Incidental Mutation 'R7332:Zfp40'
ID 569326
Institutional Source Beutler Lab
Gene Symbol Zfp40
Ensembl Gene ENSMUSG00000002617
Gene Name zinc finger protein 40
Synonyms Zfp-40, NTfin12
MMRRC Submission 045425-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7332 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 23392843-23412226 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 23395155 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 477 (C477*)
Ref Sequence ENSEMBL: ENSMUSP00000039794 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037057] [ENSMUST00000140313] [ENSMUST00000172177]
AlphaFold B1B1D3
Predicted Effect probably null
Transcript: ENSMUST00000037057
AA Change: C477*
SMART Domains Protein: ENSMUSP00000039794
Gene: ENSMUSG00000002617
AA Change: C477*

DomainStartEndE-ValueType
KRAB 43 103 2.96e-17 SMART
ZnF_C2H2 225 247 1.47e-3 SMART
ZnF_C2H2 281 302 5.77e0 SMART
ZnF_C2H2 308 330 4.34e0 SMART
ZnF_C2H2 336 358 1.82e-3 SMART
ZnF_C2H2 363 385 4.24e-4 SMART
ZnF_C2H2 391 413 2.75e-3 SMART
ZnF_C2H2 419 441 1.38e-3 SMART
ZnF_C2H2 447 469 9.58e-3 SMART
ZnF_C2H2 475 497 1.47e-3 SMART
ZnF_C2H2 503 525 8.47e-4 SMART
ZnF_C2H2 531 553 2.57e-3 SMART
ZnF_C2H2 559 581 8.47e-4 SMART
ZnF_C2H2 587 609 4.54e-4 SMART
ZnF_C2H2 615 636 1.26e1 SMART
ZnF_C2H2 642 664 5.59e-4 SMART
ZnF_C2H2 670 692 3.21e-4 SMART
ZnF_C2H2 698 720 2.24e-3 SMART
ZnF_C2H2 726 748 1.2e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000140313
AA Change: C409*
SMART Domains Protein: ENSMUSP00000121359
Gene: ENSMUSG00000002617
AA Change: C409*

DomainStartEndE-ValueType
Blast:KRAB 1 35 4e-16 BLAST
ZnF_C2H2 157 179 1.47e-3 SMART
ZnF_C2H2 213 234 5.77e0 SMART
ZnF_C2H2 240 262 4.34e0 SMART
ZnF_C2H2 268 290 1.82e-3 SMART
ZnF_C2H2 295 317 4.24e-4 SMART
ZnF_C2H2 323 345 2.75e-3 SMART
ZnF_C2H2 351 373 1.38e-3 SMART
ZnF_C2H2 379 401 9.58e-3 SMART
ZnF_C2H2 407 429 1.47e-3 SMART
ZnF_C2H2 435 457 8.47e-4 SMART
ZnF_C2H2 463 485 2.57e-3 SMART
ZnF_C2H2 491 513 8.47e-4 SMART
ZnF_C2H2 519 541 4.54e-4 SMART
ZnF_C2H2 547 568 1.26e1 SMART
ZnF_C2H2 574 596 5.59e-4 SMART
ZnF_C2H2 602 624 3.21e-4 SMART
ZnF_C2H2 630 652 2.24e-3 SMART
ZnF_C2H2 658 680 1.2e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000172177
AA Change: C477*
SMART Domains Protein: ENSMUSP00000128758
Gene: ENSMUSG00000002617
AA Change: C477*

DomainStartEndE-ValueType
KRAB 43 103 2.96e-17 SMART
ZnF_C2H2 225 247 1.47e-3 SMART
ZnF_C2H2 281 302 5.77e0 SMART
ZnF_C2H2 308 330 4.34e0 SMART
ZnF_C2H2 336 358 1.82e-3 SMART
ZnF_C2H2 363 385 4.24e-4 SMART
ZnF_C2H2 391 413 2.75e-3 SMART
ZnF_C2H2 419 441 1.38e-3 SMART
ZnF_C2H2 447 469 9.58e-3 SMART
ZnF_C2H2 475 497 1.47e-3 SMART
ZnF_C2H2 503 525 8.47e-4 SMART
ZnF_C2H2 531 553 2.57e-3 SMART
ZnF_C2H2 559 581 8.47e-4 SMART
ZnF_C2H2 587 609 4.54e-4 SMART
ZnF_C2H2 615 636 1.26e1 SMART
ZnF_C2H2 642 664 5.59e-4 SMART
ZnF_C2H2 670 692 3.21e-4 SMART
ZnF_C2H2 698 720 2.24e-3 SMART
ZnF_C2H2 726 748 1.2e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (68/68)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1l2 A G 19: 56,906,553 (GRCm39) S449P probably damaging Het
Atp6v0c A C 17: 24,388,198 (GRCm39) S21A probably benign Het
Cacna1e T C 1: 154,601,547 (GRCm39) Y40C possibly damaging Het
Cdadc1 A G 14: 59,813,213 (GRCm39) I398T possibly damaging Het
