Incidental Mutation 'R7334:Dip2a'
| ID |
569383 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dip2a
|
| Ensembl Gene |
ENSMUSG00000020231 |
| Gene Name |
disco interacting protein 2 homolog A |
| Synonyms |
Dip2, Kiaa0184-hp, 4931420H10Rik |
| MMRRC Submission |
045371-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7334 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
76098581-76181194 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 76110080 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1179
(S1179P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101057
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036033]
[ENSMUST00000105417]
[ENSMUST00000160048]
|
| AlphaFold |
Q8BWT5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000036033
AA Change: S1169P
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000043710
Gene: ENSMUSG00000020231
AA Change: S1169P
| Domain | Start | End | E-Value | Type |
|---|
|
DMAP_binding
|
9 |
122 |
2.55e-35 |
SMART |
|
low complexity region
|
173 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
281 |
293 |
N/A |
INTRINSIC |
|
Pfam:AMP-binding
|
330 |
806 |
4.3e-26 |
PFAM |
|
Pfam:AMP-binding
|
982 |
1456 |
1.4e-52 |
PFAM |
|
low complexity region
|
1487 |
1498 |
N/A |
INTRINSIC |
|
low complexity region
|
1511 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105417
AA Change: S1179P
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000101057
Gene: ENSMUSG00000020231
AA Change: S1179P
| Domain | Start | End | E-Value | Type |
|---|
|
DMAP_binding
|
9 |
122 |
2.55e-35 |
SMART |
|
low complexity region
|
173 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
281 |
293 |
N/A |
INTRINSIC |
|
Pfam:AMP-binding
|
330 |
806 |
6.6e-28 |
PFAM |
|
Pfam:AMP-binding
|
992 |
1466 |
7.3e-65 |
PFAM |
|
low complexity region
|
1497 |
1508 |
N/A |
INTRINSIC |
|
low complexity region
|
1521 |
1542 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000160048
AA Change: S1130P
PolyPhen 2
Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000125184
Gene: ENSMUSG00000020231
AA Change: S1130P
| Domain | Start | End | E-Value | Type |
|---|
|
DMAP_binding
|
9 |
83 |
7.94e-23 |
SMART |
|
low complexity region
|
134 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
242 |
254 |
N/A |
INTRINSIC |
|
Pfam:AMP-binding
|
291 |
767 |
5.3e-26 |
PFAM |
|
Pfam:AMP-binding
|
943 |
1417 |
1.7e-52 |
PFAM |
|
low complexity region
|
1448 |
1459 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1493 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6693 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (75/76) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene may be involved in axon patterning in the central nervous system. This gene is not highly expressed. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2fm3 |
T |
A |
3: 59,776,380 (GRCm39) |
C184S |
probably damaging |
Het |
| Acadm |
G |
T |
3: 153,644,698 (GRCm39) |
S9* |
probably null |
Het |
| Acot10 |
C |
T |
15: 20,665,629 (GRCm39) |
V371I |
possibly damaging |
Het |
| Adam8 |
T |
C |
7: 139,568,903 (GRCm39) |
E199G |
probably damaging |
Het |
| Aldh18a1 |
A |
T |
19: 40,539,696 (GRCm39) |
W762R |
probably damaging |
Het |
| Aldh1a1 |
T |
A |
19: 20,599,075 (GRCm39) |
V162E |
probably damaging |
Het |
| Alms1 |
A |
G |
6: 85,618,432 (GRCm39) |
D2357G |
probably damaging |
Het |
| Arfgef1 |
G |
T |
1: 10,254,685 (GRCm39) |
Q718K |
probably damaging |
Het |
| Arid5b |
A |
C |
10: 68,079,007 (GRCm39) |
V110G |
possibly damaging |
Het |
| Bpifb3 |
T |
A |
2: 153,761,654 (GRCm39) |
D34E |
probably damaging |
Het |
| Cacfd1 |
C |
T |
2: 26,905,558 (GRCm39) |
A85V |
possibly damaging |
Het |
| Cep57l1 |
C |
A |
10: 41,597,596 (GRCm39) |
S345I |
probably benign |
Het |
| Cibar2 |
T |
C |
8: 120,901,589 (GRCm39) |
T39A |
probably damaging |
Het |
| Clca3b |
G |
A |
3: 144,542,417 (GRCm39) |
R462* |
probably null |
Het |
| Cyp26c1 |
G |
A |
19: 37,677,323 (GRCm39) |
V251I |
probably benign |
Het |
| Dnal1 |
T |
C |
12: 84,173,780 (GRCm39) |
L27P |
probably damaging |
Het |
| Dock7 |
A |
G |
4: 98,864,180 (GRCm39) |
V1288A |
unknown |
Het |
| Elmod1 |
A |
T |
9: 53,841,508 (GRCm39) |
|
probably null |
Het |
| Epb41l5 |
T |
G |
1: 119,551,679 (GRCm39) |
K102T |
probably damaging |
Het |
| Fermt3 |
T |
C |
19: 6,980,406 (GRCm39) |
I358V |
probably benign |
Het |
| Frmd3 |
A |
G |
4: 74,079,955 (GRCm39) |
I316V |
probably benign |
Het |
| Fryl |
T |
C |
5: 73,204,839 (GRCm39) |
|
probably null |
Het |
| Gm4131 |
T |
A |
14: 62,702,356 (GRCm39) |
H204L |
possibly damaging |
Het |
| Hmcn2 |
G |
A |
2: 31,325,806 (GRCm39) |
G4278R |
probably damaging |
Het |
| Hmcn2 |
A |
G |
2: 31,343,147 (GRCm39) |
S4558G |
possibly damaging |
Het |
| Igkv1-132 |
A |
G |
6: 67,737,108 (GRCm39) |
T25A |
probably benign |
Het |
| Kcp |
T |
C |
6: 29,485,511 (GRCm39) |
E1161G |
probably damaging |
Het |
| Macf1 |
A |
T |
4: 123,293,235 (GRCm39) |
I5371K |
probably damaging |
Het |
| Malrd1 |
T |
A |
2: 16,011,529 (GRCm39) |
C1670S |
probably damaging |
Het |
| Mfsd13a |
T |
A |
19: 46,356,809 (GRCm39) |
V270E |
probably damaging |
Het |
| Mroh1 |
A |
G |
15: 76,311,838 (GRCm39) |
I524V |
probably benign |
Het |
| Mta1 |
T |
C |
12: 113,090,418 (GRCm39) |
S175P |
possibly damaging |
Het |
| Myo7a |
C |
T |
7: 97,728,573 (GRCm39) |
R800H |
probably benign |
Het |
| Ncald |
T |
A |
15: 37,397,524 (GRCm39) |
Y52F |
probably damaging |
Het |
| Nherf1 |
C |
T |
11: 115,054,593 (GRCm39) |
A81V |
possibly damaging |
Het |
| Nomo1 |
T |
C |
7: 45,732,692 (GRCm39) |
S1152P |
probably damaging |
Het |
| Nr3c1 |
A |
G |
18: 39,620,090 (GRCm39) |
F66L |
probably benign |
Het |
| Nrf1 |
T |
C |
6: 30,118,970 (GRCm39) |
L363S |
probably benign |
Het |
| Or4n4 |
C |
A |
14: 50,519,036 (GRCm39) |
V225F |
probably benign |
Het |
| Or8b12b |
A |
T |
9: 37,684,293 (GRCm39) |
I113F |
probably damaging |
Het |
| Osbpl3 |
A |
G |
6: 50,321,886 (GRCm39) |
M300T |
possibly damaging |
Het |
| Parpbp |
T |
A |
10: 87,947,617 (GRCm39) |
N339I |
probably damaging |
Het |
| Pdlim5 |
A |
T |
3: 141,950,678 (GRCm39) |
H578Q |
probably damaging |
Het |
| Pear1 |
T |
C |
3: 87,657,532 (GRCm39) |
N1009S |
probably damaging |
Het |
| Pnpla8 |
A |
G |
12: 44,358,286 (GRCm39) |
I745M |
probably damaging |
Het |
| Pom121l12 |
C |
A |
11: 14,549,681 (GRCm39) |
T129K |
probably damaging |
Het |
| Ppp1r14a |
T |
C |
7: 28,992,687 (GRCm39) |
S130P |
probably damaging |
Het |
| Prss12 |
A |
C |
3: 123,280,780 (GRCm39) |
L488F |
probably benign |
Het |
| Psd3 |
C |
T |
8: 68,361,357 (GRCm39) |
V559I |
possibly damaging |
Het |
| Rrh |
T |
C |
3: 129,602,631 (GRCm39) |
T364A |
probably benign |
Het |
| Shcbp1 |
A |
T |
8: 4,791,876 (GRCm39) |
M479K |
probably damaging |
Het |
| Shcbp1 |
A |
C |
8: 4,804,310 (GRCm39) |
F200C |
probably damaging |
Het |
| Slx1b |
G |
T |
7: 126,291,699 (GRCm39) |
R122S |
probably damaging |
Het |
| Spata31f1e |
G |
A |
4: 42,793,856 (GRCm39) |
T92I |
possibly damaging |
Het |
| Spidr |
A |
G |
16: 15,932,689 (GRCm39) |
|
probably null |
Het |
| St18 |
G |
A |
1: 6,872,783 (GRCm39) |
D173N |
probably benign |
Het |
| Stambpl1 |
T |
C |
19: 34,204,048 (GRCm39) |
I46T |
probably damaging |
Het |
| Syne1 |
C |
T |
10: 5,007,886 (GRCm39) |
D113N |
probably damaging |
Het |
| Tg |
G |
A |
15: 66,597,121 (GRCm39) |
V1741I |
probably benign |
Het |
| Thsd7b |
T |
A |
1: 130,123,012 (GRCm39) |
W1544R |
probably benign |
Het |
| Tiam2 |
G |
A |
17: 3,553,283 (GRCm39) |
R1120H |
possibly damaging |
Het |
| Tinag |
A |
T |
9: 76,908,931 (GRCm39) |
C337S |
probably damaging |
Het |
| Tm4sf1 |
G |
C |
3: 57,200,510 (GRCm39) |
A64G |
probably damaging |
Het |
| Tmprss6 |
A |
G |
15: 78,328,017 (GRCm39) |
Y572H |
unknown |
Het |
| Tnfrsf11a |
G |
A |
1: 105,754,854 (GRCm39) |
A309T |
possibly damaging |
Het |
| Txndc11 |
A |
G |
16: 10,946,425 (GRCm39) |
Y129H |
probably damaging |
Het |
| Ube3b |
T |
C |
5: 114,553,742 (GRCm39) |
F974S |
possibly damaging |
Het |
| Utrn |
C |
A |
10: 12,603,753 (GRCm39) |
|
probably null |
Het |
| Vmn1r58 |
T |
A |
7: 5,414,066 (GRCm39) |
M55L |
probably benign |
Het |
| Vnn1 |
T |
A |
10: 23,776,658 (GRCm39) |
S336R |
probably benign |
Het |
| Wwc2 |
T |
C |
8: 48,322,829 (GRCm39) |
Y424C |
unknown |
Het |
| Zfp507 |
T |
C |
7: 35,475,505 (GRCm39) |
I903V |
probably damaging |
Het |
| Zfp551 |
C |
T |
7: 12,150,681 (GRCm39) |
G243R |
probably damaging |
Het |
| Zfp60 |
T |
A |
7: 27,448,444 (GRCm39) |
C371S |
probably damaging |
Het |
|
| Other mutations in Dip2a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00422:Dip2a
|
APN |
10 |
76,149,070 (GRCm39) |
missense |
probably benign |
|
|
IGL00849:Dip2a
|
APN |
10 |
76,128,152 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01685:Dip2a
|
APN |
10 |
76,163,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01825:Dip2a
|
APN |
10 |
76,108,514 (GRCm39) |
nonsense |
probably null |
|
|
IGL02343:Dip2a
|
APN |
10 |
76,155,312 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02437:Dip2a
|
APN |
10 |
76,134,101 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02981:Dip2a
|
APN |
10 |
76,112,255 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL03122:Dip2a
|
APN |
10 |
76,110,880 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03261:Dip2a
|
APN |
10 |
76,140,982 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0369:Dip2a
|
UTSW |
10 |
76,134,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0522:Dip2a
|
UTSW |
10 |
76,157,365 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0962:Dip2a
|
UTSW |
10 |
76,128,266 (GRCm39) |
unclassified |
probably benign |
|
|
R1164:Dip2a
|
UTSW |
10 |
76,112,231 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1309:Dip2a
|
UTSW |
10 |
76,115,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1426:Dip2a
|
UTSW |
10 |
76,115,654 (GRCm39) |
unclassified |
probably benign |
|
|
R1636:Dip2a
|
UTSW |
10 |
76,157,412 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1823:Dip2a
|
UTSW |
10 |
76,114,336 (GRCm39) |
nonsense |
probably null |
|
|
R1830:Dip2a
|
UTSW |
10 |
76,153,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1876:Dip2a
|
UTSW |
10 |
76,153,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2284:Dip2a
|
UTSW |
10 |
76,149,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2369:Dip2a
|
UTSW |
10 |
76,149,030 (GRCm39) |
missense |
probably benign |
|
|
R4050:Dip2a
|
UTSW |
10 |
76,114,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4089:Dip2a
|
UTSW |
10 |
76,114,323 (GRCm39) |
splice site |
probably null |
|
|
R4231:Dip2a
|
UTSW |
10 |
76,155,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4715:Dip2a
|
UTSW |
10 |
76,132,240 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4752:Dip2a
|
UTSW |
10 |
76,112,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4846:Dip2a
|
UTSW |
10 |
76,157,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Dip2a
|
UTSW |
10 |
76,130,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4892:Dip2a
|
UTSW |
10 |
76,116,593 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4998:Dip2a
|
UTSW |
10 |
76,155,390 (GRCm39) |
nonsense |
probably null |
|
|
R5068:Dip2a
|
UTSW |
10 |
76,153,877 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5141:Dip2a
|
UTSW |
10 |
76,106,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5253:Dip2a
|
UTSW |
10 |
76,135,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Dip2a
|
UTSW |
10 |
76,130,357 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5324:Dip2a
|
UTSW |
10 |
76,132,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5369:Dip2a
|
UTSW |
10 |
76,128,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6272:Dip2a
|
UTSW |
10 |
76,122,241 (GRCm39) |
makesense |
probably null |
|
|
R6884:Dip2a
|
UTSW |
10 |
76,108,366 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7143:Dip2a
|
UTSW |
10 |
76,133,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7247:Dip2a
|
UTSW |
10 |
76,108,366 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7252:Dip2a
|
UTSW |
10 |
76,109,036 (GRCm39) |
missense |
not run |
|
|
R7327:Dip2a
|
UTSW |
10 |
76,108,396 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7349:Dip2a
|
UTSW |
10 |
76,121,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7360:Dip2a
|
UTSW |
10 |
76,114,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7513:Dip2a
|
UTSW |
10 |
76,149,069 (GRCm39) |
missense |
probably benign |
|
|
R7793:Dip2a
|
UTSW |
10 |
76,114,417 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7794:Dip2a
|
UTSW |
10 |
76,112,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7819:Dip2a
|
UTSW |
10 |
76,126,862 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8079:Dip2a
|
UTSW |
10 |
76,123,155 (GRCm39) |
missense |
probably benign |
|
|
R8280:Dip2a
|
UTSW |
10 |
76,100,610 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8281:Dip2a
|
UTSW |
10 |
76,112,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8286:Dip2a
|
UTSW |
10 |
76,122,297 (GRCm39) |
missense |
probably benign |
|
|
R8350:Dip2a
|
UTSW |
10 |
76,100,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8450:Dip2a
|
UTSW |
10 |
76,100,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8525:Dip2a
|
UTSW |
10 |
76,110,115 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8824:Dip2a
|
UTSW |
10 |
76,114,320 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8897:Dip2a
|
UTSW |
10 |
76,110,098 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9039:Dip2a
|
UTSW |
10 |
76,163,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9286:Dip2a
|
UTSW |
10 |
76,138,096 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9504:Dip2a
|
UTSW |
10 |
76,132,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9523:Dip2a
|
UTSW |
10 |
76,112,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9628:Dip2a
|
UTSW |
10 |
76,142,993 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9732:Dip2a
|
UTSW |
10 |
76,110,077 (GRCm39) |
missense |
probably benign |
0.11 |
|
Z1088:Dip2a
|
UTSW |
10 |
76,121,462 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1176:Dip2a
|
UTSW |
10 |
76,116,654 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1176:Dip2a
|
UTSW |
10 |
76,102,157 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1177:Dip2a
|
UTSW |
10 |
76,132,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Dip2a
|
UTSW |
10 |
76,102,156 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTTGCTACTCAGAAAGCC -3'
(R):5'- TACTGCCGTGGGTACTATTCAG -3'
Sequencing Primer
(F):5'- TTGCTACTCAGAAAGCCATAGAAG -3'
(R):5'- GGGGTATGAGCCAAGCATCTTC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation