Incidental Mutation 'R7307:Frk'
ID 567323
Institutional Source Beutler Lab
Gene Symbol Frk
Ensembl Gene ENSMUSG00000019779
Gene Name fyn-related kinase
Synonyms BSK/IYK, GTK
MMRRC Submission 045366-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.190) question?
Stock # R7307 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 34359395-34487274 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 34467934 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 316 (M316K)
Ref Sequence ENSEMBL: ENSMUSP00000019913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019913] [ENSMUST00000170771]
AlphaFold Q922K9
PDB Structure Solution structure of the SH3 domain of Fyn-related kinase [SOLUTION NMR]
Solution structure of the SH2 domain of murine Fyn-related kinase [SOLUTION NMR]
Predicted Effect probably damaging
Transcript: ENSMUST00000019913
AA Change: M316K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000019913
Gene: ENSMUSG00000019779
AA Change: M316K

DomainStartEndE-ValueType
SH3 52 116 2.76e-19 SMART
SH2 121 206 4.97e-37 SMART
TyrKc 241 494 8.58e-137 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000170771
AA Change: M316K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000130289
Gene: ENSMUSG00000019779
AA Change: M316K

DomainStartEndE-ValueType
SH3 52 116 2.76e-19 SMART
SH2 121 206 4.97e-37 SMART
TyrKc 241 494 8.58e-137 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted null mutation do not exhibit increased susceptibility to spontaneous tumors nor increased sensitivity to inoizing radiation. Epithelial tissues appear similar to controls, but circulating levels of T3 were significantly reduced. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik G A 16: 16,936,259 (GRCm39) P155L probably benign Het
Adamts12 G T 15: 11,217,899 (GRCm39) L285F probably damaging Het
Ankrd6 A T 4: 32,816,949 (GRCm39) Y393N possibly damaging Het
Arhgap45 A G 10: 79,865,016 (GRCm39) Q993R probably benign Het
Arhgef33 G C 17: 80,654,549 (GRCm39) probably null Het
B4galnt3 T C 6: 120,192,392 (GRCm39) D448G probably benign Het
Capn1 C G 19: 6,043,938 (GRCm39) E564D possibly damaging Het
Ccdc85a A G 11: 28,349,384 (GRCm39) S474P probably benign Het
Cdk12 T A 11: 98,140,626 (GRCm39) L1289* probably null Het
Cramp1 A T 17: 25,193,719 (GRCm39) N920K possibly damaging Het
Cubn C T 2: 13,345,143 (GRCm39) S2091N probably damaging Het
Ddx1 A T 12: 13,273,960 (GRCm39) I581N probably damaging Het
Dnm2 A T 9: 21,396,983 (GRCm39) N487Y probably damaging Het
Enc1 A C 13: 97,381,601 (GRCm39) N37T probably damaging Het
Ephb3 T G 16: 21,040,976 (GRCm39) I932S probably benign Het
Gdap2 C T 3: 100,109,349 (GRCm39) R25C unknown Het
Gpat2 T A 2: 127,276,810 (GRCm39) D671E probably damaging Het
Gpr179 C T 11: 97,229,672 (GRCm39) E828K probably benign Het
Greb1l T C 18: 10,538,142 (GRCm39) Y1052H probably damaging Het
Gtf2f1 C T 17: 57,314,833 (GRCm39) S69N probably damaging Het
