Mutagenetix > Incidental Mutation

Incidental Mutation 'R7303:Flnc'

567091

Institutional Source

Beutler Lab

Gene Symbol

Flnc

Ensembl Gene

ENSMUSG00000068699

Gene Name

filamin C, gamma

Synonyms

1110055E19Rik, Fln2, actin binding protein 280

MMRRC Submission

045364-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7303 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

29433255-29461882 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 29460849 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 2647 (S2647P)

Ref Sequence

ENSEMBL: ENSMUSP00000064163 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065090] [ENSMUST00000101617]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000065090
AA Change: S2647P

PolyPhen 2 Score 0.311 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000064163
Gene: ENSMUSG00000068699
AA Change: S2647P

Domain	Start	End	E-Value	Type
CH	39	141	1.17e-25	SMART
CH	162	258	2.09e-22	SMART
IG_FLMN	275	372	3.84e-38	SMART
IG_FLMN	375	472	3.73e-36	SMART
IG_FLMN	474	569	4.41e-38	SMART
IG_FLMN	571	662	3.61e-34	SMART
IG_FLMN	667	762	2.48e-41	SMART
IG_FLMN	764	865	6.7e-29	SMART
IG_FLMN	867	964	3.42e-35	SMART
IG_FLMN	966	1060	2.92e-29	SMART
IG_FLMN	1062	1153	3.69e-40	SMART
IG_FLMN	1155	1248	6.53e-41	SMART
IG_FLMN	1250	1348	7.23e-34	SMART
IG_FLMN	1350	1441	2.04e-42	SMART
IG_FLMN	1443	1537	1.75e-41	SMART
IG_FLMN	1539	1634	1.31e-40	SMART
IG_FLMN	1636	1738	1.05e-30	SMART
IG_FLMN	1777	1858	2.93e-11	SMART
IG_FLMN	1859	1950	2.55e-43	SMART
IG_FLMN	1951	2037	2.43e-17	SMART
IG_FLMN	2041	2132	1.52e-41	SMART
PDB:2E9I\|A	2133	2162	3e-7	PDB
IG_FLMN	2217	2310	2.93e-11	SMART
IG_FLMN	2314	2405	1.67e-38	SMART
IG_FLMN	2408	2500	2.56e-25	SMART
IG_FLMN	2505	2596	9.54e-34	SMART
low complexity region	2618	2628	N/A	INTRINSIC
IG_FLMN	2635	2737	2.11e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000101617
AA Change: S2614P

PolyPhen 2 Score 0.147 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000099139
Gene: ENSMUSG00000068699
AA Change: S2614P

