Mutagenetix > Incidental Mutation

Incidental Mutation 'R0639:Myo15'

56936

Institutional Source

Beutler Lab

Gene Symbol

Myo15

Ensembl Gene

ENSMUSG00000042678

Gene Name

myosin XV

Synonyms

sh2; sh-2; Myo15a

MMRRC Submission

038828-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0639 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

60469339-60528369 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 60479336 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 974 (V974D)

Ref Sequence

ENSEMBL: ENSMUSP00000091686 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071880] [ENSMUST00000081823] [ENSMUST00000094135]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000071880
AA Change: V974D

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000071777
Gene: ENSMUSG00000042678
AA Change: V974D

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1955	1974	N/A	INTRINSIC
low complexity region	1992	2006	N/A	INTRINSIC
MyTH4	2049	2195	1.8e-42	SMART
low complexity region	2396	2405	N/A	INTRINSIC
low complexity region	2451	2461	N/A	INTRINSIC
Blast:MYSc	2665	2848	2e-14	BLAST
SH3	2851	2933	1.55e-4	SMART
low complexity region	2949	2962	N/A	INTRINSIC
MyTH4	3031	3185	5.59e-48	SMART
B41	3188	3400	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000081823

SMART Domains

Protein: ENSMUSP00000080507
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
MYSc	13	697	N/A	SMART
IQ	698	720	1.63e-1	SMART
IQ	721	743	1.77e-2	SMART
IQ	744	766	2.97e2	SMART
low complexity region	787	801	N/A	INTRINSIC
MyTH4	844	990	1.8e-42	SMART
low complexity region	1191	1200	N/A	INTRINSIC
low complexity region	1246	1256	N/A	INTRINSIC
Blast:MYSc	1460	1643	7e-15	BLAST
SH3	1646	1728	1.55e-4	SMART
low complexity region	1744	1757	N/A	INTRINSIC
MyTH4	1826	1980	5.59e-48	SMART
B41	1983	2195	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000094135
AA Change: V974D

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000091686
Gene: ENSMUSG00000042678
AA Change: V974D

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1974	1988	N/A	INTRINSIC
MyTH4	2031	2177	1.8e-42	SMART
low complexity region	2378	2387	N/A	INTRINSIC
low complexity region	2433	2443	N/A	INTRINSIC
Blast:MYSc	2647	2830	2e-14	BLAST
SH3	2833	2915	1.55e-4	SMART
low complexity region	2931	2944	N/A	INTRINSIC
MyTH4	3013	3167	5.59e-48	SMART
B41	3170	3382	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000126522

SMART Domains

Protein: ENSMUSP00000120839
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
MYSc	34	716	N/A	SMART
IQ	717	739	1.63e-1	SMART
IQ	740	762	1.77e-2	SMART
IQ	763	785	2.97e2	SMART
low complexity region	806	820	N/A	INTRINSIC
MyTH4	863	1009	1.8e-42	SMART
low complexity region	1210	1219	N/A	INTRINSIC
low complexity region	1265	1275	N/A	INTRINSIC
Blast:MYSc	1479	1662	5e-15	BLAST
SH3	1665	1747	1.55e-4	SMART
low complexity region	1763	1776	N/A	INTRINSIC

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.7%
20x: 95.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in profound deafness and neurological behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600014C23Rik	C	T	17: 45,733,073 (GRCm38)	W86*	probably null	Het
5830411N06Rik	A	G	7: 140,247,959 (GRCm38)	N27D	probably benign	Het
Acadl	T	C	1: 66,857,408 (GRCm38)	H75R	probably benign	Het
Adamtsl1	T	C	4: 86,277,143 (GRCm38)	F599S	probably damaging	Het
Adrb3	T	C	8: 27,228,265 (GRCm38)	N52S	probably damaging	Het
Agbl3	T	A	6: 34,799,705 (GRCm38)	L377Q	probably damaging	Het
Akap9	T	C	5: 4,060,318 (GRCm38)	L3007P	probably damaging	Het
Amer3	T	A	1: 34,587,821 (GRCm38)	Y380*	probably null	Het
Ankrd13d	A	T	19: 4,273,019 (GRCm38)		probably null	Het
Ap4m1	T	A	5: 138,176,239 (GRCm38)	C235S	probably benign	Het
Arhgap29	T	C	3: 122,007,641 (GRCm38)	F675S	probably damaging	Het
Asah2	C	A	19: 32,008,639 (GRCm38)	V544F	probably damaging	Het
Ash2l	A	G	8: 25,823,291 (GRCm38)	I389T	possibly damaging	Het
Bend5	T	C	4: 111,433,298 (GRCm38)	S164P	probably benign	Het
Cacna1d	A	G	14: 30,171,294 (GRCm38)		probably null	Het
Cdc25b	A	G	2: 131,197,262 (GRCm38)	N516D	probably benign	Het
Cdc27	A	G	11: 104,531,734 (GRCm38)	Y125H	probably damaging	Het
Cdk5r2	C	T	1: 74,855,836 (GRCm38)	L247F	probably damaging	Het
Cenpf	C	A	1: 189,658,062 (GRCm38)	G1191V	probably benign	Het
Cops4	C	T	5: 100,537,460 (GRCm38)	T293I	possibly damaging	Het
Csmd3	A	G	15: 47,913,940 (GRCm38)	L1294P	probably damaging	Het
Dclre1a	T	C	19: 56,538,440 (GRCm38)	Y848C	probably damaging	Het
Disp2	A	T	2: 118,790,844 (GRCm38)	I686F	possibly damaging	Het
Dnah6	T	A	6: 73,022,412 (GRCm38)	Y4012F	probably benign	Het
Dnajc11	C	G	4: 151,969,936 (GRCm38)	R200G	probably damaging	Het
Dnhd1	A	T	7: 105,696,464 (GRCm38)	D2272V	possibly damaging	Het
Elane	A	C	10: 79,886,349 (GRCm38)	R5S	possibly damaging	Het
Entpd7	G	A	19: 43,691,094 (GRCm38)	V29M	probably benign	Het
Fanca	A	G	8: 123,289,359 (GRCm38)		probably null	Het
Fgl1	G	T	8: 41,191,624 (GRCm38)	T281K	probably benign	Het
Flii	T	C	11: 60,722,997 (GRCm38)		probably null	Het
Foxn1	T	C	11: 78,371,144 (GRCm38)	D133G	possibly damaging	Het
Fzd7	T	A	1: 59,484,560 (GRCm38)	M534K	probably damaging	Het
Galnt5	A	G	2: 57,999,395 (GRCm38)	T336A	probably benign	Het
Gli3	G	A	13: 15,724,715 (GRCm38)	D896N	probably damaging	Het
Gsx1	G	T	5: 147,189,946 (GRCm38)	W193L	probably damaging	Het
Gtpbp3	A	T	8: 71,492,735 (GRCm38)	I485F	probably damaging	Het
H2-M11	A	G	17: 36,547,391 (GRCm38)	T26A	probably benign	Het
Igfbp7	T	C	5: 77,351,980 (GRCm38)	D243G	probably damaging	Het
Il31ra	A	T	13: 112,525,843 (GRCm38)	D477E	possibly damaging	Het
Inmt	A	C	6: 55,171,227 (GRCm38)	V139G	probably damaging	Het
Inpp5j	T	A	11: 3,501,147 (GRCm38)	M501L	probably benign	Het
Itsn2	T	C	12: 4,712,556 (GRCm38)	F1579L	probably damaging	Het
Kat2b	C	A	17: 53,567,538 (GRCm38)	A70E	probably benign	Het
Klhl20	T	C	1: 161,093,711 (GRCm38)	E58G	probably damaging	Het
Krt79	A	T	15: 101,931,548 (GRCm38)	Y337*	probably null	Het
Krt81	C	A	15: 101,463,627 (GRCm38)	R24L	possibly damaging	Het
Letm1	T	C	5: 33,769,426 (GRCm38)	I176V	possibly damaging	Het
Lingo3	C	A	10: 80,835,784 (GRCm38)	R104L	probably benign	Het
Lrig3	T	G	10: 126,010,221 (GRCm38)	C840G	probably damaging	Het
Lrrc9	A	G	12: 72,486,288 (GRCm38)	N977S	probably damaging	Het
Lrrk2	T	A	15: 91,772,996 (GRCm38)	M1831K	probably benign	Het
Mn1	A	T	5: 111,419,316 (GRCm38)	D384V	probably damaging	Het
Morc3	C	A	16: 93,853,850 (GRCm38)	H319Q	probably damaging	Het
Morn1	T	C	4: 155,089,503 (GRCm38)	F56L	possibly damaging	Het
Mrpl53	G	T	6: 83,109,411 (GRCm38)	V64L	probably damaging	Het
Neb	A	G	2: 52,256,124 (GRCm38)	V2947A	possibly damaging	Het
Nfasc	A	C	1: 132,603,816 (GRCm38)	N737K	probably damaging	Het
Nlk	T	C	11: 78,572,277 (GRCm38)	D464G	possibly damaging	Het
Nlrc4	C	T	17: 74,426,963 (GRCm38)	R985K	probably benign	Het
Nsun6	T	C	2: 14,996,336 (GRCm38)	K470E	probably benign	Het
Nup85	T	G	11: 115,564,531 (GRCm38)	M1R	probably null	Het
Olfr887	G	A	9: 38,085,370 (GRCm38)	C178Y	probably damaging	Het
Otop1	T	C	5: 38,287,948 (GRCm38)	V150A	possibly damaging	Het
Pclo	C	T	5: 14,681,749 (GRCm38)	R296*	probably null	Het
Pdzd2	A	T	15: 12,458,058 (GRCm38)	C240S	possibly damaging	Het
Plekhg5	A	G	4: 152,114,120 (GRCm38)	T922A	probably benign	Het
Plekhm2	A	C	4: 141,642,070 (GRCm38)	L101R	probably damaging	Het
Plscr3	T	A	11: 69,847,994 (GRCm38)	C161S	probably benign	Het
Prr14l	C	T	5: 32,828,915 (GRCm38)	D1079N	probably benign	Het
Ptpru	A	T	4: 131,771,179 (GRCm38)	V1377E	possibly damaging	Het
Rab37	C	A	11: 115,158,702 (GRCm38)	D112E	probably benign	Het
Raet1e	T	A	10: 22,174,375 (GRCm38)	I19N	probably damaging	Het
Rassf5	T	C	1: 131,245,066 (GRCm38)	Y22C	probably damaging	Het
Rp1	T	C	1: 4,346,498 (GRCm38)	T1464A	probably benign	Het
Safb	T	A	17: 56,601,092 (GRCm38)		probably benign	Het
Scarf2	A	G	16: 17,806,505 (GRCm38)		probably null	Het
Sh3d19	T	C	3: 86,106,973 (GRCm38)	S415P	probably benign	Het
Slc26a9	T	A	1: 131,763,804 (GRCm38)	L595Q	probably damaging	Het
Slc4a8	T	C	15: 100,796,550 (GRCm38)	Y470H	probably damaging	Het
Slitrk3	T	C	3: 73,049,649 (GRCm38)	N597D	probably benign	Het
Spata31	T	A	13: 64,922,213 (GRCm38)	V725E	probably benign	Het
Spink12	T	A	18: 44,107,764 (GRCm38)	C72*	probably null	Het
Spink5	T	A	18: 44,012,975 (GRCm38)		probably null	Het
Stk40	C	A	4: 126,118,332 (GRCm38)	S9*	probably null	Het
Sypl	A	T	12: 32,965,421 (GRCm38)	T40S	probably damaging	Het
Tbc1d8	C	T	1: 39,391,209 (GRCm38)	E438K	probably benign	Het
Tdrd7	A	G	4: 45,989,102 (GRCm38)	T111A	probably benign	Het
Tg	A	T	15: 66,741,484 (GRCm38)		probably null	Het
Tlr5	T	A	1: 182,973,889 (GRCm38)	W253R	probably damaging	Het
Tmprss11c	C	T	5: 86,235,469 (GRCm38)	C353Y	probably damaging	Het
Tnfrsf8	T	A	4: 145,288,027 (GRCm38)	M271L	probably benign	Het
Toe1	T	C	4: 116,806,750 (GRCm38)	N21S	probably benign	Het
Tpp2	T	C	1: 43,975,447 (GRCm38)	F649L	probably benign	Het
Ttll1	G	A	15: 83,502,225 (GRCm38)	Q60*	probably null	Het
Vcp	C	T	4: 42,982,565 (GRCm38)	R709Q	probably benign	Het
Vmn1r119	T	A	7: 21,011,668 (GRCm38)	H263L	possibly damaging	Het
Vmn1r195	C	A	13: 22,278,941 (GRCm38)	Q194K	probably damaging	Het
Vmn1r33	T	C	6: 66,611,799 (GRCm38)	Y257C	probably damaging	Het
Vmn2r15	A	G	5: 109,293,015 (GRCm38)	F326L	probably benign	Het
Wbp11	A	T	6: 136,816,110 (GRCm38)		probably benign	Het
Wwp2	T	G	8: 107,517,946 (GRCm38)	V250G	probably benign	Het
Xpnpep3	T	C	15: 81,430,837 (GRCm38)	V246A	probably benign	Het
Zcchc14	G	A	8: 121,605,449 (GRCm38)	R419*	probably null	Het

Other mutations in Myo15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00845:Myo15	APN	11	60,477,779 (GRCm38)	missense	probably damaging	1.00
IGL01011:Myo15	APN	11	60,476,992 (GRCm38)	missense	probably benign	0.33
IGL01100:Myo15	APN	11	60,511,158 (GRCm38)	missense	probably damaging	1.00
IGL01357:Myo15	APN	11	60,502,289 (GRCm38)	splice site	probably benign
IGL01634:Myo15	APN	11	60,495,472 (GRCm38)	missense	probably damaging	1.00
IGL01763:Myo15	APN	11	60,521,738 (GRCm38)	missense	probably benign	0.07
IGL01901:Myo15	APN	11	60,527,434 (GRCm38)	utr 3 prime	probably benign
IGL01931:Myo15	APN	11	60,496,138 (GRCm38)	missense	probably damaging	1.00
IGL02006:Myo15	APN	11	60,511,128 (GRCm38)	missense	probably damaging	1.00
IGL02041:Myo15	APN	11	60,506,863 (GRCm38)	missense	probably damaging	0.99
IGL02094:Myo15	APN	11	60,510,647 (GRCm38)	unclassified	probably benign
IGL02122:Myo15	APN	11	60,483,466 (GRCm38)	missense	probably benign	0.23
IGL02153:Myo15	APN	11	60,498,397 (GRCm38)	missense	probably damaging	1.00
IGL02328:Myo15	APN	11	60,526,607 (GRCm38)	missense	probably benign	0.13
IGL02330:Myo15	APN	11	60,477,161 (GRCm38)	missense	possibly damaging	0.94
IGL02431:Myo15	APN	11	60,510,639 (GRCm38)	missense	possibly damaging	0.73
IGL02639:Myo15	APN	11	60,478,621 (GRCm38)	missense	probably benign
IGL02659:Myo15	APN	11	60,491,783 (GRCm38)	splice site	probably benign
IGL02800:Myo15	APN	11	60,502,369 (GRCm38)	missense	probably damaging	1.00
IGL02812:Myo15	APN	11	60,477,179 (GRCm38)	missense	probably benign	0.15
IGL02863:Myo15	APN	11	60,478,127 (GRCm38)	missense	probably damaging	1.00
IGL02873:Myo15	APN	11	60,483,482 (GRCm38)	missense	probably damaging	1.00
IGL02990:Myo15	APN	11	60,479,440 (GRCm38)	missense	probably benign	0.02
IGL03011:Myo15	APN	11	60,509,531 (GRCm38)	splice site	probably benign
IGL03243:Myo15	APN	11	60,496,518 (GRCm38)	missense	probably damaging	1.00
IGL03297:Myo15	APN	11	60,479,141 (GRCm38)	missense	probably damaging	1.00
novichok	UTSW	11	60,481,740 (GRCm38)	critical splice donor site	probably null
parker	UTSW	11	60,520,914 (GRCm38)	critical splice donor site	probably null
Typhoon	UTSW	11	60,487,425 (GRCm38)	critical splice donor site	probably null
PIT4131001:Myo15	UTSW	11	60,495,454 (GRCm38)	missense	probably damaging	1.00
PIT4131001:Myo15	UTSW	11	60,483,127 (GRCm38)	missense	probably damaging	1.00
R0133:Myo15	UTSW	11	60,477,850 (GRCm38)	missense	possibly damaging	0.94
R0265:Myo15	UTSW	11	60,514,897 (GRCm38)	critical splice acceptor site	probably null
R0389:Myo15	UTSW	11	60,478,538 (GRCm38)	missense	probably benign
R0416:Myo15	UTSW	11	60,511,174 (GRCm38)	missense	probably damaging	1.00
R0449:Myo15	UTSW	11	60,509,596 (GRCm38)	missense	possibly damaging	0.92
R0477:Myo15	UTSW	11	60,520,914 (GRCm38)	critical splice donor site	probably null
R0543:Myo15	UTSW	11	60,479,051 (GRCm38)	missense	probably benign
R0546:Myo15	UTSW	11	60,506,313 (GRCm38)	missense	probably damaging	1.00
R0555:Myo15	UTSW	11	60,521,638 (GRCm38)	missense	probably damaging	1.00
R0723:Myo15	UTSW	11	60,478,977 (GRCm38)	missense	possibly damaging	0.94
R0837:Myo15	UTSW	11	60,487,251 (GRCm38)	missense	probably damaging	0.98
R0865:Myo15	UTSW	11	60,491,688 (GRCm38)	missense	probably damaging	1.00
R0899:Myo15	UTSW	11	60,477,185 (GRCm38)	missense	possibly damaging	0.87
R1022:Myo15	UTSW	11	60,479,616 (GRCm38)	missense	probably benign	0.00
R1024:Myo15	UTSW	11	60,479,616 (GRCm38)	missense	probably benign	0.00
R1035:Myo15	UTSW	11	60,510,558 (GRCm38)	unclassified	probably benign
R1109:Myo15	UTSW	11	60,493,066 (GRCm38)	missense	probably damaging	1.00
R1170:Myo15	UTSW	11	60,479,407 (GRCm38)	missense	probably benign	0.04
R1241:Myo15	UTSW	11	60,499,430 (GRCm38)	missense	possibly damaging	0.58
R1392:Myo15	UTSW	11	60,477,974 (GRCm38)	missense	possibly damaging	0.95
R1392:Myo15	UTSW	11	60,477,974 (GRCm38)	missense	possibly damaging	0.95
R1434:Myo15	UTSW	11	60,504,331 (GRCm38)	missense	probably benign	0.00
R1450:Myo15	UTSW	11	60,495,482 (GRCm38)	missense	probably damaging	1.00
R1456:Myo15	UTSW	11	60,508,202 (GRCm38)	missense	probably damaging	1.00
R1468:Myo15	UTSW	11	60,506,006 (GRCm38)	missense	probably damaging	1.00
R1468:Myo15	UTSW	11	60,506,006 (GRCm38)	missense	probably damaging	1.00
R1548:Myo15	UTSW	11	60,488,238 (GRCm38)	missense	probably damaging	1.00
R1551:Myo15	UTSW	11	60,492,965 (GRCm38)	missense	possibly damaging	0.70
R1571:Myo15	UTSW	11	60,518,464 (GRCm38)	missense	probably damaging	1.00
R1662:Myo15	UTSW	11	60,501,701 (GRCm38)	missense	probably damaging	1.00
R1777:Myo15	UTSW	11	60,514,936 (GRCm38)	missense	probably benign
R1778:Myo15	UTSW	11	60,478,412 (GRCm38)	missense	possibly damaging	0.57
R1847:Myo15	UTSW	11	60,499,495 (GRCm38)	nonsense	probably null
R1875:Myo15	UTSW	11	60,507,528 (GRCm38)	missense	probably damaging	0.99
R1944:Myo15	UTSW	11	60,502,083 (GRCm38)	missense	probably damaging	0.99
R1945:Myo15	UTSW	11	60,502,083 (GRCm38)	missense	probably damaging	0.99
R2013:Myo15	UTSW	11	60,494,231 (GRCm38)	missense	probably damaging	1.00
R2107:Myo15	UTSW	11	60,491,810 (GRCm38)	missense	probably damaging	1.00
R2108:Myo15	UTSW	11	60,491,810 (GRCm38)	missense	probably damaging	1.00
R2112:Myo15	UTSW	11	60,494,168 (GRCm38)	missense	probably damaging	0.99
R2147:Myo15	UTSW	11	60,510,229 (GRCm38)	missense	possibly damaging	0.66
R2196:Myo15	UTSW	11	60,510,021 (GRCm38)	nonsense	probably null
R2207:Myo15	UTSW	11	60,506,034 (GRCm38)	missense	probably benign	0.01
R2245:Myo15	UTSW	11	60,509,099 (GRCm38)	missense	probably damaging	1.00
R2367:Myo15	UTSW	11	60,517,238 (GRCm38)	missense	probably damaging	0.99
R2374:Myo15	UTSW	11	60,478,843 (GRCm38)	missense	possibly damaging	0.88
R2438:Myo15	UTSW	11	60,483,052 (GRCm38)	missense	probably damaging	1.00
R3154:Myo15	UTSW	11	60,479,360 (GRCm38)	splice site	probably null
R3423:Myo15	UTSW	11	60,510,300 (GRCm38)	critical splice donor site	probably null
R3551:Myo15	UTSW	11	60,509,663 (GRCm38)	missense	possibly damaging	0.93
R3552:Myo15	UTSW	11	60,509,663 (GRCm38)	missense	possibly damaging	0.93
R3612:Myo15	UTSW	11	60,477,679 (GRCm38)	missense	probably damaging	1.00
R3620:Myo15	UTSW	11	60,478,642 (GRCm38)	missense	possibly damaging	0.63
R3713:Myo15	UTSW	11	60,479,231 (GRCm38)	missense	possibly damaging	0.55
R3714:Myo15	UTSW	11	60,479,231 (GRCm38)	missense	possibly damaging	0.55
R3715:Myo15	UTSW	11	60,479,231 (GRCm38)	missense	possibly damaging	0.55
R3783:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3784:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3785:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3786:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3787:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3894:Myo15	UTSW	11	60,504,319 (GRCm38)	missense	probably benign	0.00
R3962:Myo15	UTSW	11	60,479,828 (GRCm38)	missense	probably benign	0.00
R4082:Myo15	UTSW	11	60,487,196 (GRCm38)	missense	possibly damaging	0.92
R4555:Myo15	UTSW	11	60,496,937 (GRCm38)	missense	probably damaging	1.00
R4641:Myo15	UTSW	11	60,503,041 (GRCm38)	missense	probably damaging	1.00
R4665:Myo15	UTSW	11	60,504,879 (GRCm38)	critical splice acceptor site	probably null
R4713:Myo15	UTSW	11	60,479,930 (GRCm38)	missense	probably benign	0.21
R4820:Myo15	UTSW	11	60,476,915 (GRCm38)	missense	probably damaging	0.98
R5013:Myo15	UTSW	11	60,491,667 (GRCm38)	missense	probably damaging	1.00
R5051:Myo15	UTSW	11	60,487,425 (GRCm38)	critical splice donor site	probably null
R5187:Myo15	UTSW	11	60,503,614 (GRCm38)	missense	probably damaging	1.00
R5230:Myo15	UTSW	11	60,502,848 (GRCm38)	missense	possibly damaging	0.68
R5277:Myo15	UTSW	11	60,477,114 (GRCm38)	nonsense	probably null
R5345:Myo15	UTSW	11	60,497,538 (GRCm38)	missense	probably damaging	0.99
R5349:Myo15	UTSW	11	60,493,583 (GRCm38)	missense	probably damaging	1.00
R5356:Myo15	UTSW	11	60,498,366 (GRCm38)	missense	probably damaging	1.00
R5445:Myo15	UTSW	11	60,520,777 (GRCm38)	nonsense	probably null
R5477:Myo15	UTSW	11	60,477,677 (GRCm38)	missense	probably damaging	1.00
R5629:Myo15	UTSW	11	60,479,752 (GRCm38)	missense	probably benign
R5728:Myo15	UTSW	11	60,488,896 (GRCm38)	missense	probably damaging	1.00
R5818:Myo15	UTSW	11	60,497,951 (GRCm38)	missense	probably benign	0.06
R5952:Myo15	UTSW	11	60,479,420 (GRCm38)	missense	possibly damaging	0.50
R6338:Myo15	UTSW	11	60,478,133 (GRCm38)	missense	probably damaging	0.99
R6467:Myo15	UTSW	11	60,526,661 (GRCm38)	critical splice donor site	probably null
R6488:Myo15	UTSW	11	60,478,487 (GRCm38)	missense	possibly damaging	0.86
R6521:Myo15	UTSW	11	60,502,369 (GRCm38)	missense	probably damaging	1.00
R6645:Myo15	UTSW	11	60,477,292 (GRCm38)	missense	probably benign	0.00
R6702:Myo15	UTSW	11	60,492,992 (GRCm38)	missense	probably benign	0.16
R6703:Myo15	UTSW	11	60,492,992 (GRCm38)	missense	probably benign	0.16
R6821:Myo15	UTSW	11	60,524,475 (GRCm38)	missense	probably damaging	1.00
R6882:Myo15	UTSW	11	60,524,006 (GRCm38)	missense	probably damaging	1.00
R6908:Myo15	UTSW	11	60,506,006 (GRCm38)	missense	probably damaging	1.00
R6932:Myo15	UTSW	11	60,499,494 (GRCm38)	missense	probably damaging	1.00
R6958:Myo15	UTSW	11	60,503,625 (GRCm38)	missense	probably benign	0.07
R7041:Myo15	UTSW	11	60,506,006 (GRCm38)	missense	probably damaging	1.00
R7149:Myo15	UTSW	11	60,510,010 (GRCm38)	missense	possibly damaging	0.56
R7163:Myo15	UTSW	11	60,498,369 (GRCm38)	missense
R7229:Myo15	UTSW	11	60,496,495 (GRCm38)	missense	probably benign	0.08
R7347:Myo15	UTSW	11	60,477,961 (GRCm38)	missense	probably benign
R7368:Myo15	UTSW	11	60,490,915 (GRCm38)	splice site	probably null
R7392:Myo15	UTSW	11	60,505,976 (GRCm38)	missense
R7414:Myo15	UTSW	11	60,483,483 (GRCm38)	missense
R7461:Myo15	UTSW	11	60,505,152 (GRCm38)	missense
R7609:Myo15	UTSW	11	60,488,811 (GRCm38)	missense
R7613:Myo15	UTSW	11	60,505,152 (GRCm38)	missense
R7734:Myo15	UTSW	11	60,510,282 (GRCm38)	missense	probably benign
R7748:Myo15	UTSW	11	60,504,901 (GRCm38)	missense
R7767:Myo15	UTSW	11	60,502,096 (GRCm38)	missense
R7769:Myo15	UTSW	11	60,509,149 (GRCm38)	missense
R7894:Myo15	UTSW	11	60,491,137 (GRCm38)	missense
R7919:Myo15	UTSW	11	60,526,530 (GRCm38)	missense	probably damaging	1.00
R8100:Myo15	UTSW	11	60,517,190 (GRCm38)	missense	probably damaging	1.00
R8124:Myo15	UTSW	11	60,507,453 (GRCm38)	missense
R8129:Myo15	UTSW	11	60,508,200 (GRCm38)	missense
R8428:Myo15	UTSW	11	60,496,415 (GRCm38)	missense	probably damaging	1.00
R8706:Myo15	UTSW	11	60,479,617 (GRCm38)	missense	probably benign
R8735:Myo15	UTSW	11	60,510,853 (GRCm38)	critical splice acceptor site	probably null
R8739:Myo15	UTSW	11	60,477,262 (GRCm38)	missense	probably benign	0.06
R8790:Myo15	UTSW	11	60,487,221 (GRCm38)	missense
R8790:Myo15	UTSW	11	60,476,536 (GRCm38)	missense	possibly damaging	0.73
R8822:Myo15	UTSW	11	60,476,914 (GRCm38)	missense	probably damaging	0.99
R8907:Myo15	UTSW	11	60,526,608 (GRCm38)	missense
R8931:Myo15	UTSW	11	60,477,194 (GRCm38)	missense	probably benign
R9061:Myo15	UTSW	11	60,502,866 (GRCm38)	missense
R9124:Myo15	UTSW	11	60,479,126 (GRCm38)	missense	probably benign	0.37
R9297:Myo15	UTSW	11	60,495,073 (GRCm38)	missense	probably null
R9347:Myo15	UTSW	11	60,483,729 (GRCm38)	missense
R9417:Myo15	UTSW	11	60,487,417 (GRCm38)	missense
R9456:Myo15	UTSW	11	60,501,842 (GRCm38)	missense
R9460:Myo15	UTSW	11	60,481,740 (GRCm38)	critical splice donor site	probably null
R9615:Myo15	UTSW	11	60,483,494 (GRCm38)	missense
R9630:Myo15	UTSW	11	60,517,162 (GRCm38)	missense	probably damaging	1.00
R9746:Myo15	UTSW	11	60,487,408 (GRCm38)	nonsense	probably null
X0021:Myo15	UTSW	11	60,482,359 (GRCm38)	nonsense	probably null
X0066:Myo15	UTSW	11	60,478,220 (GRCm38)	missense	probably damaging	1.00
X0067:Myo15	UTSW	11	60,478,618 (GRCm38)	missense	possibly damaging	0.88
Z1176:Myo15	UTSW	11	60,498,403 (GRCm38)	missense
Z1176:Myo15	UTSW	11	60,488,258 (GRCm38)	missense
Z1176:Myo15	UTSW	11	60,524,441 (GRCm38)	missense	probably damaging	1.00
Z1177:Myo15	UTSW	11	60,495,475 (GRCm38)	missense
Z1177:Myo15	UTSW	11	60,488,837 (GRCm38)	missense
Z1177:Myo15	UTSW	11	60,477,523 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCAGAAACACCGTGGACAGTTCCC -3'
(R):5'- AGGCGCTGAGTCGTAAAACCTTC -3'

Sequencing Primer
(F):5'- GTGGACAGTTCCCCCATTG -3'
(R):5'- GAGTCGTAAAACCTTCCTCTCCG -3'

Posted On

2013-07-11