Incidental Mutation 'R7324:Tmprss15'
ID 568781
Institutional Source Beutler Lab
Gene Symbol Tmprss15
Ensembl Gene ENSMUSG00000022857
Gene Name transmembrane protease, serine 15
Synonyms Prss7, enterokinase, enteropeptidase, A130097D21Rik
MMRRC Submission 045418-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7324 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 78749896-78887985 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78758907 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 937 (Y937C)
Ref Sequence ENSEMBL: ENSMUSP00000023566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023566] [ENSMUST00000060402]
AlphaFold P97435
Predicted Effect probably damaging
Transcript: ENSMUST00000023566
AA Change: Y937C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000023566
Gene: ENSMUSG00000022857
AA Change: Y937C

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 228 268 1.74e-4 SMART
CUB 270 379 1.54e-11 SMART
MAM 387 549 7.33e-54 SMART
low complexity region 551 567 N/A INTRINSIC
CUB 569 679 1.72e-32 SMART
LDLa 687 724 7.32e-12 SMART
SR 723 813 3.12e-5 SMART
Tryp_SPc 829 1064 1.48e-95 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000060402
AA Change: Y922C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000052034
Gene: ENSMUSG00000022857
AA Change: Y922C

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 213 253 1.74e-4 SMART
CUB 255 364 1.54e-11 SMART
MAM 372 534 7.33e-54 SMART
low complexity region 536 552 N/A INTRINSIC
CUB 554 664 1.72e-32 SMART
LDLa 672 709 7.32e-12 SMART
SR 708 798 3.12e-5 SMART
Tryp_SPc 814 1049 1.48e-95 SMART
Meta Mutation Damage Score 0.5766 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 99% (81/82)
MGI Phenotype FUNCTION: This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg5 T C 17: 84,983,667 (GRCm39) D124G possibly damaging Het
Ackr3 C G 1: 90,141,923 (GRCm39) N127K probably damaging Het
AL732309.1 A C 2: 25,136,151 (GRCm39) M21R possibly damaging Het
Ankrd52 C A 10: 128,222,032 (GRCm39) T552K possibly damaging Het
Arhgap28 T C 17: 68,202,879 (GRCm39) probably null Het
Arid5b A T 10: 67,964,752 (GRCm39) N306K probably benign Het
C1qtnf3 A C 15: 10,952,707 (GRCm39) K56N probably benign Het
C2 C T 17: 35,100,664 (GRCm39) G52D probably benign Het
Casz1 C T 4: 149,031,490 (GRCm39) T1247M probably damaging Het
Cc2d2b A G 19: 40,797,552 (GRCm39) D778G unknown Het
Cdh5 A G 8: 104,869,425 (GRCm39) D717G probably damaging Het
Clca3a2 G A 3: 144,514,372 (GRCm39) A445V probably damaging Het
Clca3b T A 3: 144,547,181 (GRCm39) M319L possibly damaging Het
Csmd1 G A 8: 16,108,721 (GRCm39) S1894L probably damaging Het
Csnk1g3 A G 18: 54,052,090 (GRCm39) T220A probably damaging Het
Cyp2d10 T G 15: 82,287,961 (GRCm39) T381P probably damaging Het
Ddb2 G A 2: 91,067,229 (GRCm39) probably benign Het
Ddx24 C A 12: 103,382,518 (GRCm39) L688F probably damaging Het
Dennd4c T C 4: 86,747,975 (GRCm39) L1615P unknown Het
Dnah8 T A 17: 31,003,099 (GRCm39) D3599E probably benign Het
Dst T C 1: 34,045,305 (GRCm39) S13P possibly damaging Het
Efcab12 T C 6: 115,800,555 (GRCm39) D156G probably benign Het
Enpp2 A G 15: 54,741,170 (GRCm39) probably null Het
