Mutagenetix > Incidental Mutations

Incidental Mutation 'R7059:Olfr671'

568530

Institutional Source

Beutler Lab

Gene Symbol

Olfr671

Ensembl Gene

ENSMUSG00000094531

Gene Name

olfactory receptor 671

Synonyms

GA_x6K02T2PBJ9-7604826-7603885, MOR32-12

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R7059 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

104972896-104979126 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 104976017 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150911 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078710] [ENSMUST00000210963] [ENSMUST00000210963] [ENSMUST00000217091] [ENSMUST00000217091]

Predicted Effect

probably benign
Transcript: ENSMUST00000078710

SMART Domains

Protein: ENSMUSP00000077774
Gene: ENSMUSG00000094531

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	311	1.4e-117	PFAM
Pfam:7TM_GPCR_Srsx	37	308	3.7e-7	PFAM
Pfam:7tm_1	43	293	1.5e-17	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000210963

Predicted Effect

probably null
Transcript: ENSMUST00000210963

Predicted Effect

probably null
Transcript: ENSMUST00000217091

Predicted Effect

probably null
Transcript: ENSMUST00000217091

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

98% (54/55)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9430097D07Rik	T	C	2: 32,574,497		probably benign	Het
9930021J03Rik	T	A	19: 29,719,545	E849D	probably benign	Het
Abca16	A	G	7: 120,421,748	T5A	probably benign	Het
Abraxas1	T	C	5: 100,806,237	D349G	probably benign	Het
Adcyap1r1	T	A	6: 55,491,310	L405Q	probably damaging	Het
Aqp5	A	T	15: 99,594,246	T125S	probably benign	Het
Asah1	A	T	8: 41,347,069	N169K	probably damaging	Het
Atl3	A	G	19: 7,533,968	N515D	probably benign	Het
Atl3	A	C	19: 7,533,969	N520T	probably benign	Het
Atp6v1c2	C	A	12: 17,289,004	E249*	probably null	Het
Bcl2a1b	T	A	9: 89,199,760	I134K	probably damaging	Het
Btbd10	C	T	7: 113,329,922	R159H	probably damaging	Het
Chmp6	T	C	11: 119,916,040	F7L	probably damaging	Het
Colq	C	A	14: 31,526,034	C409F	probably damaging	Het
Cpox	T	A	16: 58,670,927	V167E	probably damaging	Het
Cul3	T	C	1: 80,276,424	Y545C	probably benign	Het
Dqx1	C	T	6: 83,064,809	A544V	probably benign	Het
Dzip3	A	G	16: 48,980,942	I73T	probably benign	Het
Epha3	T	A	16: 63,568,455	Y810F	probably damaging	Het
Esp36	A	T	17: 38,417,051	I113N	unknown	Het
Fbxw17	T	A	13: 50,432,548	W429R	probably damaging	Het
Fcrls	A	T	3: 87,257,340	I293N	possibly damaging	Het
Fhad1	CGG	CG	4: 141,918,291		probably null	Het
Gm8126	T	A	14: 43,261,518	L148H	probably benign	Het
Gpr39	C	A	1: 125,677,959	S208Y	probably damaging	Het
Heatr5a	T	C	12: 51,888,234	E1662G	probably damaging	Het
Hgfac	T	A	5: 35,044,429	L302Q	possibly damaging	Het
Itih1	G	A	14: 30,931,309	H721Y	possibly damaging	Het
Kat8	A	G	7: 127,924,903	I372V	probably benign	Het
Kcnk1	T	A	8: 126,029,727	Y329*	probably null	Het
Kcns2	A	T	15: 34,838,835	I115F	probably damaging	Het
Kif1a	C	T	1: 93,046,829		probably benign	Het
Lcn2	T	A	2: 32,387,596	D127V	possibly damaging	Het
Lrfn1	T	C	7: 28,466,930	V583A	possibly damaging	Het
Map3k1	T	C	13: 111,772,778	I55V	probably benign	Het
Mapk9	T	C	11: 49,867,047		probably null	Het
Mrpl18	A	G	17: 12,913,781	S154P	possibly damaging	Het
Mst1	C	A	9: 108,084,064	H524Q	probably benign	Het
Mtpap	T	C	18: 4,396,202	L498P	probably damaging	Het
Myl3	C	T	9: 110,742,037		probably benign	Het
Myrfl	T	C	10: 116,849,206	T90A	probably benign	Het
Mzf1	G	T	7: 13,053,058	S28R	probably damaging	Het
Olfm1	T	C	2: 28,222,616	S205P	probably damaging	Het
Prrc2a	G	A	17: 35,157,388	P809S	probably damaging	Het
Rab5c	G	A	11: 100,719,963	R40C	probably damaging	Het
Rbm48	A	T	5: 3,590,625	C251*	probably null	Het
Rxfp1	A	T	3: 79,652,269	V415E	probably damaging	Het
Slc12a6	T	A	2: 112,352,912	L748Q	probably damaging	Het
Slc19a3	T	A	1: 83,022,369	Y309F	probably damaging	Het
Slc36a1	A	G	11: 55,223,672	D192G	probably damaging	Het
Slc38a4	G	T	15: 97,009,014	S281*	probably null	Het
Syne1	A	T	10: 5,346,859	S1201T	probably damaging	Het
Tex15	C	A	8: 33,574,730	T1396K	possibly damaging	Het
Zswim8	G	T	14: 20,714,573		probably null	Het

Other mutations in Olfr671

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01359:Olfr671	APN	7	104975986	unclassified	probably null
IGL02154:Olfr671	APN	7	104975981	start codon destroyed	probably null	0.14
IGL02308:Olfr671	APN	7	104975458	missense	possibly damaging	0.84
IGL02794:Olfr671	APN	7	104975389	missense	probably benign
R0919:Olfr671	UTSW	7	104975312	nonsense	probably null
R1819:Olfr671	UTSW	7	104975398	missense	probably benign	0.01
R1972:Olfr671	UTSW	7	104975899	missense	possibly damaging	0.63
R2025:Olfr671	UTSW	7	104975244	missense	probably benign	0.01
R4910:Olfr671	UTSW	7	104975479	missense	possibly damaging	0.88
R5442:Olfr671	UTSW	7	104975228	missense	possibly damaging	0.80
R5554:Olfr671	UTSW	7	104975982	start codon destroyed	probably null	0.99
R5932:Olfr671	UTSW	7	104975655	missense	probably damaging	1.00
R6683:Olfr671	UTSW	7	104975968	missense	probably benign
R6962:Olfr671	UTSW	7	104975373	missense	probably benign	0.00
R7000:Olfr671	UTSW	7	104975131	missense	probably damaging	1.00
R7276:Olfr671	UTSW	7	104975650	missense	possibly damaging	0.62
R7425:Olfr671	UTSW	7	104975061	nonsense	probably null
R7688:Olfr671	UTSW	7	104975125	missense	possibly damaging	0.60
R8043:Olfr671	UTSW	7	104975873	nonsense	probably null
R8074:Olfr671	UTSW	7	104975727	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGGCTCATGAAGACTGTGTTC -3'
(R):5'- TGGTGGCTCGATACCTGATG -3'

Sequencing Primer
(F):5'- AAGACTGTGTTCAGCTTGGATCAC -3'
(R):5'- TGGCTCGATACCTGATGCCATG -3'

Posted On

2019-08-16