Mutagenetix > Incidental Mutation

Incidental Mutation 'R7308:Dnah11'

567408

Institutional Source

Beutler Lab

Gene Symbol

Dnah11

Ensembl Gene

ENSMUSG00000018581

Gene Name

dynein, axonemal, heavy chain 11

Synonyms

b2b598Clo, b2b1289Clo, b2b1203Clo, Dnahc11, avc4, b2b1279Clo, b2b1727Clo, lrd

MMRRC Submission

045323-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.661) question?

Stock #

R7308 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

117841717-118162778 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 117959010 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 2958 (S2958P)

Ref Sequence

ENSEMBL: ENSMUSP00000081867 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084806]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000084806
AA Change: S2958P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000081867
Gene: ENSMUSG00000018581
AA Change: S2958P

Domain	Start	End	E-Value	Type
low complexity region	18	28	N/A	INTRINSIC
Pfam:DHC_N1	218	794	1.6e-162	PFAM
low complexity region	1266	1282	N/A	INTRINSIC
Pfam:DHC_N2	1297	1705	1e-130	PFAM
low complexity region	1757	1773	N/A	INTRINSIC
AAA	1869	1963	1.51e0	SMART
Pfam:AAA_5	2150	2286	1.6e-12	PFAM
AAA	2474	2619	1.48e-1	SMART
AAA	2819	2931	4.57e-1	SMART
Pfam:MT	3069	3413	3.2e-162	PFAM
Pfam:AAA_9	3434	3656	2.9e-88	PFAM
Pfam:Dynein_heavy	3790	4486	7.1e-235	PFAM

