Incidental Mutation 'R7336:Agrn'
ID |
569480 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Agrn
|
Ensembl Gene |
ENSMUSG00000041936 |
Gene Name |
agrin |
Synonyms |
Agrin, NMF380, nmf380 |
MMRRC Submission |
045426-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.458)
|
Stock # |
R7336 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
4 |
Chromosomal Location |
156249747-156281945 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
A to T
at 156259371 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Cysteine to Stop codon
at position 828
(C828*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000137931
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071248]
[ENSMUST00000105574]
[ENSMUST00000105575]
[ENSMUST00000180572]
|
AlphaFold |
A2ASQ1 |
Predicted Effect |
probably null
Transcript: ENSMUST00000071248
AA Change: C721*
|
SMART Domains |
Protein: ENSMUSP00000071229 Gene: ENSMUSG00000041936 AA Change: C721*
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1139 |
5.57e-35 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000105574
AA Change: C721*
|
SMART Domains |
Protein: ENSMUSP00000101199 Gene: ENSMUSG00000041936 AA Change: C721*
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1136 |
2.26e-35 |
SMART |
low complexity region
|
1142 |
1169 |
N/A |
INTRINSIC |
low complexity region
|
1183 |
1198 |
N/A |
INTRINSIC |
EGF
|
1214 |
1249 |
1.49e-4 |
SMART |
LamG
|
1274 |
1410 |
4e-45 |
SMART |
EGF
|
1434 |
1468 |
2.23e-3 |
SMART |
EGF
|
1473 |
1507 |
7.13e-2 |
SMART |
LamG
|
1542 |
1678 |
6.51e-36 |
SMART |
EGF
|
1699 |
1735 |
4.35e-6 |
SMART |
LamG
|
1771 |
1907 |
5.01e-37 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000105575
AA Change: C721*
|
SMART Domains |
Protein: ENSMUSP00000101200 Gene: ENSMUSG00000041936 AA Change: C721*
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1136 |
2.26e-35 |
SMART |
low complexity region
|
1142 |
1169 |
N/A |
INTRINSIC |
low complexity region
|
1183 |
1198 |
N/A |
INTRINSIC |
EGF
|
1214 |
1249 |
1.49e-4 |
SMART |
LamG
|
1274 |
1410 |
4e-45 |
SMART |
EGF
|
1434 |
1468 |
2.23e-3 |
SMART |
EGF
|
1473 |
1507 |
7.13e-2 |
SMART |
LamG
|
1542 |
1682 |
9.2e-36 |
SMART |
EGF
|
1703 |
1739 |
4.35e-6 |
SMART |
LamG
|
1794 |
1930 |
5.01e-37 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000180572
AA Change: C828*
|
SMART Domains |
Protein: ENSMUSP00000137931 Gene: ENSMUSG00000041936 AA Change: C828*
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
Pfam:NtA
|
32 |
159 |
5.1e-91 |
PFAM |
FOLN
|
173 |
198 |
8.25e-6 |
SMART |
KAZAL
|
198 |
244 |
1.22e-17 |
SMART |
FOLN
|
249 |
273 |
7.58e-5 |
SMART |
EGF_like
|
249 |
288 |
7.38e1 |
SMART |
KAZAL
|
273 |
319 |
1.51e-13 |
SMART |
KAZAL
|
348 |
391 |
1.8e-6 |
SMART |
KAZAL
|
417 |
463 |
1.55e-10 |
SMART |
FOLN
|
469 |
491 |
8.25e-6 |
SMART |
KAZAL
|
491 |
536 |
1.14e-17 |
SMART |
KAZAL
|
556 |
601 |
6.43e-17 |
SMART |
FOLN
|
603 |
626 |
2.94e-2 |
SMART |
KAZAL
|
614 |
666 |
8.96e-16 |
SMART |
low complexity region
|
672 |
679 |
N/A |
INTRINSIC |
KAZAL
|
706 |
752 |
1.12e-16 |
SMART |
EGF_Lam
|
795 |
846 |
3.29e-15 |
SMART |
EGF_Lam
|
849 |
893 |
6.7e-7 |
SMART |
FOLN
|
902 |
924 |
1.94e-2 |
SMART |
KAZAL
|
924 |
