Incidental Mutation 'R7222:Trim30a'
ID 568683
Institutional Source Beutler Lab
Gene Symbol Trim30a
Ensembl Gene ENSMUSG00000030921
Gene Name tripartite motif-containing 30A
Synonyms Rpt-1, Rpt1, Trim30
MMRRC Submission 045294-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R7222 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 104058232-104114400 bp(-) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) T to C at 104070639 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000076189 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076922]
AlphaFold P15533
PDB Structure Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30 [SOLUTION NMR]
Predicted Effect probably null
Transcript: ENSMUST00000076922
SMART Domains Protein: ENSMUSP00000076189
Gene: ENSMUSG00000030921

DomainStartEndE-ValueType
RING 15 58 2.88e-10 SMART
BBOX 91 132 3.52e-14 SMART
coiled coil region 173 241 N/A INTRINSIC
low complexity region 255 265 N/A INTRINSIC
Pfam:SPRY 349 493 1.6e-8 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (49/50)
MGI Phenotype PHENOTYPE: Homozygous null mice show increased CD4/CD8 ratio with age, an abnormal CD4+ T cell response upon TCR activation, and reduced effector function of CD4+ T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,082,519 (GRCm39) N1151K probably benign Het
Add3 T C 19: 53,205,277 (GRCm39) V9A unknown Het
Ankar A G 1: 72,705,514 (GRCm39) I832T probably damaging Het
Arhgef10l C A 4: 140,248,580 (GRCm39) W785L probably damaging Het
Atp7b G A 8: 22,512,394 (GRCm39) Q490* probably null Het
Chrna5 A G 9: 54,905,347 (GRCm39) D53G probably benign Het
Clip1 T A 5: 123,749,904 (GRCm39) N993I probably damaging Het
Cyp3a59 A T 5: 146,033,385 (GRCm39) probably null Het
Dnah3 T A 7: 119,670,746 (GRCm39) N651Y probably benign Het
Dop1a T C 9: 86,404,929 (GRCm39) probably null Het
Eva1c AGGGTGTCCTGTACGAAGGACTTCCGGG AGGG 16: 90,701,072 (GRCm39) probably benign Het
Flg T A 3: 93,195,621 (GRCm39) S74T unknown Het
Fras1 T C 5: 96,784,045 (GRCm39) Y850H probably damaging Het
Fras1 A T 5: 96,784,668 (GRCm39) T884S probably benign Het
Fsip2 A G 2: 82,814,015 (GRCm39) T3445A probably benign Het
Herc1 C A 9: 66,374,781 (GRCm39) P3237H probably damaging Het
Ifi35 A G 11: 101,348,341 (GRCm39) N123S probably benign Het
Igkv1-117 A T 6: 68,098,733 (GRCm39) D94V probably damaging Het
Kif1b T C 4: 149,309,614 (GRCm39) D764G probably damaging Het
Lztr1 A G 16: 17,341,996 (GRCm39) E657G possibly damaging Het
Mmd2 G T 5: 142,553,682 (GRCm39) L160I probably benign Het
Muc2 A T 7: 141,290,758 (GRCm39) T15S Het
Muc6 T A 7: 141,214,428 (GRCm39) H2835L unknown Het
Myo1h G A 5: 114,493,322 (GRCm39) probably null Het
Or10v5 C A 19: 11,806,021 (GRCm39) R123L probably damaging Het
Or51ag1 A G 7: 103,155,664 (GRCm39) V163A possibly damaging Het
Or52n4 T C 7: 104,293,937 (GRCm39) D214G probably damaging Het
Or5d43 T A 2: 88,104,809 (GRCm39) M195L probably benign Het
Or5p72 A G 7: 108,021,844 (GRCm39) D22G probably benign Het
Or6c219 A G 10: 129,781,758 (GRCm39) Y58H probably damaging Het
Or7g32 A T 9: 19,388,763 (GRCm39) V261E probably damaging Het
Osbpl7 A G 11: 96,951,364 (GRCm39) T684A probably damaging Het
P2ry14 T C 3: 59,022,803 (GRCm39) K219R probably benign Het
Pde4d A T 13: 109,894,113 (GRCm39) H156L probably damaging Het
Polq G T 16: 36,906,995 (GRCm39) E2319* probably null Het
Ranbp3 T G 17: 57,017,211 (GRCm39) V409G probably damaging Het
Sart3 T C 5: 113,884,717 (GRCm39) D629G probably benign Het
Selenon T A 4: 134,275,288 (GRCm39) T137S possibly damaging Het
Setd2 T A 9: 110,380,530 (GRCm39) D55E Het
Slamf8 G A 1: 172,411,775 (GRCm39) T240I possibly damaging Het
Slc39a10 A G 1: 46,858,452 (GRCm39) L615P possibly damaging Het
Speer1e T A 5: 11,233,080 (GRCm39) N14K probably damaging Het
Tbce T C 13: 14,172,735 (GRCm39) D505G probably damaging Het
Tenm3 C T 8: 48,754,004 (GRCm39) G800R probably damaging Het
Terf2ip T C 8: 112,738,547 (GRCm39) V145A possibly damaging Het
Tmprss7 T C 16: 45,511,256 (GRCm39) I41V probably benign Het
