Incidental Mutation 'R7021:Obox5'
ID568365
Institutional Source Beutler Lab
Gene Symbol Obox5
Ensembl Gene ENSMUSG00000074366
Gene Nameoocyte specific homeobox 5
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.133) question?
Stock #R7021 (G1)
Quality Score225.009
Status Validated
Chromosome7
Chromosomal Location15750131-15759800 bp(+) (GRCm38)
Type of Mutationsplice site (3 bp from exon)
DNA Base Change (assembly) A to G at 15757756 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134468 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098802] [ENSMUST00000098802] [ENSMUST00000173053] [ENSMUST00000173053] [ENSMUST00000173455] [ENSMUST00000173455]
Predicted Effect probably null
Transcript: ENSMUST00000098802
SMART Domains Protein: ENSMUSP00000096400
Gene: ENSMUSG00000074366

DomainStartEndE-ValueType
low complexity region 62 74 N/A INTRINSIC
HOX 94 156 2e-17 SMART
Predicted Effect probably null
Transcript: ENSMUST00000098802
SMART Domains Protein: ENSMUSP00000096400
Gene: ENSMUSG00000074366

DomainStartEndE-ValueType
low complexity region 62 74 N/A INTRINSIC
HOX 94 156 2e-17 SMART
Predicted Effect probably null
Transcript: ENSMUST00000173053
SMART Domains Protein: ENSMUSP00000134618
Gene: ENSMUSG00000074366

DomainStartEndE-ValueType
low complexity region 62 74 N/A INTRINSIC
HOX 94 156 2e-17 SMART
Predicted Effect probably null
Transcript: ENSMUST00000173053
SMART Domains Protein: ENSMUSP00000134618
Gene: ENSMUSG00000074366

DomainStartEndE-ValueType
low complexity region 62 74 N/A INTRINSIC
HOX 94 156 2e-17 SMART
Predicted Effect probably null
Transcript: ENSMUST00000173455
SMART Domains Protein: ENSMUSP00000134468
Gene: ENSMUSG00000074366

DomainStartEndE-ValueType
low complexity region 62 74 N/A INTRINSIC
HOX 94 156 2e-17 SMART
Predicted Effect probably null
Transcript: ENSMUST00000173455
SMART Domains Protein: ENSMUSP00000134468
Gene: ENSMUSG00000074366

DomainStartEndE-ValueType
low complexity region 62 74 N/A INTRINSIC
HOX 94 156 2e-17 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 99% (75/76)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 C T 12: 118,931,925 V379I probably benign Het
Adamts15 T C 9: 30,921,480 Y253C probably damaging Het
Ahsa1 T C 12: 87,271,380 S37P possibly damaging Het
Arnt2 A T 7: 84,343,942 L130H probably damaging Het
Atp8b5 T A 4: 43,355,618 F533I probably damaging Het
Best1 A G 19: 9,986,779 V439A probably benign Het
Bicc1 A G 10: 70,961,148 V127A probably damaging Het
Brd7 T C 8: 88,347,004 T253A probably benign Het
Btd A G 14: 31,667,831 D503G probably benign Het
Ccdc80 A G 16: 45,104,441 E646G probably damaging Het
Ccl25 A G 8: 4,349,641 probably benign Het
Ccnf C A 17: 24,242,231 W150L probably damaging Het
Cdk11b A T 4: 155,641,567 probably benign Het
Cfap73 T C 5: 120,630,084 E203G probably benign Het
Cmya5 T C 13: 93,093,555 E1675G possibly damaging Het
Copg1 T A 6: 87,894,105 Y268N possibly damaging Het
Csnk2a1 T A 2: 152,260,812 H126Q probably damaging Het
Ctbs G A 3: 146,454,948 G90D probably damaging Het
Ctnna2 T C 6: 77,636,905 Y221C probably damaging Het
Cypt12 C T 3: 17,948,471 R3C unknown Het
D630003M21Rik A T 2: 158,216,750 M410K possibly damaging Het
Dnah9 A T 11: 65,981,231 N2724K probably benign Het
Dok3 T C 13: 55,524,284 T194A probably benign Het
Edem3 T G 1: 151,755,672 S36A probably benign Het
Eed C T 7: 89,980,519 E3K possibly damaging Het
Efcab2 A G 1: 178,481,360 I143V probably benign Het
Ensa A T 3: 95,627,048 probably null Het
Galnt16 A T 12: 80,580,052 E219V probably damaging Het
Gfra3 C A 18: 34,690,880 R347L probably benign Het
Gm13178 A C 4: 144,715,492 L63R probably damaging Het
Gm2042 T A 12: 87,960,239 I442K probably damaging Het
Gpld1 A T 13: 24,984,708 D735V probably damaging Het
Hspg2 T C 4: 137,542,269 S2253P possibly damaging Het
Kit T C 5: 75,620,967 I352T probably benign Het
Klra6 A T 6: 130,018,858 V179E possibly damaging Het
Lctl T A 9: 64,132,793 probably null Het
Lman1 C A 18: 65,991,643 V342L probably benign Het
Lrrn2 T C 1: 132,938,784 L529P probably damaging Het
Mab21l2 A G 3: 86,547,486 I69T probably benign Het
Mapkapk5 G T 5: 121,527,211 A327E probably benign Het
Mex3b G T 7: 82,869,872 R465L possibly damaging Het
Mgat3 A G 15: 80,212,454 N494S probably damaging Het
Mgat4c A G 10: 102,388,428 R168G possibly damaging Het
Mkks A G 2: 136,876,087 probably null Het
Muc16 G T 9: 18,554,919 H7368N unknown Het
Muc16 T C 9: 18,550,831 probably null Het
Nbeal1 G A 1: 60,261,586 probably null Het
Notch2 T C 3: 98,135,446 S1376P probably benign Het
Olfr16 T C 1: 172,956,927 I44T probably benign Het
Olfr765 A T 10: 129,047,030 I11N probably damaging Het
Pbrm1 A G 14: 31,067,816 I807V probably damaging Het
Pitrm1 T A 13: 6,578,557 V962E probably damaging Het
Pkd2l1 T C 19: 44,154,208 Q465R probably damaging Het
Pla1a A G 16: 38,400,882 I372T probably damaging Het
Prmt5 A C 14: 54,515,388 F122C probably damaging Het
Prrc2b T A 2: 32,221,486 S1905T probably damaging Het
Ptprf T G 4: 118,223,904 K1163N probably benign Het
Rab3ip A G 10: 116,939,378 V25A probably damaging Het
Raf1 T C 6: 115,620,339 probably null Het
Rnf180 T C 13: 105,270,921 E40G probably benign Het
Rpl6 T A 5: 121,208,909 M289K probably benign Het
Slc25a32 A G 15: 39,099,926 F167L probably benign Het
Slc30a2 G A 4: 134,347,415 R161Q probably damaging Het
Slc4a4 T A 5: 89,040,346 probably null Het
Sppl2a A G 2: 126,927,743 probably null Het
Tbr1 T A 2: 61,807,344 D82E probably benign Het
Tbx10 A T 19: 3,998,961 T291S probably benign Het
Tlr1 T A 5: 64,925,713 H507L possibly damaging Het
Trim37 A C 11: 87,167,509 T338P probably benign Het
Trpv5 T C 6: 41,653,270 T629A probably benign Het
Ttc14 T A 3: 33,803,497 I249N probably damaging Het
Uhrf1 A G 17: 56,320,450 T661A probably benign Het
Vmn2r65 A G 7: 84,947,379 I156T probably benign Het
Vwde T C 6: 13,186,906 N861D probably damaging Het
Zan A G 5: 137,423,951 C2802R unknown Het
Other mutations in Obox5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01151:Obox5 APN 7 15758591 missense possibly damaging 0.73
IGL02105:Obox5 APN 7 15758575 missense probably benign 0.10
IGL02590:Obox5 APN 7 15757592 missense possibly damaging 0.51
IGL02642:Obox5 APN 7 15758047 missense probably benign 0.01
IGL02700:Obox5 APN 7 15758963 missense possibly damaging 0.70
IGL03129:Obox5 APN 7 15758759 missense probably damaging 0.99
R0312:Obox5 UTSW 7 15757560 missense probably damaging 0.98
R0463:Obox5 UTSW 7 15757646 missense probably damaging 0.99
R0467:Obox5 UTSW 7 15758007 missense possibly damaging 0.73
R0899:Obox5 UTSW 7 15758875 missense probably benign 0.04
R1574:Obox5 UTSW 7 15758633 missense probably damaging 0.99
R1574:Obox5 UTSW 7 15758633 missense probably damaging 0.99
R2017:Obox5 UTSW 7 15758882 missense probably benign 0.02
R3711:Obox5 UTSW 7 15758788 missense probably benign 0.33
R4391:Obox5 UTSW 7 15757974 nonsense probably null
R5217:Obox5 UTSW 7 15757868 splice site probably null
R5357:Obox5 UTSW 7 15757538 start codon destroyed probably null 0.94
R5424:Obox5 UTSW 7 15758882 missense probably benign 0.09
R5559:Obox5 UTSW 7 15757597 missense probably benign 0.19
R6533:Obox5 UTSW 7 15757607 missense probably benign 0.14
R7097:Obox5 UTSW 7 15758807 missense probably damaging 0.99
R7122:Obox5 UTSW 7 15758807 missense probably damaging 0.99
R7180:Obox5 UTSW 7 15757924 missense probably benign 0.00
R7395:Obox5 UTSW 7 15758743 missense probably damaging 1.00
R7398:Obox5 UTSW 7 15758788 missense probably benign 0.33
R8111:Obox5 UTSW 7 15758616 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCATCCAAAACTTCAAGTGG -3'
(R):5'- CACAGTGCGTTCTTTTCGAAAC -3'

Sequencing Primer
(F):5'- CTTCAAGTGGCTTCAAATATACCC -3'
(R):5'- CGAAACTTTCTTGAAGCCATTGGG -3'
Posted On2019-07-10