Mutagenetix > Incidental Mutation

Incidental Mutation 'R0639:Il31ra'

56953

Institutional Source

Beutler Lab

Gene Symbol

Il31ra

Ensembl Gene

ENSMUSG00000050377

Gene Name

interleukin 31 receptor A

Synonyms

GLM-R, GPL

MMRRC Submission

038828-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0639 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

112649439-112717266 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 112662377 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 477 (D477E)

Ref Sequence

ENSEMBL: ENSMUSP00000153382 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051756] [ENSMUST00000223752] [ENSMUST00000223819] [ENSMUST00000224510] [ENSMUST00000224576]

AlphaFold

Q8K5B1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000051756
AA Change: D558E

PolyPhen 2 Score 0.917 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000058045
Gene: ENSMUSG00000050377
AA Change: D558E

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
FN3	115	198	7.75e0	SMART
Blast:FN3	216	297	1e-40	BLAST
FN3	325	394	1.15e1	SMART
FN3	408	490	7.18e-3	SMART
low complexity region	508	522	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223577

Predicted Effect

probably benign
Transcript: ENSMUST00000223752

Predicted Effect

possibly damaging
Transcript: ENSMUST00000223819
AA Change: D585E

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224070

Predicted Effect

possibly damaging
Transcript: ENSMUST00000224510
AA Change: D477E

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)