971 |
3.9e-16 |
SMART |
low complexity region
|
996 |
1013 |
N/A |
INTRINSIC |
low complexity region
|
1056 |
1085 |
N/A |
INTRINSIC |
SEA
|
1121 |
1243 |
2.26e-35 |
SMART |
low complexity region
|
1249 |
1276 |
N/A |
INTRINSIC |
low complexity region
|
1290 |
1305 |
N/A |
INTRINSIC |
EGF
|
1321 |
1356 |
1.49e-4 |
SMART |
LamG
|
1381 |
1517 |
4e-45 |
SMART |
EGF
|
1541 |
1575 |
2.23e-3 |
SMART |
EGF
|
1580 |
1614 |
7.13e-2 |
SMART |
LamG
|
1649 |
1785 |
6.51e-36 |
SMART |
EGF
|
1806 |
1842 |
4.35e-6 |
SMART |
LamG
|
1878 |
2014 |
5.01e-37 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
99% (80/81) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] PHENOTYPE: Nullizygous mice display embryonic failure of NMJ formation, inability to breathe or move and perinatal lethality. Homozygotes for an ENU-induced allele show poor hindlimb motor control, myopathy, muscle atrophy, spasms and fiber-type switching, NMJ disaggregation, camptodactyly and premature death. [provided by MGI curators]
|
Allele List at MGI |
All alleles(12) : Targeted, knock-out(4) Targeted, other(1) Gene trapped(7) |
Other mutations in this stock |
Total: 79 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl2fm1 |
G |
A |
3: 59,840,174 (GRCm39) |
|
probably null |
Het |
Abca15 |
A |
T |
7: 119,987,456 (GRCm39) |
Q1247H |
possibly damaging |
Het |
Acsf2 |
G |
C |
11: 94,462,476 (GRCm39) |
Q180E |
probably benign |
Het |
Adamts8 |
A |
G |
9: 30,873,363 (GRCm39) |
D856G |
probably benign |
Het |
Ankub1 |
T |
C |
3: 57,573,108 (GRCm39) |
T205A |
probably benign |
Het |
Atm |
A |
T |
9: 53,373,803 (GRCm39) |
Y2150N |
possibly damaging |
Het |
Barhl1 |
A |
G |
2: 28,799,855 (GRCm39) |
F257L |
probably benign |
Het |
Bcat2 |
T |
A |
7: 45,224,909 (GRCm39) |
C27S |
probably benign |
Het |
Bod1l |
G |
A |
5: 41,978,867 (GRCm39) |
R816C |
probably damaging |
Het |
Btg3 |
A |
G |
16: 78,161,695 (GRCm39) |
Y172H |
probably benign |
Het |
Cacna1d |
T |
C |
14: 29,767,239 (GRCm39) |
D1940G |
probably benign |
Het |
Catsperg2 |
T |
A |
7: 29,406,026 (GRCm39) |
N624I |
possibly damaging |
Het |
Ccdc146 |
A |
G |
5: 21,508,110 (GRCm39) |
V646A |
probably benign |
Het |
Ccp110 |
C |
T |
7: 118,321,433 (GRCm39) |
P363S |
probably damaging |
Het |
Cct4 |
C |
A |
11: 22,951,564 (GRCm39) |
T377K |
possibly damaging |
Het |
Cemip2 |
C |
A |
19: 21,803,509 (GRCm39) |
Y847* |
probably null |
Het |
Cep350 |
T |
A |
1: 155,738,022 (GRCm39) |
H2607L |
probably benign |
Het |
Cfap46 |
A |
G |
7: 139,200,020 (GRCm39) |
F1954L |
unknown |
Het |
Chat |
C |
T |
14: 32,145,213 (GRCm39) |
|
probably null |
Het |
Clasp2 |
A |
G |
9: 113,705,421 (GRCm39) |
|
probably null |
Het |
Cldn9 |
T |
C |
17: 23,901,989 (GRCm39) |
D212G |
probably benign |
Het |
Cp |
G |
A |
3: 20,018,696 (GRCm39) |
|
probably null |
Het |
Cyfip1 |
T |
A |
7: 55,576,148 (GRCm39) |
I1108N |
possibly damaging |
Het |
Dnah14 |
A |
G |
1: 181,625,299 (GRCm39) |
D4060G |
probably damaging |
Het |
Dpyd |
A |
G |
3: 118,858,570 (GRCm39) |
T595A |
probably damaging |
Het |
Eps8 |
G |
A |
6: 137,486,211 (GRCm39) |
R434C |
possibly damaging |
Het |
Fasl |
A |
G |
1: 161,615,557 (GRCm39) |
Y100H |
probably damaging |
Het |
Fkbp9 |
A |
T |
6: 56,826,712 (GRCm39) |
N104I |
probably damaging |
Het |
Frmd4a |
A |
G |
2: 4,478,025 (GRCm39) |
T65A |
possibly damaging |
Het |
Gm1110 |
T |
C |
9: 26,825,653 (GRCm39) |
N102S |
probably damaging |
Het |
Gm2381 |
T |
C |
7: 42,471,804 (GRCm39) |
Q25R |
possibly damaging |
Het |
Gtpbp2 |
A |
G |
17: 46,472,239 (GRCm39) |
Y58C |
probably damaging |
Het |
H2-T3 |
C |
A |
17: 36,498,237 (GRCm39) |
K269N |
probably damaging |
Het |
Icosl |
C |
A |
10: 77,909,707 (GRCm39) |
Y217* |
probably null |
Het |
Il17rd |
G |
T |
14: 26,809,503 (GRCm39) |
R153L |
probably benign |
Het |
Kif17 |
C |
A |
4: 138,025,617 (GRCm39) |
T973K |
possibly damaging |
Het |
Klk1b16 |
A |
G |
7: 43,790,907 (GRCm39) |
I236M |
probably benign |
Het |
Lgmn |
G |
A |
12: 102,389,998 (GRCm39) |
|
probably benign |
Het |
Lmbr1l |
T |
C |
15: 98,811,468 (GRCm39) |
D54G |
possibly damaging |
Het |
Lrrc49 |
A |
T |
9: 60,584,474 (GRCm39) |
I196N |
possibly damaging |
Het |
Maml1 |
C |
T |
11: 50,157,276 (GRCm39) |
A300T |
possibly damaging |
Het |
Mapkap1 |
A |
T |
2: 34,423,829 (GRCm39) |
Q293L |
possibly damaging |
Het |
Mki67 |
T |
C |
7: 135,315,568 (GRCm39) |
T69A |
probably benign |
Het |
Mlph |
G |
A |
1: 90,849,705 (GRCm39) |
|
probably null |
Het |
Myh1 |
A |
T |
11: 67,111,435 (GRCm39) |
M1625L |
probably benign |
Het |
Myh3 |
G |
T |
11: 66,981,847 (GRCm39) |
R781L |
probably benign |
Het |
Nckap5 |
A |
T |
1: 125,953,786 (GRCm39) |
I922K |
probably benign |
Het |
Nlrp5 |
T |
A |
7: 23,117,059 (GRCm39) |
M261K |
probably damaging |
Het |
Or1e1d-ps1 |
G |
A |
11: 73,819,663 (GRCm39) |
M204I |
probably benign |
Het |
Or4f47 |
A |
T |
2: 111,972,514 (GRCm39) |
S75C |
possibly damaging |
Het |
Or5af1 |
T |
A |
11: 58,722,750 (GRCm39) |
Y257N |
probably damaging |
Het |
Or8g52 |
A |
G |
9: 39,630,906 (GRCm39) |
N128D |
probably benign |
Het |
Pak1 |
T |
A |
7: 97,538,179 (GRCm39) |
V262E |
probably benign |
Het |
Pigw |
A |
T |
11: 84,767,930 (GRCm39) |
D466E |
probably damaging |
Het |
Pira2 |
A |
T |
7: 3,847,344 (GRCm39) |
L115Q |
probably damaging |
Het |
Rbm15 |
A |
C |
3: 107,240,432 (GRCm39) |
|
probably benign |
Het |
Rfx1 |
A |
G |
8: 84,800,385 (GRCm39) |
|
probably benign |
Het |
Rfx7 |
A |
G |
9: 72,500,639 (GRCm39) |
Y133C |
probably damaging |
Het |
Serpinb9d |
T |
A |
13: 33,384,702 (GRCm39) |
D226E |
probably benign |
Het |
Sgk3 |
G |
A |
1: 9,954,701 (GRCm39) |
A271T |
possibly damaging |
Het |
Sh2d5 |
T |
A |
4: 137,984,150 (GRCm39) |
C173S |
probably benign |
Het |
Skint8 |
T |
C |
4: 111,796,769 (GRCm39) |
V291A |
probably benign |
Het |
Slc22a27 |
T |
A |
19: 7,904,054 (GRCm39) |
N28Y |
probably benign |
Het |
Slc25a54 |
G |
A |
3: 109,023,751 (GRCm39) |
V449I |
probably benign |
Het |
Slc39a9 |
T |
C |
12: 80,726,316 (GRCm39) |
F255S |
probably damaging |
Het |
Spata31d1c |
C |
T |
13: 65,183,942 (GRCm39) |
H495Y |
probably damaging |
Het |
Stab2 |
G |
A |
10: 86,805,049 (GRCm39) |
Q310* |
probably null |
Het |
Supt16 |
C |
A |
14: 52,408,948 (GRCm39) |
A809S |
possibly damaging |
Het |
Tenm3 |
A |
T |
8: 48,689,212 (GRCm39) |
M2125K |
possibly damaging |
Het |
Tex2 |
G |
A |
11: 106,439,685 (GRCm39) |
T565M |
unknown |
Het |
Tll1 |
G |
A |