Ephx2 A G 14: 66,322,803 (GRCm39) V490A probably damaging Het
Etnppl A G 3: 130,423,224 (GRCm39) N308D probably damaging Het
F5 TCAGAAGACCTCCTCCCCAGACCTGGGCCAGGTGCCCCTTTCTCCAGATGACAACCAGAAGACCTCCTCCCCAGACCTGGGTCAGGTGTCCCTTTCTCCAGATGATAACCAGAAGACCTCCTCCCCAGACCTGGGTCAGGTGCCCCTTTCTCTAGATGACAACCAGAAGACGACCTCCCCAGACCTGGGTCAGGTGCCCCTTTCTCCAGATGACAACCAGA TCAGAAGACCTCCTCCCCAGACCTGGGTCAGGTGTCCCTTTCTCCAGATGATAACCAGAAGACCTCCTCCCCAGACCTGGGTCAGGTGCCCCTTTCTCTAGATGACAACCAGAAGACGACCTCCCCAGACCTGGGTCAGGTGCCCCTTTCTCCAGATGACAACCAGA 1: 164,021,150 (GRCm39) probably benign Het
Fam162b A T 10: 51,466,282 (GRCm39) probably null Het
Fancl A G 11: 26,353,362 (GRCm39) E86G probably damaging Het
Flii G A 11: 60,609,866 (GRCm39) T615I probably benign Het
Fndc7 G T 3: 108,779,537 (GRCm39) Q336K probably benign Het
Gm26661 T C 14: 7,791,911 (GRCm38) C109R unknown Het
H2-DMb1 T C 17: 34,378,436 (GRCm39) probably null Het
H2-T10 C T 17: 36,430,189 (GRCm39) G251R probably damaging Het
Harbi1 T C 2: 91,551,044 (GRCm39) I339T probably benign Het
Hsp90aa1 A G 12: 110,661,659 (GRCm39) M119T unknown Het
Ighe T A 12: 113,235,954 (GRCm39) Y124F Het
Ighv7-1 T C 12: 113,860,149 (GRCm39) Y81C probably damaging Het
Ilkap A T 1: 91,313,115 (GRCm39) probably null Het
Inpp5a A G 7: 139,105,586 (GRCm39) D179G probably damaging Het
Itgad A T 7: 127,788,979 (GRCm39) D510V probably damaging Het
Kcnn2 A T 18: 45,693,138 (GRCm39) H238L probably benign Het
Kctd17 T A 15: 78,319,842 (GRCm39) C189S probably damaging Het
Larp4b C A 13: 9,208,616 (GRCm39) A423E probably benign Het
Llgl2 A G 11: 115,741,556 (GRCm39) E562G possibly damaging Het
Macf1 T C 4: 123,268,218 (GRCm39) T6734A probably benign Het
Maz G A 7: 126,623,765 (GRCm39) T377M probably damaging Het
Mmrn1 G T 6: 60,921,917 (GRCm39) G125* probably null Het
Mvp A G 7: 126,592,781 (GRCm39) S377P probably benign Het
Nin C T 12: 70,090,508 (GRCm39) R969Q Het
Nktr C T 9: 121,556,427 (GRCm39) T35I probably damaging Het
Nktr T A 9: 121,577,357 (GRCm39) M475K possibly damaging Het
Nod2 T A 8: 89,379,694 (GRCm39) V65D probably damaging Het
Opa1 A T 16: 29,405,799 (GRCm39) E121D probably benign Het
Or10w3 C T 19: 13,704,270 (GRCm39) A215V probably benign Het
Or1r1 A G 11: 73,874,669 (GRCm39) V255A probably benign Het
Or2n1c T C 17: 38,519,607 (GRCm39) V157A probably benign Het
Or4a76 A T 2: 89,460,447 (GRCm39) I265N possibly damaging Het
Or5ac21 T C 16: 59,123,611 (GRCm39) F32L probably benign Het
Or5b123 A G 19: 13,596,942 (GRCm39) I96V probably benign Het
Or6c88 T A 10: 129,406,718 (GRCm39) S65T probably damaging Het
Or7e174 A T 9: 20,012,726 (GRCm39) I224F possibly damaging Het
Osbpl2 A G 2: 179,791,994 (GRCm39) T233A probably benign Het
Pcp4l1 G A 1: 171,002,034 (GRCm39) A42V possibly damaging Het
Plekhh3 T A 11: 101,061,600 (GRCm39) D38V possibly damaging Het
Prtg C T 9: 72,798,122 (GRCm39) A696V probably damaging Het
Ptpn14 T G 1: 189,595,621 (GRCm39) V748G possibly damaging Het
Reg2 A T 6: 78,383,137 (GRCm39) D28V probably benign Het
Rhpn1 A T 15: 75,576,246 (GRCm39) I2F possibly damaging Het
Rundc3a A G 11: 102,290,799 (GRCm39) E294G possibly damaging Het
Scara3 T A 14: 66,168,865 (GRCm39) I251L probably benign Het
Slc23a2 G A 2: 131,931,043 (GRCm39) T152I probably damaging Het
Slc39a2 T G 14: 52,131,650 (GRCm39) S74A possibly damaging Het
Tpp2 T C 1: 44,017,938 (GRCm39) L779S probably damaging Het
Tssk2 T C 16: 17,717,227 (GRCm39) V210A possibly damaging Het
Ttn T A 2: 76,725,937 (GRCm39) T6100S unknown Het
Tufm G A 7: 126,088,759 (GRCm39) E317K possibly damaging Het
Vinac1 T C 2: 128,879,772 (GRCm39) D718G unknown Het
Wdfy4 A G 14: 32,769,271 (GRCm39) S2219P Het
Wtap T C 17: 13,199,833 (GRCm39) N50S possibly damaging Het
Other mutations in Tmprss15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Tmprss15 APN 16 78,782,882 (GRCm39) missense possibly damaging 0.87
IGL00477:Tmprss15 APN 16 78,818,301 (GRCm39) missense probably damaging 1.00
IGL01583:Tmprss15 APN 16 78,868,149 (GRCm39) missense probably benign
IGL01896:Tmprss15 APN 16 78,887,678 (GRCm39) missense probably benign 0.22
IGL02052:Tmprss15 APN 16 78,884,394 (GRCm39) missense probably damaging 1.00
IGL02374:Tmprss15 APN 16 78,832,056 (GRCm39) missense probably benign 0.00
IGL02505:Tmprss15 APN 16 78,784,629 (GRCm39) missense probably benign 0.00
IGL02632:Tmprss15 APN 16 78,782,790 (GRCm39) missense probably damaging 0.98
IGL02674:Tmprss15 APN 16 78,798,682 (GRCm39) missense possibly damaging 0.72
beached UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
Cellulite UTSW 16 78,754,259 (GRCm39) missense probably damaging 1.00
lolling UTSW 16 78,800,298 (GRCm39) missense probably benign 0.26
miniature UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
PIT1430001:Tmprss15 UTSW 16 78,821,640 (GRCm39) critical splice donor site probably null
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0195:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.05
R0335:Tmprss15 UTSW 16 78,821,630 (GRCm39) splice site probably benign
R0514:Tmprss15 UTSW 16 78,765,155 (GRCm39) missense probably benign 0.05
R0552:Tmprss15 UTSW 16 78,821,637 (GRCm39) splice site probably null
R0675:Tmprss15 UTSW 16 78,782,838 (GRCm39) missense probably damaging 0.98
R0739:Tmprss15 UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
R1435:Tmprss15 UTSW 16 78,818,342 (GRCm39) missense probably benign 0.03
R1446:Tmprss15 UTSW 16 78,875,846 (GRCm39) missense probably benign 0.01
R1572:Tmprss15 UTSW 16 78,887,717 (GRCm39) missense probably benign 0.00
R1708:Tmprss15 UTSW 16 78,850,958 (GRCm39) missense possibly damaging 0.95
R1893:Tmprss15 UTSW 16 78,868,306 (GRCm39) missense probably benign
R2403:Tmprss15 UTSW 16 78,854,578 (GRCm39) missense probably damaging 1.00
R2866:Tmprss15 UTSW 16 78,832,121 (GRCm39) missense possibly damaging 0.65
R2913:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R2914:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R3425:Tmprss15 UTSW 16 78,800,321 (GRCm39) missense possibly damaging 0.83
R3703:Tmprss15 UTSW 16 78,851,030 (GRCm39) critical splice acceptor site probably null
R3916:Tmprss15 UTSW 16 78,782,884 (GRCm39) missense probably damaging 1.00
R3950:Tmprss15 UTSW 16 78,870,074 (GRCm39) missense probably benign 0.04
R4332:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.15
R4392:Tmprss15 UTSW 16 78,821,326 (GRCm39) missense probably damaging 1.00
R4515:Tmprss15 UTSW 16 78,754,244 (GRCm39) missense probably benign 0.00