Predicted Effect

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
PHENOTYPE: Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	T	C	7: 120,022,993 (GRCm39)	I43T	probably benign	Het
Ankar	G	A	1: 72,690,953 (GRCm39)	Q1175*	probably null	Het
Aqr	G	A	2: 113,934,543 (GRCm39)	A1366V	possibly damaging	Het
Arhgap45	G	A	10: 79,862,392 (GRCm39)		probably null	Het
Atf7ip	T	A	6: 136,542,087 (GRCm39)	M607K	probably benign	Het
BC028528	CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT	CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT	3: 95,795,448 (GRCm39)		probably benign	Het
BC028528	ACTGGTTCTGTGGTC	ACTGGTTCTGTGGTCCCTGGTTCTGTGGTC	3: 95,795,481 (GRCm39)		probably benign	Het
BC028528	TCACTGGTTCTGTGGTCACTGGTTCTGTGG	TCACTGGTTCTGTGGCCACTGGTTCTGTGGTCACTGGTTCTGTGG	3: 95,795,464 (GRCm39)		probably benign	Het
Bcar3	T	A	3: 122,302,142 (GRCm39)	V279E	probably benign	Het
Cd96	C	T	16: 45,892,097 (GRCm39)		probably null	Het
Cdca2	G	A	14: 67,932,440 (GRCm39)	P488S	probably benign	Het
Cfhr4	A	G	1: 139,682,041 (GRCm39)	V185A	possibly damaging	Het
Col4a2	T	G	8: 11,456,856 (GRCm39)		probably null	Het
Cyp4a12a	A	G	4: 115,184,955 (GRCm39)	R379G	possibly damaging	Het
Defb34	A	G	8: 19,176,395 (GRCm39)	S29G	probably benign	Het
Dync1h1	A	G	12: 110,631,596 (GRCm39)	D4431G	possibly damaging	Het
Egfem1	A	T	3: 29,206,015 (GRCm39)	H84L	probably benign	Het
Enah	A	T	1: 181,733,950 (GRCm39)		probably null	Het
Fam178b	G	T	1: 36,698,488 (GRCm39)	Q78K	probably benign	Het
Glb1	A	G	9: 114,302,931 (GRCm39)	N589S	probably damaging	Het
Gm1527	C	T	3: 28,956,429 (GRCm39)	H132Y	probably benign	Het
Gm5799	A	G	14: 43,781,164 (GRCm39)	R22G	possibly damaging	Het
Grip2	T	C	6: 91,755,669 (GRCm39)	D617G	possibly damaging	Het
Hax1	A	T	3: 89,905,873 (GRCm39)	D5E	possibly damaging	Het
Hic1	A	G	11: 75,057,977 (GRCm39)	L304P	probably damaging	Het
Hmox1	T	A	8: 75,823,647 (GRCm39)	I105N	probably damaging	Het
Hormad1	T	C	3: 95,469,866 (GRCm39)	S38P	probably damaging	Het
Hspa4	A	G	11: 53,157,930 (GRCm39)	S558P	possibly damaging	Het
Kcnf1	T	A	12: 17,224,730 (GRCm39)	H497L	probably benign	Het
Kcnma1	C	T	14: 23,381,003 (GRCm39)	D1022N	probably damaging	Het
Kcnt1	T	C	2: 25,790,475 (GRCm39)	F479S	possibly damaging	Het
Krba1	T	C	6: 48,383,273 (GRCm39)	V203A	probably benign	Het
Lct	G	T	1: 128,246,824 (GRCm39)	P233Q	probably benign	Het
Ly75	T	C	2: 60,164,859 (GRCm39)	D773G	probably benign	Het
Malt1	T	C	18: 65,582,680 (GRCm39)		probably null	Het
Man1a2	A	T	3: 100,527,421 (GRCm39)	L333Q	probably damaging	Het
Mtus1	T	C	8: 41,535,965 (GRCm39)	T584A	probably benign	Het
Myof	A	T	19: 37,899,359 (GRCm39)	S1800R	probably damaging	Het
Nbea	A	C	3: 55,998,452 (GRCm39)	C118W	probably damaging	Het
Nsd3	A	T	8: 26,130,740 (GRCm39)	D35V	probably damaging	Het
Ntaq1	T	C	15: 58,016,006 (GRCm39)	V85A	possibly damaging	Het
Or11g24	G	A	14: 50,662,722 (GRCm39)	V249I	possibly damaging	Het
Or2y1c	G	A	11: 49,360,754 (GRCm39)		probably benign	Het
Pcnx3	C	T	19: 5,736,175 (GRCm39)	R217H	possibly damaging	Het
Pcsk4	G	A	10: 80,159,007 (GRCm39)	P462L	probably benign	Het
Pdia5	T	G	16: 35,276,879 (GRCm39)	K96N	probably damaging	Het
Pik3c2a	T	C	7: 115,973,074 (GRCm39)	Y707C	probably damaging	Het
Ppig	A	T	2: 69,579,806 (GRCm39)	N447Y	unknown	Het
Ppp1r9b	T	C	11: 94,895,397 (GRCm39)	L695P	possibly damaging	Het
Proser1	C	T	3: 53,386,125 (GRCm39)	A669V	probably benign	Het
Rdx	A	T	9: 51,980,170 (GRCm39)	K254N	probably damaging	Het
Slc35f2	T	C	9: 53,705,294 (GRCm39)	S95P	probably benign	Het
Slc4a3	T	A	1: 75,534,006 (GRCm39)	S1118T	probably benign	Het
Slf1	G	A	13: 77,199,287 (GRCm39)	P698L	probably benign	Het
Sptbn2	A	G	19: 4,801,602 (GRCm39)	E2338G	probably benign	Het
Taok3	T	A	5: 117,338,216 (GRCm39)	Y91*	probably null	Het
Tbc1d31	C	T	15: 57,816,212 (GRCm39)	L649F	probably damaging	Het
Tdpoz8	A	G	3: 92,981,872 (GRCm39)	T223A	probably benign	Het
Tmem132b	A	T	5: 125,864,710 (GRCm39)	I939F	possibly damaging	Het
Trav17	T	A	14: 54,044,436 (GRCm39)	Y69N	probably benign	Het
Trmt13	T	C	3: 116,388,388 (GRCm39)	D16G	probably benign	Het
Upf2	T	A	2: 5,978,329 (GRCm39)	Y398N	unknown	Het
Vmn1r238	T	C	18: 3,122,875 (GRCm39)	T180A	probably benign	Het
Zfp738	A	T	13: 67,817,672 (GRCm39)	I773N	probably benign	Het
Zscan4e	A	T	7: 11,041,080 (GRCm39)	M264K	probably benign	Het

Other mutations in Dnah11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Dnah11	APN	12	118,162,480 (GRCm39)	missense	probably benign	0.28
IGL00422:Dnah11	APN	12	118,031,831 (GRCm39)	missense	probably damaging	1.00
IGL00436:Dnah11	APN	12	118,000,194 (GRCm39)	missense	possibly damaging	0.56
IGL00540:Dnah11	APN	12	118,150,657 (GRCm39)	missense	probably benign	0.01
IGL00687:Dnah11	APN	12	117,885,739 (GRCm39)	splice site	probably benign
IGL00833:Dnah11	APN	12	118,143,315 (GRCm39)	missense	probably damaging	1.00
IGL00906:Dnah11	APN	12	117,874,937 (GRCm39)	missense	probably damaging	1.00
IGL00952:Dnah11	APN	12	118,160,386 (GRCm39)	missense	possibly damaging	0.56
IGL01111:Dnah11	APN	12	118,106,669 (GRCm39)	splice site	probably benign
IGL01121:Dnah11	APN	12	118,014,430 (GRCm39)	missense	probably benign	0.02
IGL01143:Dnah11	APN	12	117,976,475 (GRCm39)	missense	probably damaging	1.00
IGL01359:Dnah11	APN	12	117,946,734 (GRCm39)	missense	probably damaging	0.99
IGL01372:Dnah11	APN	12	118,156,134 (GRCm39)	missense	probably damaging	1.00
IGL01410:Dnah11	APN	12	118,010,991 (GRCm39)	nonsense	probably null
IGL01418:Dnah11	APN	12	117,951,217 (GRCm39)	nonsense	probably null
IGL01444:Dnah11	APN	12	117,983,967 (GRCm39)	missense	possibly damaging	0.91
IGL01606:Dnah11	APN	12	117,946,767 (GRCm39)	missense	probably benign	0.15
IGL01645:Dnah11	APN	12	118,150,733 (GRCm39)	missense	possibly damaging	0.90
IGL01932:Dnah11	APN	12	118,156,005 (GRCm39)	splice site	probably benign
IGL02104:Dnah11	APN	12	118,156,125 (GRCm39)	missense	probably benign
IGL02151:Dnah11	APN	12	118,023,623 (GRCm39)	splice site	probably benign
IGL02189:Dnah11	APN	12	118,046,314 (GRCm39)	missense	probably benign	0.00
IGL02417:Dnah11	APN	12	118,020,915 (GRCm39)	missense	probably damaging	1.00
IGL02421:Dnah11	APN	12	118,150,637 (GRCm39)	missense	probably damaging	1.00
IGL02444:Dnah11	APN	12	117,939,608 (GRCm39)	splice site	probably benign
IGL02474:Dnah11	APN	12	117,991,180 (GRCm39)	splice site	probably null
IGL02526:Dnah11	APN	12	118,143,353 (GRCm39)	missense	possibly damaging	0.70
IGL02887:Dnah11	APN	12	117,874,775 (GRCm39)	missense	probably damaging	1.00
IGL03011:Dnah11	APN	12	117,976,112 (GRCm39)	missense	probably benign	0.08
IGL03061:Dnah11	APN	12	117,866,856 (GRCm39)	missense	probably damaging	1.00
IGL03182:Dnah11	APN	12	117,994,026 (GRCm39)	missense	probably damaging	0.99
IGL03220:Dnah11	APN	12	118,069,720 (GRCm39)	missense	probably benign
IGL03238:Dnah11	APN	12	118,073,633 (GRCm39)	missense	probably damaging	1.00
IGL03493:Dnah11	APN	12	117,976,533 (GRCm39)	missense	probably benign	0.00
P0045:Dnah11	UTSW	12	117,994,062 (GRCm39)	missense	probably benign
R0009:Dnah11	UTSW	12	118,009,257 (GRCm39)	missense	possibly damaging	0.90
R0066:Dnah11	UTSW	12	118,090,621 (GRCm39)	missense	probably benign	0.05
R0172:Dnah11	UTSW	12	117,951,188 (GRCm39)	missense	probably damaging	1.00
R0206:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0206:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0208:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0230:Dnah11	UTSW	12	117,946,791 (GRCm39)	nonsense	probably null
R0270:Dnah11	UTSW	12	118,004,748 (GRCm39)	missense	probably damaging	1.00
R0311:Dnah11	UTSW	12	118,090,868 (GRCm39)	missense	probably benign	0.03
R0325:Dnah11	UTSW	12	117,976,074 (GRCm39)	missense	probably benign
R0370:Dnah11	UTSW	12	117,958,962 (GRCm39)	missense	probably benign
R0416:Dnah11	UTSW	12	117,874,793 (GRCm39)	missense	probably damaging	1.00
R0505:Dnah11	UTSW	12	118,070,245 (GRCm39)	missense	probably damaging	1.00
R0540:Dnah11	UTSW	12	118,046,246 (GRCm39)	missense	probably damaging	1.00
R0554:Dnah11	UTSW	12	117,894,913 (GRCm39)	missense	probably benign	0.01
R0607:Dnah11	UTSW	12	118,046,246 (GRCm39)	missense	probably damaging	1.00
R0620:Dnah11	UTSW	12	117,951,204 (GRCm39)	missense	probably damaging	1.00
R0635:Dnah11	UTSW	12	117,971,731 (GRCm39)	missense	probably damaging	1.00
R0755:Dnah11	UTSW	12	118,162,360 (GRCm39)	missense	probably benign	0.17
R0755:Dnah11	UTSW	12	117,918,564 (GRCm39)	missense	possibly damaging	0.95
R0789:Dnah11	UTSW	12	117,874,967 (GRCm39)	missense	probably damaging	1.00
R0833:Dnah11	UTSW	12	118,160,397 (GRCm39)	missense	probably benign	0.01
R0835:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R0836:Dnah11	UTSW	12	118,160,397 (GRCm39)	missense	probably benign	0.01
R0846:Dnah11	UTSW	12	117,897,585 (GRCm39)	missense	probably damaging	0.97
R0865:Dnah11	UTSW	12	118,154,579 (GRCm39)	nonsense	probably null
R0928:Dnah11	UTSW	12	118,009,297 (GRCm39)	missense	probably damaging	1.00
R0939:Dnah11	UTSW	12	118,024,142 (GRCm39)	missense	probably damaging	1.00
R1203:Dnah11	UTSW	12	117,897,547 (GRCm39)	missense	possibly damaging	0.81
R1394:Dnah11	UTSW	12	117,936,099 (GRCm39)	missense	possibly damaging	0.75
R1398:Dnah11	UTSW	12	118,020,841 (GRCm39)	nonsense	probably null
R1465:Dnah11	UTSW	12	118,002,430 (GRCm39)	missense	probably damaging	1.00
R1465:Dnah11	UTSW	12	118,002,430 (GRCm39)	missense	probably damaging	1.00
R1500:Dnah11	UTSW	12	117,976,564 (GRCm39)	splice site	probably null
R1535:Dnah11	UTSW	12	117,982,465 (GRCm39)	missense	probably damaging	1.00
R1539:Dnah11	UTSW	12	117,894,991 (GRCm39)	missense	probably benign	0.01
R1554:Dnah11	UTSW	12	118,046,234 (GRCm39)	missense	possibly damaging	0.92
R1574:Dnah11	UTSW	12	118,024,052 (GRCm39)	missense	probably damaging	1.00
R1574:Dnah11	UTSW	12	118,024,052 (GRCm39)	missense	probably damaging	1.00
R1615:Dnah11	UTSW	12	118,014,457 (GRCm39)	missense	probably damaging	1.00
R1618:Dnah11	UTSW	12	117,979,200 (GRCm39)	missense	probably damaging	0.98
R1638:Dnah11	UTSW	12	117,979,154 (GRCm39)	missense	possibly damaging	0.81
R1659:Dnah11	UTSW	12	118,084,459 (GRCm39)	missense	possibly damaging	0.94
R1671:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1678:Dnah11	UTSW	12	117,897,580 (GRCm39)	missense	possibly damaging	0.50
R1699:Dnah11	UTSW	12	118,154,603 (GRCm39)	missense	probably damaging	1.00
R1712:Dnah11	UTSW	12	118,160,379 (GRCm39)	missense	probably benign	0.32
R1728:Dnah11	UTSW	12	117,880,666 (GRCm39)	missense	probably damaging	1.00
R1729:Dnah11	UTSW	12	117,880,666 (GRCm39)	missense	probably damaging	1.00
R1764:Dnah11	UTSW	12	118,154,560 (GRCm39)	missense	probably benign	0.31
R1780:Dnah11	UTSW	12	117,991,293 (GRCm39)	missense	probably damaging	1.00
R1789:Dnah11	UTSW	12	118,002,515 (GRCm39)	missense	probably damaging	0.99
R1800:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1863:Dnah11	UTSW	12	118,027,587 (GRCm39)	missense	possibly damaging	0.92
R1892:Dnah11	UTSW	12	118,070,209 (GRCm39)	missense	possibly damaging	0.53
R1907:Dnah11	UTSW	12	118,091,291 (GRCm39)	missense	possibly damaging	0.66
R1964:Dnah11	UTSW	12	118,106,027 (GRCm39)	missense	possibly damaging	0.56
R1967:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1997:Dnah11	UTSW	12	118,046,203 (GRCm39)	missense	possibly damaging	0.64
R2086:Dnah11	UTSW	12	118,077,606 (GRCm39)	missense	possibly damaging	0.82
R2092:Dnah11	UTSW	12	117,976,451 (GRCm39)	missense	possibly damaging	0.50
R2108:Dnah11	UTSW	12	117,984,088 (GRCm39)	missense	probably damaging	1.00
R2140:Dnah11	UTSW	12	117,972,545 (GRCm39)	missense	probably benign	0.01
R2261:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2261:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2262:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2262:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2263:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2263:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2328:Dnah11	UTSW	12	117,850,421 (GRCm39)	missense	probably damaging	0.98
R2352:Dnah11	UTSW	12	117,892,065 (GRCm39)	missense	probably damaging	1.00
R2410:Dnah11	UTSW	12	117,991,262 (GRCm39)	missense	probably damaging	1.00
R2885:Dnah11	UTSW	12	117,951,162 (GRCm39)	nonsense	probably null
R3499:Dnah11	UTSW	12	117,874,758 (GRCm39)	missense	probably damaging	1.00
R3741:Dnah11	UTSW	12	118,095,076 (GRCm39)	missense	probably benign	0.05
R3742:Dnah11	UTSW	12	118,095,076 (GRCm39)	missense	probably benign	0.05
R3779:Dnah11	UTSW	12	118,094,448 (GRCm39)	splice site	probably benign
R3785:Dnah11	UTSW	12	117,981,337 (GRCm39)	missense	probably damaging	1.00
R3883:Dnah11	UTSW	12	117,942,188 (GRCm39)	splice site	probably benign
R4014:Dnah11	UTSW	12	117,938,649 (GRCm39)	missense	probably benign	0.16
R4043:Dnah11	UTSW	12	117,843,678 (GRCm39)	missense	probably damaging	1.00
R4072:Dnah11	UTSW	12	118,070,227 (GRCm39)	missense	probably damaging	1.00
R4073:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4074:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4076:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4201:Dnah11	UTSW	12	117,930,394 (GRCm39)	missense	possibly damaging	0.63
R4224:Dnah11	UTSW	12	118,094,627 (GRCm39)	missense	probably benign	0.06
R4233:Dnah11	UTSW	12	117,880,526 (GRCm39)	missense	probably damaging	1.00
R4358:Dnah11	UTSW	12	118,089,578 (GRCm39)	nonsense	probably null
R4430:Dnah11	UTSW	12	117,946,746 (GRCm39)	missense	probably benign	0.26
R4465:Dnah11	UTSW	12	117,951,186 (GRCm39)	missense	probably benign	0.09
R4489:Dnah11	UTSW	12	117,880,631 (GRCm39)	missense	probably benign	0.31
R4572:Dnah11	UTSW	12	117,973,860 (GRCm39)	missense	probably benign	0.00
R4574:Dnah11	UTSW	12	117,975,990 (GRCm39)	critical splice donor site	probably null
R4657:Dnah11	UTSW	12	118,156,162 (GRCm39)	missense	probably benign	0.02
R4709:Dnah11	UTSW	12	117,982,495 (GRCm39)	missense	probably benign	0.26
R4740:Dnah11	UTSW	12	118,084,279 (GRCm39)	missense	probably benign	0.28
R4803:Dnah11	UTSW	12	118,091,343 (GRCm39)	missense	possibly damaging	0.50
R4896:Dnah11	UTSW	12	117,958,935 (GRCm39)	missense	probably damaging	1.00
R4908:Dnah11	UTSW	12	118,090,618 (GRCm39)	missense	probably benign	0.37
R5018:Dnah11	UTSW	12	118,094,463 (GRCm39)	missense	probably benign	0.00
R5071:Dnah11	UTSW	12	118,046,188 (GRCm39)	nonsense	probably null
R5074:Dnah11	UTSW	12	118,046,188 (GRCm39)	nonsense	probably null
R5080:Dnah11	UTSW	12	118,162,565 (GRCm39)	start codon destroyed	probably null	0.01
R5097:Dnah11	UTSW	12	117,981,435 (GRCm39)	missense	probably damaging	1.00
R5131:Dnah11	UTSW	12	117,918,486 (GRCm39)	missense	probably damaging	1.00
R5215:Dnah11	UTSW	12	118,121,096 (GRCm39)	missense	probably benign	0.09
R5252:Dnah11	UTSW	12	118,089,676 (GRCm39)	missense	probably damaging	1.00
R5296:Dnah11	UTSW	12	117,847,151 (GRCm39)	missense	probably damaging	1.00
R5308:Dnah11	UTSW	12	118,049,415 (GRCm39)	missense	possibly damaging	0.60
R5368:Dnah11	UTSW	12	117,918,628 (GRCm39)	missense	probably damaging	1.00
R5383:Dnah11	UTSW	12	118,049,432 (GRCm39)	missense	probably damaging	0.99
R5499:Dnah11	UTSW	12	118,070,209 (GRCm39)	missense	possibly damaging	0.53
R5503:Dnah11	UTSW	12	117,844,186 (GRCm39)	critical splice donor site	probably null
R5546:Dnah11	UTSW	12	117,939,583 (GRCm39)	missense	possibly damaging	0.83
R5578:Dnah11	UTSW	12	117,982,537 (GRCm39)	missense	probably damaging	0.99
R5657:Dnah11	UTSW	12	117,847,352 (GRCm39)	missense	probably damaging	1.00
R5702:Dnah11	UTSW	12	118,077,642 (GRCm39)	missense	probably benign	0.04
R5706:Dnah11	UTSW	12	117,987,670 (GRCm39)	missense	probably damaging	1.00
R5727:Dnah11	UTSW	12	118,090,841 (GRCm39)	missense	probably damaging	1.00
R5737:Dnah11	UTSW	12	118,156,125 (GRCm39)	missense	probably benign
R5884:Dnah11	UTSW	12	118,141,269 (GRCm39)	missense	probably benign	0.00
R5900:Dnah11	UTSW	12	118,046,166 (GRCm39)	splice site	probably null
R5905:Dnah11	UTSW	12	117,918,659 (GRCm39)	missense	probably damaging	1.00
R5928:Dnah11	UTSW	12	117,878,371 (GRCm39)	splice site	probably null
R5973:Dnah11	UTSW	12	118,074,687 (GRCm39)	missense	probably benign	0.02
R6024:Dnah11	UTSW	12	117,994,007 (GRCm39)	missense	probably benign	0.34
R6056:Dnah11	UTSW	12	117,892,191 (GRCm39)	missense	probably benign	0.03
R6075:Dnah11	UTSW	12	118,068,586 (GRCm39)	missense	probably damaging	1.00
R6092:Dnah11	UTSW	12	117,892,191 (GRCm39)	missense	probably benign
R6191:Dnah11	UTSW	12	118,154,632 (GRCm39)	missense	probably benign
R6197:Dnah11	UTSW	12	118,143,482 (GRCm39)	missense	probably benign	0.03
R6262:Dnah11	UTSW	12	117,894,913 (GRCm39)	missense	probably damaging	0.98
R6321:Dnah11	UTSW	12	118,106,027 (GRCm39)	missense	possibly damaging	0.56
R6454:Dnah11	UTSW	12	117,880,590 (GRCm39)	missense	probably benign	0.01
R6614:Dnah11	UTSW	12	117,850,411 (GRCm39)	missense	possibly damaging	0.72
R6694:Dnah11	UTSW	12	118,150,617 (GRCm39)	splice site	probably null
R6712:Dnah11	UTSW	12	118,014,457 (GRCm39)	missense	probably damaging	1.00
R6720:Dnah11	UTSW	12	118,009,381 (GRCm39)	missense	probably damaging	1.00
