 115,158,821 (GRCm38)	C5*	probably null	Het
Itgb2l	A	C	16: 96,426,796 (GRCm38)	Y502*	probably null	Het
Jakmip1	G	A	5: 37,127,473 (GRCm38)	V635I	probably benign	Het
Krt23	C	T	11: 99,483,856 (GRCm38)	M270I	probably benign	Het
Larp1b	C	T	3: 40,985,444 (GRCm38)	A344V		Het
Lin28b	T	C	10: 45,419,186 (GRCm38)	M134V	probably benign	Het
Lrrc19	T	A	4: 94,638,390 (GRCm38)	Y310F	probably benign	Het
Lyst	T	A	13: 13,680,237 (GRCm38)	D2397E	probably benign	Het
Map6	A	G	7: 99,336,533 (GRCm38)	N751S	possibly damaging	Het
Mgrn1	G	A	16: 4,932,220 (GRCm38)	D494N	probably benign	Het
Myh6	A	G	14: 54,947,174 (GRCm38)	F1567L	probably benign	Het
Myo9b	T	C	8: 71,325,905 (GRCm38)	V461A	probably benign	Het
Ncan	A	T	8: 70,115,211 (GRCm38)	S84T	probably damaging	Het
Nlrp9a	G	A	7: 26,571,269 (GRCm38)	C908Y	probably damaging	Het
Olfr1264	A	T	2: 90,021,527 (GRCm38)	Y180N	probably damaging	Het
Olfr1289	A	G	2: 111,483,354 (GRCm38)		probably null	Het
Olfr659	T	A	7: 104,670,718 (GRCm38)	N5K	probably damaging	Het
Olfr949-ps1	A	T	9: 39,364,834 (GRCm38)	M92L	probably benign	Het
Parp4	CTTCCTCCCCCTCCCCTTCTCTCTGCTGGCACCCATATTCCTCCCCCTCCCCTTCTCTCTGCTGGCACCCATCTTCCTCCCCCTCCCCTTCTCCCTGCTGGCACCCATATTCCTCCCCCTCCCC	CTTCCTCCCCCTCCCCTTCTCTCTGCTGGCACCCATCTTCCTCCCCCTCCCCTTCTCCCTGCTGGCACCCATATTCCTCCCCCTCCCC	14: 56,647,846 (GRCm38)		probably benign	Het
Pld1	C	A	3: 28,087,286 (GRCm38)	T666K	probably damaging	Het
Pnpla6	A	G	8: 3,538,068 (GRCm38)	Y1107C	probably damaging	Het
Pramel7	A	C	2: 87,492,362 (GRCm38)	N19K	probably benign	Het
Prh1	C	G	6: 132,571,758 (GRCm38)	P76R	unknown	Het
Prkd2	T	C	7: 16,845,940 (GRCm38)	V121A	possibly damaging	Het
Ptprq	G	A	10: 107,635,506 (GRCm38)	Q1345*	probably null	Het
Ryr3	T	A	2: 112,902,603 (GRCm38)	T653S	probably benign	Het
Sall2	G	T	14: 52,314,411 (GRCm38)	Y442*	probably null	Het
Slc23a2	A	C	2: 132,089,106 (GRCm38)	F158V	probably benign	Het
Smg1	C	A	7: 118,166,099 (GRCm38)	R1954L	unknown	Het
Snx31	G	A	15: 36,523,450 (GRCm38)	T362I	probably damaging	Het
Taf3	G	T	2: 9,952,090 (GRCm38)	T422K	probably damaging	Het
Tcfl5	T	C	2: 180,642,165 (GRCm38)	D142G	probably benign	Het
Tmx1	A	G	12: 70,460,551 (GRCm38)	T188A	probably damaging	Het
Tnfrsf11a	A	G	1: 105,808,141 (GRCm38)		probably null	Het
Trio	A	T	15: 27,871,289 (GRCm38)	C640S	possibly damaging	Het
Ulk4	T	G	9: 121,255,124 (GRCm38)	N427T	probably damaging	Het
Vmn1r202	T	C	13: 22,501,702 (GRCm38)	M182V	probably benign	Het
Vmn1r214	C	T	13: 23,034,669 (GRCm38)	A111V	probably benign	Het

Other mutations in Dync2h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Dync2h1	APN	9	7,158,839 (GRCm38)	missense	probably benign	0.42