Hid1 A C 11: 115,239,308 (GRCm39) I785S probably damaging Het
Hmcn2 T C 2: 31,233,093 (GRCm39) I214T probably damaging Het
Hsd3b5 G T 3: 98,527,085 (GRCm39) F120L probably damaging Het
Kif16b C T 2: 142,554,851 (GRCm39) R649Q probably benign Het
Kif17 A T 4: 137,989,954 (GRCm39) E47D probably benign Het
Kmt2b T C 7: 30,279,896 (GRCm39) H1368R probably damaging Het
Kmt2d A T 15: 98,747,299 (GRCm39) S3342T unknown Het
Krt82 A G 15: 101,451,342 (GRCm39) C356R probably damaging Het
Lrit2 A G 14: 36,794,156 (GRCm39) K407E probably benign Het
Malt1 T A 18: 65,584,640 (GRCm39) H325Q possibly damaging Het
Mccc2 T G 13: 100,125,108 (GRCm39) D187A possibly damaging Het
Mgll T A 6: 88,791,103 (GRCm39) probably null Het
Mindy2 T G 9: 70,518,241 (GRCm39) E449A possibly damaging Het
Muc5b G A 7: 141,396,031 (GRCm39) V96M unknown Het
Nlrp4e A G 7: 23,020,953 (GRCm39) E480G probably benign Het
Nup98 A G 7: 101,784,002 (GRCm39) I1093T probably benign Het
Or13a26 G A 7: 140,285,060 (GRCm39) V299I probably benign Het
Or1j4 G A 2: 36,740,137 (GRCm39) M26I probably benign Het
Or4g7 A T 2: 111,309,105 (GRCm39) probably benign Het
Or52a20 G T 7: 103,366,173 (GRCm39) R124L probably damaging Het
Pcdhb6 A T 18: 37,468,531 (GRCm39) H484L probably benign Het
Phldb1 T C 9: 44,605,344 (GRCm39) T604A possibly damaging Het
Pitpnm3 G T 11: 71,961,790 (GRCm39) A275D probably damaging Het
Polr2a A T 11: 69,638,118 (GRCm39) probably null Het
Polr3a A G 14: 24,510,055 (GRCm39) C960R probably benign Het
Pou6f2 G A 13: 18,414,298 (GRCm39) A159V Het
Pramel11 A C 4: 143,623,345 (GRCm39) Y276* probably null Het
Pramel51 A C 12: 88,148,519 (GRCm39) C32W probably damaging Het
Psmc4 A G 7: 27,742,085 (GRCm39) V303A probably benign Het
Ptdss2 A G 7: 140,731,645 (GRCm39) N151S possibly damaging Het
Ptprk T A 10: 28,465,004 (GRCm39) Y1295* probably null Het
Rbm19 A G 5: 120,324,283 (GRCm39) K881E possibly damaging Het
Rcan2 T A 17: 44,331,993 (GRCm39) Y183* probably null Het
Rnd1 T C 15: 98,568,680 (GRCm39) E166G probably damaging Het
Rnf113a2 T A 12: 84,464,953 (GRCm39) C282S probably damaging Het
S100b G A 10: 76,092,926 (GRCm39) G20R probably benign Het
Sae1 G T 7: 16,102,469 (GRCm39) Y168* probably null Het
Samd9l C A 6: 3,372,600 (GRCm39) G1554* probably null Het
Samhd1 T C 2: 156,976,940 (GRCm39) S55G probably benign Het
Sgsm1 T C 5: 113,421,512 (GRCm39) D525G probably benign Het
Slc28a3 A T 13: 58,710,986 (GRCm39) M512K probably damaging Het
Slc9b2 T A 3: 135,024,151 (GRCm39) N67K probably benign Het
Smarca4 T A 9: 21,550,096 (GRCm39) I402N probably damaging Het
St7l T C 3: 104,796,669 (GRCm39) F261L probably benign Het
Syde2 T A 3: 145,721,553 (GRCm39) V1140D probably damaging Het
Syt6 T A 3: 103,494,788 (GRCm39) I251N probably damaging Het
Taok2 T C 7: 126,465,990 (GRCm39) E916G probably damaging Het
Tecta A G 9: 42,289,288 (GRCm39) S426P probably damaging Het
Thra T C 11: 98,655,134 (GRCm39) I338T probably damaging Het
