Mutagenetix > Incidental Mutation

Incidental Mutation 'R0639:Dnah6'

56910

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

MMRRC Submission

038828-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.116) question?

Stock #

R0639 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

73017606-73221651 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 73022412 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 4012 (Y4012F)

Ref Sequence

ENSEMBL: ENSMUSP00000144791 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000064948
AA Change: Y4012F

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: Y4012F

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114040
AA Change: Y3960F

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: Y3960F

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000204053
AA Change: Y4012F

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: Y4012F

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204577

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.7%
20x: 95.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600014C23Rik	C	T	17: 45,733,073	W86*	probably null	Het
5830411N06Rik	A	G	7: 140,247,959	N27D	probably benign	Het
Acadl	T	C	1: 66,857,408	H75R	probably benign	Het
Adamtsl1	T	C	4: 86,277,143	F599S	probably damaging	Het
Adrb3	T	C	8: 27,228,265	N52S	probably damaging	Het
Agbl3	T	A	6: 34,799,705	L377Q	probably damaging	Het
Akap9	T	C	5: 4,060,318	L3007P	probably damaging	Het
Amer3	T	A	1: 34,587,821	Y380*	probably null	Het
Ankrd13d	A	T	19: 4,273,019		probably null	Het
Ap4m1	T	A	5: 138,176,239	C235S	probably benign	Het
Arhgap29	T	C	3: 122,007,641	F675S	probably damaging	Het
Asah2	C	A	19: 32,008,639	V544F	probably damaging	Het
Ash2l	A	G	8: 25,823,291	I389T	possibly damaging	Het
Bend5	T	C	4: 111,433,298	S164P	probably benign	Het
Cacna1d	A	G	14: 30,171,294		probably null	Het
Cdc25b	A	G	2: 131,197,262	N516D	probably benign	Het
Cdc27	A	G	11: 104,531,734	Y125H	probably damaging	Het
Cdk5r2	C	T	1: 74,855,836	L247F	probably damaging	Het
Cenpf	C	A	1: 189,658,062	G1191V	probably benign	Het
Cops4	C	T	5: 100,537,460	T293I	possibly damaging	Het
Csmd3	A	G	15: 47,913,940	L1294P	probably damaging	Het
Dclre1a	T	C	19: 56,538,440	Y848C	probably damaging	Het
Disp2	A	T	2: 118,790,844	I686F	possibly damaging	Het
Dnajc11	C	G	4: 151,969,936	R200G	probably damaging	Het
Dnhd1	A	T	7: 105,696,464	D2272V	possibly damaging	Het
Elane	A	C	10: 79,886,349	R5S	possibly damaging	Het
Entpd7	G	A	19: 43,691,094	V29M	probably benign	Het
Fanca	A	G	8: 123,289,359		probably null	Het
Fgl1	G	T	8: 41,191,624	T281K	probably benign	Het
Flii	T	C	11: 60,722,997		probably null	Het
Foxn1	T	C	11: 78,371,144	D133G	possibly damaging	Het
Fzd7	T	A	1: 59,484,560	M534K	probably damaging	Het
Galnt5	A	G	2: 57,999,395	T336A	probably benign	Het
Gli3	G	A	13: 15,724,715	D896N	probably damaging	Het
Gsx1	G	T	5: 147,189,946	W193L	probably damaging	Het
Gtpbp3	A	T	8: 71,492,735	I485F	probably damaging	Het
H2-M11	A	G	17: 36,547,391	T26A	probably benign	Het
Igfbp7	T	C	5: 77,351,980	D243G	probably damaging	Het
Il31ra	A	T	13: 112,525,843	D477E	possibly damaging	Het
Inmt	A	C	6: 55,171,227	V139G	probably damaging	Het
Inpp5j	T	A	11: 3,501,147	M501L	probably benign	Het
Itsn2	T	C	12: 4,712,556	F1579L	probably damaging	Het
Kat2b	C	A	17: 53,567,538	A70E	probably benign	Het
Klhl20	T	C	1: 161,093,711	E58G	probably damaging	Het
Krt79	A	T	15: 101,931,548	Y337*	probably null	Het
Krt81	C	A	15: 101,463,627	R24L	possibly damaging	Het
Letm1	T	C	5: 33,769,426	I176V	possibly damaging	Het
Lingo3	C	A	10: 80,835,784	R104L	probably benign	Het
Lrig3	T	G	10: 126,010,221	C840G	probably damaging	Het
Lrrc9	A	G	12: 72,486,288	N977S	probably damaging	Het
Lrrk2	T	A	15: 91,772,996	M1831K	probably benign	Het
Mn1	A	T	5: 111,419,316	D384V	probably damaging	Het
Morc3	C	A	16: 93,853,850	H319Q	probably damaging	Het
Morn1	T	C	4: 155,089,503	F56L	possibly damaging	Het
Mrpl53	G	T	6: 83,109,411	V64L	probably damaging	Het
Myo15	T	A	11: 60,479,336	V974D	probably benign	Het
Neb	A	G	2: 52,256,124	V2947A	possibly damaging	Het
Nfasc	A	C	1: 132,603,816	N737K	probably damaging	Het
Nlk	T	C	11: 78,572,277	D464G	possibly damaging	Het
Nlrc4	C	T	17: 74,426,963	R985K	probably benign	Het
Nsun6	T	C	2: 14,996,336	K470E	probably benign	Het
Nup85	T	G	11: 115,564,531	M1R	probably null	Het
Olfr887	G	A	9: 38,085,370	C178Y	probably damaging	Het
Otop1	T	C	5: 38,287,948	V150A	possibly damaging	Het
Pclo	C	T	5: 14,681,749	R296*	probably null	Het
Pdzd2	A	T	15: 12,458,058	C240S	possibly damaging	Het
Plekhg5	A	G	4: 152,114,120	T922A	probably benign	Het
Plekhm2	A	C	4: 141,642,070	L101R	probably damaging	Het
Plscr3	T	A	11: 69,847,994	C161S	probably benign	Het
Prr14l	C	T	5: 32,828,915	D1079N	probably benign	Het
Ptpru	A	T	4: 131,771,179	V1377E	possibly damaging	Het
Rab37	C	A	11: 115,158,702	D112E	probably benign	Het
Raet1e	T	A	10: 22,174,375	I19N	probably damaging	Het
Rassf5	T	C	1: 131,245,066	Y22C	probably damaging	Het
Rp1	T	C	1: 4,346,498	T1464A	probably benign	Het
Safb	T	A	17: 56,601,092		probably benign	Het
Scarf2	A	G	16: 17,806,505		probably null	Het
Sh3d19	T	C	3: 86,106,973	S415P	probably benign	Het
Slc26a9	T	A	1: 131,763,804	L595Q	probably damaging	Het
Slc4a8	T	C	15: 100,796,550	Y470H	probably damaging	Het
Slitrk3	T	C	3: 73,049,649	N597D	probably benign	Het
Spata31	T	A	13: 64,922,213	V725E	probably benign	Het
Spink12	T	A	18: 44,107,764	C72*	probably null	Het
Spink5	T	A	18: 44,012,975		probably null	Het
Stk40	C	A	4: 126,118,332	S9*	probably null	Het
Sypl	A	T	12: 32,965,421	T40S	probably damaging	Het
Tbc1d8	C	T	1: 39,391,209	E438K	probably benign	Het
Tdrd7	A	G	4: 45,989,102	T111A	probably benign	Het
Tg	A	T	15: 66,741,484		probably null	Het
Tlr5	T	A	1: 182,973,889	W253R	probably damaging	Het
Tmprss11c	C	T	5: 86,235,469	C353Y	probably damaging	Het
Tnfrsf8	T	A	4: 145,288,027	M271L	probably benign	Het
Toe1	T	C	4: 116,806,750	N21S	probably benign	Het
Tpp2	T	C	1: 43,975,447	F649L	probably benign	Het
Ttll1	G	A	15: 83,502,225	Q60*	probably null	Het
Vcp	C	T	4: 42,982,565	R709Q	probably benign	Het
Vmn1r119	T	A	7: 21,011,668	H263L	possibly damaging	Het
Vmn1r195	C	A	13: 22,278,941	Q194K	probably damaging	Het
Vmn1r33	T	C	6: 66,611,799	Y257C	probably damaging	Het
Vmn2r15	A	G	5: 109,293,015	F326L	probably benign	Het
Wbp11	A	T	6: 136,816,110		probably benign	Het
Wwp2	T	G	8: 107,517,946	V250G	probably benign	Het
Xpnpep3	T	C	15: 81,430,837	V246A	probably benign	Het
Zcchc14	G	A	8: 121,605,449	R419*	probably null	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73195737	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73086207	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73195761	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73195620	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73195620	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73195620	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73212434	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73123771	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73195620	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73156350	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73033526	splice site	probably benign
IGL00972:Dnah6	APN	6	73083157	splice site	probably benign
IGL00975:Dnah6	APN	6	73173390	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73074781	splice site	probably benign
IGL01307:Dnah6	APN	6	73065725	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73173456	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73092178	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73074748	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73024252	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73144718	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73144718	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73075802	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73076660	nonsense	probably null
IGL01736:Dnah6	APN	6	73188377	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73065776	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73135801	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73032569	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73060143	missense	probably benign
IGL02126:Dnah6	APN	6	73103166	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	73017797	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73133650	splice site	probably benign
IGL02316:Dnah6	APN	6	73168911	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73101898	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73076640	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73027448	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	73021227	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73095104	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73121823	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73208599	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73138715	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73032587	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73069420	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73149140	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73145004	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73041054	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73144700	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73053647	splice site	probably benign
IGL03286:Dnah6	APN	6	73083085	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73075850	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73163504	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73065755	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73208641	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73101880	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73114582	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73060260	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73092172	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73092172	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73155279	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73155279	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73038734	splice site	probably benign
R0164:Dnah6	UTSW	6	73188535	splice site	probably benign
R0165:Dnah6	UTSW	6	73021323	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73082923	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73069420	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73159115	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73173558	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73069399	splice site	probably benign
R0345:Dnah6	UTSW	6	73021257	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73188359	missense	probably benign
R0362:Dnah6	UTSW	6	73208609	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73121992	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73083124	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73044774	missense	probably benign	0.15
R0673:Dnah6	UTSW	6	73123811	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73129474	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73212622	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73087602	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73035293	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73124757	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73159193	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73144965	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73159135	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73124709	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73208545	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73191619	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73027442	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73049048	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73151553	missense	probably benign
R1557:Dnah6	UTSW	6	73049131	nonsense	probably null
R1591:Dnah6	UTSW	6	73076600	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73067469	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73144963	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73100112	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73044752	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73155296	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73205732	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73124778	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73124778	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73129540	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73044761	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73160982	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73024958	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73181797	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73100088	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73181762	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73084721	nonsense	probably null
R1978:Dnah6	UTSW	6	73121970	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73095044	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73092192	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73067466	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73173419	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73027422	missense	probably benign
R2041:Dnah6	UTSW	6	73073439	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	73021182	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73144035	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73049166	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73089746	splice site	probably null
R2193:Dnah6	UTSW	6	73138640	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73100085	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73113581	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	73021109	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73156421	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73091967	splice site	probably null
R2436:Dnah6	UTSW	6	73149173	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73129331	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73129331	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73173350	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73121814	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73121814	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73032633	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73191498	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73127927	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73121992	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73089592	nonsense	probably null
R4246:Dnah6	UTSW	6	73129448	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73149484	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73118026	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73129291	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73191479	missense	probably benign
R4486:Dnah6	UTSW	6	73038746	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73178416	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73192405	missense	probably benign
R4573:Dnah6	UTSW	6	73086181	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73086181	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73152712	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73129660	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73070597	missense	probably benign
R4653:Dnah6	UTSW	6	73073457	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73037688	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73192422	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73025012	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73129530	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73095074	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73089668	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73089698	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73089698	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	73022424	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73044762	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73121788	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73192676	intron	probably benign
R4948:Dnah6	UTSW	6	73053689	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73188383	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73144815	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73044691	missense	probably benign
R5044:Dnah6	UTSW	6	73037622	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73181761	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73195634	missense	probably benign
R5186:Dnah6	UTSW	6	73067427	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73195732	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73113488	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73127861	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73074590	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73074590	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73212620	missense	probably benign
R5343:Dnah6	UTSW	6	73212616	missense	probably benign
R5375:Dnah6	UTSW	6	73123855	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73037615	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73060138	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73075734	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73086185	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73092157	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73092116	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73190419	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73159229	missense	probably benign
R5541:Dnah6	UTSW	6	73192988	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73151689	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73149525	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	73021227	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73060279	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73181722	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73086166	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73114697	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73188494	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73065815	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73065815	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73086217	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73191605	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73155418	nonsense	probably null
R6470:Dnah6	UTSW	6	73074586	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73074704	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73044732	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73173533	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73053695	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73035280	splice site	probably null
R6640:Dnah6	UTSW	6	73024293	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73138760	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73037549	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73133608	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73133542	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73212522	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73181755	nonsense	probably null
R6929:Dnah6	UTSW	6	73044773	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	73021178	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73087562	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73135680	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73038746	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73181705	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73173545	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73084760	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73144722	nonsense	probably null
R7387:Dnah6	UTSW	6	73212612	nonsense	probably null
R7388:Dnah6	UTSW	6	73192317	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73212492	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73127904	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73118099	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73027440	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73149430	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73092168	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73095206	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73124759	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73169080	splice site	probably null
R7735:Dnah6	UTSW	6	73069429	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73025720	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73127919	nonsense	probably null
R7904:Dnah6	UTSW	6	73135467	splice site	probably null
R8034:Dnah6	UTSW	6	73129225	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73160913	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73025786	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73060225	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73037566	nonsense	probably null
R8214:Dnah6	UTSW	6	73044728	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73168827	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73076599	missense	probably benign	0.31
R8273:Dnah6	UTSW	6	73195681	missense	probably benign	0.00
R8331:Dnah6	UTSW	6	73025000	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73195815	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73074651	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73138774	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73195815	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73178457	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73095188	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73168867	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73075890	intron	probably benign
R8737:Dnah6	UTSW	6	73067445	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73179828	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73065773	missense	probably benign
R8809:Dnah6	UTSW	6	73032563	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73127954	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73144173	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	73021148	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73178498	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73144751	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73142292	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73084657	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73149173	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73144046	nonsense	probably null
R9102:Dnah6	UTSW	6	73067486	missense	probably benign
R9106:Dnah6	UTSW	6	73144769	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73060203	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73121899	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73144941	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73144705	nonsense	probably null
R9200:Dnah6	UTSW	6	73027514	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73083057	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	73021278	missense	probably benign	0.22
R9378:Dnah6	UTSW	6	73212530	missense	probably benign
R9439:Dnah6	UTSW	6	73035347	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73142316	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73138767	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73191606	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73101889	missense	probably benign
RF020:Dnah6	UTSW	6	73118057	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73178518	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73037673	missense	probably damaging	1.00
X0025:Dnah6	UTSW	6	73191500	missense	probably benign	0.01
Z1176:Dnah6	UTSW	6	73087783	missense	possibly damaging	0.79
Z1176:Dnah6	UTSW	6	73133559	missense	probably benign
Z1177:Dnah6	UTSW	6	73021237	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73032526	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	73041138	missense	probably damaging	1.00
Z1177:Dnah6	UTSW	6	73155272	missense	possibly damaging	0.92

Predicted Primers

PCR Primer
(F):5'- GTGTTTGCCAAGTTCCCATTCAGTC -3'
(R):5'- AGAAAGCTCTCTGATGAGCCACAAC -3'

Sequencing Primer
(F):5'- CTTGGGGAATGAGACCCAC -3'
(R):5'- CCTGGGTTGACAGGGGG -3'

Posted On

2013-07-11