Incidental Mutation 'R7311:Morc3'
ID 567628
Institutional Source Beutler Lab
Gene Symbol Morc3
Ensembl Gene ENSMUSG00000039456
Gene Name microrchidia 3
Synonyms Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
MMRRC Submission 045367-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7311 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 93629009-93672961 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 93646061 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 218 (D218N)
Ref Sequence ENSEMBL: ENSMUSP00000144369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044068] [ENSMUST00000201097] [ENSMUST00000201754] [ENSMUST00000202261]
AlphaFold F7BJB9
Predicted Effect probably damaging
Transcript: ENSMUST00000044068
AA Change: D218N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000040152
Gene: ENSMUSG00000039456
AA Change: D218N

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000201097
AA Change: D147N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144058
Gene: ENSMUSG00000039456
AA Change: D147N

DomainStartEndE-ValueType
Blast:HATPase_c 1 70 4e-39 BLAST
Pfam:zf-CW 340 383 1.2e-16 PFAM
low complexity region 392 403 N/A INTRINSIC
low complexity region 557 566 N/A INTRINSIC
coiled coil region 692 798 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000201754
SMART Domains Protein: ENSMUSP00000144357
Gene: ENSMUSG00000039456

DomainStartEndE-ValueType
Pfam:HATPase_c 25 91 1.3e-6 PFAM
Pfam:HATPase_c_3 26 92 1.2e-8 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000202261
AA Change: D218N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144369
Gene: ENSMUSG00000039456
AA Change: D218N

