Incidental Mutation 'R7165:Clasp2'
| ID |
568706 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Clasp2
|
| Ensembl Gene |
ENSMUSG00000033392 |
| Gene Name |
CLIP associating protein 2 |
| Synonyms |
CLASP2alpha, 1500004F14Rik, CLASP2gamma, CLASP2, CLASP2beta, 8030404L10Rik |
| MMRRC Submission |
045262-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7165 (G1)
|
| Quality Score |
102.008 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
113570541-113748750 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
G to A
at 113615467 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150741
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000213663]
[ENSMUST00000216817]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000213663
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000216817
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
98% (79/81) |
| MGI Phenotype |
PHENOTYPE: Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acoxl |
C |
A |
2: 127,965,028 (GRCm39) |
A624E |
probably benign |
Het |
| Adnp |
A |
G |
2: 168,024,287 (GRCm39) |
S1003P |
probably benign |
Het |
| Akap8l |
T |
C |
17: 32,557,386 (GRCm39) |
D75G |
probably damaging |
Het |
| Ap4e1 |
A |
T |
2: 126,905,238 (GRCm39) |
T970S |
possibly damaging |
Het |
| Asb3 |
T |
A |
11: 30,979,029 (GRCm39) |
N106K |
probably damaging |
Het |
| Atp1a3 |
T |
C |
7: 24,678,390 (GRCm39) |
I988V |
probably benign |
Het |
| Camta1 |
A |
G |
4: 151,169,157 (GRCm39) |
L198S |
possibly damaging |
Het |
| Ccdc77 |
A |
G |
6: 120,327,193 (GRCm39) |
L84P |
probably damaging |
Het |
| Ccne1 |
C |
T |
7: 37,798,726 (GRCm39) |
A298T |
probably damaging |
Het |
| Cdc42bpb |
T |
A |
12: 111,287,951 (GRCm39) |
E532V |
probably damaging |
Het |
| Cntnap5b |
C |
A |
1: 100,003,887 (GRCm39) |
T289N |
possibly damaging |
Het |
| Dcun1d4 |
A |
G |
5: 73,648,538 (GRCm39) |
|
probably null |
Het |
| Dnah14 |
A |
G |
1: 181,532,100 (GRCm39) |
T2296A |
probably benign |
Het |
| Dnaja4 |
A |
T |
9: 54,616,516 (GRCm39) |
Q173L |
probably damaging |
Het |
| Dync2h1 |
G |
A |
9: 7,050,479 (GRCm39) |
A3190V |
probably benign |
Het |
| Frrs1 |
T |
A |
3: 116,671,920 (GRCm39) |
I6N |
probably benign |
Het |
| Fscn1 |
T |
C |
5: 142,957,801 (GRCm39) |
V477A |
probably benign |
Het |
| Fsip2 |
G |
A |
2: 82,811,541 (GRCm39) |
G2620E |
possibly damaging |
Het |
| Glp1r |
C |
T |
17: 31,128,297 (GRCm39) |
A92V |
probably benign |
Het |
| Gpr137b |
A |
T |
13: 13,542,205 (GRCm39) |
M204K |
probably damaging |
Het |
| Gstm1 |
A |
G |
3: 107,923,693 (GRCm39) |
V104A |
probably benign |
Het |
| Gtf2e1 |
A |
T |
16: 37,356,228 (GRCm39) |
N101K |
probably damaging |
Het |
| Igsf9b |
T |
C |
9: 27,245,536 (GRCm39) |
F1168L |
probably benign |
Het |
| Itpr2 |
A |
T |
6: 146,195,589 (GRCm39) |
V1629E |
probably damaging |
Het |
| Kat14 |
A |
G |
2: 144,235,918 (GRCm39) |
T428A |
probably benign |
Het |
| Kif21b |
T |
C |
1: 136,077,186 (GRCm39) |
Y403H |
probably damaging |
Het |
| Lpcat1 |
G |
C |
13: 73,662,649 (GRCm39) |
A533P |
probably benign |
Het |
| Lrp2 |
A |
T |
2: 69,336,917 (GRCm39) |
I1285N |
probably damaging |
Het |
| Mboat1 |
A |
T |
13: 30,408,398 (GRCm39) |
Y187F |
probably damaging |
Het |
| Mkx |
T |
C |
18: 7,002,525 (GRCm39) |
N7S |
probably damaging |
Het |
| Mrps27 |
A |
T |
13: 99,551,307 (GRCm39) |
T357S |
possibly damaging |
Het |
| Muc21 |
A |
G |
17: 35,932,870 (GRCm39) |
S439P |
unknown |
Het |
| Naa35 |
A |
G |
13: 59,733,997 (GRCm39) |
D9G |
probably benign |
Het |
| Ncoa4 |
T |
A |
14: 31,897,940 (GRCm39) |
N253K |