IGL00310:Dync2h1	APN	9	7,155,072 (GRCm38)	splice site	probably benign
IGL00499:Dync2h1	APN	9	7,168,700 (GRCm38)	missense	possibly damaging	0.95
IGL00579:Dync2h1	APN	9	7,035,728 (GRCm38)	splice site	probably benign
IGL00660:Dync2h1	APN	9	7,075,797 (GRCm38)	missense	probably damaging	0.98
IGL00964:Dync2h1	APN	9	7,174,881 (GRCm38)	splice site	probably benign
IGL01025:Dync2h1	APN	9	7,162,789 (GRCm38)	missense	probably damaging	1.00
IGL01093:Dync2h1	APN	9	7,145,611 (GRCm38)	missense	probably benign	0.01
IGL01108:Dync2h1	APN	9	7,176,771 (GRCm38)	missense	possibly damaging	0.87
IGL01126:Dync2h1	APN	9	7,116,588 (GRCm38)	missense	probably benign	0.00
IGL01474:Dync2h1	APN	9	7,102,493 (GRCm38)	missense	probably benign	0.01
IGL01531:Dync2h1	APN	9	7,071,111 (GRCm38)	missense	probably benign	0.11
IGL01548:Dync2h1	APN	9	7,071,922 (GRCm38)	missense	probably damaging	1.00
IGL01621:Dync2h1	APN	9	7,140,897 (GRCm38)	critical splice donor site	probably null
IGL01672:Dync2h1	APN	9	7,118,884 (GRCm38)	nonsense	probably null
IGL01681:Dync2h1	APN	9	7,142,196 (GRCm38)	splice site	probably null
IGL01685:Dync2h1	APN	9	7,142,297 (GRCm38)	missense	probably damaging	1.00
IGL01724:Dync2h1	APN	9	7,081,077 (GRCm38)	missense	probably benign	0.03
IGL01738:Dync2h1	APN	9	7,114,922 (GRCm38)	missense	possibly damaging	0.77
IGL01783:Dync2h1	APN	9	7,118,822 (GRCm38)	unclassified	probably benign
IGL01813:Dync2h1	APN	9	7,122,799 (GRCm38)	missense	probably damaging	1.00
IGL01931:Dync2h1	APN	9	7,114,973 (GRCm38)	missense	probably damaging	1.00
IGL01931:Dync2h1	APN	9	7,011,207 (GRCm38)	missense	probably benign	0.33
IGL02105:Dync2h1	APN	9	7,075,892 (GRCm38)	missense	probably damaging	1.00
IGL02137:Dync2h1	APN	9	7,134,349 (GRCm38)	missense	probably benign
IGL02140:Dync2h1	APN	9	7,147,791 (GRCm38)	missense	probably benign
IGL02175:Dync2h1	APN	9	7,111,548 (GRCm38)	missense	possibly damaging	0.91
IGL02283:Dync2h1	APN	9	7,125,912 (GRCm38)	missense	probably damaging	0.99
IGL02305:Dync2h1	APN	9	7,122,678 (GRCm38)	missense	probably benign
IGL02342:Dync2h1	APN	9	7,142,246 (GRCm38)	missense	probably damaging	1.00
IGL02367:Dync2h1	APN	9	7,158,926 (GRCm38)	missense	probably damaging	0.98
IGL02458:Dync2h1	APN	9	7,117,422 (GRCm38)	missense	probably damaging	1.00
IGL02563:Dync2h1	APN	9	7,035,700 (GRCm38)	missense	possibly damaging	0.95
IGL02825:Dync2h1	APN	9	6,955,901 (GRCm38)	splice site	probably benign
IGL02955:Dync2h1	APN	9	7,142,864 (GRCm38)	missense	probably benign	0.00
IGL02992:Dync2h1	APN	9	7,137,074 (GRCm38)	missense	probably benign	0.01
