Incidental Mutation 'R7327:Myh15'
ID 569019
Institutional Source Beutler Lab
Gene Symbol Myh15
Ensembl Gene ENSMUSG00000092009
Gene Name myosin, heavy chain 15
Synonyms EG667772
MMRRC Submission 045420-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R7327 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 48877849-49019467 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 48993369 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 1668 (R1668L)
Ref Sequence ENSEMBL: ENSMUSP00000127539 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168680]
AlphaFold E9Q264
Predicted Effect possibly damaging
Transcript: ENSMUST00000168680
AA Change: R1668L

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000127539
Gene: ENSMUSG00000092009
AA Change: R1668L

DomainStartEndE-ValueType
Pfam:Myosin_N 30 70 5.2e-12 PFAM
MYSc 76 770 N/A SMART
Pfam:Myosin_tail_1 836 1915 9.5e-118 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf3 C T 16: 20,367,430 (GRCm39) T3I probably benign Het
Ahi1 T A 10: 20,862,976 (GRCm39) V717E probably damaging Het
Anapc4 A G 5: 53,002,672 (GRCm39) T238A probably damaging Het
Arhgap27 A T 11: 103,251,367 (GRCm39) C120* probably null Het
Bdp1 A T 13: 100,178,040 (GRCm39) V1943D probably damaging Het
Cdc14b A G 13: 64,373,461 (GRCm39) V141A probably damaging Het
Cfap46 G T 7: 139,215,062 (GRCm39) probably null Het
Cgnl1 C A 9: 71,633,165 (GRCm39) R62L possibly damaging Het
Chaf1a A G 17: 56,369,573 (GRCm39) S522G probably benign Het
Cox19 A G 5: 139,328,402 (GRCm39) F37S probably damaging Het
Csmd1 G A 8: 16,108,721 (GRCm39) S1894L probably damaging Het
Cyp4a12a A T 4: 115,184,756 (GRCm39) R346W probably damaging Het
Dip2a A C 10: 76,108,396 (GRCm39) C1315G probably benign Het
Dmxl2 A C 9: 54,308,869 (GRCm39) W1961G probably damaging Het
Dst T C 1: 34,240,486 (GRCm39) L1945P probably damaging Het
Efr3a A G 15: 65,691,627 (GRCm39) S92G probably damaging Het
Ep300 C T 15: 81,511,515 (GRCm39) T865I unknown Het
Ercc6 A G 14: 32,248,361 (GRCm39) E304G probably benign Het
Filip1l A C 16: 57,391,300 (GRCm39) E629D probably damaging Het
Frem1 G A 4: 82,938,992 (GRCm39) T30I possibly damaging Het
Glb1 T C 9: 114,246,126 (GRCm39) F59S probably benign Het
Gli3 T C 13: 15,900,144 (GRCm39) L1177P probably benign Het
Gpatch2l A G 12: 86,303,646 (GRCm39) T223A probably damaging Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
Hmcn1 A T 1: 150,479,565 (GRCm39) M4633K probably benign Het
Hoxc8 T A 15: 102,899,542 (GRCm39) Y111N probably damaging Het
Ifi207 A G 1: 173,556,581 (GRCm39) L726P probably benign Het
Iqcn T A 8: 71,169,453 (GRCm39) M1181K possibly damaging Het
Iqgap2 T A 13: 95,772,163 (GRCm39) M1339L probably benign Het
Kif21b A G 1: 136,087,387 (GRCm39) Q901R possibly damaging Het
Krtap4-8 C A 11: 99,671,234 (GRCm39) C79F unknown Het
Ldb3 T C 14: 34,293,759 (GRCm39) N155S probably damaging Het
Mad2l1 T A 6: 66,516,794 (GRCm39) V162E probably benign Het
Map7 T A 10: 20,109,208 (GRCm39) V87E unknown Het
Mndal A T 1: 173,703,185 (GRCm39) D73E unknown Het
Msantd1 T C 5: 35,075,039 (GRCm39) S34P probably damaging Het
Myh14 T C 7: 44,260,977 (GRCm39) Q1838R possibly damaging Het
Ncoa7 A G 10: 30,565,796 (GRCm39) M666T probably damaging Het
Nol6 A T 4: 41,116,686 (GRCm39) L944Q probably benign Het
