Incidental Mutation 'R7322:Olfr362'
ID568193
Institutional Source Beutler Lab
Gene Symbol Olfr362
Ensembl Gene ENSMUSG00000075377
Gene Nameolfactory receptor 362
SynonymsMOR158-1, GA_x6K02T2NLDC-33797415-33796462
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #R7322 (G1)
Quality Score225.009
Status Not validated
Chromosome2
Chromosomal Location37101706-37117910 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 37105591 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glycine at position 20 (R20G)
Ref Sequence ENSEMBL: ENSMUSP00000150819 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100144] [ENSMUST00000213817] [ENSMUST00000215927]
Predicted Effect probably null
Transcript: ENSMUST00000100144
AA Change: R20G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000097722
Gene: ENSMUSG00000075377
AA Change: R20G

DomainStartEndE-ValueType
Pfam:7tm_4 32 313 6.3e-50 PFAM
Pfam:7TM_GPCR_Srsx 36 164 1.6e-7 PFAM
Pfam:7tm_1 42 295 1.3e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213817
AA Change: R20G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably null
Transcript: ENSMUST00000215927
AA Change: R20G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 A T 4: 53,067,151 V1352D probably damaging Het
Adam33 C T 2: 131,053,694 C567Y probably damaging Het
Alppl2 C A 1: 87,087,462 G422C probably benign Het
Ang T A 14: 51,101,411 I3K unknown Het
Ankrd10 A T 8: 11,615,841 V253E probably damaging Het
Arhgef17 T C 7: 100,877,797 I806V probably benign Het
Atp10b T C 11: 43,212,547 L586P probably damaging Het
Bdkrb1 T C 12: 105,604,304 V43A possibly damaging Het
Brinp3 C T 1: 146,682,688 R117* probably null Het
Brwd1 A T 16: 96,066,119 M172K probably damaging Het
Bsn G A 9: 108,126,421 R262* probably null Het
Bst2 A C 8: 71,537,207 L74R probably damaging Het
C1qa T C 4: 136,896,154 *246W probably null Het
Cadm2 G A 16: 66,882,846 T42M probably damaging Het
Ccdc150 A G 1: 54,259,966 T34A probably benign Het
Ccdc178 G A 18: 22,105,549 T337M probably benign Het
Ccl8 T C 11: 82,116,582 V81A probably damaging Het
Dgcr6 A G 16: 18,070,907 T69A unknown Het
Dnah10 A G 5: 124,821,269 D3762G probably benign Het
Eif3d T C 15: 77,961,676 T382A probably benign Het
Epb41 A T 4: 131,989,719 Y375N probably damaging Het
Epb41l1 A T 2: 156,503,851 H258L probably damaging Het
Fbn1 A C 2: 125,479,195 I81S possibly damaging Het
Fzd5 A G 1: 64,735,328 S425P probably damaging Het
Gfra2 T A 14: 70,968,391 V398D probably benign Het
Gm3755 A G 14: 7,448,178 L130P Het
Grin3b A G 10: 79,975,695 Y705C probably damaging Het
Hmcn2 A G 2: 31,459,081 D4944G probably damaging Het
Hoxd11 T C 2: 74,684,011 L295P probably damaging Het
Ighv1-81 C A 12: 115,920,667 G16C possibly damaging Het
Kcna5 T C 6: 126,533,791 D458G possibly damaging Het
Klb A T 5: 65,383,364 E933D probably benign Het
Lrp1 A T 10: 127,545,564 M3855K probably benign Het
Map3k4 A T 17: 12,270,946 L533I probably damaging Het
Mrps6 C A 16: 92,058,447 Y4* probably null Het
Nabp1 A T 1: 51,473,070 V105E probably damaging Het
Naip6 T A 13: 100,299,388 N876Y possibly damaging Het
Nlrp2 T C 7: 5,308,645 S944G possibly damaging Het
Nr4a3 A T 4: 48,083,238 E590D probably benign Het
Olfr1054 C T 2: 86,332,564 S264N probably benign Het
Olfr1106 A T 2: 87,048,479 Y252* probably null Het
Olfr1564 A G 17: 33,215,699 I215T probably damaging Het
Olfr597 T A 7: 103,321,287 V292E Het
Pcp4l1 G A 1: 171,174,465 A42V possibly damaging Het
Pdzd2 T C 15: 12,437,162 D451G probably damaging Het
Pkd2l1 A G 19: 44,157,690 S142P probably benign Het
Postn T C 3: 54,370,280 L232P probably damaging Het
Prss8 T C 7: 127,929,563 T33A probably benign Het
Rapgef2 A T 3: 79,145,823 M1K probably null Het
Rasa3 T C 8: 13,595,857 N161S possibly damaging Het
Riox1 G A 12: 83,950,668 probably benign Het
Rmdn2 A T 17: 79,621,611 K97N probably damaging Het
Sgo1 A G 17: 53,677,057 L431P probably damaging Het
Slc9a8 T A 2: 167,451,302 V217E probably damaging Het
Slco2b1 C T 7: 99,691,848 G21D not run Het
Spata31d1d C A 13: 59,726,976 R915L probably benign Het
Stk17b A T 1: 53,765,945 N152K probably benign Het
Syne2 T A 12: 75,984,024 I3634N probably damaging Het
Tnfrsf9 A G 4: 150,934,337 D155G probably damaging Het
Tnrc6a T A 7: 123,171,508 D840E probably benign Het
Tyk2 G A 9: 21,110,204 S902L probably benign Het
Unc119 T C 11: 78,348,623 S235P probably damaging Het
Vav1 A C 17: 57,302,266 D394A probably benign Het
Vezf1 T A 11: 88,081,584 I439K possibly damaging Het
Zadh2 A G 18: 84,095,135 Y312C probably damaging Het
Zfp335 A T 2: 164,910,821 M1K probably null Het
Zfp715 T C 7: 43,311,138 T10A possibly damaging Het
Zmynd11 C T 13: 9,690,409 E382K possibly damaging Het
Other mutations in Olfr362
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02032:Olfr362 APN 2 37104761 missense probably damaging 1.00
IGL02141:Olfr362 APN 2 37105425 missense probably benign 0.00
IGL02444:Olfr362 APN 2 37104774 missense probably damaging 0.99
IGL02453:Olfr362 APN 2 37105197 missense probably benign 0.22
R0699:Olfr362 UTSW 2 37105062 missense possibly damaging 0.92
R1053:Olfr362 UTSW 2 37105464 missense probably damaging 1.00
R1387:Olfr362 UTSW 2 37104868 missense probably benign 0.24
R4914:Olfr362 UTSW 2 37105158 missense possibly damaging 0.67
R4918:Olfr362 UTSW 2 37105158 missense possibly damaging 0.67
R5009:Olfr362 UTSW 2 37105455 missense possibly damaging 0.92
R5114:Olfr362 UTSW 2 37104802 missense probably damaging 1.00
R5301:Olfr362 UTSW 2 37105198 missense probably benign 0.01
R7440:Olfr362 UTSW 2 37105169 missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- ACTGTGGATAGTCCCAAGTCTATC -3'
(R):5'- GGAATGAGCTTCTAGAATGGGTTAG -3'

Sequencing Primer
(F):5'- TCCCAAGTCTATCATGGAGAGGC -3'
(R):5'- TGGGTTAGAAAAATAGACATAAGGGG -3'
Posted On2019-06-26