8: 64,478,176 (GRCm39) |
A859V |
probably damaging |
Het |
Tmem106c |
C |
T |
15: 97,867,512 (GRCm39) |
T232I |
possibly damaging |
Het |
Trim65 |
T |
G |
11: 116,019,116 (GRCm39) |
D141A |
probably benign |
Het |
Trim80 |
T |
C |
11: 115,332,042 (GRCm39) |
F78S |
probably damaging |
Het |
Txnrd1 |
T |
A |
10: 82,709,051 (GRCm39) |
I83N |
probably benign |
Het |
Vnn3 |
G |
A |
10: 23,727,806 (GRCm39) |
G72D |
probably benign |
Het |
Wasl |
G |
T |
6: 24,619,686 (GRCm39) |
P278Q |
unknown |
Het |
Wdr62 |
A |
T |
7: 29,943,342 (GRCm39) |
L951Q |
probably damaging |
Het |
Zfp760 |
C |
T |
17: 21,942,814 (GRCm39) |
T663I |
unknown |
Het |
|
Other mutations in Agrn |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00479:Agrn
|
APN |
4 |
156,255,029 (GRCm39) |
splice site |
probably benign |
|
IGL00811:Agrn
|
APN |
4 |
156,253,231 (GRCm39) |
missense |
possibly damaging |
0.70 |
IGL01066:Agrn
|
APN |
4 |
156,261,800 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01412:Agrn
|
APN |
4 |
156,255,491 (GRCm39) |
splice site |
probably benign |
|
IGL01414:Agrn
|
APN |
4 |
156,279,696 (GRCm39) |
splice site |
probably null |
|
IGL02075:Agrn
|
APN |
4 |
156,254,667 (GRCm39) |
missense |
probably benign |
0.40 |
IGL02609:Agrn
|
APN |
4 |
156,259,680 (GRCm39) |
splice site |
probably benign |
|
IGL02669:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02671:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02672:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02674:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02724:Agrn
|
APN |
4 |
156,257,264 (GRCm39) |
nonsense |
probably null |
|
IGL02804:Agrn
|
APN |
4 |
156,258,512 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02986:Agrn
|
APN |
4 |
156,263,311 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL03160:Agrn
|
APN |
4 |
156,254,820 (GRCm39) |
missense |
probably damaging |
0.98 |
BB004:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
BB014:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
F6893:Agrn
|
UTSW |
4 |
156,258,636 (GRCm39) |
missense |
probably benign |
|
R0092:Agrn
|
UTSW |
4 |
156,263,410 (GRCm39) |
missense |
probably damaging |
1.00 |
R0100:Agrn
|
UTSW |
4 |
156,259,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R0100:Agrn
|
UTSW |
4 |
156,259,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R0482:Agrn
|
UTSW |
4 |
156,258,012 (GRCm39) |
missense |
probably damaging |
0.98 |
R0531:Agrn
|
UTSW |
4 |
156,263,891 (GRCm39) |
missense |
probably benign |
0.38 |
R0536:Agrn
|
UTSW |
4 |
156,264,010 (GRCm39) |
missense |
probably benign |
0.01 |
R0690:Agrn
|
UTSW |
4 |
156,258,910 (GRCm39) |
missense |
probably damaging |
1.00 |
R0750:Agrn
|
UTSW |
4 |
156,251,394 (GRCm39) |
nonsense |
probably null |
|
R1079:Agrn
|
UTSW |
4 |
156,261,682 (GRCm39) |
missense |
probably damaging |
1.00 |
R1199:Agrn
|
UTSW |
4 |
156,256,756 (GRCm39) |
missense |
probably benign |
0.00 |
R1222:Agrn
|
UTSW |
4 |
156,261,842 (GRCm39) |
missense |
probably damaging |
0.99 |
R1534:Agrn
|
UTSW |
4 |
156,261,141 (GRCm39) |
missense |
probably damaging |
1.00 |
R1587:Agrn
|
UTSW |
4 |
156,263,897 (GRCm39) |
missense |
probably damaging |
0.99 |
R1625:Agrn
|
UTSW |
4 |
