Incidental Mutation 'R7331:Il1r2'
ID 569219
Institutional Source Beutler Lab
Gene Symbol Il1r2
Ensembl Gene ENSMUSG00000026073
Gene Name interleukin 1 receptor, type II
Synonyms Il1r-2, IL-1 receptor beta chain, CD121b
MMRRC Submission 045424-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7331 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 40123872-40164390 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 40162409 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 351 (T351A)
Ref Sequence ENSEMBL: ENSMUSP00000027243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027243] [ENSMUST00000195770]
AlphaFold P27931
Predicted Effect probably benign
Transcript: ENSMUST00000027243
AA Change: T351A

PolyPhen 2 Score 0.111 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000027243
Gene: ENSMUSG00000026073
AA Change: T351A

DomainStartEndE-ValueType
IG 49 138 2.48e-8 SMART
IG 149 241 1.6e-2 SMART
IG 255 354 1.32e-3 SMART
transmembrane domain 359 381 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000195770
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik A T 13: 77,331,728 (GRCm39) H47L possibly damaging Het
Adgrf5 T C 17: 43,748,484 (GRCm39) S438P probably damaging Het
Atg16l2 C A 7: 100,948,255 (GRCm39) K96N probably damaging Het
Bglap2 A T 3: 88,285,567 (GRCm39) M35K possibly damaging Het
Btbd1 T A 7: 81,465,720 (GRCm39) I209L probably damaging Het
Cdc34 T C 10: 79,521,146 (GRCm39) Y148H probably damaging Het
Clcc1 A G 3: 108,575,394 (GRCm39) D157G probably damaging Het
Csmd2 A T 4: 128,458,021 (GRCm39) probably null Het
Ctsj G A 13: 61,151,645 (GRCm39) S90L probably benign Het
Cycs A G 6: 50,542,532 (GRCm39) F37L probably benign Het
Dync2li1 T A 17: 84,955,086 (GRCm39) C248* probably null Het
Dzank1 A T 2: 144,332,190 (GRCm39) I382N probably benign Het
Eif4a3l2 G A 6: 116,529,130 (GRCm39) V336I probably benign Het
Enpp2 T C 15: 54,739,066 (GRCm39) I406V probably damaging Het
Ero1b A G 13: 12,615,015 (GRCm39) E282G probably damaging Het
Fastkd5 A T 2: 130,457,647 (GRCm39) N314K possibly damaging Het
Fbh1 A T 2: 11,768,797 (GRCm39) C300S probably benign Het
Fchsd1 T C 18: 38,101,823 (GRCm39) I49V possibly damaging Het
Foxn1 A G 11: 78,249,615 (GRCm39) Y637H probably damaging Het
Gabarap A G 11: 69,885,298 (GRCm39) E101G possibly damaging Het
Gm7247 A G 14: 51,601,792 (GRCm39) R22G probably damaging Het
Gm7694 A T 1: 170,129,180 (GRCm39) D116E possibly damaging Het
Gm9508 A G 10: 77,532,629 (GRCm39) C147R unknown Het
Gpr152 A G 19: 4,192,608 (GRCm39) M50V probably damaging Het
Hunk T A 16: 90,269,450 (GRCm39) N331K possibly damaging Het
Iqub A G 6: 24,500,393 (GRCm39) V287A possibly damaging Het
Lix1 A T 17: 17,647,474 (GRCm39) T47S probably benign Het
Lrp1b A T 2: 40,553,622 (GRCm39) probably null Het
Nup107 G A 10: 117,606,103 (GRCm39) T500I probably damaging Het
Phf21b G C 15: 84,675,295 (GRCm39) R405G probably benign Het
Piezo2 A G 18: 63,241,101 (GRCm39) V709A probably damaging Het
Psme3ip1 T A 8: 95,309,564 (GRCm39) K143* probably null Het
Rfc1 T C 5: 65,468,387 (GRCm39) T109A probably damaging Het
Rpa1 A G 11: 75,203,941 (GRCm39) V302A probably damaging Het
Ryr2 A G 13: 11,760,517 (GRCm39) I1522T probably benign Het
Ryr3 C A 2: 112,594,010 (GRCm39) R2578L possibly damaging Het
Scgb2b18 C T 7: 32,872,681 (GRCm39) W41* probably null Het
Sdccag8 C G 1: 176,695,856 (GRCm39) Q387E possibly damaging Het
Slc25a17 G A 15: 81,213,346 (GRCm39) T119M probably damaging Het
Slc45a4 G T 15: 73,477,489 (GRCm39) Q16K probably benign Het
Slc4a1 G A 11: 102,252,245 (GRCm39) probably benign Het
Slc7a14 T C 3: 31,311,880 (GRCm39) T47A probably benign Het
Stard6 A G 18: 70,616,553 (GRCm39) R71G probably damaging Het
Tecr A G 8: 84,298,564 (GRCm39) V321A probably damaging Het
Ttc3 T A 16: 94,195,218 (GRCm39) F290L probably benign Het
Uqcc1 A G 2: 155,753,731 (GRCm39) V48A probably benign Het
V1rd19 T A 7: 23,703,308 (GRCm39) I258N probably damaging Het
Zar1 T A 5: 72,737,655 (GRCm39) E249V possibly damaging Het
Zfp101 T C 17: 33,601,559 (GRCm39) T66A possibly damaging Het
Zyx A G 6: 42,328,593 (GRCm39) H230R probably benign Het
Other mutations in Il1r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01945:Il1r2 APN 1 40,141,613 (GRCm39) missense possibly damaging 0.66
IGL02673:Il1r2 APN 1 40,154,323 (GRCm39) missense probably damaging 1.00
R0019:Il1r2 UTSW 1 40,164,210 (GRCm39) missense probably damaging 1.00
R0019:Il1r2 UTSW 1 40,164,210 (GRCm39) missense probably damaging 1.00
R0299:Il1r2 UTSW 1 40,162,309 (GRCm39) nonsense probably null
R0499:Il1r2 UTSW 1 40,162,309 (GRCm39) nonsense probably null
R0607:Il1r2 UTSW 1 40,144,615 (GRCm39) missense probably benign 0.06
R1435:Il1r2 UTSW 1 40,144,459 (GRCm39) missense probably damaging 0.99
R1925:Il1r2 UTSW 1 40,154,308 (GRCm39) missense probably damaging 0.99
R2209:Il1r2 UTSW 1 40,154,298 (GRCm39) missense probably benign 0.02
R2240:Il1r2 UTSW 1 40,144,630 (GRCm39) missense probably damaging 1.00
R4997:Il1r2 UTSW 1 40,160,206 (GRCm39) critical splice donor site probably null
R7273:Il1r2 UTSW 1 40,151,167 (GRCm39) missense probably benign 0.06
R7401:Il1r2 UTSW 1 40,162,370 (GRCm39) missense probably damaging 1.00
R7751:Il1r2 UTSW 1 40,162,371 (GRCm39) missense probably damaging 1.00
R7841:Il1r2 UTSW 1 40,144,628 (GRCm39) missense probably damaging 1.00
R8363:Il1r2 UTSW 1 40,160,095 (GRCm39) missense probably damaging 1.00
R8470:Il1r2 UTSW 1 40,162,416 (GRCm39) missense probably damaging 1.00
R8520:Il1r2 UTSW 1 40,144,499 (GRCm39) missense probably damaging 1.00
R8871:Il1r2 UTSW 1 40,144,424 (GRCm39) missense probably benign 0.11
R9148:Il1r2 UTSW 1 40,151,258 (GRCm39) missense probably damaging 0.99
R9176:Il1r2 UTSW 1 40,144,478 (GRCm39) missense probably damaging 1.00
R9558:Il1r2 UTSW 1 40,162,422 (GRCm39) missense probably damaging 1.00
R9646:Il1r2 UTSW 1 40,162,362 (GRCm39) missense probably damaging 1.00
X0010:Il1r2 UTSW 1 40,157,141 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- TGCTCTGCATACATACATCATGC -3'
(R):5'- ACATGTATGTACAACGCTCTCTC -3'

Sequencing Primer
(F):5'- GCATACATACATCATGCTCTGAATAC -3'
(R):5'- GTATGTACAACGCTCTCTCTCTCAC -3'
Posted On 2019-09-13