IGL02996:Dync2h1	APN	9	6,935,279 (GRCm38)	missense	probably damaging	0.99
IGL03224:Dync2h1	APN	9	7,076,235 (GRCm38)	missense	probably benign	0.32
IGL03226:Dync2h1	APN	9	7,125,918 (GRCm38)	missense	probably benign
IGL03233:Dync2h1	APN	9	7,101,525 (GRCm38)	missense	possibly damaging	0.90
deinonychus	UTSW	9	7,159,478 (GRCm38)	splice site	probably null
R0016:Dync2h1	UTSW	9	7,144,346 (GRCm38)	splice site	probably benign
R0016:Dync2h1	UTSW	9	7,144,346 (GRCm38)	splice site	probably benign
R0043:Dync2h1	UTSW	9	7,005,574 (GRCm38)	missense	probably benign	0.05
R0109:Dync2h1	UTSW	9	7,111,487 (GRCm38)	missense	probably damaging	1.00
R0109:Dync2h1	UTSW	9	7,111,487 (GRCm38)	missense	probably damaging	1.00
R0121:Dync2h1	UTSW	9	7,001,327 (GRCm38)	splice site	probably benign
R0277:Dync2h1	UTSW	9	7,129,046 (GRCm38)	missense	probably benign
R0360:Dync2h1	UTSW	9	7,113,182 (GRCm38)	missense	possibly damaging	0.62
R0362:Dync2h1	UTSW	9	7,005,487 (GRCm38)	splice site	probably null
R0389:Dync2h1	UTSW	9	7,167,244 (GRCm38)	splice site	probably null
R0443:Dync2h1	UTSW	9	7,167,244 (GRCm38)	splice site	probably null
R0496:Dync2h1	UTSW	9	7,155,180 (GRCm38)	missense	probably benign	0.42
R0506:Dync2h1	UTSW	9	7,113,153 (GRCm38)	missense	probably benign	0.05
R0511:Dync2h1	UTSW	9	7,122,692 (GRCm38)	missense	probably benign	0.00
R0540:Dync2h1	UTSW	9	7,051,480 (GRCm38)	missense	probably benign	0.00
R0550:Dync2h1	UTSW	9	7,120,954 (GRCm38)	splice site	probably null
R0564:Dync2h1	UTSW	9	7,139,432 (GRCm38)	missense	probably damaging	1.00
R0607:Dync2h1	UTSW	9	7,051,480 (GRCm38)	missense	probably benign	0.00
R0699:Dync2h1	UTSW	9	7,103,680 (GRCm38)	missense	probably benign	0.00
R0725:Dync2h1	UTSW	9	7,015,497 (GRCm38)	missense	possibly damaging	0.93
R0835:Dync2h1	UTSW	9	7,116,642 (GRCm38)	critical splice acceptor site	probably null
R0837:Dync2h1	UTSW	9	7,077,979 (GRCm38)	missense	probably benign	0.07
R0894:Dync2h1	UTSW	9	7,041,734 (GRCm38)	splice site	probably benign
R0938:Dync2h1	UTSW	9	7,002,658 (GRCm38)	missense	probably benign	0.02
R1056:Dync2h1	UTSW	9	7,147,731 (GRCm38)	missense	probably benign	0.15
R1081:Dync2h1	UTSW	9	7,005,488 (GRCm38)	critical splice donor site	probably null
R1178:Dync2h1	UTSW	9	7,101,193 (GRCm38)	splice site	probably benign
R1243:Dync2h1	UTSW	9	7,120,882 (GRCm38)	missense	probably benign
R1295:Dync2h1	UTSW	9	7,075,752 (GRCm38)	splice site	probably benign
R1304:Dync2h1	UTSW	9	7,102,318 (GRCm38)	missense	probably damaging	1.00
R1387:Dync2h1	UTSW	9	7,125,816 (GRCm38)	missense	probably benign
