Incidental Mutation 'R7316:Tpp2'
ID |
567929 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tpp2
|
Ensembl Gene |
ENSMUSG00000041763 |
Gene Name |
tripeptidyl peptidase II |
Synonyms |
TppII |
MMRRC Submission |
045413-MU
|
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.589)
|
Stock # |
R7316 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
1 |
Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 44009591 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Alanine
at position 475
(V475A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000085244
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
|
AlphaFold |
Q64514 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000087933
AA Change: V475A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
SMART Domains |
Protein: ENSMUSP00000085244 Gene: ENSMUSG00000041763 AA Change: V475A
Domain | Start | End | E-Value | Type |
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000186441
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000188302
AA Change: V475A
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
SMART Domains |
Protein: ENSMUSP00000140474 Gene: ENSMUSG00000041763 AA Change: V475A
Domain | Start | End | E-Value | Type |
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000188313
AA Change: V475A
PolyPhen 2
Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
|
SMART Domains |
Protein: ENSMUSP00000139918 Gene: ENSMUSG00000041763 AA Change: V475A
Domain | Start | End | E-Value | Type |
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000189388
AA Change: V475A
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
SMART Domains |
Protein: ENSMUSP00000140562 Gene: ENSMUSG00000041763 AA Change: V475A
Domain | Start | End | E-Value | Type |
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
Validation Efficiency |
99% (93/94) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008] PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 94 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4933434E20Rik |
G |
A |
3: 89,969,020 (GRCm39) |
M214I |
probably benign |
Het |
Aadat |
G |
T |
8: 60,979,668 (GRCm39) |
G177C |
probably damaging |
Het |
Adam4 |
T |
C |
12: 81,466,498 (GRCm39) |
I708V |
probably benign |
Het |
Aip |
T |
C |
19: 4,164,793 (GRCm39) |
N264S |
probably benign |
Het |
Alox8 |
A |
T |
11: 69,077,064 (GRCm39) |
D505E |
probably benign |
Het |
Ap3d1 |
A |
T |
10: 80,553,693 (GRCm39) |
I518N |
probably damaging |
Het |
Arf3 |
G |
A |
15: 98,638,874 (GRCm39) |
Q128* |
probably null |
Het |
Asph |
A |
G |
4: 9,537,746 (GRCm39) |
V344A |
probably benign |
Het |
Birc6 |
A |
T |
17: 74,911,489 (GRCm39) |
R1500S |
probably damaging |
Het |
Bptf |
G |
A |
11: 106,963,935 (GRCm39) |
T1753I |
probably damaging |
Het |
Bptf |
A |
T |
11: 107,001,740 (GRCm39) |
C457* |
probably null |
Het |
Brpf3 |
T |
A |
17: 29,033,660 (GRCm39) |
I568N |
probably damaging |
Het |
Btnl4 |
G |
C |
17: 34,688,031 (GRCm39) |
N582K |
probably benign |
Het |
Camsap3 |
C |
A |
8: 3,654,648 (GRCm39) |
P773T |
possibly damaging |
Het |
Capsl |
A |
T |
15: 9,461,888 (GRCm39) |
I95L |
probably benign |
Het |
Cd96 |
T |
A |
16: 45,890,016 (GRCm39) |
M336L |
probably benign |
Het |
Cdan1 |
A |
T |
2: 120,558,813 (GRCm39) |
|
probably null |
Het |
Chd3 |
A |
T |
11: 69,236,394 (GRCm39) |
L1939Q |
probably damaging |
Het |
Cngb3 |
A |
T |