Or5h27 A T 16: 59,006,376 (GRCm39) F157I unknown Het
Orc1 A G 4: 108,445,911 (GRCm39) T10A probably benign Het
Pcp4l1 G A 1: 171,002,034 (GRCm39) A42V possibly damaging Het
Pglyrp2 C T 17: 32,634,893 (GRCm39) A490T probably benign Het
Pirb A T 7: 3,720,187 (GRCm39) C395* probably null Het
Ppp1r11 T C 17: 37,261,900 (GRCm39) R12G possibly damaging Het
Prlr A G 15: 10,346,524 (GRCm39) D290G probably benign Het
Ptpn21 G T 12: 98,646,360 (GRCm39) R1033S probably damaging Het
Rad54l2 A G 9: 106,570,660 (GRCm39) L1220P possibly damaging Het
Rufy3 G A 5: 88,790,811 (GRCm39) R504H probably damaging Het
Scgb2b21 C T 7: 33,219,330 (GRCm39) V25I probably benign Het
Sh3bgrl2 T C 9: 83,430,542 (GRCm39) S11P possibly damaging Het
Slain2 A T 5: 73,132,002 (GRCm39) T498S probably benign Het
Slc12a4 C T 8: 106,682,347 (GRCm39) G121S probably damaging Het
Slc30a9 A T 5: 67,499,462 (GRCm39) I307F probably damaging Het
Snap91 C T 9: 86,655,598 (GRCm39) G800R unknown Het
Tnc G T 4: 63,882,999 (GRCm39) probably null Het
Trav21-dv12 T C 14: 54,113,514 (GRCm39) probably benign Het
Txk A T 5: 72,873,226 (GRCm39) I228N probably damaging Het
Vac14 T C 8: 111,438,252 (GRCm39) Y622H probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Wdr35 T G 12: 9,037,312 (GRCm39) M306R probably benign Het
Zan A T 5: 137,463,494 (GRCm39) S562T probably benign Het
Other mutations in Myh15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00943:Myh15 APN 16 48,986,176 (GRCm39) missense probably damaging 0.98
IGL01095:Myh15 APN 16 48,952,378 (GRCm39) missense probably damaging 1.00
IGL01343:Myh15 APN 16 48,976,040 (GRCm39) missense probably benign 0.09
IGL01474:Myh15 APN 16 48,952,461 (GRCm39) missense probably damaging 1.00
IGL01572:Myh15 APN 16 48,920,585 (GRCm39) missense possibly damaging 0.55
IGL01595:Myh15 APN 16 48,993,312 (GRCm39) missense probably damaging 1.00
IGL01632:Myh15 APN 16 48,881,874 (GRCm39) missense probably benign 0.00
IGL01638:Myh15 APN 16 48,889,843 (GRCm39) missense probably damaging 1.00
IGL01667:Myh15 APN 16 49,015,942 (GRCm39) missense probably benign 0.20
IGL01715:Myh15 APN 16 48,877,847 (GRCm39) unclassified probably benign
IGL01833:Myh15 APN 16 48,934,421 (GRCm39) missense probably damaging 1.00
IGL02004:Myh15 APN 16 48,930,892 (GRCm39) splice site probably benign
IGL02033:Myh15 APN 16 48,965,707 (GRCm39) missense probably benign 0.05
IGL02148:Myh15 APN 16 48,936,678 (GRCm39) missense probably damaging 1.00
IGL02225:Myh15 APN 16 48,911,526 (GRCm39) missense probably benign 0.14
IGL02249:Myh15 APN 16 48,930,847 (GRCm39) missense probably damaging 0.99
IGL02505:Myh15 APN 16 48,937,626 (GRCm39) missense possibly damaging 0.90
IGL02622:Myh15 APN 16 48,997,317 (GRCm39) missense probably benign 0.02
IGL02814:Myh15 APN 16 48,965,801 (GRCm39) splice site probably benign
IGL02869:Myh15 APN 16 48,965,767 (GRCm39) missense probably benign
IGL02879:Myh15 APN 16 48,993,422 (GRCm39) missense possibly damaging 0.68
IGL02881:Myh15 APN 16 48,937,628 (GRCm39) missense possibly damaging 0.51
IGL03077:Myh15 APN 16 48,916,901 (GRCm39) missense probably benign 0.10
IGL03354:Myh15 APN 16 48,992,373 (GRCm39) missense probably benign 0.01
IGL03411:Myh15 APN 16 48,980,330 (GRCm39) missense possibly damaging 0.58
ANU74:Myh15 UTSW 16 48,993,295 (GRCm39) missense possibly damaging 0.58
P0027:Myh15 UTSW 16 48,901,571 (GRCm39) missense possibly damaging 0.77
PIT1430001:Myh15 UTSW 16 49,017,254 (GRCm39) critical splice donor site probably null
R0017:Myh15 UTSW 16 48,983,423 (GRCm39) missense probably damaging 0.97
R0038:Myh15 UTSW 16 48,891,504 (GRCm39) splice site probably benign
R0149:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0361:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0373:Myh15 UTSW 16 49,003,322 (GRCm39) missense possibly damaging 0.86
R0433:Myh15 UTSW 16 48,965,599 (GRCm39) missense probably damaging 1.00
R0525:Myh15 UTSW 16 48,952,414 (GRCm39) missense probably benign 0.03
R0586:Myh15 UTSW 16 48,992,250 (GRCm39) splice site probably benign
R0601:Myh15 UTSW 16 48,881,944 (GRCm39) missense probably damaging 1.00
R0717:Myh15 UTSW 16 48,963,356 (GRCm39) missense probably benign 0.03
R0963:Myh15 UTSW 16 48,952,512 (GRCm39) missense probably damaging 0.97
R1075:Myh15 UTSW 16 48,940,417 (GRCm39) missense possibly damaging 0.63
R1143:Myh15 UTSW 16 48,885,449 (GRCm39) missense probably benign 0.02
R1200:Myh15 UTSW 16 48,916,882 (GRCm39) missense probably damaging 1.00
R1644:Myh15 UTSW 16 48,952,566 (GRCm39) missense probably benign 0.12
R1646:Myh15 UTSW 16 49,015,931 (GRCm39) missense probably damaging 1.00
R1720:Myh15 UTSW 16 48,913,145 (GRCm39) missense probably damaging 1.00
R1768:Myh15 UTSW 16 48,983,498 (GRCm39) missense probably benign 0.27
R1881:Myh15 UTSW 16 48,891,446 (GRCm39) missense probably damaging 0.98
R2048:Myh15 UTSW 16 48,975,928 (GRCm39) missense probably damaging 0.99
R2064:Myh15 UTSW 16 48,975,984 (GRCm39) missense possibly damaging 0.50
R2184:Myh15 UTSW 16 48,957,874 (GRCm39) missense probably damaging 0.99
R2212:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R2216:Myh15 UTSW 16 48,986,201 (GRCm39) nonsense probably null
R2321:Myh15 UTSW 16 48,933,436 (GRCm39) missense possibly damaging 0.93
R2327:Myh15 UTSW 16 48,963,313 (GRCm39) missense probably benign 0.01
R2395:Myh15 UTSW 16 48,889,877 (GRCm39) missense probably benign 0.04
R2399:Myh15 UTSW 16 48,957,952 (GRCm39) missense probably damaging 0.97
R3413:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R4234:Myh15 UTSW 16 48,983,405 (GRCm39) missense probably benign 0.04
R4382:Myh15 UTSW 16 48,963,306 (GRCm39) missense probably benign 0.03
R4421:Myh15 UTSW 16 48,929,707 (GRCm39) missense probably damaging 0.99
R4580:Myh15 UTSW 16 48,885,388 (GRCm39) missense possibly damaging 0.93
R4657:Myh15 UTSW 16 48,992,421 (GRCm39) nonsense probably null
R4780:Myh15 UTSW 16 48,940,420 (GRCm39) missense probably benign 0.13
R5004:Myh15 UTSW 16 48,952,411 (GRCm39) missense probably damaging 0.99
R5175:Myh15 UTSW 16 48,889,789 (GRCm39) missense possibly damaging 0.85
R5189:Myh15 UTSW 16 48,921,870 (GRCm39) missense probably benign 0.20
R5311:Myh15 UTSW 16 48,986,204 (GRCm39) missense possibly damaging 0.94
R5318:Myh15 UTSW 16 48,930,834 (GRCm39) missense probably damaging 0.99
R5404:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R5415:Myh15 UTSW 16 48,937,658 (GRCm39) missense probably null 1.00
R5558:Myh15 UTSW 16 48,889,900 (GRCm39) missense probably benign 0.32
R5977:Myh15 UTSW 16 48,973,866 (GRCm39) missense probably damaging 1.00
R6004:Myh15 UTSW 16 48,980,062 (GRCm39) missense probably benign 0.00