Cfap44 T A 16: 44,250,191 (GRCm39) D756E probably damaging Het
Clcnkb A T 4: 141,141,243 (GRCm39) L104Q probably null Het
Clk1 G A 1: 58,451,853 (GRCm39) H421Y probably benign Het
Cmpk2 A T 12: 26,528,061 (GRCm39) D426V probably damaging Het
Cmya5 A G 13: 93,229,061 (GRCm39) L2009S possibly damaging Het
Col5a2 C G 1: 45,419,325 (GRCm39) D1252H probably damaging Het
Coro1b A G 19: 4,199,356 (GRCm39) K5R probably benign Het
Csmd2 A G 4: 128,313,360 (GRCm39) T1346A Het
Csrp1 G T 1: 135,667,149 (GRCm39) W4L probably benign Het
Cyp3a25 A G 5: 145,929,817 (GRCm39) I184T probably damaging Het
Egfl7 C A 2: 26,480,725 (GRCm39) R128S probably benign Het
Fggy A T 4: 95,511,719 (GRCm39) N157I probably damaging Het
Gldc A T 19: 30,093,926 (GRCm39) L697Q probably damaging Het
Gm4952 T A 19: 12,604,373 (GRCm39) Y262N probably damaging Het
Gsap T A 5: 21,495,119 (GRCm39) M821K probably benign Het
Hps1 T C 19: 42,766,351 (GRCm39) probably null Het
Hsbp1l1 T C 18: 80,280,038 (GRCm39) probably benign Het
Igfbp7 G A 5: 77,499,803 (GRCm39) T220I probably damaging Het
Ints3 T C 3: 90,322,819 (GRCm39) Q137R probably damaging Het
Kcna6 A G 6: 126,716,292 (GRCm39) F199S possibly damaging Het
Kirrel1 T C 3: 86,995,705 (GRCm39) I410V probably benign Het
Llgl2 T C 11: 115,739,125 (GRCm39) V332A probably damaging Het
Lrrc27 A G 7: 138,822,661 (GRCm39) I517M probably damaging Het
Mas1 T C 17: 13,061,106 (GRCm39) T106A probably benign Het
Mast4 T A 13: 102,887,932 (GRCm39) Y1159F possibly damaging Het
Mmp2 A G 8: 93,576,780 (GRCm39) D601G probably damaging Het
Mycbp2 T A 14: 103,434,793 (GRCm39) I2217F probably damaging Het
Mycbp2 A G 14: 103,393,889 (GRCm39) S2891P probably damaging Het
Naip6 A G 13: 100,437,209 (GRCm39) V438A possibly damaging Het
Or4g17 A G 2: 111,209,738 (GRCm39) H131R not run Het
Pdf T C 8: 107,775,173 (GRCm39) R20G probably benign Het
Pfdn2 T C 1: 171,184,162 (GRCm39) L47P probably damaging Het
Pik3c2g C A 6: 139,841,981 (GRCm39) N795K Het
Ppip5k1 A T 2: 121,142,450 (GRCm39) V1333D probably damaging Het
Pramel51 T C 12: 88,143,187 (GRCm39) T339A possibly damaging Het
Prss44 A T 9: 110,644,530 (GRCm39) I213F probably damaging Het
Rbm47 A G 5: 66,183,557 (GRCm39) Y349H probably damaging Het
Rcl1 A T 19: 29,108,096 (GRCm39) T253S probably benign Het
Rdh1 A G 10: 127,595,754 (GRCm39) probably benign Het
Scn7a C T 2: 66,522,898 (GRCm39) W935* probably null Het
Sec24b T C 3: 129,835,042 (GRCm39) N52S probably benign Het
Serpinb5 A T 1: 106,800,091 (GRCm39) I94L probably benign Het
Setx T C 2: 29,036,638 (GRCm39) V1041A probably benign Het
Slco3a1 G A 7: 73,968,232 (GRCm39) A496V possibly damaging Het
Spag5 T A 11: 78,204,205 (GRCm39) L486* probably null Het
Spink5 T C 18: 44,115,317 (GRCm39) I183T probably damaging Het
Srd5a1 T C 13: 69,759,173 (GRCm39) Y65C probably benign Het
Ssh2 T A 11: 77,344,349 (GRCm39) I778N possibly damaging Het
Sstr1 C T 12: 58,260,172 (GRCm39) S265L probably damaging Het
Syne2 T A 12: 76,014,529 (GRCm39) probably null Het
Tctn1 A T 5: 122,399,547 (GRCm39) D92E probably damaging Het
Tiam2 A G 17: 3,503,644 (GRCm39) I940M probably damaging Het
Tmeff2 T C 1: 51,018,599 (GRCm39) W194R unknown Het
Tomm20 T C 8: 127,663,903 (GRCm39) T94A probably benign Het
Ucn2 A G 9: 108,815,532 (GRCm39) N98S probably benign Het
V1rd19 A T 7: 23,702,743 (GRCm39) I70L probably benign Het
Vmn1r18 A G 6: 57,367,503 (GRCm39) L17P probably benign Het
Vmn2r61 A G 7: 41,909,534 (GRCm39) T20A probably benign Het
Wdr59 G A 8: 112,220,986 (GRCm39) T182I Het
Zfp68 A G 5: 138,604,830 (GRCm39) S498P possibly damaging Het
Zfp729b T C 13: 67,757,755 (GRCm39) probably null Het
Zfp846 T G 9: 20,505,521 (GRCm39) N460K probably benign Het
Zim1 T C 7: 6,680,352 (GRCm39) Y437C probably damaging Het
Other mutations in Zfp40
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00719:Zfp40 APN 17 23,394,716 (GRCm39) missense probably benign 0.18
IGL02664:Zfp40 APN 17 23,395,960 (GRCm39) missense probably benign 0.14
IGL02729:Zfp40 APN 17 23,397,285 (GRCm39) missense probably damaging 0.99
R1288:Zfp40 UTSW 17 23,401,136 (GRCm39) missense probably benign 0.01
R1450:Zfp40 UTSW 17 23,394,232 (GRCm39) missense probably benign 0.15
R1535:Zfp40 UTSW 17 23,394,843 (GRCm39) missense probably damaging 1.00
R1655:Zfp40 UTSW 17 23,396,240 (GRCm39) missense probably benign 0.01
R1797:Zfp40 UTSW 17 23,394,514 (GRCm39) missense possibly damaging 0.93
R2254:Zfp40 UTSW 17 23,397,344 (GRCm39) missense possibly damaging 0.92
R3764:Zfp40 UTSW 17 23,396,101 (GRCm39) missense possibly damaging 0.49
R4356:Zfp40 UTSW 17 23,396,164 (GRCm39) missense probably benign 0.15
R4402:Zfp40 UTSW 17 23,395,693 (GRCm39) missense possibly damaging 0.49
R4781:Zfp40 UTSW 17 23,394,629 (GRCm39) missense probably damaging 0.99
R4792:Zfp40 UTSW 17 23,396,008 (GRCm39) missense possibly damaging 0.79
R6142:Zfp40 UTSW 17 23,395,311 (GRCm39) missense probably benign 0.40
R6179:Zfp40 UTSW 17 23,397,354 (GRCm39) missense possibly damaging 0.51
R6759:Zfp40 UTSW 17 23,395,510 (GRCm39) missense possibly damaging 0.95
R7294:Zfp40 UTSW 17 23,395,411 (GRCm39) missense possibly damaging 0.60
R7386:Zfp40 UTSW 17 23,395,981 (GRCm39) missense probably damaging 0.96
R7462:Zfp40 UTSW 17 23,397,362 (GRCm39) missense possibly damaging 0.71
R7479:Zfp40 UTSW 17 23,396,292 (GRCm39) missense probably benign 0.23
R7641:Zfp40 UTSW 17 23,397,257 (GRCm39) missense possibly damaging 0.92
R7725:Zfp40 UTSW 17 23,397,251 (GRCm39) missense probably benign 0.38
R7825:Zfp40 UTSW 17 23,395,301 (GRCm39) missense probably benign 0.24
R7839:Zfp40 UTSW 17 23,395,963 (GRCm39) missense probably damaging 0.99
R7881:Zfp40 UTSW 17 23,410,440 (GRCm39) unclassified probably benign
R8501:Zfp40 UTSW 17 23,397,272 (GRCm39) missense probably damaging 0.99
R8722:Zfp40 UTSW 17 23,395,157 (GRCm39) missense probably damaging 1.00
R8853:Zfp40 UTSW 17 23,394,691 (GRCm39) missense possibly damaging 0.95
R8945:Zfp40 UTSW 17 23,401,201 (GRCm39) missense probably benign
R9206:Zfp40 UTSW 17 23,394,551 (GRCm39) missense probably damaging 0.98
R9208:Zfp40 UTSW 17 23,394,551 (GRCm39) missense probably damaging 0.98
R9406:Zfp40 UTSW 17 23,396,129 (GRCm39) missense possibly damaging 0.91
R9640:Zfp40 UTSW 17 23,394,493 (GRCm39) missense probably damaging 1.00
R9765:Zfp40 UTSW 17 23,395,863 (GRCm39) nonsense probably null
X0022:Zfp40 UTSW 17 23,396,128 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGCTTTCCTGATAAAACACTTGTC -3'
(R):5'- TCCTCCTCTTCAGGTCTTCAAAGA -3'

Sequencing Primer
(F):5'- CTGATGTGTTCTAAGATCCGAGAC -3'
(R):5'- GTGCTGAATGTAACAAATGCTTC -3'
Posted On 2019-09-13