probably damaging |
Het |
| Neb |
A |
G |
2: 52,160,318 (GRCm39) |
Y2232H |
probably damaging |
Het |
| Nlk |
G |
A |
11: 78,481,793 (GRCm39) |
Q223* |
probably null |
Het |
| Npas2 |
T |
A |
1: 39,331,798 (GRCm39) |
I71N |
possibly damaging |
Het |
| Nup107 |
T |
A |
10: 117,609,267 (GRCm39) |
Q364L |
probably damaging |
Het |
| Or8g17 |
T |
A |
9: 38,934,566 (GRCm39) |
|
probably benign |
Het |
| Otof |
C |
T |
5: 30,532,964 (GRCm39) |
G1593S |
probably damaging |
Het |
| Panx3 |
G |
T |
9: 37,575,381 (GRCm39) |
H160Q |
probably damaging |
Het |
| Pappa |
T |
A |
4: 65,180,110 (GRCm39) |
H990Q |
probably damaging |
Het |
| Pax4 |
G |
A |
6: 28,446,136 (GRCm39) |
P119L |
probably damaging |
Het |
| Pcdhb20 |
T |
A |
18: 37,638,123 (GRCm39) |
D216E |
probably damaging |
Het |
| Pcdhgb8 |
T |
A |
18: 37,896,231 (GRCm39) |
S434T |
possibly damaging |
Het |
| Pf4 |
T |
C |
5: 90,920,448 (GRCm39) |
V3A |
probably benign |
Het |
| Phf24 |
T |
C |
4: 42,938,325 (GRCm39) |
S229P |
probably benign |
Het |
| Plcd3 |
A |
G |
11: 102,970,439 (GRCm39) |
F200S |
probably damaging |
Het |
| Ppp1r16a |
A |
G |
15: 76,575,104 (GRCm39) |
H4R |
probably damaging |
Het |
| Pramel15 |
A |
G |
4: 144,099,389 (GRCm39) |
C459R |
probably damaging |
Het |
| Prdm10 |
A |
G |
9: 31,227,738 (GRCm39) |
|
probably null |
Het |
| Prim2 |
A |
G |
1: 33,667,474 (GRCm39) |
|
probably null |
Het |
| Prkg1 |
T |
A |
19: 30,562,599 (GRCm39) |
H550L |
probably damaging |
Het |
| Prrc2c |
G |
T |
1: 162,501,086 (GRCm39) |
T2809N |
possibly damaging |
Het |
| Ptx3 |
A |
G |
3: 66,132,391 (GRCm39) |
E304G |
probably benign |
Het |
| Ralgps2 |
A |
G |
1: 156,655,818 (GRCm39) |
F369L |
probably benign |
Het |
| Rasgrp1 |
G |
A |
2: 117,168,885 (GRCm39) |
T31I |
probably benign |
Het |
| Rbsn |
A |
T |
6: 92,168,315 (GRCm39) |
M373K |
probably benign |
Het |
| Rnf168 |
C |
G |
16: 32,101,179 (GRCm39) |
R120G |
probably benign |
Het |
| Rp1 |
A |
G |
1: 4,420,140 (GRCm39) |
I324T |
probably damaging |
Het |
| Samd11 |
T |
C |
4: 156,336,747 (GRCm39) |
S31G |
probably benign |
Het |
| Sart3 |
A |
T |
5: 113,884,056 (GRCm39) |
L652Q |
probably benign |
Het |
| Scrn2 |
A |
G |
11: 96,924,634 (GRCm39) |
E421G |
probably benign |
Het |
| Sik2 |
A |
T |
9: 50,828,397 (GRCm39) |
L215Q |
probably damaging |
Het |
| Speer4a3 |
AACT |
A |
5: 26,155,849 (GRCm39) |
|
probably benign |
Het |
| Stard9 |
A |
T |
2: 120,534,639 (GRCm39) |
K3632M |
probably damaging |
Het |
| Swt1 |
A |
T |
1: 151,264,428 (GRCm39) |
D695E |
probably damaging |
Het |
| Tead3 |
T |
A |
17: 28,552,228 (GRCm39) |
M357L |
probably benign |
Het |
| Tgfbi |
A |
T |
13: 56,775,829 (GRCm39) |
T292S |
probably damaging |
Het |
| Tmc7 |
T |
C |
7: 118,155,157 (GRCm39) |
H247R |
probably benign |
Het |
| Trmt10b |
T |
A |
4: 45,308,549 (GRCm39) |
D236E |
probably damaging |
Het |
| Tshz1 |
C |
A |
18: 84,034,052 (GRCm39) |
V119L |
probably damaging |
Het |
| Ttn |
A |
C |
2: 76,658,258 (GRCm39) |
V12374G |
unknown |
Het |
| Tubgcp2 |
A |
G |
7: 139,585,274 (GRCm39) |
Y484H |
probably damaging |
Het |
| Ubr4 |
G |
C |
4: 139,177,824 (GRCm39) |
A1947P |
|
Het |
| Uggt1 |
A |
C |
1: 36,194,188 (GRCm39) |
V1350G |
probably benign |
Het |
| Vmn1r173 |
A |
T |
7: 23,402,076 (GRCm39) |
M104L |
probably benign |
Het |
| Xirp1 |
A |
T |
9: 119,848,113 (GRCm39) |
C257S |
probably damaging |
Het |
| Zfyve26 |
A |
G |
12: 79,327,179 (GRCm39) |
S724P |
probably damaging |
Het |
| Zmpste24 |
A |
T |
4: 120,940,091 (GRCm39) |
L185Q |
probably null |
Het |
| Zpld1 |
G |
A |
16: 55,052,594 (GRCm39) |