R6742:Dnah11	UTSW	12	118,077,629 (GRCm39)	missense	possibly damaging	0.82
R6806:Dnah11	UTSW	12	117,951,411 (GRCm39)	splice site	probably null
R6895:Dnah11	UTSW	12	117,958,926 (GRCm39)	missense	probably damaging	0.99
R6939:Dnah11	UTSW	12	118,070,297 (GRCm39)	missense	probably damaging	1.00
R6940:Dnah11	UTSW	12	118,162,503 (GRCm39)	missense	probably benign
R6945:Dnah11	UTSW	12	118,024,045 (GRCm39)	missense	probably damaging	1.00
R6958:Dnah11	UTSW	12	117,897,544 (GRCm39)	missense	probably damaging	1.00
R6970:Dnah11	UTSW	12	118,072,679 (GRCm39)	missense	probably benign	0.00
R6976:Dnah11	UTSW	12	118,162,378 (GRCm39)	missense	probably benign	0.16
R7000:Dnah11	UTSW	12	117,981,396 (GRCm39)	missense	probably damaging	1.00
R7011:Dnah11	UTSW	12	117,885,753 (GRCm39)	frame shift	probably null
R7101:Dnah11	UTSW	12	118,031,880 (GRCm39)	missense	probably benign
R7106:Dnah11	UTSW	12	117,924,884 (GRCm39)	missense	probably benign	0.15
R7203:Dnah11	UTSW	12	118,009,257 (GRCm39)	missense	possibly damaging	0.90
R7219:Dnah11	UTSW	12	118,090,624 (GRCm39)	missense	probably benign	0.00
R7219:Dnah11	UTSW	12	118,004,830 (GRCm39)	missense	possibly damaging	0.95
R7361:Dnah11	UTSW	12	117,982,477 (GRCm39)	missense	probably damaging	1.00
R7367:Dnah11	UTSW	12	117,951,177 (GRCm39)	missense	possibly damaging	0.59
R7399:Dnah11	UTSW	12	118,089,520 (GRCm39)	missense	probably damaging	1.00
R7399:Dnah11	UTSW	12	117,991,212 (GRCm39)	missense	probably benign	0.00
R7404:Dnah11	UTSW	12	118,068,543 (GRCm39)	missense	probably benign	0.36
R7473:Dnah11	UTSW	12	117,866,911 (GRCm39)	missense	probably benign	0.19
R7545:Dnah11	UTSW	12	117,894,939 (GRCm39)	missense	probably damaging	1.00
R7608:Dnah11	UTSW	12	118,104,505 (GRCm39)	splice site	probably null
R7625:Dnah11	UTSW	12	118,160,377 (GRCm39)	missense	probably benign
R7761:Dnah11	UTSW	12	117,987,648 (GRCm39)	missense	probably damaging	1.00
R7879:Dnah11	UTSW	12	118,004,744 (GRCm39)	missense	probably damaging	1.00
R7881:Dnah11	UTSW	12	117,951,237 (GRCm39)	missense	probably benign	0.04
R7904:Dnah11	UTSW	12	117,867,003 (GRCm39)	missense	possibly damaging	0.72
R8100:Dnah11	UTSW	12	117,930,368 (GRCm39)	missense	probably damaging	0.99
R8179:Dnah11	UTSW	12	117,842,284 (GRCm39)	missense	possibly damaging	0.90
R8192:Dnah11	UTSW	12	117,976,181 (GRCm39)	missense	probably benign
R8254:Dnah11	UTSW	12	117,842,259 (GRCm39)	missense	possibly damaging	0.89
R8268:Dnah11	UTSW	12	117,991,243 (GRCm39)	nonsense	probably null
R8272:Dnah11	UTSW	12	118,074,752 (GRCm39)	missense	probably benign	0.01
R8344:Dnah11	UTSW	12	118,049,466 (GRCm39)	missense	probably benign	0.00
R8515:Dnah11	UTSW	12	117,939,533 (GRCm39)	missense	probably damaging	1.00
R8528:Dnah11	UTSW	12	117,972,538 (GRCm39)	missense	probably damaging	0.96
R8557:Dnah11	UTSW	12	117,842,247 (GRCm39)	missense	probably benign
R8676:Dnah11	UTSW	12	118,154,539 (GRCm39)	missense	probably damaging	1.00
R8738:Dnah11	UTSW	12	118,049,384 (GRCm39)	critical splice donor site	probably null
R8773:Dnah11	UTSW	12	117,958,950 (GRCm39)	missense	possibly damaging	0.94
R8818:Dnah11	UTSW	12	117,874,764 (GRCm39)	missense	probably damaging	1.00
