Incidental Mutation 'R7293:Parp4'
ID 566584
Institutional Source Beutler Lab
Gene Symbol Parp4
Ensembl Gene ENSMUSG00000054509
Gene Name poly (ADP-ribose) polymerase family, member 4
Synonyms VPARP, Adprtl1, C030027K23Rik, VAULT3, p193, PH5P, E230037B21Rik
MMRRC Submission 045398-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # R7293 (G1)
Quality Score 139.467
Status Not validated
Chromosome 14
Chromosomal Location 56813076-56897251 bp(+) (GRCm39)
Type of Mutation small deletion (12 aa in frame mutation)
DNA Base Change (assembly) CTTCCTCCCCCTCCCCTTCTCTCTGCTGGCACCCATATTCCTCCCCCTCCCCTTCTCTCTGCTGGCACCCATCTTCCTCCCCCTCCCCTTCTCCCTGCTGGCACCCATATTCCTCCCCCTCCCC to CTTCCTCCCCCTCCCCTTCTCTCTGCTGGCACCCATCTTCCTCCCCCTCCCCTTCTCCCTGCTGGCACCCATATTCCTCCCCCTCCCC at 56885303 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000124258 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161553]
AlphaFold E9PYK3
Predicted Effect probably benign
Transcript: ENSMUST00000161553
SMART Domains Protein: ENSMUSP00000124258
Gene: ENSMUSG00000054509

DomainStartEndE-ValueType
BRCT 3 84 4.32e-9 SMART
low complexity region 97 104 N/A INTRINSIC
SCOP:d1a26_1 252 352 2e-19 SMART
Pfam:PARP 371 559 1.8e-50 PFAM
VIT 600 728 1.5e-57 SMART
VWA 867 1030 6.08e-13 SMART
Blast:14_3_3 1149 1205 5e-10 BLAST
low complexity region 1255 1264 N/A INTRINSIC
low complexity region 1348 1362 N/A INTRINSIC
low complexity region 1371 1394 N/A INTRINSIC
internal_repeat_1 1395 1416 4.48e-6 PROSPERO
Pfam:Drf_FH1 1443 1542 3.3e-15 PFAM
low complexity region 1553 1587 N/A INTRINSIC
internal_repeat_2 1588 1608 2.45e-5 PROSPERO
low complexity region 1695 1708 N/A INTRINSIC
low complexity region 1739 1750 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 97% (74/76)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 G A 19: 43,795,492 (GRCm39) G416E probably damaging Het
Acsl5 G T 19: 55,279,642 (GRCm39) W460L probably damaging Het
Adam2 A G 14: 66,272,634 (GRCm39) F614S probably benign Het
Adamts5 G A 16: 85,696,833 (GRCm39) T108I probably benign Het
Agmat C T 4: 141,483,246 (GRCm39) Q227* probably null Het
Alg11 A G 8: 22,555,395 (GRCm39) N219D probably damaging Het
Amhr2 A G 15: 102,355,828 (GRCm39) T258A probably benign Het
Ankrd53 A G 6: 83,740,178 (GRCm39) E82G probably null Het
Blzf1 T A 1: 164,123,452 (GRCm39) T292S possibly damaging Het
Capza1 T C 3: 104,748,151 (GRCm39) D71G probably benign Het
Cc2d1b T C 4: 108,488,873 (GRCm39) F770L probably benign Het
Cckbr A T 7: 105,083,852 (GRCm39) Q260L probably benign Het
Cep162 T C 9: 87,085,836 (GRCm39) T1163A probably benign Het
Chd9 T C 8: 91,760,707 (GRCm39) S2151P unknown Het
Clk1 T A 1: 58,453,772 (GRCm39) T301S probably benign Het
Cmya5 T A 13: 93,229,305 (GRCm39) S1928C possibly damaging Het
Col24a1 C T 3: 145,192,059 (GRCm39) Q1273* probably null Het
Col4a4 T C 1: 82,501,664 (GRCm39) D363G unknown Het
Copb1 A T 7: 113,818,837 (GRCm39) M827K probably damaging Het
Crocc C T 4: 140,770,867 (GRCm39) A351T probably benign Het
Crybg1 T C 10: 43,879,428 (GRCm39) T587A probably damaging Het
Csrnp3 A G 2: 65,779,344 (GRCm39) R19G probably damaging Het
Cyb5rl T C 4: 106,938,143 (GRCm39) I165T probably damaging Het
Dnah1 A T 14: 31,009,820 (GRCm39) I1916N probably damaging Het
Dvl1 T C 4: 155,940,625 (GRCm39) M415T possibly damaging Het
Dync2h1 A G 9: 7,001,454 (GRCm39) S3845P possibly damaging Het
Eif3b A G 5: 140,405,183 (GRCm39) Q23R probably benign Het
Esam G T 9: 37,449,020 (GRCm39) R376L probably damaging Het
Fat3 G C 9: 15,826,336 (GRCm39) H391D Het
Fat3 A C 9: 15,826,592 (GRCm39) S305R Het
Fgd3 T C 13: 49,418,134 (GRCm39) D644G probably benign Het
Fgf7 T C 2: 125,877,672 (GRCm39) L13P probably damaging Het
Gas2l1 A G 11: 5,014,338 (GRCm39) Y41H probably damaging Het
Glg1 A T 8: 111,895,375 (GRCm39) I812N probably damaging Het
Glp1r C T 17: 31,143,599 (GRCm39) H212Y probably benign Het
Gm5622 G T 14: 51,893,339 (GRCm39) E89* probably null Het
Gpr158 G A 2: 21,581,750 (GRCm39) V410I possibly damaging Het
Ighv1-53 A T 12: 115,122,441 (GRCm39) C5* probably null Het
Itgb2l A C 16: 96,227,996 (GRCm39) Y502* probably null Het
Jakmip1 G A 5: 37,284,817 (GRCm39) V635I probably benign Het
Kplce A T 3: 92,776,126 (GRCm39) C186S probably benign Het
Krt23 C T 11: 99,374,682 (GRCm39) M270I probably benign Het
Larp1b C T 3: 40,939,879 (GRCm39) A344V Het
Lin28b T C 10: 45,295,282 (GRCm39) M134V probably benign Het
Lrrc19 T A 4: 94,526,627 (GRCm39) Y310F probably benign Het
Lyst T A 13: 13,854,822 (GRCm39) D2397E probably benign Het
Map6 A G 7: 98,985,740 (GRCm39) N751S possibly damaging Het
Mgrn1 G A 16: 4,750,084 (GRCm39) D494N probably benign Het
Myh6 A G 14: 55,184,631 (GRCm39) F1567L probably benign Het
Myo9b T C 8: 71,778,549 (GRCm39) V461A probably benign Het
Ncan A T 8: 70,567,861 (GRCm39) S84T probably damaging Het
Nlrp9a G A 7: 26,270,694 (GRCm39) C908Y probably damaging Het
Or4c3 A T 2: 89,851,871 (GRCm39) Y180N probably damaging Het
Or4f4b A G 2: 111,313,699 (GRCm39) probably null Het
Or52n20 T A 7: 104,319,925 (GRCm39) N5K probably damaging Het
Or8g31-ps1 A T 9: 39,276,130 (GRCm39) M92L probably benign Het
Pld1 C A 3: 28,141,435 (GRCm39) T666K probably damaging Het
Pnpla6 A G 8: 3,588,068 (GRCm39) Y1107C probably damaging Het
Pramel7 A C 2: 87,322,706 (GRCm39) N19K probably benign Het
Prh1 C G 6: 132,548,721 (GRCm39) P76R unknown Het
Prkd2 T C 7: 16,579,865 (GRCm39) V121A possibly damaging Het
Ptprq G A 10: 107,471,367 (GRCm39) Q1345* probably null Het
Ryr3 T A 2: 112,732,948 (GRCm39) T653S probably benign Het
Sall2 G T 14: 52,551,868 (GRCm39) Y442* probably null Het
Slc23a2 A C 2: 131,931,026 (GRCm39) F158V probably benign Het