Trub1 A T 19: 57,461,135 (GRCm39) Y137F probably damaging Het
Vps13b T C 15: 35,841,691 (GRCm39) F2574L probably benign Het
Ythdf3 T C 3: 16,237,664 (GRCm39) S2P possibly damaging Het
Zc3h13 T A 14: 75,567,981 (GRCm39) D1091E probably damaging Het
Zdhhc6 A G 19: 55,301,682 (GRCm39) Y100H probably damaging Het
Other mutations in Frk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Frk APN 10 34,360,239 (GRCm39) missense probably damaging 0.98
IGL01402:Frk APN 10 34,423,381 (GRCm39) missense probably damaging 1.00
IGL02197:Frk APN 10 34,360,330 (GRCm39) missense probably damaging 1.00
IGL02289:Frk APN 10 34,360,362 (GRCm39) missense probably damaging 0.99
IGL02618:Frk APN 10 34,459,960 (GRCm39) missense possibly damaging 0.88
IGL02885:Frk APN 10 34,360,067 (GRCm39) missense probably benign 0.03
IGL03256:Frk APN 10 34,483,838 (GRCm39) missense probably benign 0.00
R0299:Frk UTSW 10 34,360,367 (GRCm39) critical splice donor site probably null
R0697:Frk UTSW 10 34,483,833 (GRCm39) missense probably benign 0.12
R1033:Frk UTSW 10 34,484,454 (GRCm39) missense probably damaging 1.00
R1583:Frk UTSW 10 34,467,806 (GRCm39) critical splice acceptor site probably null
R1793:Frk UTSW 10 34,483,878 (GRCm39) missense probably benign 0.05
R2248:Frk UTSW 10 34,484,527 (GRCm39) missense probably benign 0.10
R3084:Frk UTSW 10 34,483,950 (GRCm39) missense probably damaging 1.00
R3086:Frk UTSW 10 34,483,950 (GRCm39) missense probably damaging 1.00
R3765:Frk UTSW 10 34,360,001 (GRCm39) start codon destroyed probably null 0.98
R3766:Frk UTSW 10 34,360,001 (GRCm39) start codon destroyed probably null 0.98
R3906:Frk UTSW 10 34,460,052 (GRCm39) missense probably benign 0.00
R4163:Frk UTSW 10 34,467,868 (GRCm39) missense probably damaging 0.98
R4486:Frk UTSW 10 34,484,377 (GRCm39) missense probably benign 0.10
R4591:Frk UTSW 10 34,481,829 (GRCm39) missense probably benign 0.03
R4821:Frk UTSW 10 34,360,233 (GRCm39) missense probably benign 0.01
R5070:Frk UTSW 10 34,360,280 (GRCm39) nonsense probably null
R6172:Frk UTSW 10 34,467,961 (GRCm39) missense probably damaging 1.00
R6572:Frk UTSW 10 34,459,963 (GRCm39) missense probably benign 0.00
R6619:Frk UTSW 10 34,481,835 (GRCm39) missense probably benign 0.22
R7486:Frk UTSW 10 34,423,292 (GRCm39) nonsense probably null
R7916:Frk UTSW 10 34,360,021 (GRCm39) missense possibly damaging 0.74
R8341:Frk UTSW 10 34,462,279 (GRCm39) missense probably damaging 1.00
R8675:Frk UTSW 10 34,484,493 (GRCm39) missense probably benign 0.00
R8801:Frk UTSW 10 34,423,402 (GRCm39) missense possibly damaging 0.78
R9608:Frk UTSW 10 34,481,873 (GRCm39) critical splice donor site probably null
Z1177:Frk UTSW 10 34,460,001 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CAGGAGGCAATCATGGTGTTTC -3'
(R):5'- TAGTAGTTGAGCTGGTCATGTTAAC -3'

Sequencing Primer
(F):5'- CTGTGGGGATAGGAATGCCTCAG -3'
(R):5'- GAGCTGGTCATGTTAACATTCATTC -3'
Posted On 2019-06-26