4: 19,425,599 (GRCm39) |
Y469F |
probably benign |
Het |
Cp |
T |
C |
3: 20,026,916 (GRCm39) |
L448P |
probably damaging |
Het |
Csnk1g2 |
T |
C |
10: 80,475,687 (GRCm39) |
V418A |
possibly damaging |
Het |
Dag1 |
A |
T |
9: 108,086,701 (GRCm39) |
S147T |
probably benign |
Het |
Dnajc25 |
T |
A |
4: 59,017,693 (GRCm39) |
Y117* |
probably null |
Het |
Dpysl2 |
A |
T |
14: 67,100,044 (GRCm39) |
M64K |
possibly damaging |
Het |
Dus3l |
A |
G |
17: 57,072,551 (GRCm39) |
H38R |
possibly damaging |
Het |
Eme2 |
G |
A |
17: 25,113,840 (GRCm39) |
R62W |
probably damaging |
Het |
Enox1 |
A |
T |
14: 77,958,298 (GRCm39) |
M616L |
probably benign |
Het |
Epb41l4b |
T |
A |
4: 57,019,867 (GRCm39) |
T708S |
probably benign |
Het |
Fat2 |
A |
T |
11: 55,176,893 (GRCm39) |
I1534N |
probably damaging |
Het |
Fer1l5 |
A |
G |
1: 36,457,197 (GRCm39) |
T1649A |
probably benign |
Het |
Fmo9 |
A |
G |
1: 166,491,215 (GRCm39) |
V421A |
probably benign |
Het |
Fsip2 |
A |
C |
2: 82,820,035 (GRCm39) |
Y5256S |
possibly damaging |
Het |
Gapvd1 |
G |
A |
2: 34,594,681 (GRCm39) |
L804F |
probably damaging |
Het |
Garin1a |
A |
G |
6: 29,286,101 (GRCm39) |
M187V |
probably benign |
Het |
Gen1 |
A |
G |
12: 11,291,470 (GRCm39) |
V838A |
probably benign |
Het |
Gnptab |
A |
T |
10: 88,236,572 (GRCm39) |
N59I |
probably damaging |
Het |
Grm5 |
A |
G |
7: 87,624,473 (GRCm39) |
T347A |
probably benign |
Het |
Gsdmc3 |
T |
C |
15: 63,730,251 (GRCm39) |
N438D |
possibly damaging |
Het |
Hmcn1 |
A |
G |
1: 150,608,697 (GRCm39) |
L1495S |
probably damaging |
Het |
Ift70a1 |
A |
T |
2: 75,811,201 (GRCm39) |
L294Q |
probably damaging |
Het |
Islr2 |
T |
C |
9: 58,105,250 (GRCm39) |
E714G |
probably damaging |
Het |
Larp4 |
A |
T |
15: 99,898,898 (GRCm39) |
M430L |
probably benign |
Het |
Lpcat2b |
A |
G |
5: 107,580,979 (GRCm39) |
I103V |
not run |
Het |
Lrguk |
C |
T |
6: 34,080,191 (GRCm39) |
S1142F |
unknown |
Het |
Lrit2 |
G |
T |
14: 36,790,815 (GRCm39) |
V165F |
probably damaging |
Het |
Mast3 |
T |
A |
8: 71,232,432 (GRCm39) |
I1182F |
probably damaging |
Het |
Mcm6 |
C |
T |
1: 128,287,245 (GRCm39) |
D20N |
probably damaging |
Het |
Mief1 |
A |
G |
15: 80,133,598 (GRCm39) |
I218M |
probably damaging |
Het |
Mmp2 |
A |
G |
8: 93,567,038 (GRCm39) |
T453A |
probably benign |
Het |
Ms4a18 |
T |
A |
19: 10,979,360 (GRCm39) |
S219C |
probably damaging |
Het |
Myo5c |
A |
T |
9: 75,176,920 (GRCm39) |
T622S |
probably benign |
Het |
Neb |
A |
T |
2: 52,161,450 (GRCm39) |
M2114K |
possibly damaging |
Het |
Nemp1 |
T |
A |
10: 127,525,212 (GRCm39) |
L122* |
probably null |
Het |
Nkx2-1 |
T |
C |
12: 56,581,583 (GRCm39) |
N88S |
probably benign |
Het |
Nr2c2 |
T |
A |
6: 92,131,444 (GRCm39) |
C202S |
probably damaging |
Het |
Ntsr1 |
A |
C |
2: 180,142,545 (GRCm39) |
D112A |
probably damaging |
Het |
Or14j3 |
A |
G |
17: 37,901,026 (GRCm39) |
S73P |
probably damaging |
Het |
Or56a41 |
A |
T |
7: 104,740,107 (GRCm39) |
H246Q |
probably damaging |
Het |
Or6n2 |
A |
T |
1: 173,897,727 (GRCm39) |
I288F |
probably benign |
Het |
Osbp2 |
C |
A |
11: 3,676,431 (GRCm39) |
R73L |
probably damaging |
Het |
Pbp2 |
T |
A |
6: 135,286,830 (GRCm39) |
E172D |
probably damaging |
Het |
Pcdhgc3 |
T |
C |
18: 37,941,501 (GRCm39) |
I634T |
probably benign |
Het |
Pcnx1 |
T |
C |
12: 82,042,323 (GRCm39) |
S38P |
probably benign |
Het |
Phyh |
A |
T |
2: 4,940,855 (GRCm39) |