Traj49 A T 14: 54,406,160 (GRCm39) N6I Het
Ubr4 T A 4: 139,190,684 (GRCm39) S905T unknown Het
Unc93a2 A G 17: 7,643,866 (GRCm39) S148P probably damaging Het
Zfp948 T A 17: 21,808,102 (GRCm39) H431Q probably damaging Het
Zfyve1 A G 12: 83,601,779 (GRCm39) F525L probably benign Het
Other mutations in Trim30a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02677:Trim30a APN 7 104,085,120 (GRCm39) missense probably damaging 1.00
IGL02944:Trim30a APN 7 104,084,984 (GRCm39) missense probably benign 0.19
IGL03135:Trim30a APN 7 104,060,348 (GRCm39) missense probably damaging 0.98
BB009:Trim30a UTSW 7 104,078,545 (GRCm39) missense probably benign 0.00
BB019:Trim30a UTSW 7 104,078,545 (GRCm39) missense probably benign 0.00
R0049:Trim30a UTSW 7 104,078,559 (GRCm39) critical splice acceptor site probably null
R0049:Trim30a UTSW 7 104,078,559 (GRCm39) critical splice acceptor site probably null
R0682:Trim30a UTSW 7 104,078,389 (GRCm39) missense probably damaging 1.00
R1773:Trim30a UTSW 7 104,085,108 (GRCm39) missense probably damaging 1.00
R1862:Trim30a UTSW 7 104,060,405 (GRCm39) missense probably damaging 0.99
R1872:Trim30a UTSW 7 104,078,417 (GRCm39) missense probably benign 0.01
R1986:Trim30a UTSW 7 104,060,672 (GRCm39) missense probably damaging 1.00
R1991:Trim30a UTSW 7 104,079,437 (GRCm39) splice site probably benign
R2259:Trim30a UTSW 7 104,060,711 (GRCm39) missense probably damaging 1.00
R2571:Trim30a UTSW 7 104,078,533 (GRCm39) missense possibly damaging 0.93
R3719:Trim30a UTSW 7 104,060,370 (GRCm39) missense probably benign 0.00
R3880:Trim30a UTSW 7 104,060,396 (GRCm39) missense probably benign
R3910:Trim30a UTSW 7 104,060,348 (GRCm39) missense probably damaging 0.98
R3911:Trim30a UTSW 7 104,060,348 (GRCm39) missense probably damaging 0.98
R3912:Trim30a UTSW 7 104,060,348 (GRCm39) missense probably damaging 0.98
R4343:Trim30a UTSW 7 104,084,799 (GRCm39) missense probably benign 0.00
R4572:Trim30a UTSW 7 104,060,395 (GRCm39) nonsense probably null
R4587:Trim30a UTSW 7 104,084,851 (GRCm39) nonsense probably null
R4997:Trim30a UTSW 7 104,060,827 (GRCm39) missense probably benign 0.21
R5051:Trim30a UTSW 7 104,060,913 (GRCm39) intron probably benign
R5414:Trim30a UTSW 7 104,060,348 (GRCm39) missense probably damaging 1.00
R5613:Trim30a UTSW 7 104,079,389 (GRCm39) missense probably damaging 1.00
R5930:Trim30a UTSW 7 104,070,657 (GRCm39) missense possibly damaging 0.95
R6262:Trim30a UTSW 7 104,060,741 (GRCm39) missense probably benign 0.00
R7133:Trim30a UTSW 7 104,078,533 (GRCm39) missense possibly damaging 0.93
R7739:Trim30a UTSW 7 104,079,386 (GRCm39) missense possibly damaging 0.50
R7797:Trim30a UTSW 7 104,060,407 (GRCm39) missense possibly damaging 0.86
R7803:Trim30a UTSW 7 104,060,604 (GRCm39) nonsense probably null
R7836:Trim30a UTSW 7 104,084,802 (GRCm39) missense probably benign 0.06
R7908:Trim30a UTSW 7 104,070,656 (GRCm39) missense probably benign 0.01
R7932:Trim30a UTSW 7 104,078,545 (GRCm39) missense probably benign 0.00
R7934:Trim30a UTSW 7 104,061,448 (GRCm39) missense probably damaging 1.00
R8240:Trim30a UTSW 7 104,070,663 (GRCm39) missense probably benign 0.01
R8405:Trim30a UTSW 7 104,060,749 (GRCm39) nonsense probably null
R8778:Trim30a UTSW 7 104,060,772 (GRCm39) missense probably benign 0.30
R8825:Trim30a UTSW 7 104,060,529 (GRCm39) nonsense probably null
R9022:Trim30a UTSW 7 104,084,956 (GRCm39) missense probably benign 0.03
R9423:Trim30a UTSW 7 104,078,410 (GRCm39) missense probably damaging 1.00
R9492:Trim30a UTSW 7 104,078,330 (GRCm39) missense probably damaging 0.99
X0012:Trim30a UTSW 7 104,079,410 (GRCm39) nonsense probably null
Z1088:Trim30a UTSW 7 104,084,861 (GRCm39) missense probably damaging 1.00
Z1177:Trim30a UTSW 7 104,060,670 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCACTGATCCAGCTCATTAGATATC -3'
(R):5'- TGGTCTCCAATGCCTGGTAAC -3'

Sequencing Primer
(F):5'- GATCCAGCTCATTAGATATCCATAAC -3'
(R):5'- TAAGTCAAATAAAGAGACATGCACC -3'
Posted On 2019-09-11