R1513:Dync2h1	UTSW	9	7,103,663 (GRCm38)	missense	possibly damaging	0.74
R1557:Dync2h1	UTSW	9	7,140,911 (GRCm38)	missense	probably damaging	1.00
R1568:Dync2h1	UTSW	9	7,157,553 (GRCm38)	missense	probably null	0.02
R1570:Dync2h1	UTSW	9	7,176,926 (GRCm38)	missense	probably benign	0.12
R1670:Dync2h1	UTSW	9	6,993,942 (GRCm38)	missense	possibly damaging	0.82
R1713:Dync2h1	UTSW	9	7,131,891 (GRCm38)	missense	probably benign
R1766:Dync2h1	UTSW	9	7,015,526 (GRCm38)	critical splice acceptor site	probably null
R1773:Dync2h1	UTSW	9	7,128,256 (GRCm38)	missense	probably damaging	1.00
R1786:Dync2h1	UTSW	9	7,081,084 (GRCm38)	missense	probably damaging	1.00
R1848:Dync2h1	UTSW	9	7,049,166 (GRCm38)	missense	probably benign	0.01
R1850:Dync2h1	UTSW	9	7,001,448 (GRCm38)	missense	probably benign	0.00
R1935:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1936:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1937:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1939:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1940:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1944:Dync2h1	UTSW	9	7,001,377 (GRCm38)	missense	probably damaging	1.00
R1976:Dync2h1	UTSW	9	7,129,045 (GRCm38)	missense	probably benign
R2012:Dync2h1	UTSW	9	7,169,589 (GRCm38)	missense	probably benign	0.00
R2020:Dync2h1	UTSW	9	7,162,925 (GRCm38)	missense	probably benign	0.25
R2020:Dync2h1	UTSW	9	7,122,772 (GRCm38)	missense	probably damaging	0.99
R2024:Dync2h1	UTSW	9	7,129,062 (GRCm38)	missense	probably damaging	0.97
R2038:Dync2h1	UTSW	9	6,967,226 (GRCm38)	missense	probably damaging	0.99
R2045:Dync2h1	UTSW	9	7,160,171 (GRCm38)	missense	probably damaging	1.00
R2060:Dync2h1	UTSW	9	7,162,802 (GRCm38)	missense	possibly damaging	0.92
R2094:Dync2h1	UTSW	9	7,148,735 (GRCm38)	missense	probably benign	0.18
R2129:Dync2h1	UTSW	9	7,175,289 (GRCm38)	missense	possibly damaging	0.94
R2130:Dync2h1	UTSW	9	7,011,253 (GRCm38)	missense	probably damaging	1.00
R2136:Dync2h1	UTSW	9	7,122,772 (GRCm38)	missense	probably damaging	0.99
R2164:Dync2h1	UTSW	9	7,124,797 (GRCm38)	missense	probably damaging	1.00
R2242:Dync2h1	UTSW	9	7,037,828 (GRCm38)	splice site	probably null
R2255:Dync2h1	UTSW	9	6,955,905 (GRCm38)	critical splice donor site	probably null
R2357:Dync2h1	UTSW	9	7,081,053 (GRCm38)	missense	probably benign	0.03
R2389:Dync2h1	UTSW	9	7,122,618 (GRCm38)	missense	possibly damaging	0.82
R2412:Dync2h1	UTSW	9	7,144,246 (GRCm38)	missense	probably benign	0.01
R2885:Dync2h1	UTSW	9	7,102,329 (GRCm38)	missense	probably damaging	1.00
R2909:Dync2h1	UTSW	9	7,049,114 (GRCm38)	missense	probably damaging	1.00
R3434:Dync2h1	UTSW	9	7,011,236 (GRCm38)	missense	probably benign
R3719:Dync2h1	UTSW	9	7,006,882 (GRCm38)	splice site	probably benign
R3723:Dync2h1	UTSW	9	7,041,658 (GRCm38)	missense	probably benign	0.17
R3800:Dync2h1	UTSW	9	7,101,525 (GRCm38)	missense	possibly damaging	0.90
R3803:Dync2h1	UTSW	9	6,935,293 (GRCm38)	missense	probably benign	0.00
R3936:Dync2h1	UTSW	9	7,001,482 (GRCm38)	missense	probably damaging	1.00
R3941:Dync2h1	UTSW	9	7,124,825 (GRCm38)	missense	probably benign
R3950:Dync2h1	UTSW	9	7,112,061 (GRCm38)	nonsense	probably null
R4004:Dync2h1	UTSW	9	7,117,404 (GRCm38)	missense	probably damaging	1.00
R4091:Dync2h1	UTSW	9	7,131,881 (GRCm38)	missense	probably benign	0.01
R4233:Dync2h1	UTSW	9	7,134,360 (GRCm38)	missense	probably benign	0.02
R4302:Dync2h1	UTSW	9	7,077,880 (GRCm38)	missense	probably benign	0.02
R4451:Dync2h1	UTSW	9	6,983,477 (GRCm38)	missense	probably benign	0.02
R4512:Dync2h1	UTSW	9	7,085,009 (GRCm38)	nonsense	probably null
R4596:Dync2h1	UTSW	9	6,992,595 (GRCm38)	missense	probably benign
R4604:Dync2h1	UTSW	9	7,140,995 (GRCm38)	missense	probably benign	0.00
R4614:Dync2h1	UTSW	9	7,011,290 (GRCm38)	missense	probably benign	0.03
R4667:Dync2h1	UTSW	9	7,051,411 (GRCm38)	missense	probably benign	0.00
R4671:Dync2h1	UTSW	9	7,169,640 (GRCm38)	missense	possibly damaging	0.82
R4714:Dync2h1	UTSW	9	7,118,932 (GRCm38)	missense	possibly damaging	0.86
R4716:Dync2h1	UTSW	9	7,142,648 (GRCm38)	critical splice donor site	probably null
R4736:Dync2h1	UTSW	9	7,006,862 (GRCm38)	missense	probably benign	0.00
R4807:Dync2h1	UTSW	9	7,139,422 (GRCm38)	missense	probably benign	0.31
R4850:Dync2h1	UTSW	9	7,134,364 (GRCm38)	missense	probably benign	0.14
R4862:Dync2h1	UTSW	9	7,147,717 (GRCm38)	missense	probably benign
R4899:Dync2h1	UTSW	9	7,131,921 (GRCm38)	nonsense	probably null
R4971:Dync2h1	UTSW	9	7,131,949 (GRCm38)	missense	probably benign
R5040:Dync2h1	UTSW	9	6,992,625 (GRCm38)	missense	probably benign	0.09
R5054:Dync2h1	UTSW	9	7,085,007 (GRCm38)	missense	possibly damaging	0.63
R5274:Dync2h1	UTSW	9	7,116,540 (GRCm38)	missense	probably benign	0.00
R5307:Dync2h1	UTSW	9	7,155,099 (GRCm38)	missense	probably damaging	1.00
R5347:Dync2h1	UTSW	9	7,129,727 (GRCm38)	missense	probably damaging	1.00
R5372:Dync2h1	UTSW	9	7,176,962 (GRCm38)	unclassified	probably benign
R5384:Dync2h1	UTSW	9	7,016,791 (GRCm38)	missense	probably damaging	0.99
R5385:Dync2h1	UTSW	9	7,016,791 (GRCm38)	missense	probably damaging	0.99
R5394:Dync2h1	UTSW	9	7,120,899 (GRCm38)	nonsense	probably null
R5402:Dync2h1	UTSW	9	7,114,949 (GRCm38)	missense	probably damaging	1.00