Predicted Effect

probably benign
Transcript: ENSMUST00000224576

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.7%
20x: 95.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous null mice display no apparent abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600014C23Rik	C	T	17: 46,043,999 (GRCm39)	W86*	probably null	Het
Acadl	T	C	1: 66,896,567 (GRCm39)	H75R	probably benign	Het
Adamtsl1	T	C	4: 86,195,380 (GRCm39)	F599S	probably damaging	Het
Adrb3	T	C	8: 27,718,293 (GRCm39)	N52S	probably damaging	Het
Agbl3	T	A	6: 34,776,640 (GRCm39)	L377Q	probably damaging	Het
Akap9	T	C	5: 4,110,318 (GRCm39)	L3007P	probably damaging	Het
Amer3	T	A	1: 34,626,902 (GRCm39)	Y380*	probably null	Het
Ankrd13d	A	T	19: 4,323,047 (GRCm39)		probably null	Het
Ap4m1	T	A	5: 138,174,501 (GRCm39)	C235S	probably benign	Het
Arhgap29	T	C	3: 121,801,290 (GRCm39)	F675S	probably damaging	Het
Asah2	C	A	19: 31,986,039 (GRCm39)	V544F	probably damaging	Het
Ash2l	A	G	8: 26,313,319 (GRCm39)	I389T	possibly damaging	Het
Bend5	T	C	4: 111,290,495 (GRCm39)	S164P	probably benign	Het
Cacna1d	A	G	14: 29,893,251 (GRCm39)		probably null	Het
Cdc25b	A	G	2: 131,039,182 (GRCm39)	N516D	probably benign	Het
Cdc27	A	G	11: 104,422,560 (GRCm39)	Y125H	probably damaging	Het
Cdk5r2	C	T	1: 74,894,995 (GRCm39)	L247F	probably damaging	Het
Cenpf	C	A	1: 189,390,259 (GRCm39)	G1191V	probably benign	Het
Cops4	C	T	5: 100,685,326 (GRCm39)	T293I	possibly damaging	Het
Csmd3	A	G	15: 47,777,336 (GRCm39)	L1294P	probably damaging	Het
Dclre1a	T	C	19: 56,526,872 (GRCm39)	Y848C	probably damaging	Het
Disp2	A	T	2: 118,621,325 (GRCm39)	I686F	possibly damaging	Het
Dnah6	T	A	6: 72,999,395 (GRCm39)	Y4012F	probably benign	Het
Dnajc11	C	G	4: 152,054,393 (GRCm39)	R200G	probably damaging	Het
Dnhd1	A	T	7: 105,345,671 (GRCm39)	D2272V	possibly damaging	Het
Elane	A	C	10: 79,722,183 (GRCm39)	R5S	possibly damaging	Het
Entpd7	G	A	19: 43,679,533 (GRCm39)	V29M	probably benign	Het
Fanca	A	G	8: 124,016,098 (GRCm39)		probably null	Het
Fgl1	G	T	8: 41,644,661 (GRCm39)	T281K	probably benign	Het
Flii	T	C	11: 60,613,823 (GRCm39)		probably null	Het
Foxn1	T	C	11: 78,261,970 (GRCm39)	D133G	possibly damaging	Het
Fzd7	T	A	1: 59,523,719 (GRCm39)	M534K	probably damaging	Het
Galnt5	A	G	2: 57,889,407 (GRCm39)	T336A	probably benign	Het
Gli3	G	A	13: 15,899,300 (GRCm39)	D896N	probably damaging	Het
Gsx1	G	T	5: 147,126,756 (GRCm39)	W193L	probably damaging	Het
Gtpbp3	A	T	8: 71,945,379 (GRCm39)	I485F	probably damaging	Het
H2-M11	A	G	17: 36,858,283 (GRCm39)	T26A	probably benign	Het
Igfbp7	T	C	5: 77,499,827 (GRCm39)	D243G	probably damaging	Het
Inmt	A	C	6: 55,148,212 (GRCm39)	V139G	probably damaging	Het
Inpp5j	T	A	11: 3,451,147 (GRCm39)	M501L	probably benign	Het
Itsn2	T	C	12: 4,762,556 (GRCm39)	F1579L	probably damaging	Het
Kat2b	C	A	17: 53,874,566 (GRCm39)	A70E	probably benign	Het
Klhl20	T	C	1: 160,921,281 (GRCm39)	E58G	probably damaging	Het
Krt79	A	T	15: 101,839,983 (GRCm39)	Y337*	probably null	Het
Krt81	C	A	15: 101,361,508 (GRCm39)	R24L	possibly damaging	Het
Letm1	T	C	5: 33,926,770 (GRCm39)	I176V	possibly damaging	Het
Lingo3	C	A	10: 80,671,618 (GRCm39)	R104L	probably benign	Het
Lrig3	T	G	10: 125,846,090 (GRCm39)	C840G	probably damaging	Het
Lrrc9	A	G	12: 72,533,062 (GRCm39)	N977S	probably damaging	Het
Lrrk2	T	A	15: 91,657,199 (GRCm39)	M1831K	probably benign	Het