156,257,317 (GRCm39) |
missense |
probably damaging |
1.00 |
R1698:Agrn
|
UTSW |
4 |
156,251,015 (GRCm39) |
missense |
probably benign |
0.03 |
R1717:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R1718:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R1721:Agrn
|
UTSW |
4 |
156,259,630 (GRCm39) |
nonsense |
probably null |
|
R1765:Agrn
|
UTSW |
4 |
156,261,284 (GRCm39) |
nonsense |
probably null |
|
R1840:Agrn
|
UTSW |
4 |
156,251,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R1865:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R2105:Agrn
|
UTSW |
4 |
156,261,756 (GRCm39) |
nonsense |
probably null |
|
R2265:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2266:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2269:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2382:Agrn
|
UTSW |
4 |
156,260,973 (GRCm39) |
missense |
probably damaging |
0.97 |
R2497:Agrn
|
UTSW |
4 |
156,258,268 (GRCm39) |
missense |
probably benign |
0.28 |
R2509:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2510:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2511:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2994:Agrn
|
UTSW |
4 |
156,251,785 (GRCm39) |
missense |
possibly damaging |
0.79 |
R3824:Agrn
|
UTSW |
4 |
156,253,759 (GRCm39) |
missense |
probably damaging |
1.00 |
R4736:Agrn
|
UTSW |
4 |
156,256,858 (GRCm39) |
missense |
probably benign |
0.38 |
R4755:Agrn
|
UTSW |
4 |
156,257,979 (GRCm39) |
intron |
probably benign |
|
R4853:Agrn
|
UTSW |
4 |
156,270,007 (GRCm39) |
critical splice donor site |
probably null |
|
R4878:Agrn
|
UTSW |
4 |
156,255,302 (GRCm39) |
missense |
probably damaging |
1.00 |
R5117:Agrn
|
UTSW |
4 |
156,270,010 (GRCm39) |
missense |
probably benign |
0.30 |
R5228:Agrn
|
UTSW |
4 |
156,251,403 (GRCm39) |
missense |
probably damaging |
1.00 |
R5236:Agrn
|
UTSW |
4 |
156,263,315 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5269:Agrn
|
UTSW |
4 |
156,253,447 (GRCm39) |
missense |
probably benign |
0.10 |
R5282:Agrn
|
UTSW |
4 |
156,257,492 (GRCm39) |
missense |
probably damaging |
1.00 |
R5449:Agrn
|
UTSW |
4 |
156,251,737 (GRCm39) |
critical splice donor site |
probably null |
|
R5560:Agrn
|
UTSW |
4 |
156,262,954 (GRCm39) |
missense |
probably damaging |
0.99 |
R5668:Agrn
|
UTSW |
4 |
156,251,770 (GRCm39) |
missense |
probably damaging |
0.97 |
R5725:Agrn
|
UTSW |
4 |
156,258,332 (GRCm39) |
missense |
probably benign |
0.25 |
R5967:Agrn
|
UTSW |
4 |
156,259,560 (GRCm39) |
missense |
probably damaging |
1.00 |
R6226:Agrn
|
UTSW |
4 |
156,258,066 (GRCm39) |
missense |
probably damaging |
0.96 |
R6338:Agrn
|
UTSW |
4 |
156,255,042 (GRCm39) |
missense |
probably benign |
0.17 |
R6351:Agrn
|
UTSW |
4 |
156,263,891 (GRCm39) |
missense |
probably benign |
0.00 |
R6437:Agrn
|
UTSW |
4 |
156,261,235 (GRCm39) |
missense |
probably damaging |
0.96 |
R6490:Agrn
|
UTSW |
4 |
156,251,819 (GRCm39) |
nonsense |
probably null |
|
R6909:Agrn
|
UTSW |
4 |
156,261,464 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7110:Agrn
|
UTSW |
4 |
156,263,332 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7123:Agrn
|
UTSW |
4 |
156,257,297 (GRCm39) |
missense |
probably benign |
|
R7163:Agrn
|
UTSW |
4 |