R4619:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4620:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4754:Tmprss15 UTSW 16 78,851,012 (GRCm39) missense probably damaging 0.98
R4853:Tmprss15 UTSW 16 78,757,479 (GRCm39) missense probably benign
R5159:Tmprss15 UTSW 16 78,800,298 (GRCm39) missense probably benign 0.26
R5441:Tmprss15 UTSW 16 78,868,335 (GRCm39) critical splice acceptor site probably null
R5824:Tmprss15 UTSW 16 78,831,201 (GRCm39) missense probably damaging 0.99
R5970:Tmprss15 UTSW 16 78,854,547 (GRCm39) missense probably benign 0.00
R6224:Tmprss15 UTSW 16 78,821,266 (GRCm39) missense probably benign 0.08
R6257:Tmprss15 UTSW 16 78,769,113 (GRCm39) missense probably damaging 1.00
R6313:Tmprss15 UTSW 16 78,759,058 (GRCm39) missense probably benign 0.16
R6368:Tmprss15 UTSW 16 78,802,945 (GRCm39) splice site probably null
R6525:Tmprss15 UTSW 16 78,800,266 (GRCm39) missense probably damaging 0.97
R6587:Tmprss15 UTSW 16 78,868,317 (GRCm39) missense probably benign
R6894:Tmprss15 UTSW 16 78,872,702 (GRCm39) nonsense probably null
R7018:Tmprss15 UTSW 16 78,821,741 (GRCm39) missense possibly damaging 0.78
R7180:Tmprss15 UTSW 16 78,764,886 (GRCm39) missense probably damaging 0.97
R7337:Tmprss15 UTSW 16 78,868,164 (GRCm39) missense probably benign 0.01
R7558:Tmprss15 UTSW 16 78,800,302 (GRCm39) missense possibly damaging 0.55
R7732:Tmprss15 UTSW 16 78,800,308 (GRCm39) missense probably benign 0.11
R7792:Tmprss15 UTSW 16 78,800,275 (GRCm39) missense probably damaging 1.00
R7829:Tmprss15 UTSW 16 78,784,538 (GRCm39) missense probably benign 0.02
R7998:Tmprss15 UTSW 16 78,798,731 (GRCm39) missense possibly damaging 0.79
R8009:Tmprss15 UTSW 16 78,887,751 (GRCm39) missense probably damaging 0.96
R8145:Tmprss15 UTSW 16 78,757,473 (GRCm39) missense probably damaging 1.00
R8183:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R8221:Tmprss15 UTSW 16 78,821,223 (GRCm39) missense probably damaging 0.99
R8294:Tmprss15 UTSW 16 78,868,176 (GRCm39) missense probably benign
R8537:Tmprss15 UTSW 16 78,884,403 (GRCm39) missense probably damaging 0.99
R8735:Tmprss15 UTSW 16 78,798,702 (GRCm39) missense possibly damaging 0.88
R8858:Tmprss15 UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
R8869:Tmprss15 UTSW 16 78,750,834 (GRCm39) nonsense probably null
R8884:Tmprss15 UTSW 16 78,821,657 (GRCm39) missense probably benign 0.00
R9014:Tmprss15 UTSW 16 78,872,691 (GRCm39) missense probably benign 0.04
R9075:Tmprss15 UTSW 16 78,754,259 (GRCm39) missense probably damaging 1.00
R9351:Tmprss15 UTSW 16 78,832,086 (GRCm39) missense probably damaging 1.00
R9393:Tmprss15 UTSW 16 78,754,211 (GRCm39) missense probably benign 0.01
R9747:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R9767:Tmprss15 UTSW 16 78,875,977 (GRCm39) missense probably damaging 1.00
R9783:Tmprss15 UTSW 16 78,887,890 (GRCm39) start gained probably benign
RF005:Tmprss15 UTSW 16 78,750,689 (GRCm39) makesense probably null
Predicted Primers PCR Primer
(F):5'- CACAGTTCCAGATGTTTCTCCATTAG -3'
(R):5'- AGAAATCTAGATCCAACCAGATGG -3'

Sequencing Primer
(F):5'- CTGTAAGAGTTCCCTAAAGCTGG -3'
(R):5'- AACCAGATGGACAGCAGTC -3'
Posted On 2019-09-13