Mn1	A	T	5: 111,567,182 (GRCm39)	D384V	probably damaging	Het
Morc3	C	A	16: 93,650,738 (GRCm39)	H319Q	probably damaging	Het
Morn1	T	C	4: 155,173,960 (GRCm39)	F56L	possibly damaging	Het
Mrpl53	G	T	6: 83,086,392 (GRCm39)	V64L	probably damaging	Het
Myo15a	T	A	11: 60,370,162 (GRCm39)	V974D	probably benign	Het
Neb	A	G	2: 52,146,136 (GRCm39)	V2947A	possibly damaging	Het
Nfasc	A	C	1: 132,531,554 (GRCm39)	N737K	probably damaging	Het
Nlk	T	C	11: 78,463,103 (GRCm39)	D464G	possibly damaging	Het
Nlrc4	C	T	17: 74,733,958 (GRCm39)	R985K	probably benign	Het
Nsun6	T	C	2: 15,001,147 (GRCm39)	K470E	probably benign	Het
Nup85	T	G	11: 115,455,357 (GRCm39)	M1R	probably null	Het
Or8b39	G	A	9: 37,996,666 (GRCm39)	C178Y	probably damaging	Het
Otop1	T	C	5: 38,445,292 (GRCm39)	V150A	possibly damaging	Het
Pclo	C	T	5: 14,731,763 (GRCm39)	R296*	probably null	Het
Pdzd2	A	T	15: 12,458,144 (GRCm39)	C240S	possibly damaging	Het
Plekhg5	A	G	4: 152,198,577 (GRCm39)	T922A	probably benign	Het
Plekhm2	A	C	4: 141,369,381 (GRCm39)	L101R	probably damaging	Het
Plscr3	T	A	11: 69,738,820 (GRCm39)	C161S	probably benign	Het
Prr14l	C	T	5: 32,986,259 (GRCm39)	D1079N	probably benign	Het
Ptpru	A	T	4: 131,498,490 (GRCm39)	V1377E	possibly damaging	Het
Rab37	C	A	11: 115,049,528 (GRCm39)	D112E	probably benign	Het
Raet1e	T	A	10: 22,050,274 (GRCm39)	I19N	probably damaging	Het
Rassf5	T	C	1: 131,172,803 (GRCm39)	Y22C	probably damaging	Het
Rp1	T	C	1: 4,416,721 (GRCm39)	T1464A	probably benign	Het
Safb	T	A	17: 56,908,092 (GRCm39)		probably benign	Het
Scarf2	A	G	16: 17,624,369 (GRCm39)		probably null	Het
Scart2	A	G	7: 139,827,872 (GRCm39)	N27D	probably benign	Het
Sh3d19	T	C	3: 86,014,280 (GRCm39)	S415P	probably benign	Het
Slc26a9	T	A	1: 131,691,542 (GRCm39)	L595Q	probably damaging	Het
Slc4a8	T	C	15: 100,694,431 (GRCm39)	Y470H	probably damaging	Het
Slitrk3	T	C	3: 72,956,982 (GRCm39)	N597D	probably benign	Het
Spata31	T	A	13: 65,070,027 (GRCm39)	V725E	probably benign	Het
Spink12	T	A	18: 44,240,831 (GRCm39)	C72*	probably null	Het
Spink5	T	A	18: 44,146,042 (GRCm39)		probably null	Het
Stk40	C	A	4: 126,012,125 (GRCm39)	S9*	probably null	Het
Sypl1	A	T	12: 33,015,420 (GRCm39)	T40S	probably damaging	Het
Tbc1d8	C	T	1: 39,430,290 (GRCm39)	E438K	probably benign	Het
Tdrd7	A	G	4: 45,989,102 (GRCm39)	T111A	probably benign	Het
Tg	A	T	15: 66,613,333 (GRCm39)		probably null	Het
Tlr5	T	A	1: 182,801,454 (GRCm39)	W253R	probably damaging	Het
Tmprss11c	C	T	5: 86,383,328 (GRCm39)	C353Y	probably damaging	Het
Tnfrsf8	T	A	4: 145,014,597 (GRCm39)	M271L	probably benign	Het
Toe1	T	C	4: 116,663,947 (GRCm39)	N21S	probably benign	Het
Tpp2	T	C	1: 44,014,607 (GRCm39)	F649L	probably benign	Het
Ttll1	G	A	15: 83,386,426 (GRCm39)	Q60*	probably null	Het
Vcp	C	T	4: 42,982,565 (GRCm39)	R709Q	probably benign	Het
Vmn1r119	T	A	7: 20,745,593 (GRCm39)	H263L	possibly damaging	Het
Vmn1r195	C	A	13: 22,463,111 (GRCm39)	Q194K	probably damaging	Het
Vmn1r33	T	C	6: 66,588,783 (GRCm39)	Y257C	probably damaging	Het
Vmn2r15	A	G	5: 109,440,881 (GRCm39)	F326L	probably benign	Het
Wbp11	A	T	6: 136,793,108 (GRCm39)		probably benign	Het
Wwp2	T	G	8: 108,244,578 (GRCm39)	V250G	probably benign	Het
Xpnpep3	T	C	15: 81,315,038 (GRCm39)	V246A	probably benign	Het
Zcchc14	G	A	8: 122,332,188 (GRCm39)	R419*	probably null	Het