156,262,966 (GRCm39) |
missense |
probably damaging |
1.00 |
R7180:Agrn
|
UTSW |
4 |
156,256,296 (GRCm39) |
missense |
probably benign |
0.00 |
R7251:Agrn
|
UTSW |
4 |
156,259,063 (GRCm39) |
missense |
probably damaging |
1.00 |
R7289:Agrn
|
UTSW |
4 |
156,263,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R7335:Agrn
|
UTSW |
4 |
156,260,989 (GRCm39) |
missense |
probably damaging |
1.00 |
R7406:Agrn
|
UTSW |
4 |
156,256,758 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7460:Agrn
|
UTSW |
4 |
156,258,881 (GRCm39) |
missense |
probably damaging |
0.98 |
R7531:Agrn
|
UTSW |
4 |
156,254,261 (GRCm39) |
missense |
probably damaging |
1.00 |
R7585:Agrn
|
UTSW |
4 |
156,255,131 (GRCm39) |
missense |
probably benign |
0.08 |
R7646:Agrn
|
UTSW |
4 |
156,279,811 (GRCm39) |
missense |
probably damaging |
0.99 |
R7652:Agrn
|
UTSW |
4 |
156,253,675 (GRCm39) |
critical splice donor site |
probably null |
|
R7714:Agrn
|
UTSW |
4 |
156,279,854 (GRCm39) |
missense |
probably damaging |
1.00 |
R7751:Agrn
|
UTSW |
4 |
156,260,886 (GRCm39) |
missense |
probably damaging |
1.00 |
R7852:Agrn
|
UTSW |
4 |
156,253,514 (GRCm39) |
missense |
probably benign |
0.01 |
R7927:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
R8039:Agrn
|
UTSW |
4 |
156,253,468 (GRCm39) |
missense |
probably benign |
0.12 |
R8056:Agrn
|
UTSW |
4 |
156,254,868 (GRCm39) |
missense |
probably benign |
|
R8061:Agrn
|
UTSW |
4 |
156,263,411 (GRCm39) |
missense |
probably damaging |
1.00 |
R8158:Agrn
|
UTSW |
4 |
156,258,346 (GRCm39) |
missense |
probably benign |
|
R8159:Agrn
|
UTSW |
4 |
156,256,825 (GRCm39) |
missense |
probably benign |
0.27 |
R8325:Agrn
|
UTSW |
4 |
156,258,119 (GRCm39) |
missense |
probably benign |
0.01 |
R8338:Agrn
|
UTSW |
4 |
156,253,018 (GRCm39) |
missense |
probably benign |
0.01 |
R8739:Agrn
|
UTSW |
4 |
156,257,045 (GRCm39) |
missense |
probably benign |
|
R8956:Agrn
|
UTSW |
4 |
156,250,995 (GRCm39) |
missense |
probably damaging |
0.99 |
R9094:Agrn
|
UTSW |
4 |
156,253,264 (GRCm39) |
missense |
probably benign |
0.01 |
R9112:Agrn
|
UTSW |
4 |
156,261,514 (GRCm39) |
missense |
probably damaging |
1.00 |
R9384:Agrn
|
UTSW |
4 |
156,257,106 (GRCm39) |
missense |
probably damaging |
1.00 |
R9472:Agrn
|
UTSW |
4 |
156,254,841 (GRCm39) |
missense |
|
|
R9619:Agrn
|
UTSW |
4 |
156,258,490 (GRCm39) |
missense |
probably benign |
0.00 |
R9629:Agrn
|
UTSW |
4 |
156,257,094 (GRCm39) |
nonsense |
probably null |
|
R9732:Agrn
|
UTSW |
4 |
156,258,446 (GRCm39) |
missense |
probably benign |
0.13 |
R9749:Agrn
|
UTSW |
4 |
156,258,114 (GRCm39) |
missense |
probably benign |
0.02 |
R9757:Agrn
|
UTSW |
4 |
156,261,235 (GRCm39) |
missense |
probably benign |
0.03 |
R9792:Agrn
|
UTSW |
4 |
156,261,129 (GRCm39) |
missense |
probably benign |
0.09 |
R9793:Agrn
|
UTSW |
4 |
156,261,129 (GRCm39) |
missense |
probably benign |
0.09 |
Z1177:Agrn
|
UTSW |
4 |
156,264,033 (GRCm39) |
missense |
possibly damaging |
0.95 |
Z1177:Agrn
|
UTSW |
4 |
156,256,001 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- ACCTGGATACGTTTCCCAAC -3'
(R):5'- AGGACAATGTCACTGCTGC -3'
Sequencing Primer
(F):5'- GGATACGTTTCCCAACCTGCC -3'
(R):5'- TCCCAGTGAGTATTTGAGCCCAG -3'
|
Posted On |
2019-09-13 |