R6275:Myh15 UTSW 16 48,965,610 (GRCm39) missense probably benign 0.00
R6381:Myh15 UTSW 16 48,921,844 (GRCm39) missense probably damaging 1.00
R6448:Myh15 UTSW 16 48,992,295 (GRCm39) missense probably damaging 0.99
R6516:Myh15 UTSW 16 48,957,996 (GRCm39) missense probably benign 0.19
R6752:Myh15 UTSW 16 49,003,290 (GRCm39) missense probably damaging 1.00
R6847:Myh15 UTSW 16 48,965,451 (GRCm39) missense possibly damaging 0.70
R6868:Myh15 UTSW 16 48,889,766 (GRCm39) missense probably damaging 1.00
R6889:Myh15 UTSW 16 48,973,474 (GRCm39) missense possibly damaging 0.75
R6896:Myh15 UTSW 16 48,933,434 (GRCm39) missense probably benign 0.44
R6955:Myh15 UTSW 16 48,901,598 (GRCm39) critical splice donor site probably null
R6984:Myh15 UTSW 16 48,930,775 (GRCm39) missense probably damaging 1.00
R7046:Myh15 UTSW 16 48,929,662 (GRCm39) nonsense probably null
R7095:Myh15 UTSW 16 48,992,272 (GRCm39) missense possibly damaging 0.90
R7098:Myh15 UTSW 16 48,997,420 (GRCm39) missense possibly damaging 0.53
R7134:Myh15 UTSW 16 48,901,705 (GRCm39) missense possibly damaging 0.86
R7159:Myh15 UTSW 16 48,881,937 (GRCm39) missense probably damaging 0.97
R7244:Myh15 UTSW 16 49,017,149 (GRCm39) missense probably damaging 1.00
R7278:Myh15 UTSW 16 48,911,468 (GRCm39) missense probably damaging 0.98
R7309:Myh15 UTSW 16 48,916,828 (GRCm39) missense probably benign 0.34
R7418:Myh15 UTSW 16 48,975,900 (GRCm39) missense possibly damaging 0.69
R7937:Myh15 UTSW 16 48,976,009 (GRCm39) missense probably benign 0.00
R8053:Myh15 UTSW 16 48,963,302 (GRCm39) missense possibly damaging 0.89
R8313:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8315:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8316:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8317:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8342:Myh15 UTSW 16 48,913,120 (GRCm39) missense probably benign
R8379:Myh15 UTSW 16 48,901,551 (GRCm39) missense probably benign
R8445:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8707:Myh15 UTSW 16 48,973,450 (GRCm39) missense probably damaging 1.00
R8729:Myh15 UTSW 16 48,881,851 (GRCm39) missense probably damaging 0.97
R8773:Myh15 UTSW 16 49,015,900 (GRCm39) missense possibly damaging 0.89
R8869:Myh15 UTSW 16 48,997,366 (GRCm39) missense probably benign
R8890:Myh15 UTSW 16 48,959,130 (GRCm39) missense probably damaging 1.00
R9026:Myh15 UTSW 16 49,007,433 (GRCm39) missense probably damaging 1.00
R9063:Myh15 UTSW 16 48,913,118 (GRCm39) missense probably benign 0.00
R9290:Myh15 UTSW 16 48,997,375 (GRCm39) missense probably damaging 1.00
R9630:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R9710:Myh15 UTSW 16 48,959,044 (GRCm39) missense probably damaging 1.00
X0012:Myh15 UTSW 16 48,963,341 (GRCm39) missense probably damaging 1.00
X0020:Myh15 UTSW 16 48,986,237 (GRCm39) missense probably damaging 1.00
Z1176:Myh15 UTSW 16 48,916,894 (GRCm39) missense probably damaging 0.98
Z1177:Myh15 UTSW 16 48,980,189 (GRCm39) missense probably benign 0.09
Z1177:Myh15 UTSW 16 48,975,981 (GRCm39) missense probably damaging 0.97
Z1177:Myh15 UTSW 16 48,901,591 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CTGCCTTCCAGGGTTACTTAG -3'
(R):5'- GAACTGCTTCTTTCAACCAGCC -3'

Sequencing Primer
(F):5'- GCCTTCCAGGGTTACTTAGAAAATC -3'
(R):5'- AGCCAACTGCACGAATGG -3'
Posted On 2019-09-13