Other mutations in Il31ra

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00095:Il31ra	APN	13	112,684,012 (GRCm39)	missense	possibly damaging	0.94
IGL00639:Il31ra	APN	13	112,686,093 (GRCm39)	nonsense	probably null
IGL01640:Il31ra	APN	13	112,668,292 (GRCm39)	missense	possibly damaging	0.58
IGL02009:Il31ra	APN	13	112,670,401 (GRCm39)	missense	probably damaging	0.98
IGL02431:Il31ra	APN	13	112,666,830 (GRCm39)	missense	probably damaging	1.00
IGL02675:Il31ra	APN	13	112,660,886 (GRCm39)	missense	probably benign	0.00
IGL02718:Il31ra	APN	13	112,666,903 (GRCm39)	nonsense	probably null
IGL03388:Il31ra	APN	13	112,682,746 (GRCm39)	missense	probably damaging	1.00
IGL03408:Il31ra	APN	13	112,662,422 (GRCm39)	missense	probably benign	0.21
R0482:Il31ra	UTSW	13	112,664,015 (GRCm39)	missense	possibly damaging	0.89
R0905:Il31ra	UTSW	13	112,668,207 (GRCm39)	missense	probably damaging	1.00
R0948:Il31ra	UTSW	13	112,666,912 (GRCm39)	missense	possibly damaging	0.81
R1420:Il31ra	UTSW	13	112,668,286 (GRCm39)	missense	probably damaging	1.00
R1538:Il31ra	UTSW	13	112,684,000 (GRCm39)	missense	possibly damaging	0.91
R1776:Il31ra	UTSW	13	112,677,773 (GRCm39)	missense	probably damaging	0.97
R1931:Il31ra	UTSW	13	112,677,756 (GRCm39)	missense	probably damaging	1.00
R2006:Il31ra	UTSW	13	112,666,890 (GRCm39)	missense	probably damaging	1.00
R2134:Il31ra	UTSW	13	112,680,422 (GRCm39)	missense	possibly damaging	0.94
R3103:Il31ra	UTSW	13	112,666,885 (GRCm39)	missense	probably damaging	1.00
R4089:Il31ra	UTSW	13	112,688,453 (GRCm39)	nonsense	probably null
R4742:Il31ra	UTSW	13	112,660,501 (GRCm39)	nonsense	probably null
R4787:Il31ra	UTSW	13	112,664,079 (GRCm39)	missense	possibly damaging	0.82
R5154:Il31ra	UTSW	13	112,660,531 (GRCm39)	missense	possibly damaging	0.87
R5193:Il31ra	UTSW	13	112,660,864 (GRCm39)	missense	probably benign	0.34
R5402:Il31ra	UTSW	13	112,660,669 (GRCm39)	missense	probably benign	0.01
R5743:Il31ra	UTSW	13	112,664,021 (GRCm39)	missense	possibly damaging	0.89
R5917:Il31ra	UTSW	13	112,682,846 (GRCm39)	missense	probably benign
R6126:Il31ra	UTSW	13	112,666,908 (GRCm39)	missense	probably damaging	1.00
R6414:Il31ra	UTSW	13	112,660,441 (GRCm39)	missense	possibly damaging	0.90
R6580:Il31ra	UTSW	13	112,688,476 (GRCm39)	missense	possibly damaging	0.90
R6727:Il31ra	UTSW	13	112,683,902 (GRCm39)	missense	probably damaging	1.00
R6783:Il31ra	UTSW	13	112,688,522 (GRCm39)	critical splice acceptor site	probably null
R6912:Il31ra	UTSW	13	112,685,998 (GRCm39)	missense	probably damaging	0.99
R6925:Il31ra	UTSW	13	112,664,063 (GRCm39)	missense	possibly damaging	0.56
R7187:Il31ra	UTSW	13	112,682,845 (GRCm39)	missense	probably benign	0.04
R7210:Il31ra	UTSW	13	112,686,034 (GRCm39)	missense	possibly damaging	0.95
R7236:Il31ra	UTSW	13	112,660,439 (GRCm39)	makesense	probably null
R7323:Il31ra	UTSW	13	112,688,497 (GRCm39)	missense	probably damaging	1.00
R7618:Il31ra	UTSW	13	112,688,514 (GRCm39)	missense	possibly damaging	0.66
R7783:Il31ra	UTSW	13	112,677,785 (GRCm39)	missense	probably benign
R8353:Il31ra	UTSW	13	112,660,717 (GRCm39)	missense	probably damaging	1.00
R8453:Il31ra	UTSW	13	112,660,717 (GRCm39)	missense	probably damaging	1.00
R8679:Il31ra	UTSW	13	112,662,372 (GRCm39)	missense	possibly damaging	0.81
R8890:Il31ra	UTSW	13	112,660,861 (GRCm39)	missense	possibly damaging	0.95
R9032:Il31ra	UTSW	13	112,660,628 (GRCm39)	missense
R9077:Il31ra	UTSW	13	112,670,361 (GRCm39)	missense	probably benign	0.00
R9085:Il31ra	UTSW	13	112,660,628 (GRCm39)	missense
R9147:Il31ra	UTSW	13	112,670,276 (GRCm39)	missense	probably benign	0.01
R9148:Il31ra	UTSW	13	112,670,276 (GRCm39)	missense	probably benign	0.01
R9158:Il31ra	UTSW	13	112,670,394 (GRCm39)	nonsense	probably null
R9178:Il31ra	UTSW	13	112,677,780 (GRCm39)	missense	probably damaging	1.00
R9250:Il31ra	UTSW	13	112,669,508 (GRCm39)	missense	probably damaging	1.00
R9260:Il31ra	UTSW	13	112,668,202 (GRCm39)	missense	probably damaging	0.98
R9312:Il31ra	UTSW	13	112,686,023 (GRCm39)	missense	probably benign	0.01
R9381:Il31ra	UTSW	13	112,668,253 (GRCm39)	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- CTCCCCATCAGAAAGCCAATCTGTG -3'
(R):5'- TGGTTGCCTTTAATAAACCCTGCCC -3'

Sequencing Primer
(F):5'- TTCCAGTCCAGAGTGCAAGTC -3'
(R):5'- CTTAGCTCAGCCACACATTATG -3'

Posted On

2013-07-11