R5446:Dync2h1	UTSW	9	7,144,217 (GRCm38)	missense	probably benign
R5538:Dync2h1	UTSW	9	7,168,630 (GRCm38)	intron	probably benign
R5551:Dync2h1	UTSW	9	7,031,718 (GRCm38)	missense	possibly damaging	0.74
R5619:Dync2h1	UTSW	9	7,118,885 (GRCm38)	missense	probably benign	0.02
R5621:Dync2h1	UTSW	9	7,120,909 (GRCm38)	missense	possibly damaging	0.86
R5652:Dync2h1	UTSW	9	7,116,638 (GRCm38)	missense	probably benign	0.45
R5655:Dync2h1	UTSW	9	7,148,659 (GRCm38)	missense	probably benign	0.01
R5689:Dync2h1	UTSW	9	7,169,689 (GRCm38)	missense	probably damaging	1.00
R5725:Dync2h1	UTSW	9	7,169,528 (GRCm38)	missense	probably benign	0.21
R5742:Dync2h1	UTSW	9	7,165,762 (GRCm38)	missense	possibly damaging	0.64
R5817:Dync2h1	UTSW	9	6,996,905 (GRCm38)	missense	probably damaging	1.00
R5852:Dync2h1	UTSW	9	7,011,290 (GRCm38)	missense	probably benign	0.03
R5898:Dync2h1	UTSW	9	7,148,717 (GRCm38)	missense	probably benign	0.00
R5916:Dync2h1	UTSW	9	7,102,309 (GRCm38)	critical splice donor site	probably null
R5939:Dync2h1	UTSW	9	7,037,801 (GRCm38)	missense	probably damaging	0.99
R5942:Dync2h1	UTSW	9	7,117,466 (GRCm38)	nonsense	probably null
R5982:Dync2h1	UTSW	9	6,955,986 (GRCm38)	missense	probably benign	0.00
R6029:Dync2h1	UTSW	9	7,157,646 (GRCm38)	missense	probably benign
R6125:Dync2h1	UTSW	9	7,168,706 (GRCm38)	missense	probably damaging	1.00
R6209:Dync2h1	UTSW	9	7,165,677 (GRCm38)	missense	probably benign	0.01
R6247:Dync2h1	UTSW	9	7,135,078 (GRCm38)	missense	probably damaging	1.00
R6294:Dync2h1	UTSW	9	7,084,986 (GRCm38)	missense	probably benign	0.01
R6328:Dync2h1	UTSW	9	7,165,717 (GRCm38)	missense	probably benign	0.00
R6376:Dync2h1	UTSW	9	7,165,703 (GRCm38)	missense	probably benign	0.21
R6394:Dync2h1	UTSW	9	7,168,331 (GRCm38)	missense	probably damaging	0.99
R6539:Dync2h1	UTSW	9	7,159,478 (GRCm38)	splice site	probably null
R6554:Dync2h1	UTSW	9	7,037,699 (GRCm38)	missense	probably benign	0.39
R6559:Dync2h1	UTSW	9	7,139,501 (GRCm38)	missense	possibly damaging	0.72
R6563:Dync2h1	UTSW	9	7,120,819 (GRCm38)	missense	probably benign	0.27
R6807:Dync2h1	UTSW	9	7,041,718 (GRCm38)	missense	probably benign	0.10
R6848:Dync2h1	UTSW	9	7,159,632 (GRCm38)	missense	probably benign	0.22
R6901:Dync2h1	UTSW	9	7,131,855 (GRCm38)	missense	probably damaging	1.00
R6921:Dync2h1	UTSW	9	7,102,549 (GRCm38)	missense	probably benign
R6997:Dync2h1	UTSW	9	7,168,743 (GRCm38)	missense	probably null	0.00
R7084:Dync2h1	UTSW	9	7,113,214 (GRCm38)	missense	possibly damaging	0.72
R7113:Dync2h1	UTSW	9	7,075,788 (GRCm38)	missense	probably benign	0.03
R7131:Dync2h1	UTSW	9	7,075,786 (GRCm38)	missense	probably damaging	1.00