K252* |
probably null |
Het |
Plcb3 |
C |
T |
19: 6,943,753 (GRCm39) |
|
probably null |
Het |
Ppargc1b |
T |
C |
18: 61,440,909 (GRCm39) |
S670G |
probably damaging |
Het |
Prorp |
A |
G |
12: 55,351,429 (GRCm39) |
D246G |
probably damaging |
Het |
Ptprc |
T |
C |
1: 137,992,509 (GRCm39) |
Y1067C |
probably damaging |
Het |
Pwwp2b |
A |
C |
7: 138,836,140 (GRCm39) |
E527A |
probably benign |
Het |
Pzp |
T |
C |
6: 128,490,736 (GRCm39) |
D409G |
probably damaging |
Het |
Rbfox2 |
A |
T |
15: 77,016,929 (GRCm39) |
N148K |
possibly damaging |
Het |
Resf1 |
T |
C |
6: 149,228,136 (GRCm39) |
L394P |
probably damaging |
Het |
Rps24 |
T |
C |
14: 24,540,757 (GRCm39) |
|
probably benign |
Het |
Slc35e4 |
T |
C |
11: 3,862,584 (GRCm39) |
K202E |
probably damaging |
Het |
Spata7 |
C |
T |
12: 98,624,871 (GRCm39) |
R258W |
probably damaging |
Het |
Spen |
A |
T |
4: 141,204,365 (GRCm39) |
S1421T |
unknown |
Het |
Svep1 |
T |
A |
4: 58,068,763 (GRCm39) |
I3008F |
possibly damaging |
Het |
Tbc1d1 |
G |
T |
5: 64,492,620 (GRCm39) |
|
probably null |
Het |
Thsd4 |
T |
A |
9: 59,894,642 (GRCm39) |
H772L |
probably benign |
Het |
Tle1 |
T |
C |
4: 72,036,529 (GRCm39) |
I769V |
probably benign |
Het |
Tm4sf19 |
T |
A |
16: 32,226,466 (GRCm39) |
S127T |
possibly damaging |
Het |
Tmprss9 |
C |
A |
10: 80,730,813 (GRCm39) |
R780S |
probably benign |
Het |
Ttn |
A |
G |
2: 76,692,509 (GRCm39) |
V471A |
|
Het |
Ttn |
A |
T |
2: 76,597,257 (GRCm39) |
N19885K |
probably damaging |
Het |
Tub |
A |
T |
7: 108,629,378 (GRCm39) |
T478S |
possibly damaging |
Het |
Ube2q2l |
T |
C |
6: 136,378,276 (GRCm39) |
K185E |
possibly damaging |
Het |
Vmn2r88 |
A |
T |
14: 51,651,712 (GRCm39) |
Y342F |
|
Het |
Wdr18 |
C |
A |
10: 79,801,059 (GRCm39) |
D157E |
probably benign |
Het |
Xrra1 |
A |
T |
7: 99,525,423 (GRCm39) |
|
probably null |
Het |
Zc3h4 |
G |
C |
7: 16,169,260 (GRCm39) |
G1198A |
unknown |
Het |
Zfp568 |
A |
T |
7: 29,721,681 (GRCm39) |
I209F |
possibly damaging |
Het |
Zfp787 |
C |
A |
7: 6,158,523 (GRCm39) |
|
probably benign |
Het |
Zfp974 |
A |
T |
7: 27,609,863 (GRCm39) |
Y621N |
possibly damaging |
Het |
Zyg11b |
A |
G |
4: 108,107,699 (GRCm39) |
I493T |
possibly damaging |
Het |
|
Other mutations in Tpp2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
R0003:Tpp2
|
UTSW |
1 |
43,999,299 (GRCm39) |
missense |
possibly damaging |
0.94 |
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
R4963:Tpp2
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
R5073:Tpp2
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
R7454:Tpp2
|
UTSW |
1 |
43,993,819 (GRCm39) |
missense |
probably benign |
0.01 |
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
R7700:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
R8032:Tpp2
|
UTSW |
1 |
44,014,628 (GRCm39) |
missense |
possibly damaging |
0.82 |
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
R8519:Tpp2
|
UTSW |
1 |
44,016,365 (GRCm39) |
critical splice acceptor site |
probably null |
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
R9176:Tpp2
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
R9513:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
Predicted Primers |
PCR Primer
(F):5'- AAGTACTTGTGTGATGCAAGC -3'
(R):5'- CCACATCTAAAGTTTAGACATGCTG -3'
Sequencing Primer
(F):5'- GTGTGATGCAAGCAGTTTAAATC -3'
(R):5'- GACATGCTGAATCACTATTACAGAGC -3'
|
Posted On |
2019-06-26 |