R8855:Dnah11	UTSW	12	118,156,107 (GRCm39)	missense	probably benign	0.03
R8866:Dnah11	UTSW	12	118,156,107 (GRCm39)	missense	probably benign	0.03
R8881:Dnah11	UTSW	12	118,090,550 (GRCm39)	missense	probably benign	0.05
R8881:Dnah11	UTSW	12	118,077,647 (GRCm39)	missense	probably benign	0.00
R8920:Dnah11	UTSW	12	118,077,674 (GRCm39)	missense	probably damaging	0.99
R8944:Dnah11	UTSW	12	118,091,381 (GRCm39)	missense	possibly damaging	0.63
R8945:Dnah11	UTSW	12	117,987,718 (GRCm39)	missense	probably benign	0.36
R8962:Dnah11	UTSW	12	117,918,630 (GRCm39)	missense	probably damaging	1.00
R8962:Dnah11	UTSW	12	117,916,273 (GRCm39)	missense	probably damaging	1.00
R9059:Dnah11	UTSW	12	118,094,578 (GRCm39)	missense	probably benign	0.00
R9155:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9162:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9164:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9171:Dnah11	UTSW	12	117,894,918 (GRCm39)	missense	probably damaging	0.99
R9186:Dnah11	UTSW	12	118,154,632 (GRCm39)	missense	probably benign
R9205:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9208:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9234:Dnah11	UTSW	12	117,951,095 (GRCm39)	missense	probably damaging	1.00
R9264:Dnah11	UTSW	12	117,991,262 (GRCm39)	missense	probably damaging	1.00
R9290:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9291:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9315:Dnah11	UTSW	12	118,143,341 (GRCm39)	missense	probably benign	0.11
R9353:Dnah11	UTSW	12	118,143,434 (GRCm39)	missense	probably benign	0.00
R9375:Dnah11	UTSW	12	117,884,703 (GRCm39)	missense	possibly damaging	0.67
R9392:Dnah11	UTSW	12	118,141,290 (GRCm39)	missense	probably benign	0.00
R9392:Dnah11	UTSW	12	118,011,055 (GRCm39)	nonsense	probably null
R9433:Dnah11	UTSW	12	117,976,007 (GRCm39)	missense	probably damaging	1.00
R9511:Dnah11	UTSW	12	117,878,352 (GRCm39)	missense	probably damaging	1.00
R9526:Dnah11	UTSW	12	118,150,711 (GRCm39)	missense	probably damaging	0.98
R9566:Dnah11	UTSW	12	117,938,728 (GRCm39)	missense	possibly damaging	0.69
R9673:Dnah11	UTSW	12	117,982,513 (GRCm39)	missense	possibly damaging	0.91
R9705:Dnah11	UTSW	12	118,094,770 (GRCm39)	missense	probably damaging	1.00
R9716:Dnah11	UTSW	12	118,024,148 (GRCm39)	missense	probably damaging	0.99
R9746:Dnah11	UTSW	12	117,842,311 (GRCm39)	nonsense	probably null
R9764:Dnah11	UTSW	12	117,884,704 (GRCm39)	missense	probably benign	0.05
RF023:Dnah11	UTSW	12	117,918,585 (GRCm39)	missense	probably damaging	1.00
RF047:Dnah11	UTSW	12	117,973,818 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,858,747 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,946,704 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah11	UTSW	12	118,094,534 (GRCm39)	missense	probably damaging	0.97
Z1176:Dnah11	UTSW	12	118,090,854 (GRCm39)	missense	probably benign	0.00
Z1176:Dnah11	UTSW	12	117,894,912 (GRCm39)	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- ACTGAAAGTGGCTGACCGAG -3'
(R):5'- AAAGTCAATGCTACCTTGCACC -3'

Sequencing Primer
(F):5'- CCTGCCAATAGTGTACTGAGACTTG -3'
(R):5'- AATGCTACCTTGCACCTTGCTG -3'

Posted On

2019-06-26