A340V |
probably benign |
Het |
|
| Other mutations in Clasp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00772:Clasp2
|
APN |
9 |
113,735,060 (GRCm39) |
splice site |
probably benign |
|
|
IGL00885:Clasp2
|
APN |
9 |
113,740,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01314:Clasp2
|
APN |
9 |
113,735,195 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01344:Clasp2
|
APN |
9 |
113,642,360 (GRCm39) |
splice site |
probably null |
|
|
IGL01567:Clasp2
|
APN |
9 |
113,709,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02238:Clasp2
|
APN |
9 |
113,709,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02299:Clasp2
|
APN |
9 |
113,709,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02323:Clasp2
|
APN |
9 |
113,697,794 (GRCm39) |
splice site |
probably benign |
|
|
IGL02635:Clasp2
|
APN |
9 |
113,737,910 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02645:Clasp2
|
APN |
9 |
113,719,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02976:Clasp2
|
APN |
9 |
113,735,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03190:Clasp2
|
APN |
9 |
113,673,208 (GRCm39) |
nonsense |
probably null |
|
|
IGL03219:Clasp2
|
APN |
9 |
113,677,545 (GRCm39) |
splice site |
probably benign |
|
|
PIT4810001:Clasp2
|
UTSW |
9 |
113,735,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0067:Clasp2
|
UTSW |
9 |
113,689,209 (GRCm39) |
splice site |
probably benign |
|
|
R0067:Clasp2
|
UTSW |
9 |
113,689,209 (GRCm39) |
splice site |
probably benign |
|
|
R0421:Clasp2
|
UTSW |
9 |
113,683,370 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0432:Clasp2
|
UTSW |
9 |
113,738,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0458:Clasp2
|
UTSW |
9 |
113,735,292 (GRCm39) |
splice site |
probably null |
|
|
R0865:Clasp2
|
UTSW |
9 |
113,740,568 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R0972:Clasp2
|
UTSW |
9 |
113,676,773 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1037:Clasp2
|
UTSW |
9 |
113,725,702 (GRCm39) |
splice site |
probably benign |
|
|
R1925:Clasp2
|
UTSW |
9 |
113,735,265 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2015:Clasp2
|
UTSW |
9 |
113,740,568 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R2066:Clasp2
|
UTSW |
9 |
113,735,225 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2330:Clasp2
|
UTSW |
9 |
113,705,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2568:Clasp2
|
UTSW |
9 |
113,707,832 (GRCm39) |
missense |
probably benign |
|
|
R3011:Clasp2
|
UTSW |
9 |
113,730,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3879:Clasp2
|
UTSW |
9 |
113,719,029 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3915:Clasp2
|
UTSW |
9 |
113,737,805 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3928:Clasp2
|
UTSW |
9 |
113,735,173 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4323:Clasp2
|
UTSW |
9 |
113,719,027 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4571:Clasp2
|
UTSW |
9 |
113,676,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Clasp2
|
UTSW |
9 |
113,732,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5445:Clasp2
|
UTSW |
9 |
113,733,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5564:Clasp2
|
UTSW |
9 |
113,641,836 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5697:Clasp2
|
UTSW |
9 |
113,689,190 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5780:Clasp2
|
UTSW |
9 |
113,679,220 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5787:Clasp2
|
UTSW |
9 |
113,691,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6011:Clasp2
|
UTSW |
9 |
113,705,315 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6026:Clasp2
|
UTSW |
9 |
113,740,646 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6090:Clasp2
|
UTSW |
9 |
113,681,803 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6262:Clasp2
|
UTSW |
9 |
113,705,420 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6427:Clasp2
|
UTSW |
9 |
113,721,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Clasp2
|
UTSW |
9 |
113,602,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6586:Clasp2
|
UTSW |
9 |
113,642,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6628:Clasp2
|
UTSW |
9 |
113,725,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6745:Clasp2
|
UTSW |
9 |
113,704,338 (GRCm39) |
nonsense |
probably null |
|
|
R7032:Clasp2
|
UTSW |
9 |
113,683,391 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7221:Clasp2
|
UTSW |
9 |
113,681,825 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7336:Clasp2
|
UTSW |
9 |
113,705,421 (GRCm39) |
splice site |
probably null |
|
|
R7583:Clasp2
|
UTSW |
9 |
113,737,755 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7774:Clasp2
|
UTSW |
9 |
113,677,804 (GRCm39) |
splice site |
probably null |
|
|
R7895:Clasp2
|
UTSW |
9 |
113,733,016 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8084:Clasp2
|
UTSW |
9 |
113,676,823 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8109:Clasp2
|
UTSW |
9 |
113,740,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8171:Clasp2
|
UTSW |
9 |
113,732,974 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8230:Clasp2
|
UTSW |
9 |
113,721,482 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8810:Clasp2
|
UTSW |
9 |
113,728,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8879:Clasp2
|
UTSW |
9 |
113,602,773 (GRCm39) |
missense |
probably benign |
0.39 |
|
R8888:Clasp2
|
UTSW |
9 |
113,732,936 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8889:Clasp2
|
UTSW |
9 |
113,709,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8892:Clasp2
|
UTSW |
9 |
113,709,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8922:Clasp2
|
UTSW |
9 |
113,725,728 (GRCm39) |
nonsense |
probably null |
|
|
R9042:Clasp2
|
UTSW |
9 |
113,735,065 (GRCm39) |
missense |
probably benign |
|
|
R9195:Clasp2
|
UTSW |
9 |
113,671,045 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9355:Clasp2
|
UTSW |
9 |
113,664,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9481:Clasp2
|
UTSW |
9 |
113,670,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9502:Clasp2
|
UTSW |
9 |
113,737,866 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9523:Clasp2
|
UTSW |
9 |
113,705,372 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9525:Clasp2
|
UTSW |
9 |
113,740,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9653:Clasp2
|
UTSW |
9 |
113,670,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9699:Clasp2
|
UTSW |
9 |
113,738,614 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9738:Clasp2
|
UTSW |
9 |
113,590,665 (GRCm39) |
nonsense |
probably null |
|
|
R9775:Clasp2
|
UTSW |
9 |
113,725,740 (GRCm39) |
missense |
probably benign |
|
|
X0022:Clasp2
|
UTSW |
9 |
113,681,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Clasp2
|
UTSW |
9 |
113,599,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Clasp2
|
UTSW |
9 |
113,737,863 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGAGGAGTTTCACAAGCTCCTG -3'
(R):5'- CGCCAGAATTCTGAACTTCATC -3'
Sequencing Primer
(F):5'- GCTCCTGAAAAATGTCCAAGTG -3'
(R):5'- TGGCAAGTACCATTTCTAATCTAGG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation