Mutagenetix > Incidental Mutation

Incidental Mutation 'R7335:Nynrin'

569451

Institutional Source

Beutler Lab

Gene Symbol

Nynrin

Ensembl Gene

ENSMUSG00000075592

Gene Name

NYN domain and retroviral integrase containing

Synonyms

MMRRC Submission

045372-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7335 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

56091572-56112193 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 56101371 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 347 (T347S)

Ref Sequence

ENSEMBL: ENSMUSP00000098098 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100529] [ENSMUST00000168479] [ENSMUST00000227465]

AlphaFold

Q5DTZ0

Predicted Effect

probably benign
Transcript: ENSMUST00000100529
AA Change: T347S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000098098
Gene: ENSMUSG00000075592
AA Change: T347S

Domain	Start	End	E-Value	Type
low complexity region	581	606	N/A	INTRINSIC
Pfam:RNase_Zc3h12a	739	890	1.6e-54	PFAM
low complexity region	938	952	N/A	INTRINSIC
low complexity region	1212	1228	N/A	INTRINSIC
low complexity region	1390	1397	N/A	INTRINSIC
PDB:3S3O\|B	1478	1706	6e-8	PDB
SCOP:d1cxqa_	1552	1646	2e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000168479
AA Change: T347S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129557
Gene: ENSMUSG00000075592
AA Change: T347S

Domain	Start	End	E-Value	Type
low complexity region	581	606	N/A	INTRINSIC
Pfam:RNase_Zc3h12a	739	890	5.5e-54	PFAM
low complexity region	938	952	N/A	INTRINSIC
low complexity region	1212	1228	N/A	INTRINSIC
low complexity region	1390	1397	N/A	INTRINSIC
PDB:3S3O\|B	1478	1706	6e-8	PDB
SCOP:d1cxqa_	1552	1646	2e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000227465

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (56/56)

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts2	A	G	11: 50,493,093 (GRCm39)	S35G	probably benign	Het
Adcy6	G	T	15: 98,501,757 (GRCm39)	Q286K	probably benign	Het
Agrn	A	G	4: 156,260,989 (GRCm39)	S676P	probably damaging	Het
Arpp21	A	T	9: 112,005,319 (GRCm39)		probably null	Het
Bmal2	A	G	6: 146,711,217 (GRCm39)	M74V	probably benign	Het
C1rb	A	T	6: 124,552,238 (GRCm39)	I319F	possibly damaging	Het
C2cd3	T	C	7: 100,071,810 (GRCm39)	V629A		Het
Cacna1i	T	G	15: 80,259,776 (GRCm39)	F1287C	probably damaging	Het
Catspere2	A	G	1: 177,926,074 (GRCm39)	I247V	probably benign	Het
Cd101	C	G	3: 100,926,045 (GRCm39)	A229P	probably benign	Het
Cdh23	T	C	10: 60,140,895 (GRCm39)	D3151G	probably damaging	Het
Cenpc1	C	A	5: 86,182,212 (GRCm39)	K557N	possibly damaging	Het
Col6a4	G	A	9: 105,954,091 (GRCm39)	T416M	possibly damaging	Het
Cyp2c67	A	T	19: 39,628,451 (GRCm39)	C164*	probably null	Het
Dop1b	A	G	16: 93,544,396 (GRCm39)	E179G	probably benign	Het
Duoxa2	A	T	2: 122,131,821 (GRCm39)	Y170F	possibly damaging	Het
Fras1	A	G	5: 96,884,829 (GRCm39)	K2569R	possibly damaging	Het
Fsip2	C	A	2: 82,813,462 (GRCm39)	H3260Q	probably benign	Het
Gm3402	T	C	5: 146,452,043 (GRCm39)	I121T	probably benign	Het
Herc3	T	A	6: 58,853,773 (GRCm39)	H606Q	possibly damaging	Het
Hmcn2	T	C	2: 31,282,169 (GRCm39)	V1927A	possibly damaging	Het
Hnf4g	A	G	3: 3,717,924 (GRCm39)	H347R	possibly damaging	Het
Hs3st3a1	A	G	11: 64,411,163 (GRCm39)	T234A	probably benign	Het
Hyal1	G	T	9: 107,456,359 (GRCm39)	V379L	probably benign	Het
Ighv1-19	A	G	12: 114,672,571 (GRCm39)		probably benign	Het
Iqcc	T	A	4: 129,510,501 (GRCm39)	Q338L	not run	Het
Kdm5b	T	C	1: 134,488,177 (GRCm39)	V34A	probably damaging	Het
Lgals4	T	C	7: 28,540,571 (GRCm39)	F225L	probably benign	Het
Lmtk3	C	T	7: 45,444,581 (GRCm39)	T1088I	unknown	Het
Magel2	A	T	7: 62,030,524 (GRCm39)	S1143C	unknown	Het
Mapk4	A	T	18: 74,070,338 (GRCm39)	L185Q	possibly damaging	Het
Mtcl2	T	C	2: 156,872,925 (GRCm39)	Q862R	possibly damaging	Het
Ncam1	A	G	9: 49,418,211 (GRCm39)	S1030P		Het
Pak5	T	C	2: 135,940,219 (GRCm39)	T532A	probably damaging	Het
Pcdhb15	A	G	18: 37,607,389 (GRCm39)	E207G	probably damaging	Het
Pde6h	T	C	6: 136,940,211 (GRCm39)	W66R	probably damaging	Het
Pmaip1	T	C	18: 66,591,885 (GRCm39)		probably null	Het
Prkd3	A	G	17: 79,261,995 (GRCm39)	F774S	probably damaging	Het
Prox1	T	A	1: 189,894,042 (GRCm39)	R134S	possibly damaging	Het
Ptpn22	T	A	3: 103,793,335 (GRCm39)	H495Q	probably damaging	Het
Ptprj	G	T	2: 90,271,126 (GRCm39)	Q1201K	probably benign	Het
Rp1l1	A	G	14: 64,269,447 (GRCm39)	S1678G	probably benign	Het
Sez6l	G	T	5: 112,724,678 (GRCm39)		probably null	Het
Sgcg	T	A	14: 61,477,816 (GRCm39)	Y91F	probably damaging	Het
Skint2	C	T	4: 112,481,415 (GRCm39)	L93F	probably damaging	Het
Slc22a22	A	T	15: 57,126,771 (GRCm39)	D99E	probably benign	Het
Slco3a1	A	G	7: 73,934,090 (GRCm39)	I694T	probably damaging	Het
Smurf2	A	T	11: 106,736,911 (GRCm39)	I305N	possibly damaging	Het
Stac3	T	A	10: 127,340,769 (GRCm39)	V178D	probably benign	Het
Suclg2	G	A	6: 95,543,444 (GRCm39)	A329V	probably damaging	Het
Suclg2	T	A	6: 95,543,441 (GRCm39)	N330I	probably damaging	Het
Tas2r118	C	T	6: 23,969,749 (GRCm39)	C104Y	probably damaging	Het
Tom1l2	T	G	11: 60,135,991 (GRCm39)	E327D	probably benign	Het
Trit1	T	C	4: 122,910,572 (GRCm39)	M57T	possibly damaging	Het
Vav1	G	A	17: 57,603,720 (GRCm39)	S134N	probably benign	Het
Vmn2r82	T	C	10: 79,214,722 (GRCm39)	L235P	probably damaging	Het
Zfp735	T	A	11: 73,602,379 (GRCm39)	V441E	possibly damaging	Het

Other mutations in Nynrin

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Nynrin	APN	14	56,105,905 (GRCm39)	missense	probably benign	0.38
IGL01131:Nynrin	APN	14	56,110,142 (GRCm39)	missense	probably damaging	1.00
IGL01357:Nynrin	APN	14	56,107,874 (GRCm39)	missense	probably benign
IGL01537:Nynrin	APN	14	56,109,502 (GRCm39)	missense	possibly damaging	0.87
IGL01583:Nynrin	APN	14	56,107,968 (GRCm39)	missense	probably damaging	1.00
IGL01726:Nynrin	APN	14	56,101,611 (GRCm39)	missense	probably benign
IGL02161:Nynrin	APN	14	56,101,441 (GRCm39)	missense	probably damaging	1.00
IGL02167:Nynrin	APN	14	56,100,792 (GRCm39)	missense	probably damaging	1.00
IGL02247:Nynrin	APN	14	56,109,167 (GRCm39)	nonsense	probably null
IGL02302:Nynrin	APN	14	56,105,962 (GRCm39)	missense	probably benign	0.43
IGL02524:Nynrin	APN	14	56,108,931 (GRCm39)	missense	possibly damaging	0.73
IGL02600:Nynrin	APN	14	56,101,449 (GRCm39)	missense	probably benign	0.38
IGL02639:Nynrin	APN	14	56,108,112 (GRCm39)	missense	probably damaging	1.00
IGL02654:Nynrin	APN	14	56,100,716 (GRCm39)	missense	possibly damaging	0.95
IGL02659:Nynrin	APN	14	56,103,554 (GRCm39)	unclassified	probably benign
IGL02736:Nynrin	APN	14	56,108,366 (GRCm39)	missense	probably damaging	1.00
IGL02949:Nynrin	APN	14	56,109,837 (GRCm39)	missense	probably damaging	0.99
PIT4458001:Nynrin	UTSW	14	56,101,425 (GRCm39)	missense	probably benign	0.39
R0017:Nynrin	UTSW	14	56,109,852 (GRCm39)	missense	probably damaging	1.00
R0078:Nynrin	UTSW	14	56,100,789 (GRCm39)	missense	probably damaging	1.00
R0211:Nynrin	UTSW	14	56,109,255 (GRCm39)	missense	probably benign	0.08
R0211:Nynrin	UTSW	14	56,109,255 (GRCm39)	missense	probably benign	0.08
R0413:Nynrin	UTSW	14	56,109,648 (GRCm39)	missense	possibly damaging	0.90
R0609:Nynrin	UTSW	14	56,110,218 (GRCm39)	missense	probably damaging	1.00
R0626:Nynrin	UTSW	14	56,105,492 (GRCm39)	missense	probably damaging	1.00
R1205:Nynrin	UTSW	14	56,091,646 (GRCm39)	intron	probably benign
R1222:Nynrin	UTSW	14	56,100,998 (GRCm39)	missense	probably benign	0.02
R1385:Nynrin	UTSW	14	56,102,356 (GRCm39)	missense	probably benign	0.00
R1820:Nynrin	UTSW	14	56,107,835 (GRCm39)	missense	possibly damaging	0.95
R1829:Nynrin	UTSW	14	56,110,404 (GRCm39)	missense	possibly damaging	0.50
R1874:Nynrin	UTSW	14	56,100,950 (GRCm39)	missense	probably benign	0.04
R1927:Nynrin	UTSW	14	56,101,049 (GRCm39)	missense	probably benign	0.00
R2233:Nynrin	UTSW	14	56,109,524 (GRCm39)	missense	possibly damaging	0.83
R3018:Nynrin	UTSW	14	56,100,867 (GRCm39)	missense	probably benign	0.00
R3154:Nynrin	UTSW	14	56,101,044 (GRCm39)	missense	possibly damaging	0.46
R3853:Nynrin	UTSW	14	56,101,562 (GRCm39)	missense	probably benign	0.24
R4648:Nynrin	UTSW	14	56,110,351 (GRCm39)	nonsense	probably null
R4722:Nynrin	UTSW	14	56,091,852 (GRCm39)	missense	probably damaging	0.97
R4735:Nynrin	UTSW	14	56,107,625 (GRCm39)	missense	probably benign	0.03
R4736:Nynrin	UTSW	14	56,101,454 (GRCm39)	missense	probably damaging	1.00
R4780:Nynrin	UTSW	14	56,100,720 (GRCm39)	missense	probably damaging	1.00
R4804:Nynrin	UTSW	14	56,102,326 (GRCm39)	missense	probably benign
R4816:Nynrin	UTSW	14	56,109,458 (GRCm39)	missense	probably damaging	1.00
R5307:Nynrin	UTSW	14	56,101,263 (GRCm39)	missense	probably damaging	1.00
R5372:Nynrin	UTSW	14	56,105,948 (GRCm39)	missense	probably benign	0.01
R5432:Nynrin	UTSW	14	56,101,923 (GRCm39)	missense	possibly damaging	0.80
R5800:Nynrin	UTSW	14	56,108,088 (GRCm39)	missense	probably damaging	1.00
R5825:Nynrin	UTSW	14	56,101,683 (GRCm39)	missense	probably benign	0.00
R6149:Nynrin	UTSW	14	56,091,780 (GRCm39)	missense	possibly damaging	0.83
R6244:Nynrin	UTSW	14	56,105,485 (GRCm39)	missense	probably damaging	1.00
R6350:Nynrin	UTSW	14	56,105,533 (GRCm39)	missense	probably benign	0.19
R6379:Nynrin	UTSW	14	56,107,848 (GRCm39)	missense	probably damaging	1.00
R6437:Nynrin	UTSW	14	56,109,227 (GRCm39)	missense	probably benign	0.00
R6501:Nynrin	UTSW	14	56,100,989 (GRCm39)	missense	probably benign
R6702:Nynrin	UTSW	14	56,101,935 (GRCm39)	missense	possibly damaging	0.80
R6703:Nynrin	UTSW	14	56,101,935 (GRCm39)	missense	possibly damaging	0.80
R6907:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R6908:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R6928:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R6934:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R6935:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R7197:Nynrin	UTSW	14	56,109,380 (GRCm39)	missense	probably benign	0.00
R7204:Nynrin	UTSW	14	56,110,190 (GRCm39)	missense	probably damaging	1.00
R7272:Nynrin	UTSW	14	56,107,872 (GRCm39)	missense	probably damaging	1.00
R7361:Nynrin	UTSW	14	56,107,857 (GRCm39)	missense	possibly damaging	0.71
R7368:Nynrin	UTSW	14	56,107,968 (GRCm39)	missense	probably damaging	1.00
R7443:Nynrin	UTSW	14	56,108,873 (GRCm39)	missense	probably benign	0.18
R7584:Nynrin	UTSW	14	56,109,041 (GRCm39)	missense	probably damaging	1.00
R7677:Nynrin	UTSW	14	56,107,693 (GRCm39)	missense	probably benign
R7723:Nynrin	UTSW	14	56,109,502 (GRCm39)	missense	possibly damaging	0.87
R7776:Nynrin	UTSW	14	56,103,420 (GRCm39)	missense	probably damaging	1.00
R7787:Nynrin	UTSW	14	56,107,980 (GRCm39)	missense	probably benign
R7842:Nynrin	UTSW	14	56,102,553 (GRCm39)	missense	probably damaging	1.00
R7852:Nynrin	UTSW	14	56,108,886 (GRCm39)	missense	probably damaging	0.96
R8040:Nynrin	UTSW	14	56,108,982 (GRCm39)	missense	probably benign	0.01
R8159:Nynrin	UTSW	14	56,102,517 (GRCm39)	missense	probably benign
R8159:Nynrin	UTSW	14	56,100,587 (GRCm39)	missense	probably damaging	0.99
R8258:Nynrin	UTSW	14	56,100,815 (GRCm39)	missense	possibly damaging	0.95
R8259:Nynrin	UTSW	14	56,100,815 (GRCm39)	missense	possibly damaging	0.95
R8343:Nynrin	UTSW	14	56,101,248 (GRCm39)	missense	probably benign
R8504:Nynrin	UTSW	14	56,107,703 (GRCm39)	missense	probably benign	0.01
R8671:Nynrin	UTSW	14	56,107,899 (GRCm39)	missense	possibly damaging	0.52
R8691:Nynrin	UTSW	14	56,110,106 (GRCm39)	missense	probably damaging	1.00
R8777:Nynrin	UTSW	14	56,109,120 (GRCm39)	missense	probably benign
R8777-TAIL:Nynrin	UTSW	14	56,109,120 (GRCm39)	missense	probably benign
R9041:Nynrin	UTSW	14	56,108,753 (GRCm39)	missense	possibly damaging	0.83
R9346:Nynrin	UTSW	14	56,100,495 (GRCm39)	missense	probably benign	0.01
R9366:Nynrin	UTSW	14	56,100,587 (GRCm39)	missense	probably damaging	0.99
R9690:Nynrin	UTSW	14	56,108,204 (GRCm39)	missense	probably benign	0.00
RF007:Nynrin	UTSW	14	56,103,658 (GRCm39)	splice site	probably null

Predicted Primers

PCR Primer
(F):5'- TGGACTTTCTCTAGGGACCAG -3'
(R):5'- TCCAGCTTTAAGGGCAAAGG -3'

Sequencing Primer
(F):5'- CTTTCTCTAGGGACCAGTCTAACAAG -3'
(R):5'- CTTTAAGGGCAAAGGATTCCGTC -3'

Posted On

2019-09-13