Mutagenetix > Incidental Mutation

Incidental Mutation 'R7299:Vmn2r107'

566895

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R7299 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20345616 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 64 (I64M)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably benign
Transcript: ENSMUST00000042090
AA Change: I64M

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: I64M

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.2%

Validation Efficiency

99% (71/72)

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432M17Rik	A	C	3: 121,679,446	K83N	unknown	Het
Abca13	A	T	11: 9,294,649	N2171Y	probably damaging	Het
Abcc8	G	A	7: 46,105,498	T1532I	possibly damaging	Het
Abtb2	A	T	2: 103,702,424		probably null	Het
Agk	A	T	6: 40,329,517	T7S	possibly damaging	Het
Akap9	C	A	5: 4,032,696	T1940K	probably damaging	Het
Armc4	T	C	18: 7,222,635	K545E	probably damaging	Het
BC024978	G	A	7: 27,201,123	A176T	probably damaging	Het
Ccdc8	A	G	7: 16,996,031	T482A	unknown	Het
Cd2ap	G	A	17: 42,830,013	R212*	probably null	Het
Cenpt	G	A	8: 105,849,904	Q45*	probably null	Het
Cnga1	T	C	5: 72,605,432	I246M	probably benign	Het
Cnot7	A	G	8: 40,507,545	I74T	probably damaging	Het
Cog6	T	C	3: 53,002,507	S275G	probably benign	Het
Csmd2	C	A	4: 128,528,262	D2797E		Het
Ddx24	A	G	12: 103,419,450	M298T	possibly damaging	Het
Eif2b3	T	A	4: 117,052,822	S185T	probably benign	Het
Ergic2	T	A	6: 148,188,112	Y249F	probably damaging	Het
Exoc1	T	A	5: 76,542,159	M182K	probably damaging	Het
Fhdc1	T	C	3: 84,444,540	E1126G	probably damaging	Het
Gabrr2	T	A	4: 33,095,284	M391K	probably benign	Het
Gap43	T	C	16: 42,292,252	K49E	probably damaging	Het
Gata4	T	A	14: 63,203,742	T276S	probably damaging	Het
Gca	C	T	2: 62,689,976	P160L	probably benign	Het
Ghdc	C	T	11: 100,768,116	V397I	possibly damaging	Het
Gm3409	T	A	5: 146,539,547	D169E	probably benign	Het
Gtf3c3	G	A	1: 54,417,708	P511L	probably benign	Het
Hal	T	C	10: 93,492,561	V233A	probably benign	Het
Ighv1-4	T	C	12: 114,487,288	I67V	probably benign	Het
Itgb8	T	C	12: 119,202,461	N112D	probably benign	Het
Klhl38	G	A	15: 58,322,980	R118W	probably damaging	Het
Krtap26-1	T	C	16: 88,647,244	Y163C	possibly damaging	Het
Kyat1	T	C	2: 30,191,995	D44G	probably benign	Het
Mob1a	G	A	6: 83,338,449		probably null	Het
Mst1r	G	T	9: 107,914,790	A842S	possibly damaging	Het
Nhsl1	A	G	10: 18,527,671		probably null	Het
Nos1	A	T	5: 117,867,905	D230V	possibly damaging	Het
Nppb	T	C	4: 147,986,323	S52P	probably benign	Het
Olfml3	T	C	3: 103,735,860	K402E	probably damaging	Het
Olfr1496	G	A	19: 13,781,324	W235*	probably null	Het
Pcdha3	G	A	18: 36,946,924	E240K	possibly damaging	Het
Podxl	G	T	6: 31,524,436	P395T	probably damaging	Het
Prr5l	T	A	2: 101,717,286	D298V	probably damaging	Het
Ptpro	G	A	6: 137,441,144		probably null	Het
Rad9b	A	G	5: 122,352,614	V13A	possibly damaging	Het
Ralgps1	T	C	2: 33,157,873	K365R	probably benign	Het
Reep1	A	T	6: 71,761,389	I44L	probably benign	Het
Ripor2	T	C	13: 24,725,001	I1034T	possibly damaging	Het
Rtn4ip1	T	C	10: 43,936,020	Y338H	probably damaging	Het
Shisa5	G	T	9: 109,054,884		probably benign	Het
Snx24	G	T	18: 53,340,172	V63F	probably damaging	Het
Svep1	G	A	4: 58,046,587	Q3515*	probably null	Het
Tfap2a	T	C	13: 40,721,308	K276E	probably damaging	Het
Tmem158	C	A	9: 123,260,301	S82I	probably damaging	Het
Tmem263	T	A	10: 85,114,397		probably null	Het
Tmtc3	G	T	10: 100,447,474	H740N	not run	Het
Tnrc6a	A	C	7: 123,170,913	N642T	probably benign	Het
Top3a	A	T	11: 60,748,148	F559I	probably damaging	Het
Trak1	A	G	9: 121,451,863		probably null	Het
Trpc4	T	C	3: 54,317,627	I799T	possibly damaging	Het
Ttc7	T	C	17: 87,346,542	I549T	possibly damaging	Het
Tysnd1	C	A	10: 61,696,549	P327T	possibly damaging	Het
Ulk4	T	A	9: 121,145,059	D969V	probably benign	Het
Vcan	T	A	13: 89,705,266	Y525F	probably benign	Het
Vmn1r204	G	A	13: 22,556,805	S202N	probably damaging	Het
Wrn	A	G	8: 33,292,718	F728S	probably damaging	Het
Zfp280b	C	G	10: 76,038,703	Q139E	probably damaging	Het
Zfp322a	C	A	13: 23,357,143	G143V	probably damaging	Het
Zfp322a	C	T	13: 23,357,144	G143S	probably benign	Het
Zfp418	T	A	7: 7,182,828	C597S	possibly damaging	Het
Zfp568	A	G	7: 30,017,244	T190A	probably benign	Het
Zfyve26	A	T	12: 79,282,984	V476D	probably benign	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- GACCAATGTGCTAATAGGATGTTCTCC -3'
(R):5'- TCCTCCTGAGTGTGGAATATAATCC -3'

Sequencing Primer
(F):5'- GGATGTTCTCCTGGATTTTTATCTTC -3'
(R):5'- TGGCTACACCCATTACGT -3'

Posted On

2019-06-26