Domain	Start	End	E-Value	Type
CH	39	141	1.17e-25	SMART
CH	162	258	2.09e-22	SMART
IG_FLMN	275	372	3.84e-38	SMART
IG_FLMN	375	472	3.73e-36	SMART
IG_FLMN	474	569	4.41e-38	SMART
IG_FLMN	571	662	3.61e-34	SMART
IG_FLMN	667	762	2.48e-41	SMART
IG_FLMN	764	865	6.7e-29	SMART
IG_FLMN	867	964	3.42e-35	SMART
IG_FLMN	966	1060	2.92e-29	SMART
IG_FLMN	1062	1153	3.69e-40	SMART
IG_FLMN	1155	1248	6.53e-41	SMART
IG_FLMN	1250	1348	7.23e-34	SMART
IG_FLMN	1350	1441	2.04e-42	SMART
IG_FLMN	1443	1537	1.75e-41	SMART
IG_FLMN	1539	1634	1.31e-40	SMART
IG_FLMN	1636	1738	6.11e-32	SMART
IG_FLMN	1744	1825	2.93e-11	SMART
IG_FLMN	1826	1917	2.55e-43	SMART
IG_FLMN	1918	2004	2.43e-17	SMART
IG_FLMN	2008	2099	1.52e-41	SMART
PDB:2E9I\|A	2100	2129	3e-7	PDB
IG_FLMN	2184	2277	2.93e-11	SMART
IG_FLMN	2281	2372	1.67e-38	SMART
IG_FLMN	2375	2467	2.56e-25	SMART
IG_FLMN	2472	2563	9.54e-34	SMART
low complexity region	2585	2595	N/A	INTRINSIC
IG_FLMN	2602	2704	2.11e-26	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a hypomorphic allele display neonatal lethality, respiratory failure, reduced skeletal muscle mass, and abnormal skeletal muscle fiber morphology. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca3	T	G	17: 24,617,495 (GRCm39)	L1064R	possibly damaging	Het
Abca7	A	T	10: 79,850,822 (GRCm39)	D2051V	probably benign	Het
Abcb5	T	A	12: 118,875,295 (GRCm39)	I626F	probably damaging	Het
Abcg5	A	G	17: 84,977,774 (GRCm39)	S333P	probably damaging	Het
Abl2	T	C	1: 156,468,820 (GRCm39)	S695P	probably benign	Het
Aen	C	T	7: 78,552,204 (GRCm39)	P55S	possibly damaging	Het
Afg3l1	G	T	8: 124,228,008 (GRCm39)	A598S	probably damaging	Het
Aldh16a1	A	T	7: 44,797,328 (GRCm39)	L160Q	probably damaging	Het
Ang	A	T	14: 51,338,973 (GRCm39)	H38L	probably benign	Het
Ankar	A	T	1: 72,698,192 (GRCm39)	I954N	probably benign	Het
Aox1	A	T	1: 58,373,924 (GRCm39)	K862*	probably null	Het
Brme1	G	C	8: 84,887,862 (GRCm39)	G71A	probably benign	Het
Cad	T	C	5: 31,217,557 (GRCm39)		probably null	Het
Cc2d2b	A	T	19: 40,797,438 (GRCm39)	Y740F	unknown	Het
Ccdc182	T	C	11: 88,185,042 (GRCm39)	Y41H	probably benign	Het
Chd9	A	G	8: 91,778,532 (GRCm39)	R2848G	unknown	Het
Chrna6	A	T	8: 27,897,019 (GRCm39)	L286*	probably null	Het
Cimap1d	G	A	10: 79,478,525 (GRCm39)	P80S	probably benign	Het
Cracr2b	A	G	7: 141,043,115 (GRCm39)		probably benign	Het
Fam184b	C	T	5: 45,699,568 (GRCm39)		probably null	Het
Ftsj3	T	C	11: 106,145,506 (GRCm39)	D76G	probably damaging	Het
Fxyd1	T	A	7: 30,753,743 (GRCm39)	M17L	probably benign	Het
Golim4	G	A	3: 75,785,360 (GRCm39)	S677L	probably damaging	Het
Gpr149	A	G	3: 62,502,491 (GRCm39)	V455A	possibly damaging	Het
H2-Q1	C	A	17: 35,540,312 (GRCm39)	S132R	probably benign	Het
H2-Q7	A	G	17: 35,659,037 (GRCm39)	I163V	probably benign	Het
Herc1	A	T	9: 66,358,098 (GRCm39)	D2393V	possibly damaging	Het
Hmgb2	A	G	8: 57,965,762 (GRCm39)	K44E	possibly damaging	Het
Itgad	A	G	7: 127,789,351 (GRCm39)	D605G	probably benign	Het
Kbtbd12	G	T	6: 88,591,094 (GRCm39)	F16L	unknown	Het
Klhl23	T	C	2: 69,655,045 (GRCm39)	I305T	probably benign	Het
Lrguk	A	T	6: 34,006,411 (GRCm39)	N7I	probably benign	Het
Lrp5	A	G	19: 3,641,774 (GRCm39)	L1396P	probably damaging	Het
Mapkapk5	T	C	5: 121,678,637 (GRCm39)	E13G	probably benign	Het
Mark3	T	C	12: 111,621,970 (GRCm39)	V704A	probably damaging	Het
Mast2	A	G	4: 116,165,508 (GRCm39)	S1303P	possibly damaging	Het
Mcm2	T	C	6: 88,864,928 (GRCm39)	D516G	probably damaging	Het
Mon2	A	T	10: 122,874,364 (GRCm39)		probably null	Het
Mrc2	T	A	11: 105,216,629 (GRCm39)	N139K	probably damaging	Het
Myh14	C	T	7: 44,261,125 (GRCm39)	E1789K	probably damaging	Het
Myh7b	T	A	2: 155,460,660 (GRCm39)	L271Q	probably damaging	Het
Oog2	A	T	4: 143,921,912 (GRCm39)	H274L	probably benign	Het
Oosp1	A	C	19: 11,645,774 (GRCm39)	S121R	probably benign	Het
Or13a28	T	C	7: 140,218,267 (GRCm39)	S218P	probably damaging	Het
Or8k3b	A	G	2: 86,521,166 (GRCm39)	V51A	probably benign	Het
Pepd	T	C	7: 34,721,197 (GRCm39)		probably null	Het
Pik3c2a	A	C	7: 116,005,178 (GRCm39)	S363R	probably benign	Het
Polr2b	T	C	5: 77,468,868 (GRCm39)	Y215H	probably benign	Het
Ppcdc	A	T	9: 57,321,958 (GRCm39)	V194E	probably benign	Het
Rabgap1l	A	C	1: 160,509,667 (GRCm39)	I470S	probably benign	Het
Scgb1b3	G	A	7: 31,075,383 (GRCm39)	A78T	probably benign	Het
Slc9a5	T	A	8: 106,083,345 (GRCm39)	L368Q	probably damaging	Het
Spef2	T	A	15: 9,647,576 (GRCm39)	I944F	possibly damaging	Het
Syne1	T	A	10: 5,206,805 (GRCm39)	H3461L	probably benign	Het
Tas2r134	A	G	2: 51,518,145 (GRCm39)	Y208C	probably benign	Het
Tasor	A	G	14: 27,193,809 (GRCm39)	E1003G	probably damaging	Het
Tm9sf3	G	A	19: 41,227,198 (GRCm39)	S291F	probably damaging	Het
Tra2a	G	A	6: 49,227,921 (GRCm39)	T69I	unknown	Het
Ube2q1	T	A	3: 89,683,898 (GRCm39)	L171Q	possibly damaging	Het
Ufd1	A	G	16: 18,636,715 (GRCm39)	T78A	probably damaging	Het
Vmn1r13	T	C	6: 57,187,587 (GRCm39)	S249P	probably damaging	Het
Wdr91	G	A	6: 34,861,258 (GRCm39)	S648L	probably benign	Het
Zfp51	T	A	17: 21,684,058 (GRCm39)	N224K	probably benign	Het

Other mutations in Flnc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00952:Flnc	APN	6	29,459,546 (GRCm39)	nonsense	probably null
IGL01099:Flnc	APN	6	29,433,617 (GRCm39)	missense	probably damaging	0.99
IGL01656:Flnc	APN	6	29,443,507 (GRCm39)	splice site	probably benign
IGL01659:Flnc	APN	6	29,448,670 (GRCm39)	missense	probably damaging	0.98
IGL01780:Flnc	APN	6	29,438,492 (GRCm39)	nonsense	probably null
IGL01935:Flnc	APN	6	29,454,279 (GRCm39)	missense	probably damaging	1.00
IGL02039:Flnc	APN	6	29,450,718 (GRCm39)	missense	probably benign	0.05
IGL02119:Flnc	APN	6	29,447,511 (GRCm39)	missense	probably damaging	0.98
IGL02122:Flnc	APN	6	29,444,335 (GRCm39)	missense	possibly damaging	0.70
IGL02236:Flnc	APN	6	29,454,375 (GRCm39)	missense	probably damaging	1.00
IGL02350:Flnc	APN	6	29,438,492 (GRCm39)	nonsense	probably null
IGL02357:Flnc	APN	6	29,438,492 (GRCm39)	nonsense	probably null
IGL02428:Flnc	APN	6	29,451,484 (GRCm39)	missense	probably damaging	1.00
IGL02496:Flnc	APN	6	29,440,684 (GRCm39)	missense	probably damaging	0.98
IGL02516:Flnc	APN	6	29,450,840 (GRCm39)	missense	probably damaging	0.99
IGL02696:Flnc	APN	6	29,446,697 (GRCm39)	missense	probably damaging	0.98
IGL03165:Flnc	APN	6	29,449,377 (GRCm39)	missense	probably damaging	1.00
IGL03190:Flnc	APN	6	29,445,636 (GRCm39)	splice site	probably benign
I1329:Flnc	UTSW	6	29,451,414 (GRCm39)	missense	probably damaging	1.00
R0111:Flnc	UTSW	6	29,454,339 (GRCm39)	missense	probably damaging	0.99
R0665:Flnc	UTSW	6	29,455,530 (GRCm39)	missense	probably damaging	1.00
R0748:Flnc	UTSW	6	29,446,343 (GRCm39)	missense	probably damaging	0.99
R0960:Flnc	UTSW	6	29,441,511 (GRCm39)	missense	probably damaging	1.00
R1328:Flnc	UTSW	6	29,438,612 (GRCm39)	missense	probably damaging	1.00
R1502:Flnc	UTSW	6	29,438,693 (GRCm39)	missense	probably benign	0.45
R1544:Flnc	UTSW	6	29,444,079 (GRCm39)	missense	probably benign	0.00
R1565:Flnc	UTSW	6	29,455,170 (GRCm39)	missense	probably damaging	1.00
R1640:Flnc	UTSW	6	29,433,806 (GRCm39)	missense	possibly damaging	0.78
R1691:Flnc	UTSW	6	29,441,213 (GRCm39)	missense	probably benign	0.09
R1818:Flnc	UTSW	6	29,457,447 (GRCm39)	missense	probably damaging	1.00
R1826:Flnc	UTSW	6	29,455,184 (GRCm39)	missense	probably damaging	0.99
R1851:Flnc	UTSW	6	29,443,478 (GRCm39)	missense	probably damaging	1.00
R1898:Flnc	UTSW	6	29,438,665 (GRCm39)	nonsense	probably null
R1905:Flnc	UTSW	6	29,459,459 (GRCm39)	missense	probably damaging	1.00
R1985:Flnc	UTSW	6	29,444,415 (GRCm39)	splice site	probably benign
R2016:Flnc	UTSW	6	29,443,796 (GRCm39)	critical splice donor site	probably null
R2017:Flnc	UTSW	6	29,443,796 (GRCm39)	critical splice donor site	probably null
R2020:Flnc	UTSW	6	29,444,362 (GRCm39)	missense	probably damaging	0.97
R2104:Flnc	UTSW	6	29,450,734 (GRCm39)	critical splice donor site	probably null
R2132:Flnc	UTSW	6	29,443,675 (GRCm39)	missense	probably damaging	1.00
R2141:Flnc	UTSW	6	29,448,674 (GRCm39)	missense	probably damaging	1.00
R2197:Flnc	UTSW	6	29,459,134 (GRCm39)	missense	probably damaging	1.00
R2202:Flnc	UTSW	6	29,459,507 (GRCm39)	missense	probably damaging	1.00
R2203:Flnc	UTSW	6	29,459,507 (GRCm39)	missense	probably damaging	1.00
R2204:Flnc	UTSW	6	29,459,507 (GRCm39)	missense	probably damaging	1.00
R2205:Flnc	UTSW	6	29,459,507 (GRCm39)	missense	probably damaging	1.00
R2209:Flnc	UTSW	6	29,455,844 (GRCm39)	missense	possibly damaging	0.91
R2248:Flnc	UTSW	6	29,451,400 (GRCm39)	missense	probably damaging	0.99
R2258:Flnc	UTSW	6	29,438,665 (GRCm39)	nonsense	probably null
R2259:Flnc	UTSW	6	29,438,665 (GRCm39)	nonsense	probably null
R2280:Flnc	UTSW	6	29,438,665 (GRCm39)	nonsense	probably null
R2281:Flnc	UTSW	6	29,438,665 (GRCm39)	nonsense	probably null
R2873:Flnc	UTSW	6	29,447,542 (GRCm39)	missense	probably damaging	0.96
R2900:Flnc	UTSW	6	29,448,584 (GRCm39)	missense	probably damaging	0.98
R3788:Flnc	UTSW	6	29,454,056 (GRCm39)	missense	probably damaging	0.99
R3799:Flnc	UTSW	6	29,443,738 (GRCm39)	missense	probably damaging	1.00
R3801:Flnc	UTSW	6	29,447,403 (GRCm39)	missense	probably damaging	0.98
R3851:Flnc	UTSW	6	29,453,718 (GRCm39)	missense	probably damaging	1.00
R3910:Flnc	UTSW	6	29,459,426 (GRCm39)	missense	probably damaging	1.00
R3982:Flnc	UTSW	6	29,442,940 (GRCm39)	missense	probably damaging	1.00
R3983:Flnc	UTSW	6	29,442,940 (GRCm39)	missense	probably damaging	1.00
R4023:Flnc	UTSW	6	29,451,634 (GRCm39)	missense	possibly damaging	0.95
R4676:Flnc	UTSW	6	29,445,153 (GRCm39)	splice site	probably null
R4694:Flnc	UTSW	6	29,443,447 (GRCm39)	missense	probably damaging	1.00
R4695:Flnc	UTSW	6	29,440,428 (GRCm39)	missense	probably damaging	0.99
R4735:Flnc	UTSW	6	29,455,812 (GRCm39)	missense	probably damaging	1.00
R4773:Flnc	UTSW	6	29,445,038 (GRCm39)	missense	possibly damaging	0.96
R4828:Flnc	UTSW	6	29,455,166 (GRCm39)	missense	probably damaging	1.00
R4856:Flnc	UTSW	6	29,447,889 (GRCm39)	missense	probably damaging	1.00
R4879:Flnc	UTSW	6	29,460,805 (GRCm39)	missense	probably damaging	0.99
R4899:Flnc	UTSW	6	29,446,842 (GRCm39)	missense	probably benign	0.17
R4906:Flnc	UTSW	6	29,447,524 (GRCm39)	missense	probably damaging	0.99
R5089:Flnc	UTSW	6	29,447,812 (GRCm39)	missense	probably damaging	0.96
R5173:Flnc	UTSW	6	29,455,537 (GRCm39)	missense	probably damaging	1.00
R5174:Flnc	UTSW	6	29,448,893 (GRCm39)	missense	possibly damaging	0.91
R5290:Flnc	UTSW	6	29,457,553 (GRCm39)	missense	probably damaging	1.00
R5338:Flnc	UTSW	6	29,444,063 (GRCm39)	missense	possibly damaging	0.47
R5352:Flnc	UTSW	6	29,449,317 (GRCm39)	missense	possibly damaging	0.85
R5397:Flnc	UTSW	6	29,441,160 (GRCm39)	missense	possibly damaging	0.87
R5431:Flnc	UTSW	6	29,456,383 (GRCm39)	missense	possibly damaging	0.74
R5481:Flnc	UTSW	6	29,441,216 (GRCm39)	missense	probably damaging	1.00
R5511:Flnc	UTSW	6	29,458,897 (GRCm39)	missense	probably damaging	1.00
R5539:Flnc	UTSW	6	29,446,229 (GRCm39)	missense	probably damaging	1.00
R5549:Flnc	UTSW	6	29,453,690 (GRCm39)	missense	probably damaging	1.00
R5567:Flnc	UTSW	6	29,444,044 (GRCm39)	nonsense	probably null
R5584:Flnc	UTSW	6	29,446,627 (GRCm39)	missense	probably damaging	0.98
R5689:Flnc	UTSW	6	29,441,591 (GRCm39)	missense	probably benign	0.03
R5753:Flnc	UTSW	6	29,433,488 (GRCm39)	missense	probably benign
R5786:Flnc	UTSW	6	29,459,536 (GRCm39)	nonsense	probably null
R5822:Flnc	UTSW	6	29,459,429 (GRCm39)	missense	probably damaging	0.98
R5823:Flnc	UTSW	6	29,461,201 (GRCm39)	missense	probably damaging	0.99
R5933:Flnc	UTSW	6	29,441,105 (GRCm39)	missense	probably damaging	0.99
R6043:Flnc	UTSW	6	29,446,607 (GRCm39)	missense	probably damaging	1.00
R6320:Flnc	UTSW	6	29,459,062 (GRCm39)	missense	probably damaging	1.00
R6337:Flnc	UTSW	6	29,454,318 (GRCm39)	missense	probably damaging	0.99
R6399:Flnc	UTSW	6	29,458,882 (GRCm39)	missense	probably damaging	1.00
R6423:Flnc	UTSW	6	29,445,155 (GRCm39)	splice site	probably null
R6540:Flnc	UTSW	6	29,446,376 (GRCm39)	missense	possibly damaging	0.96
R6547:Flnc	UTSW	6	29,448,607 (GRCm39)	missense	probably damaging	0.98
R6717:Flnc	UTSW	6	29,450,901 (GRCm39)	small deletion	probably benign
R6875:Flnc	UTSW	6	29,445,748 (GRCm39)	missense	probably damaging	1.00
R7193:Flnc	UTSW	6	29,450,870 (GRCm39)	missense	probably damaging	1.00
R7255:Flnc	UTSW	6	29,445,765 (GRCm39)	missense	probably damaging	1.00
R7413:Flnc	UTSW	6	29,452,258 (GRCm39)	missense	probably damaging	1.00
R7422:Flnc	UTSW	6	29,455,470 (GRCm39)	missense	probably damaging	1.00
R7559:Flnc	UTSW	6	29,459,009 (GRCm39)	missense	probably damaging	1.00
R7632:Flnc	UTSW	6	29,446,984 (GRCm39)	missense	probably damaging	0.98
R7651:Flnc	UTSW	6	29,444,049 (GRCm39)	missense	probably benign	0.08
R7679:Flnc	UTSW	6	29,456,789 (GRCm39)	missense	probably benign	0.00
R7697:Flnc	UTSW	6	29,456,516 (GRCm39)	missense	probably damaging	0.98
R7788:Flnc	UTSW	6	29,456,443 (GRCm39)	missense	possibly damaging	0.67
R7852:Flnc	UTSW	6	29,440,897 (GRCm39)	missense	probably damaging	1.00
R7870:Flnc	UTSW	6	29,454,306 (GRCm39)	missense	probably damaging	1.00
R7873:Flnc	UTSW	6	29,456,990 (GRCm39)	missense	possibly damaging	0.88
R7921:Flnc	UTSW	6	29,447,769 (GRCm39)	missense	possibly damaging	0.58
R7950:Flnc	UTSW	6	29,456,381 (GRCm39)	missense	possibly damaging	0.61
R7953:Flnc	UTSW	6	29,447,828 (GRCm39)	missense	probably damaging	0.99
R7970:Flnc	UTSW	6	29,447,525 (GRCm39)	missense	possibly damaging	0.96
R8071:Flnc	UTSW	6	29,457,445 (GRCm39)	missense	probably damaging	1.00
R8143:Flnc	UTSW	6	29,441,484 (GRCm39)	missense	probably benign	0.20
R8166:Flnc	UTSW	6	29,433,731 (GRCm39)	missense	probably damaging	0.99
R8167:Flnc	UTSW	6	29,455,921 (GRCm39)	missense	probably damaging	0.98
R8306:Flnc	UTSW	6	29,449,369 (GRCm39)	missense	probably benign	0.05
R8428:Flnc	UTSW	6	29,450,849 (GRCm39)	missense	probably benign	0.36
R8466:Flnc	UTSW	6	29,438,621 (GRCm39)	missense	probably damaging	0.98
R8671:Flnc	UTSW	6	29,443,501 (GRCm39)	critical splice donor site	probably null
R8885:Flnc	UTSW	6	29,455,410 (GRCm39)	missense	probably damaging	0.96
R8922:Flnc	UTSW	6	29,456,835 (GRCm39)	missense	probably damaging	0.99
R8923:Flnc	UTSW	6	29,452,236 (GRCm39)	missense	probably damaging	1.00
R8985:Flnc	UTSW	6	29,440,499 (GRCm39)	missense	probably benign	0.37
R9075:Flnc	UTSW	6	29,447,646 (GRCm39)	missense	probably damaging	0.96
R9098:Flnc	UTSW	6	29,455,518 (GRCm39)	nonsense	probably null
R9162:Flnc	UTSW	6	29,455,860 (GRCm39)	missense	probably damaging	1.00
R9199:Flnc	UTSW	6	29,441,490 (GRCm39)	missense	probably benign	0.31
R9204:Flnc	UTSW	6	29,452,353 (GRCm39)	missense	possibly damaging	0.93
R9273:Flnc	UTSW	6	29,447,815 (GRCm39)	missense	probably benign	0.08
R9411:Flnc	UTSW	6	29,441,484 (GRCm39)	missense	probably benign
R9412:Flnc	UTSW	6	29,441,484 (GRCm39)	missense	probably benign
R9413:Flnc	UTSW	6	29,441,484 (GRCm39)	missense	probably benign
R9451:Flnc	UTSW	6	29,445,462 (GRCm39)	missense	probably damaging	0.98
R9524:Flnc	UTSW	6	29,461,109 (GRCm39)	missense	probably damaging	1.00
R9575:Flnc	UTSW	6	29,454,399 (GRCm39)	missense	probably damaging	0.98
R9582:Flnc	UTSW	6	29,460,736 (GRCm39)	missense	probably damaging	0.99
R9595:Flnc	UTSW	6	29,433,720 (GRCm39)	missense	probably benign	0.05
R9664:Flnc	UTSW	6	29,457,214 (GRCm39)	missense	probably damaging	1.00
R9665:Flnc	UTSW	6	29,455,447 (GRCm39)	missense	probably damaging	1.00
R9686:Flnc	UTSW	6	29,456,434 (GRCm39)	missense	possibly damaging	0.84
Z1088:Flnc	UTSW	6	29,457,150 (GRCm39)	missense	probably damaging	1.00
Z1177:Flnc	UTSW	6	29,457,129 (GRCm39)	missense	probably damaging	1.00
Z1177:Flnc	UTSW	6	29,447,544 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AAAAGGGTAGGGAGTCCTTTTGAC -3'
(R):5'- ACCATCATCATGTTGGTGCC -3'

Sequencing Primer
(F):5'- GTCCTTTTGACTAGTCCCGTGAC -3'
(R):5'- CATCATCATGTTGGTGCCTGGAG -3'

Posted On

2019-06-26