R7165:Dync2h1	UTSW	9	7,050,479 (GRCm38)	missense	probably benign
R7196:Dync2h1	UTSW	9	7,147,715 (GRCm38)	nonsense	probably null
R7208:Dync2h1	UTSW	9	7,141,059 (GRCm38)	missense	probably damaging	1.00
R7225:Dync2h1	UTSW	9	7,142,756 (GRCm38)	missense	probably benign
R7237:Dync2h1	UTSW	9	6,993,966 (GRCm38)	missense	probably benign	0.00
R7243:Dync2h1	UTSW	9	7,102,405 (GRCm38)	missense	possibly damaging	0.64
R7291:Dync2h1	UTSW	9	6,929,590 (GRCm38)	missense	possibly damaging	0.69
R7329:Dync2h1	UTSW	9	7,011,247 (GRCm38)	missense	probably benign
R7351:Dync2h1	UTSW	9	7,167,145 (GRCm38)	missense	probably damaging	1.00
R7358:Dync2h1	UTSW	9	7,159,479 (GRCm38)	critical splice donor site	probably null
R7387:Dync2h1	UTSW	9	7,157,932 (GRCm38)	missense	possibly damaging	0.68
R7446:Dync2h1	UTSW	9	7,041,720 (GRCm38)	missense	probably benign	0.03
R7487:Dync2h1	UTSW	9	7,132,041 (GRCm38)	missense	probably benign	0.26
R7488:Dync2h1	UTSW	9	7,124,855 (GRCm38)	missense	probably benign	0.03
R7496:Dync2h1	UTSW	9	7,135,015 (GRCm38)	splice site	probably null
R7501:Dync2h1	UTSW	9	7,175,336 (GRCm38)	missense	possibly damaging	0.82
R7571:Dync2h1	UTSW	9	7,002,623 (GRCm38)	missense	probably damaging	1.00
R7627:Dync2h1	UTSW	9	7,101,111 (GRCm38)	missense	probably benign	0.00
R7639:Dync2h1	UTSW	9	7,141,254 (GRCm38)	missense	probably damaging	0.97
R7653:Dync2h1	UTSW	9	7,117,570 (GRCm38)	missense	probably benign
R7654:Dync2h1	UTSW	9	7,122,664 (GRCm38)	missense	probably damaging	1.00
R7742:Dync2h1	UTSW	9	7,076,232 (GRCm38)	missense	probably benign	0.00
R7755:Dync2h1	UTSW	9	7,015,490 (GRCm38)	missense	probably benign	0.00
R7762:Dync2h1	UTSW	9	7,129,719 (GRCm38)	missense	probably benign	0.01
R7790:Dync2h1	UTSW	9	7,114,914 (GRCm38)	missense	probably damaging	0.96
R7834:Dync2h1	UTSW	9	7,118,953 (GRCm38)	missense	probably benign	0.04
R7883:Dync2h1	UTSW	9	7,005,566 (GRCm38)	missense	possibly damaging	0.80
R7952:Dync2h1	UTSW	9	7,129,802 (GRCm38)	missense	possibly damaging	0.63
R8111:Dync2h1	UTSW	9	7,148,688 (GRCm38)	missense	probably benign	0.03
R8157:Dync2h1	UTSW	9	7,001,473 (GRCm38)	missense	possibly damaging	0.47
R8166:Dync2h1	UTSW	9	7,129,089 (GRCm38)	nonsense	probably null
R8236:Dync2h1	UTSW	9	7,080,363 (GRCm38)	intron	probably benign
R8326:Dync2h1	UTSW	9	7,147,771 (GRCm38)	missense	probably benign
R8335:Dync2h1	UTSW	9	7,084,941 (GRCm38)	missense	probably benign	0.28
R8347:Dync2h1	UTSW	9	7,116,578 (GRCm38)	missense	possibly damaging	0.81
R8372:Dync2h1	UTSW	9	7,111,514 (GRCm38)	missense	possibly damaging	0.90