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a null allele die at or within a day of birth. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001K19Rik A G 12: 110,635,184 (GRCm39) V118A probably benign Het
Accsl C T 2: 93,696,160 (GRCm39) G146D possibly damaging Het
Acsm1 A T 7: 119,237,305 (GRCm39) H206L probably damaging Het
Acta2 A G 19: 34,219,186 (GRCm39) Y339H probably damaging Het
Adcy2 T C 13: 68,779,073 (GRCm39) D989G probably damaging Het
Ahnak G A 19: 8,979,507 (GRCm39) A264T probably benign Het
Ahnak A G 19: 8,987,191 (GRCm39) D2825G possibly damaging Het
Akt1 G T 12: 112,623,587 (GRCm39) T291K probably damaging Het
Arhgap24 A G 5: 103,040,551 (GRCm39) D589G probably damaging Het
B4galnt3 G A 6: 120,192,396 (GRCm39) Q447* probably null Het
BC024063 C T 10: 81,945,993 (GRCm39) R538C possibly damaging Het
Bod1l A G 5: 41,951,676 (GRCm39) S2912P possibly damaging Het
Bysl A G 17: 47,912,710 (GRCm39) V360A possibly damaging Het
C1qb A G 4: 136,607,877 (GRCm39) V162A possibly damaging Het
Ccdc57 G A 11: 120,764,567 (GRCm39) P736L probably benign Het
Cep290 T A 10: 100,373,580 (GRCm39) F1287I probably damaging Het
Cntn1 T C 15: 92,130,156 (GRCm39) probably null Het
Col6a3 C T 1: 90,750,013 (GRCm39) G274R probably damaging Het
Cplane1 G T 15: 8,210,399 (GRCm39) V291F probably damaging Het
Cyb5r4 T C 9: 86,937,835 (GRCm39) C285R probably damaging Het
Cyp4f39 G A 17: 32,708,629 (GRCm39) C392Y probably damaging Het
Dcun1d3 A T 7: 119,458,734 (GRCm39) D100E probably damaging Het
Dhx58 A T 11: 100,588,997 (GRCm39) D516E probably benign Het
Dock5 T A 14: 68,065,951 (GRCm39) I351F probably benign Het
Elmod2 A C 8: 84,046,041 (GRCm39) probably null Het
Endov G A 11: 119,398,077 (GRCm39) A281T probably benign Het
Epyc A G 10: 97,485,562 (GRCm39) M1V probably null Het
Espnl T A 1: 91,251,290 (GRCm39) H128Q probably damaging Het
Fam20a A T 11: 109,565,454 (GRCm39) C452* probably null Het
Fam241b A G 10: 61,944,733 (GRCm39) V88A probably damaging Het
Fbxl9 A G 8: 106,042,299 (GRCm39) probably benign Het
Fgd3 A T 13: 49,450,166 (GRCm39) S28T possibly damaging Het
Fmn1 C A 2: 113,356,025 (GRCm39) P920Q unknown Het
Gpr139 G C 7: 118,744,089 (GRCm39) D165E probably benign Het
Hoxb1 A G 11: 96,257,927 (GRCm39) T286A possibly damaging Het
Ifi204 T A 1: 173,587,134 (GRCm39) E174D probably benign Het
Igf2bp2 A G 16: 21,880,632 (GRCm39) I555T possibly damaging Het
Ighv1-85 A G 12: 115,963,799 (GRCm39) I67T probably damaging Het
Ihh G C 1: 74,990,306 (GRCm39) P23R unknown Het
Irx2 T C 13: 72,779,396 (GRCm39) S227P probably damaging Het
Itga4 A G 2: 79,086,526 (GRCm39) I68V probably benign Het
Jsrp1 T A 10: 80,647,906 (GRCm39) T51S probably benign Het
Khdc4 T C 3: 88,619,002 (GRCm39) S569P probably damaging Het
Kifc2 G T 15: 76,547,010 (GRCm39) G306V probably damaging Het
L3mbtl2 T A 15: 81,551,588 (GRCm39) S85T possibly damaging Het
Lama1 T C 17: 68,074,380 (GRCm39) S944P Het
Lama4 T A 10: 38,902,631 (GRCm39) C202S probably damaging Het
Mrtfb T A 16: 13,223,718 (GRCm39) Y866* probably null Het
Myorg A G 4: 41,498,577 (GRCm39) I351T probably damaging Het
N4bp2l1 G A 5: 150,496,389 (GRCm39) T179I probably damaging Het
Narf A G 11: 121,139,976 (GRCm39) E270G probably benign Het
Nsd2 A G 5: 34,049,380 (GRCm39) D1205G probably damaging Het
Or10x1 T C 1: 174,196,759 (GRCm39) V92A probably benign Het
Or5an11 T C 19: 12,246,068 (GRCm39) V158A probably benign Het
Parl T C 16: 20,106,625 (GRCm39) T195A probably benign Het
Phrf1 A G 7: 140,820,846 (GRCm39) I158V unknown Het
Phtf1 T C 3: 103,904,980 (GRCm39) F543L possibly damaging Het
Plod2 T A 9: 92,466,611 (GRCm39) D190E probably damaging Het
Polr1a G T 6: 71,927,863 (GRCm39) K871N possibly damaging Het
Ppp2r5a A T 1: 191,089,998 (GRCm39) I252K probably damaging Het
Ptgir T A 7: 16,640,973 (GRCm39) D88E probably damaging Het
Raly T C 2: 154,699,340 (GRCm39) V48A probably damaging Het
Ripor1 T A 8: 106,344,447 (GRCm39) L527* probably null Het
Rnf213 T C 11: 119,307,373 (GRCm39) S678P Het
Rpf1 T A 3: 146,212,918 (GRCm39) Q306L probably benign Het
Rpl14 T C 9: 120,403,171 (GRCm39) I122T probably damaging Het
Scn9a C A 2: 66,314,748 (GRCm39) A1657S possibly damaging Het
Serpinb10 A G 1: 107,474,477 (GRCm39) Y213C probably damaging Het
Slc25a23 A G 17: 57,359,827 (GRCm39) L308P probably damaging Het
Smg9 T A 7: 24,120,058 (GRCm39) M387K probably benign Het
Socs3 G A 11: 117,858,614 (GRCm39) P148L probably benign Het
Susd3 A G 13: 49,401,906 (GRCm39) L14P probably benign Het
Syt14 T A 1: 192,662,858 (GRCm39) M80L probably benign Het
Tmprss2 T A 16: 97,369,616 (GRCm39) Y386F possibly damaging Het
Tmx3 T A 18: 90,558,195 (GRCm39) S416T probably benign Het
Treh A G 9: 44,597,245 (GRCm39) T555A probably benign Het
Ttc5 T G 14: 51,003,400 (GRCm39) Q428P probably damaging Het
Vmn2r73 A G 7: 85,521,192 (GRCm39) S259P possibly damaging Het
Vps4b A T 1: 106,719,434 (GRCm39) V38E probably damaging Het
Wdr83 C A 8: 85,802,890 (GRCm39) R177L probably benign Het
Zfp780b A G 7: 27,662,588 (GRCm39) F656L possibly damaging Het
Zfp995 A T 17: 22,099,641 (GRCm39) F198I probably benign Het
Zswim8 A T 14: 20,771,552 (GRCm39) Y1495F probably damaging Het
Other mutations in Morc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00561:Morc3 APN 16 93,670,283 (GRCm39) critical splice donor site probably null