Smg1 C A 7: 117,765,322 (GRCm39) R1954L unknown Het
Snx31 G A 15: 36,523,596 (GRCm39) T362I probably damaging Het
Taf3 G T 2: 9,956,901 (GRCm39) T422K probably damaging Het
Tcfl5 T C 2: 180,283,958 (GRCm39) D142G probably benign Het
Tmx1 A G 12: 70,507,325 (GRCm39) T188A probably damaging Het
Tnfrsf11a A G 1: 105,735,866 (GRCm39) probably null Het
Trio A T 15: 27,871,375 (GRCm39) C640S possibly damaging Het
Ulk4 T G 9: 121,084,190 (GRCm39) N427T probably damaging Het
Vmn1r202 T C 13: 22,685,872 (GRCm39) M182V probably benign Het
Vmn1r214 C T 13: 23,218,839 (GRCm39) A111V probably benign Het
Other mutations in Parp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00479:Parp4 APN 14 56,853,917 (GRCm39) missense possibly damaging 0.82
IGL00571:Parp4 APN 14 56,884,810 (GRCm39) missense unknown
IGL00737:Parp4 APN 14 56,821,620 (GRCm39) missense probably damaging 0.99
IGL00793:Parp4 APN 14 56,840,334 (GRCm39) missense possibly damaging 0.73
IGL01108:Parp4 APN 14 56,844,897 (GRCm39) missense probably benign 0.01
IGL01131:Parp4 APN 14 56,823,217 (GRCm39) splice site probably benign
IGL01485:Parp4 APN 14 56,859,661 (GRCm39) missense possibly damaging 0.54
IGL01704:Parp4 APN 14 56,839,783 (GRCm39) missense probably damaging 0.99
IGL01993:Parp4 APN 14 56,848,245 (GRCm39) missense possibly damaging 0.82
IGL02125:Parp4 APN 14 56,827,959 (GRCm39) missense probably benign 0.33
IGL02851:Parp4 APN 14 56,886,326 (GRCm39) missense unknown
IGL02863:Parp4 APN 14 56,886,243 (GRCm39) missense unknown
IGL03065:Parp4 APN 14 56,875,326 (GRCm39) missense probably benign 0.09
IGL03117:Parp4 APN 14 56,840,313 (GRCm39) missense probably benign 0.17
IGL03271:Parp4 APN 14 56,823,082 (GRCm39) missense probably benign 0.10
IGL03309:Parp4 APN 14 56,825,265 (GRCm39) missense probably benign 0.11
IGL03408:Parp4 APN 14 56,839,865 (GRCm39) missense probably damaging 0.99
poisonous UTSW 14 56,873,205 (GRCm39) missense possibly damaging 0.65
R0515_Parp4_195 UTSW 14 56,851,124 (GRCm39) missense probably damaging 1.00
toxic UTSW 14 56,866,615 (GRCm39) missense probably benign 0.28
venomous UTSW 14 56,827,355 (GRCm39) missense possibly damaging 0.92
virulent UTSW 14 56,825,235 (GRCm39) missense probably damaging 0.97
R0278:Parp4 UTSW 14 56,844,980 (GRCm39) missense probably damaging 0.99
R0320:Parp4 UTSW 14 56,825,953 (GRCm39) critical splice donor site probably null
R0445:Parp4 UTSW 14 56,840,205 (GRCm39) splice site probably null
R0452:Parp4 UTSW 14 56,886,300 (GRCm39) missense unknown
R0511:Parp4 UTSW 14 56,873,172 (GRCm39) splice site probably benign
R0515:Parp4 UTSW 14 56,851,124 (GRCm39) missense probably damaging 1.00
R0608:Parp4 UTSW 14 56,839,861 (GRCm39) missense probably damaging 1.00
R0800:Parp4 UTSW 14 56,827,408 (GRCm39) missense probably benign 0.00
R0959:Parp4 UTSW 14 56,885,576 (GRCm39) missense unknown
R1207:Parp4 UTSW 14 56,885,339 (GRCm39) missense unknown
R1207:Parp4 UTSW 14 56,885,339 (GRCm39) missense unknown
R1342:Parp4 UTSW 14 56,827,854 (GRCm39) missense probably damaging 1.00
R1520:Parp4 UTSW 14 56,835,863 (GRCm39) missense probably damaging 1.00
R1565:Parp4 UTSW 14 56,827,329 (GRCm39) splice site probably benign
R1574:Parp4 UTSW 14 56,839,752 (GRCm39) missense probably damaging 0.98
R1574:Parp4 UTSW 14 56,839,752 (GRCm39) missense probably damaging 0.98
R1649:Parp4 UTSW 14 56,827,885 (GRCm39) missense possibly damaging 0.95
R1666:Parp4 UTSW 14 56,861,620 (GRCm39) missense possibly damaging 0.91
R1781:Parp4 UTSW 14 56,864,838 (GRCm39) splice site probably null
R1799:Parp4 UTSW 14 56,885,589 (GRCm39) missense unknown
R1823:Parp4 UTSW 14 56,827,329 (GRCm39) splice site probably benign
R1859:Parp4 UTSW 14 56,886,372 (GRCm39) missense unknown
R1919:Parp4 UTSW 14 56,861,474 (GRCm39) missense probably damaging 1.00
R2000:Parp4 UTSW 14 56,851,181 (GRCm39) missense probably damaging 0.98
R2032:Parp4 UTSW 14 56,866,553 (GRCm39) missense possibly damaging 0.71
R2034:Parp4 UTSW 14 56,871,720 (GRCm39) missense probably damaging 1.00
R2177:Parp4 UTSW 14 56,896,746 (GRCm39) missense unknown
R2291:Parp4 UTSW 14 56,851,274 (GRCm39) missense probably damaging 1.00
R2865:Parp4 UTSW 14 56,851,181 (GRCm39) missense probably damaging 0.98
R3012:Parp4 UTSW 14 56,832,873 (GRCm39) critical splice donor site probably null
R3841:Parp4 UTSW 14 56,825,235 (GRCm39) missense probably damaging 0.97
R3913:Parp4 UTSW 14 56,857,975 (GRCm39) missense probably damaging 1.00
R4064:Parp4 UTSW 14 56,861,597 (GRCm39) missense probably benign 0.06
R4201:Parp4 UTSW 14 56,829,848 (GRCm39) missense possibly damaging 0.95
R4288:Parp4 UTSW 14 56,844,951 (GRCm39) missense probably damaging 1.00
R4360:Parp4 UTSW 14 56,866,661 (GRCm39) missense possibly damaging 0.89
R4506:Parp4 UTSW 14 56,889,761 (GRCm39) missense unknown
R4577:Parp4 UTSW 14 56,827,867 (GRCm39) missense probably benign 0.33
R4633:Parp4 UTSW 14 56,885,048 (GRCm39) missense unknown
R4762:Parp4 UTSW 14 56,848,267 (GRCm39) missense probably damaging 1.00
R4836:Parp4 UTSW 14 56,823,195 (GRCm39) missense probably benign 0.00
R4974:Parp4 UTSW 14 56,827,355 (GRCm39) missense possibly damaging 0.92
R5049:Parp4 UTSW 14 56,873,188 (GRCm39) missense possibly damaging 0.81
R5479:Parp4 UTSW 14 56,861,552 (GRCm39) missense probably benign 0.01
R5683:Parp4 UTSW 14 56,884,886 (GRCm39) nonsense probably null
R5884:Parp4 UTSW 14 56,852,207 (GRCm39) missense probably damaging 1.00
R5965:Parp4 UTSW 14 56,861,489 (GRCm39) missense probably benign 0.11
R6001:Parp4 UTSW 14 56,878,740 (GRCm39) missense probably benign 0.01
R6027:Parp4 UTSW 14 56,866,615 (GRCm39) missense probably benign 0.28
R6230:Parp4 UTSW 14 56,844,990 (GRCm39) missense probably damaging 1.00