R8421:Dync2h1	UTSW	9	7,102,477 (GRCm38)	missense	probably damaging	1.00
R8518:Dync2h1	UTSW	9	7,051,452 (GRCm38)	missense	probably benign	0.04
R8556:Dync2h1	UTSW	9	7,113,198 (GRCm38)	missense	probably benign	0.32
R8690:Dync2h1	UTSW	9	7,075,824 (GRCm38)	missense	probably damaging	1.00
R8713:Dync2h1	UTSW	9	7,141,008 (GRCm38)	nonsense	probably null
R8719:Dync2h1	UTSW	9	7,041,641 (GRCm38)	missense	probably benign	0.05
R8732:Dync2h1	UTSW	9	7,168,326 (GRCm38)	missense	probably damaging	1.00
R8744:Dync2h1	UTSW	9	7,011,220 (GRCm38)	nonsense	probably null
R8749:Dync2h1	UTSW	9	7,035,063 (GRCm38)	missense	probably benign	0.32
R8795:Dync2h1	UTSW	9	7,137,087 (GRCm38)	missense	probably benign	0.00
R8853:Dync2h1	UTSW	9	7,117,645 (GRCm38)	missense	possibly damaging	0.94
R8923:Dync2h1	UTSW	9	7,168,515 (GRCm38)	missense	probably benign
R8969:Dync2h1	UTSW	9	7,130,723 (GRCm38)	missense	probably damaging	1.00
R8988:Dync2h1	UTSW	9	7,037,727 (GRCm38)	missense	probably benign	0.00
R8997:Dync2h1	UTSW	9	7,129,003 (GRCm38)	missense	probably benign
R9025:Dync2h1	UTSW	9	7,139,462 (GRCm38)	nonsense	probably null
R9036:Dync2h1	UTSW	9	7,051,495 (GRCm38)	missense	probably damaging	1.00
R9055:Dync2h1	UTSW	9	6,996,641 (GRCm38)	intron	probably benign
R9165:Dync2h1	UTSW	9	7,114,883 (GRCm38)	missense	probably damaging	0.99
R9172:Dync2h1	UTSW	9	7,031,771 (GRCm38)	missense	probably damaging	1.00
R9286:Dync2h1	UTSW	9	6,941,668 (GRCm38)	missense	probably benign	0.01
R9312:Dync2h1	UTSW	9	7,050,413 (GRCm38)	missense	probably damaging	1.00
R9335:Dync2h1	UTSW	9	7,112,149 (GRCm38)	missense	possibly damaging	0.88
R9344:Dync2h1	UTSW	9	7,148,659 (GRCm38)	missense	probably benign	0.01
R9351:Dync2h1	UTSW	9	7,176,911 (GRCm38)	missense	probably damaging	0.98
R9367:Dync2h1	UTSW	9	7,125,730 (GRCm38)	critical splice donor site	probably null
R9613:Dync2h1	UTSW	9	7,075,769 (GRCm38)	missense	probably damaging	0.99
R9650:Dync2h1	UTSW	9	7,174,849 (GRCm38)	missense	possibly damaging	0.83
R9726:Dync2h1	UTSW	9	7,077,999 (GRCm38)	missense	possibly damaging	0.94
R9731:Dync2h1	UTSW	9	7,141,166 (GRCm38)	missense	probably benign
X0009:Dync2h1	UTSW	9	7,117,576 (GRCm38)	missense	possibly damaging	0.81
Z1176:Dync2h1	UTSW	9	7,168,730 (GRCm38)	frame shift	probably null
Z1176:Dync2h1	UTSW	9	7,142,361 (GRCm38)	missense	probably damaging	0.99
Z1177:Dync2h1	UTSW	9	7,102,427 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTCACTGATTGGGTCACATGTAG -3'
(R):5'- GAATTATTTGGTGCAAGTCGTAAGG -3'

Sequencing Primer
(F):5'- TGTCATGACCACACCTTTAAGTAC -3'
(R):5'- TTGATGCAGTTTGACTGTAT -3'

Posted On

2019-06-26