IGL01015:Morc3 APN 16 93,659,534 (GRCm39) missense probably damaging 1.00
IGL01374:Morc3 APN 16 93,641,101 (GRCm39) missense probably damaging 1.00
IGL01634:Morc3 APN 16 93,670,125 (GRCm39) missense probably benign 0.02
IGL01845:Morc3 APN 16 93,657,455 (GRCm39) missense probably damaging 0.96
IGL02202:Morc3 APN 16 93,667,749 (GRCm39) missense probably benign 0.01
IGL02478:Morc3 APN 16 93,661,844 (GRCm39) splice site probably benign
IGL03026:Morc3 APN 16 93,659,612 (GRCm39) splice site probably benign
IGL03115:Morc3 APN 16 93,667,971 (GRCm39) missense probably damaging 0.99
Ballista UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
mindy UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
Pfaff UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
shield UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
sparkle UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
Stooges UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
Sword UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R0173:Morc3 UTSW 16 93,629,094 (GRCm39) splice site probably null
R0413:Morc3 UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
R0639:Morc3 UTSW 16 93,650,738 (GRCm39) missense probably damaging 1.00
R0842:Morc3 UTSW 16 93,670,284 (GRCm39) critical splice donor site probably null
R1134:Morc3 UTSW 16 93,667,557 (GRCm39) missense probably benign
R1162:Morc3 UTSW 16 93,649,996 (GRCm39) missense probably damaging 1.00
R1498:Morc3 UTSW 16 93,650,743 (GRCm39) missense probably damaging 1.00
R1520:Morc3 UTSW 16 93,641,129 (GRCm39) missense probably damaging 0.96
R1603:Morc3 UTSW 16 93,663,391 (GRCm39) missense probably benign
R1622:Morc3 UTSW 16 93,671,694 (GRCm39) missense probably benign 0.28
R1630:Morc3 UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
R1818:Morc3 UTSW 16 93,652,398 (GRCm39) missense probably damaging 1.00
R1902:Morc3 UTSW 16 93,667,385 (GRCm39) missense probably damaging 1.00
R2090:Morc3 UTSW 16 93,663,341 (GRCm39) missense probably benign 0.23
R2261:Morc3 UTSW 16 93,650,109 (GRCm39) splice site probably benign
R2360:Morc3 UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
R2407:Morc3 UTSW 16 93,641,215 (GRCm39) critical splice donor site probably null
R2519:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R3736:Morc3 UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
R3873:Morc3 UTSW 16 93,659,324 (GRCm39) missense probably damaging 0.99
R4114:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4115:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4116:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4472:Morc3 UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R4609:Morc3 UTSW 16 93,661,856 (GRCm39) missense probably benign 0.01
R4708:Morc3 UTSW 16 93,670,126 (GRCm39) missense probably benign 0.19
R4883:Morc3 UTSW 16 93,667,250 (GRCm39) critical splice acceptor site probably null
R4945:Morc3 UTSW 16 93,668,082 (GRCm39) missense probably damaging 1.00
R4965:Morc3 UTSW 16 93,657,475 (GRCm39) nonsense probably null
R5399:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R5481:Morc3 UTSW 16 93,659,543 (GRCm39) missense probably damaging 0.99
R5540:Morc3 UTSW 16 93,644,268 (GRCm39) missense probably benign
R5970:Morc3 UTSW 16 93,663,341 (GRCm39) missense possibly damaging 0.65
R6006:Morc3 UTSW 16 93,663,381 (GRCm39) missense possibly damaging 0.67
R6044:Morc3 UTSW 16 93,663,330 (GRCm39) missense probably benign 0.02
R6045:Morc3 UTSW 16 93,671,733 (GRCm39) missense probably damaging 1.00
R6155:Morc3 UTSW 16 93,659,313 (GRCm39) missense possibly damaging 0.94
R6165:Morc3 UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
R6225:Morc3 UTSW 16 93,642,082 (GRCm39) nonsense probably null
R6240:Morc3 UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
R6835:Morc3 UTSW 16 93,644,309 (GRCm39) missense probably damaging 1.00
R6918:Morc3 UTSW 16 93,650,023 (GRCm39) missense probably benign 0.36
R6944:Morc3 UTSW 16 93,667,460 (GRCm39) missense probably benign
R7398:Morc3 UTSW 16 93,671,748 (GRCm39) missense probably damaging 1.00
R7553:Morc3 UTSW 16 93,667,824 (GRCm39) missense probably damaging 0.98
R8056:Morc3 UTSW 16 93,642,064 (GRCm39) missense probably benign 0.07
R8299:Morc3 UTSW 16 93,650,088 (GRCm39) missense probably damaging 1.00
R8317:Morc3 UTSW 16 93,659,417 (GRCm39) missense probably benign 0.25
R8542:Morc3 UTSW 16 93,644,319 (GRCm39) critical splice donor site probably null
R8697:Morc3 UTSW 16 93,667,908 (GRCm39) missense probably benign 0.00
R8739:Morc3 UTSW 16 93,657,398 (GRCm39) missense probably damaging 1.00
R9072:Morc3 UTSW 16 93,667,482 (GRCm39) missense probably benign 0.00
R9235:Morc3 UTSW 16 93,659,321 (GRCm39) missense probably damaging 1.00
R9305:Morc3 UTSW 16 93,667,302 (GRCm39) missense probably benign 0.00
R9405:Morc3 UTSW 16 93,642,036 (GRCm39) missense probably damaging 1.00
R9431:Morc3 UTSW 16 93,667,771 (GRCm39) nonsense probably null
R9440:Morc3 UTSW 16 93,649,975 (GRCm39) critical splice acceptor site probably null
R9524:Morc3 UTSW 16 93,667,401 (GRCm39) missense probably benign 0.09
R9571:Morc3 UTSW 16 93,641,107 (GRCm39) missense possibly damaging 0.89
X0023:Morc3 UTSW 16 93,644,287 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACCCCTTGCCTATGGTTTG -3'
(R):5'- CAAGCCTGCTAACAGTTATAGTAC -3'

Sequencing Primer
(F):5'- GCCTATGGTTTGCTTGCAC -3'
(R):5'- CTGGAACTCACTTTGTAGACCAGG -3'
Posted On 2019-06-26