R6242:Parp4 UTSW 14 56,832,856 (GRCm39) nonsense probably null
R6355:Parp4 UTSW 14 56,839,757 (GRCm39) missense possibly damaging 0.61
R6414:Parp4 UTSW 14 56,864,838 (GRCm39) splice site probably null
R6418:Parp4 UTSW 14 56,858,108 (GRCm39) critical splice donor site probably null
R6477:Parp4 UTSW 14 56,884,694 (GRCm39) missense probably benign 0.00
R6542:Parp4 UTSW 14 56,885,339 (GRCm39) missense unknown
R6759:Parp4 UTSW 14 56,857,947 (GRCm39) missense probably benign 0.10
R6995:Parp4 UTSW 14 56,851,196 (GRCm39) missense probably damaging 0.97
R7002:Parp4 UTSW 14 56,839,861 (GRCm39) missense probably damaging 1.00
R7026:Parp4 UTSW 14 56,858,049 (GRCm39) missense probably benign 0.01
R7062:Parp4 UTSW 14 56,852,216 (GRCm39) missense possibly damaging 0.48
R7101:Parp4 UTSW 14 56,827,430 (GRCm39) missense probably benign 0.02
R7124:Parp4 UTSW 14 56,840,256 (GRCm39) missense probably benign 0.11
R7162:Parp4 UTSW 14 56,886,333 (GRCm39) missense unknown
R7297:Parp4 UTSW 14 56,885,138 (GRCm39) missense not run
R7337:Parp4 UTSW 14 56,839,852 (GRCm39) missense probably damaging 1.00
R7539:Parp4 UTSW 14 56,873,212 (GRCm39) missense probably damaging 1.00
R7575:Parp4 UTSW 14 56,875,375 (GRCm39) missense probably benign 0.28
R7808:Parp4 UTSW 14 56,873,205 (GRCm39) missense possibly damaging 0.65
R7854:Parp4 UTSW 14 56,896,805 (GRCm39) missense unknown
R7960:Parp4 UTSW 14 56,832,708 (GRCm39) splice site probably null
R8152:Parp4 UTSW 14 56,884,703 (GRCm39) missense probably benign 0.00
R8344:Parp4 UTSW 14 56,886,186 (GRCm39) missense unknown
R8416:Parp4 UTSW 14 56,825,271 (GRCm39) critical splice donor site probably null
R8726:Parp4 UTSW 14 56,866,556 (GRCm39) missense probably benign 0.04
R8752:Parp4 UTSW 14 56,886,073 (GRCm39) missense unknown
R8804:Parp4 UTSW 14 56,853,900 (GRCm39) nonsense probably null
R9046:Parp4 UTSW 14 56,864,927 (GRCm39) missense probably damaging 0.98
R9176:Parp4 UTSW 14 56,873,274 (GRCm39) missense possibly damaging 0.54
R9303:Parp4 UTSW 14 56,852,224 (GRCm39) critical splice donor site probably null
R9303:Parp4 UTSW 14 56,832,790 (GRCm39) frame shift probably null
R9305:Parp4 UTSW 14 56,852,224 (GRCm39) critical splice donor site probably null
R9305:Parp4 UTSW 14 56,832,790 (GRCm39) frame shift probably null
R9360:Parp4 UTSW 14 56,878,775 (GRCm39) critical splice donor site probably null
R9430:Parp4 UTSW 14 56,866,673 (GRCm39) missense probably damaging 1.00
R9491:Parp4 UTSW 14 56,832,828 (GRCm39) missense probably damaging 0.99
R9729:Parp4 UTSW 14 56,885,888 (GRCm39) missense unknown
RF020:Parp4 UTSW 14 56,884,806 (GRCm39) missense unknown
Z1177:Parp4 UTSW 14 56,829,824 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCTGCAGCTCTAGTTCTG -3'
(R):5'- AGGAATATGGGTGCCACCAG -3'

Sequencing Primer
(F):5'- TGGTAGCACCCACCCTC -3'
(R):5'- GGAAGATGGGTGCCACC -3'
Posted On 2019-06-26